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WO2003034028A3 - Methodes d'identification et d'utilisation de modulateurs du recepteur gamma dependant des oestrogenes - Google Patents

Methodes d'identification et d'utilisation de modulateurs du recepteur gamma dependant des oestrogenes Download PDF

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Publication number
WO2003034028A3
WO2003034028A3 PCT/US2002/032917 US0232917W WO03034028A3 WO 2003034028 A3 WO2003034028 A3 WO 2003034028A3 US 0232917 W US0232917 W US 0232917W WO 03034028 A3 WO03034028 A3 WO 03034028A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
identifying
modulators
receptor gamma
related receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/032917
Other languages
English (en)
Other versions
WO2003034028A2 (fr
Inventor
Steven G Blanchard
Aaron Bayne Miller
Lisa A Orband-Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Priority to AU2002342058A priority Critical patent/AU2002342058A1/en
Priority to US10/491,677 priority patent/US20050074765A1/en
Priority to JP2003536715A priority patent/JP2005509628A/ja
Priority to EP02776223A priority patent/EP1436395A4/fr
Publication of WO2003034028A2 publication Critical patent/WO2003034028A2/fr
Publication of WO2003034028A3 publication Critical patent/WO2003034028A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/362—Menopause

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des méthodes d'identification de composés qui interagissent avec le récepteur gamma dépendant des oestrogènes (RGDO) et qui sont utiles dans le traitement des maladies induites par RGDO et par les récepteurs des oestrogènes (RO), des facteurs de risque et des affections. Cette invention se rapporte également à des compositions pharmaceutiques contenant des composés qui interagissent directement avec RGDO et des méthodes d'utilisation de ces compositions dans le traitement des maladies induites par RGDO et RO, des facteurs de risque et des affections.
PCT/US2002/032917 2001-10-16 2002-10-16 Methodes d'identification et d'utilisation de modulateurs du recepteur gamma dependant des oestrogenes Ceased WO2003034028A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002342058A AU2002342058A1 (en) 2001-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma
US10/491,677 US20050074765A1 (en) 2002-10-16 2002-10-16 Methods for identifying and using modulators of estrogen related receptor gamma
JP2003536715A JP2005509628A (ja) 2001-10-16 2002-10-16 エストロゲン関連受容体γのモジュレーターの特定方法および使用方法
EP02776223A EP1436395A4 (fr) 2001-10-16 2002-10-16 Methodes d'identification et d'utilisation de modulateurs du recepteur gamma dependant des oestrogenes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32988801P 2001-10-16 2001-10-16
US60/329,888 2001-10-16

Publications (2)

Publication Number Publication Date
WO2003034028A2 WO2003034028A2 (fr) 2003-04-24
WO2003034028A3 true WO2003034028A3 (fr) 2004-02-19

Family

ID=23287445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032917 Ceased WO2003034028A2 (fr) 2001-10-16 2002-10-16 Methodes d'identification et d'utilisation de modulateurs du recepteur gamma dependant des oestrogenes

Country Status (4)

Country Link
EP (1) EP1436395A4 (fr)
JP (1) JP2005509628A (fr)
AU (1) AU2002342058A1 (fr)
WO (1) WO2003034028A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655756B2 (en) 2005-05-27 2010-02-02 Johnson & Johnson Pharmaceutical Research & Development, Llc Crystallized structure of estrogen related receptor gamma in complex with bisphenol A
KR101631581B1 (ko) * 2010-06-11 2016-06-17 한국생명공학연구원 나노입자가 융합된 ｆｒｅｔ 센서 및 이를 이용한 파이토에스트로겐을 고감도로 검출하는 방법
KR101579008B1 (ko) * 2013-09-25 2015-12-22 경북대학교 산학협력단 ERR-γ 저해제를 포함하는, 망막병증의 예방 또는 치료용 약학적 조성물 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096301A (en) * 1986-10-10 2000-08-01 Industria Farmaceutica Serono Spa Combined interferon/antiestrogen therapy for treatment of breast cancer
US6218128B1 (en) * 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096301A (en) * 1986-10-10 2000-08-01 Industria Farmaceutica Serono Spa Combined interferon/antiestrogen therapy for treatment of breast cancer
US6218128B1 (en) * 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COWARD P. ET AL.: "4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 15, 17 July 2001 (2001-07-17), pages 8880 - 8884, XP002971442 *
ROLLEROVA E. ET AL.: "Intracellular estrogen receptors, their characterization and function", ENDOCR. REGUL., vol. 34, 2000, pages 203 - 218, XP002971443 *
See also references of EP1436395A4 *

Also Published As

Publication number Publication date
EP1436395A4 (fr) 2006-12-13
AU2002342058A1 (en) 2003-04-28
JP2005509628A (ja) 2005-04-14
WO2003034028A2 (fr) 2003-04-24
EP1436395A2 (fr) 2004-07-14

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