WO2003018572A1 - 3-(n-alkoxycarbonyl-n-methyl)amino-1-alkoxycarbonyl- oxy-(2-thienyl)propanes and process for preparing 3-(n- methylamino)-1-(2-thienyl)-propan-1-ol with the same - Google Patents
3-(n-alkoxycarbonyl-n-methyl)amino-1-alkoxycarbonyl- oxy-(2-thienyl)propanes and process for preparing 3-(n- methylamino)-1-(2-thienyl)-propan-1-ol with the same Download PDFInfo
- Publication number
- WO2003018572A1 WO2003018572A1 PCT/JP2002/008588 JP0208588W WO03018572A1 WO 2003018572 A1 WO2003018572 A1 WO 2003018572A1 JP 0208588 W JP0208588 W JP 0208588W WO 03018572 A1 WO03018572 A1 WO 03018572A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thienyl
- alkoxycarbonyl
- propan
- propanes
- methylamino
- Prior art date
Links
- YEJVVFOJMOHFRL-UHFFFAOYSA-N 3-(methylamino)-1-thiophen-2-ylpropan-1-ol Chemical compound CNCCC(O)C1=CC=CS1 YEJVVFOJMOHFRL-UHFFFAOYSA-N 0.000 title abstract 2
- 235000013849 propane Nutrition 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- XWCNSHMHUZCRLN-UHFFFAOYSA-N 3-(dimethylamino)-1-thiophen-2-ylpropan-1-ol Chemical compound CN(C)CCC(O)C1=CC=CS1 XWCNSHMHUZCRLN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001256621A JP2005053781A (ja) | 2001-08-27 | 2001-08-27 | 光学活性な３−（ｎ−メチルアミノ）−１−（２−チエニル）−プロパン−１−オールの製造方法 |
| JP2001-256621 | 2001-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003018572A1 true WO2003018572A1 (en) | 2003-03-06 |
Family
ID=19084413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2002/008588 WO2003018572A1 (en) | 2001-08-27 | 2002-08-26 | 3-(n-alkoxycarbonyl-n-methyl)amino-1-alkoxycarbonyl- oxy-(2-thienyl)propanes and process for preparing 3-(n- methylamino)-1-(2-thienyl)-propan-1-ol with the same |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2005053781A (ja) |
| WO (1) | WO2003018572A1 (ja) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097632A1 (fr) * | 2002-05-20 | 2003-11-27 | Mitsubishi Rayon Co., Ltd. | Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine |
| WO2008004191A2 (en) | 2006-07-03 | 2008-01-10 | Ranbaxy Laboratories Limited | Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine |
| CN105061393A (zh) * | 2015-08-07 | 2015-11-18 | 浙江华义医药有限公司 | (s)-(-)-3-甲氨基-1-(2-噻吩基)-1-丙醇的合成方法 |
| CN109535123A (zh) * | 2018-12-28 | 2019-03-29 | 凯瑞斯德生化(苏州)有限公司 | 一种(s)-3-甲氨基-1-(2-噻吩基)-1-丙醇的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0650965A1 (en) * | 1993-10-12 | 1995-05-03 | Eli Lilly And Company | Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine |
-
2001
- 2001-08-27 JP JP2001256621A patent/JP2005053781A/ja active Pending
-
2002
- 2002-08-26 WO PCT/JP2002/008588 patent/WO2003018572A1/ja active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0650965A1 (en) * | 1993-10-12 | 1995-05-03 | Eli Lilly And Company | Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine |
Non-Patent Citations (2)
| Title |
|---|
| LIU H., CHIRALITY, vol. 12, no. 1, 2000, pages 26 - 29, XP009000316 * |
| WHEELER W.J., J. LABELLED COMP. RADIOPHARM., vol. 36, no. 3, 1995, pages 213 - 223, XP009000253 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097632A1 (fr) * | 2002-05-20 | 2003-11-27 | Mitsubishi Rayon Co., Ltd. | Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine |
| WO2008004191A2 (en) | 2006-07-03 | 2008-01-10 | Ranbaxy Laboratories Limited | Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine |
| CN105061393A (zh) * | 2015-08-07 | 2015-11-18 | 浙江华义医药有限公司 | (s)-(-)-3-甲氨基-1-(2-噻吩基)-1-丙醇的合成方法 |
| CN109535123A (zh) * | 2018-12-28 | 2019-03-29 | 凯瑞斯德生化(苏州)有限公司 | 一种(s)-3-甲氨基-1-(2-噻吩基)-1-丙醇的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005053781A (ja) | 2005-03-03 |
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