[go: up one dir, main page]

WO2003014699A3 - Compositions et methodes pour detecter et quantifier l'activite de la cox-2 par le metabolisme d'acides lipoamines - Google Patents

Compositions et methodes pour detecter et quantifier l'activite de la cox-2 par le metabolisme d'acides lipoamines Download PDF

Info

Publication number
WO2003014699A3
WO2003014699A3 PCT/US2002/024864 US0224864W WO03014699A3 WO 2003014699 A3 WO2003014699 A3 WO 2003014699A3 US 0224864 W US0224864 W US 0224864W WO 03014699 A3 WO03014699 A3 WO 03014699A3
Authority
WO
WIPO (PCT)
Prior art keywords
activity
detecting
cox
metabolite
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/024864
Other languages
English (en)
Other versions
WO2003014699A8 (fr
WO2003014699A2 (fr
Inventor
Lawrence J Marnett
Jeffery J Prusakiewicz
Kevin R Kozak
Philip J Kingsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/924,082 external-priority patent/US20020106707A1/en
Application filed by Vanderbilt University filed Critical Vanderbilt University
Priority to AU2002355549A priority Critical patent/AU2002355549A1/en
Publication of WO2003014699A2 publication Critical patent/WO2003014699A2/fr
Publication of WO2003014699A8 publication Critical patent/WO2003014699A8/fr
Anticipated expiration legal-status Critical
Publication of WO2003014699A3 publication Critical patent/WO2003014699A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une méthode pour détecter une activité d'une enzyme, la COX-2, chez un sujet, ladite méthode consistant à : prélever un échantillon chez le sujet ; détecter la présence d'un métabolite d'eicosanoïdes d'acides aminés dans l'échantillon, la présence d'un tel métabolite indiquant l'activité de la COX-2 du sujet. De préférence, le métabolite d'eicosanoïdes d'acides aminés est un métabolite de PGH2-Gly ou HETE-Gly. Ce métabolite peut être détecté sur la base du métabolisme d'un substrat sélectif de la COX-2. De préférence, ce substrat est un acide lipoaminé. Mieux encore, l'acide lipoaminé est sélectionné parmi la NAGly, la N-arachidonyl-alanine, et l'acide δ-arachidonyl-aminobutuyique.
PCT/US2002/024864 2001-08-07 2002-08-06 Compositions et methodes pour detecter et quantifier l'activite de la cox-2 par le metabolisme d'acides lipoamines Ceased WO2003014699A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002355549A AU2002355549A1 (en) 2002-08-06 2002-08-06 Compositions and methods for detecting and quantifying cox-2 activity by lipoamino acid metabolism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/924,082 US20020106707A1 (en) 2000-08-07 2001-08-07 Compositions and methods for detecting and quantifying COX-2 activity and anandamide metabolites
US09/923,637 2001-08-07
US09/924,082 2001-08-07
US09/923,637 US7189504B2 (en) 2000-08-07 2001-08-07 Compositions and methods for detecting and quantifying COX-2 activity and 2-arachidonylglycerol metabolites

Publications (3)

Publication Number Publication Date
WO2003014699A2 WO2003014699A2 (fr) 2003-02-20
WO2003014699A8 WO2003014699A8 (fr) 2003-08-21
WO2003014699A3 true WO2003014699A3 (fr) 2005-03-31

Family

ID=27129873

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024864 Ceased WO2003014699A2 (fr) 2001-08-07 2002-08-06 Compositions et methodes pour detecter et quantifier l'activite de la cox-2 par le metabolisme d'acides lipoamines

Country Status (1)

Country Link
WO (1) WO2003014699A2 (fr)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CROMLISH, W.A. ET AL.: "High-Level expression of Active Human cyclooxygenase-2 in Insect Cells", ARCH.BIOCHEM.BIOPHYS, vol. 314, no. 1, October 1994 (1994-10-01), pages 193 - 199, XP002984878 *
MITCHELL, J.A. ET AL.: "Induction of Cyclo-Oxygenase-2 by Cytokines in Human Pulmanry Epithelial Cells: Regulation by Dexamethasone", BR.J.PHARMACOL, vol. 113, no. 3, November 1994 (1994-11-01), pages 1008 - 1114, XP008044617 *
SHAPPELL, S.B. ET AL.: "Alterations in Lipoxygenase and Cyclooxygenase-2 Catalytic Activity and mRNA Expression in Prostate Carcinoma", NEOPLASIA, vol. 3, no. 4, July 2001 (2001-07-01) - August 2001 (2001-08-01), pages 287 - 303, XP008044620 *

Also Published As

Publication number Publication date
WO2003014699A8 (fr) 2003-08-21
WO2003014699A2 (fr) 2003-02-20

Similar Documents

Publication Publication Date Title
WO2002066671A3 (fr) Procede perfectionne de detection de l'atp
WO2006026601A3 (fr) Dosage immunologique enzymatique homogene pour un fluide buccal
WO2002097415A3 (fr) Instruments d'analyse, biocapteurs et methodes associees
WO2008060694A3 (fr) Système et/ou procédé pour déterminer le caractère suffisant de mesures de pseudo-distances
WO2003062462A3 (fr) Methode permettant d'isoler des acides nucleiques et des proteines contenus dans un echantillon unique
GB2433134A (en) Fault detection system and method based on weighted principal component analysis
WO2003009100A3 (fr) Methodes, appareil et programmes informatiques de verification de l'integrite d'une sonde
WO2002008461A3 (fr) Methodes d'analyse et d'identification de genes transcrits et empreinte genetique
WO2004000884A3 (fr) Compositions et methodes pour le dosage de l'apo b48 et de l'apo b100
WO2000075363A3 (fr) Mesure enzymatique de l'acide mycophenolique
WO2005070086A3 (fr) Procedes et compositions pour la determination de phenotype a tolerance vis-a-vis du greffon chez un sujet
WO2004038412A3 (fr) Methode de detection d'une halitose
WO2006025983A3 (fr) Conjugues a substrat marque pour identifier des inhibiteurs d'enzyme
WO2005050203A3 (fr) Materiaux biologiques et utilisations correspondantes
WO2003014699A8 (fr) Compositions et methodes pour detecter et quantifier l'activite de la cox-2 par le metabolisme d'acides lipoamines
WO2007044422A3 (fr) Systeme et procede automatise permettant de distinguer des signaux audio reçus en reponse a un appel sortant
WO2004005888A3 (fr) Procede d'analyse et de speciation de metal et biocapteur pour executer le procede
EP1489411A4 (fr) Technique de dosage de coenzymes dans un echantillon biologique
WO2005029038A3 (fr) Detection d'ions de potassium au moyen d'enzymes sensibles aux ions
WO2007033469A3 (fr) Dosage oxydase du galactose-reactif de schiff en phase liquide
WO2007020632A3 (fr) Procedes et compositions permettant de determiner le niveau de la paraoxonase du serum active sur le plan biologique
WO2000020629A3 (fr) Quantification d'arn
AU2002250200A1 (en) Method for the detection and quantification of the fungus stachybotrys chartarum using quantitative pcr
WO2001092574A3 (fr) Methodes permettant de detecter une activite enzymatique ou une resistance a des inhibiteurs d'enzymes
WO2002010439A3 (fr) Substrats macromoleculaires pour enzymes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WPC Withdrawal of priority claims after completion of the technical preparations for international publication

Ref country code: WO

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 08/2003 UNDER (72) REPLACE "KOZACK, KEVIN, R." BY "KOZAK, KEVIN, R."

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP