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WO2003011828A3 - 3-pyridylether rerivatives and their use as analgesics - Google Patents

3-pyridylether rerivatives and their use as analgesics Download PDF

Info

Publication number
WO2003011828A3
WO2003011828A3 PCT/US2002/023686 US0223686W WO03011828A3 WO 2003011828 A3 WO2003011828 A3 WO 2003011828A3 US 0223686 W US0223686 W US 0223686W WO 03011828 A3 WO03011828 A3 WO 03011828A3
Authority
WO
WIPO (PCT)
Prior art keywords
attached
salt
integer
nitrogen
heterocyclic ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/023686
Other languages
French (fr)
Other versions
WO2003011828A2 (en
Inventor
Richard A Glennon
Billy R Martin
Malgozata Dukat
Imad M Damaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Priority to AU2002327340A priority Critical patent/AU2002327340A1/en
Publication of WO2003011828A2 publication Critical patent/WO2003011828A2/en
Publication of WO2003011828A3 publication Critical patent/WO2003011828A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A salt of general formula (I) wherein R?1, R2 and R3¿ are independently selected from the group consisting of C¿1-6? alkyl groups or any two or three of R?1, R2 and R3¿ may, together with the nitrogen to which they are attached, form a heterocyclic ring. R4 is a selected from the group of moieties which are effective to alter the solubility of the compound in physiological fluids and pharmaceutical carries, n is an integer of 0 to 5, A is selected from hydrogen or may, with the carbon to which it is attached and with any one of R?1, R2 and R3¿ and the nitrogen to which they are attached, form a heterocyclic ring X is a negatively charged counterion and p is the number of negative charges thereon, the number of molecules of the positively charged tertiary amino ion being equal to the integer p in any given salt. Preferably the salt is of formula (II) below.
PCT/US2002/023686 2001-07-31 2002-07-25 3-pyridylether rerivatives and their use as analgesics Ceased WO2003011828A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002327340A AU2002327340A1 (en) 2001-07-31 2002-07-25 3-pyridylether rerivatives and their use as analgesics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30855701P 2001-07-31 2001-07-31
US60/308,557 2001-07-31

Publications (2)

Publication Number Publication Date
WO2003011828A2 WO2003011828A2 (en) 2003-02-13
WO2003011828A3 true WO2003011828A3 (en) 2003-10-16

Family

ID=23194447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023686 Ceased WO2003011828A2 (en) 2001-07-31 2002-07-25 3-pyridylether rerivatives and their use as analgesics

Country Status (2)

Country Link
AU (1) AU2002327340A1 (en)
WO (1) WO2003011828A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040682A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories 3-pyridyloxyalkyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040682A1 (en) * 1995-06-07 1996-12-19 Abbott Laboratories 3-pyridyloxyalkyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABREO M A ET AL: "NOVEL 3-PYRIDYL ETHERS WITH SUBNANOMOLAR AFFINITY FOR CENTRAL NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, 1996, pages 817 - 825, XP002931256, ISSN: 0022-2623 *
HOLLADAY ET AL: "Neuronal Nicotinic Acetylcholine Receptros as Targets for Drug Discovery", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 26, 19 December 1997 (1997-12-19), pages 4169 - 4194, XP002124847, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
AU2002327340A1 (en) 2003-02-17
WO2003011828A2 (en) 2003-02-13

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