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WO2003014089A8 - Aminotetrahydroisoquinoline derivatives as analgesics - Google Patents

Aminotetrahydroisoquinoline derivatives as analgesics

Info

Publication number
WO2003014089A8
WO2003014089A8 PCT/US2002/023698 US0223698W WO03014089A8 WO 2003014089 A8 WO2003014089 A8 WO 2003014089A8 US 0223698 W US0223698 W US 0223698W WO 03014089 A8 WO03014089 A8 WO 03014089A8
Authority
WO
WIPO (PCT)
Prior art keywords
independently selected
group
prodrugs
hydrogen
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/023698
Other languages
French (fr)
Other versions
WO2003014089A1 (en
Inventor
Richard A Glennon
Billy R Martin
Malgozata Dukat
Imad M Damaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Publication of WO2003014089A1 publication Critical patent/WO2003014089A1/en
Anticipated expiration legal-status Critical
Publication of WO2003014089A8 publication Critical patent/WO2003014089A8/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tetrahydroisoquinolines are provided having a secondary, tertiary or quaternary amino group spaced by three carbon atoms from the ring nitrogen, and pharmaceutically acceptable salts and prodrugs thereof. Preferred compounds are of Formula (I), wherein R?1, R2 and R5¿ are independently selected from the group consisting of hydrogen, C¿1-6? alkyl and a moiety wherein any two of R?1, R2 and R5¿, together with the nitrogen to which they are attached, form a heterocyclic ring of 2 to 5 carbons, provided that R?1 and R2, and R5¿ when present, are not each hydrogen, R?3 and R4¿ are independently selected from the group of moieties which are effective to alter the solubility of the compound in physiological fluids or pharmaceutical carriers n and m are independently selected from integers of 0 to 3 and 0 to 4 respectively, p is an integer 0 or 1 and pharmaceutically acceptable salts and prodrugs thereof.
PCT/US2002/023698 2001-07-31 2002-07-25 Aminotetrahydroisoquinoline derivatives as analgesics Ceased WO2003014089A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30857801P 2001-07-31 2001-07-31
US60/308,578 2001-07-31

Publications (2)

Publication Number Publication Date
WO2003014089A1 WO2003014089A1 (en) 2003-02-20
WO2003014089A8 true WO2003014089A8 (en) 2004-05-27

Family

ID=23194528

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023698 Ceased WO2003014089A1 (en) 2001-07-31 2002-07-25 Aminotetrahydroisoquinoline derivatives as analgesics

Country Status (1)

Country Link
WO (1) WO2003014089A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10035997A1 (en) * 2000-07-25 2002-02-07 Boehringer Ingelheim Pharma Use of fused dihydropyridines for the manufacture of agents for the treatment of chronic pain

Also Published As

Publication number Publication date
WO2003014089A1 (en) 2003-02-20

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