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WO2003008081A1 - Elements encastres dans un dispositif pour le revetement de produits en morceaux - Google Patents

Elements encastres dans un dispositif pour le revetement de produits en morceaux Download PDF

Info

Publication number
WO2003008081A1
WO2003008081A1 PCT/EP2002/006236 EP0206236W WO03008081A1 WO 2003008081 A1 WO2003008081 A1 WO 2003008081A1 EP 0206236 W EP0206236 W EP 0206236W WO 03008081 A1 WO03008081 A1 WO 03008081A1
Authority
WO
WIPO (PCT)
Prior art keywords
drum
internals
products
height
mix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/006236
Other languages
German (de)
English (en)
Inventor
Armin Schweiger
Siegfried Bartetzko
Eimer Vollers
Thomas Lichtenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Healthcare AG filed Critical Bayer AG
Publication of WO2003008081A1 publication Critical patent/WO2003008081A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
    • A23G3/20—Apparatus for coating or filling sweetmeats or confectionery
    • A23G3/26—Apparatus for coating by tumbling with a liquid or powder, spraying device-associated, drum, rotating pan
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/12—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating drums

Definitions

  • the invention relates to installations in a device for painting lumpy products, in particular solid dosage forms (e.g. coated tablets, tablets or
  • drum coaters Conventional devices for painting lumpy products, also called drum coaters, comprise a rotatably mounted drum with means for blowing air into the interior of the drum and means for extracting air from the interior of the drum.
  • nozzles In the interior of the drum there are nozzles that spray the mix (e.g. solid dosage forms). Often these nozzles are arranged in the axis of rotation of the drum and spray radially outwards.
  • Such a device is disclosed for example in EP 0 545 044 A2.
  • drums known from the prior art have internals which are arranged on the inside of the rotatable drum wall. From EP 0 545 044 A2 it is known to design the exhaust air ducts in such a way that they simultaneously
  • the exhaust air ducts known from EP 0 545 044 A2 have a square, triangular or polygonal cross section. They are preferably arranged as a chicane in a herringbone pattern, i.e. at an angle to the running direction of the drum wall.
  • the internals for mixing the material usually protrude radially from the inner wall of the drum into the interior of the drum. They are arranged obliquely with respect to the axis of rotation of the drum, for example in a herringbone pattern, in order to achieve transverse mixing of the lumpy mix.
  • the height of the internals will chosen between 50 to 300 mm in order to achieve a strong forced mixing, especially in the horizontal direction.
  • the object of the invention is therefore to design internals for a device for painting lumpy products which, on the one hand, ensure good mixing and uniform painting of the material to be mixed and, on the other hand, are gentle on the product.
  • the solution to the problem according to the invention consists of internals on the inside wall of the drum which are parallel or at most at an angle of 20 °, preferably of are arranged at most 10 ° to the drum axis of rotation and have a height which corresponds to one or two product layers of the lumpy products, for example tablet layers, and is preferably in the range from 5 to 40 mm, particularly preferably in the range from 7 to 15 mm.
  • the height is independent of the drum diameter and remains constant for every mix quantity.
  • the internals can have, for example, a triangular, rectangular, semicircular or semi-conical profile.
  • the internals have an average width in the range from 5 to 40 mm, preferably in the range from 10 to 20 mm.
  • the internals on the inside wall of the drum are preferably at a distance from one another in the range from 100 to 200 mm.
  • the internals can also be perforated for cleaning purposes.
  • the advantage of the device according to the invention is that a very calm and uniform tablet bed is produced during the coating process.
  • the mix is constantly in motion in all areas so that twin formation is avoided. It does not hit the drum base due to the low height of the internals.
  • the internals with a semicircular or semi-conical profile prevent damage to the lower product layer if the mix slides over the internals due to gravity.
  • the coating result particularly of sensitive tablet shapes, can be significantly improved.
  • the tablets are significantly less damaged and coated more evenly.
  • the device for coating tablets with the internals according to the invention leads to one despite the low internals good longitudinal and transverse mixing of the mixed bed. Mixing in both the horizontal and vertical directions is comparable to conventional internals.
  • FIG. 1 drum with the internals of the invention.
  • FIG. 1 drum with rectangular internals in cross section.
  • Figure 3 a) drum with triangular internals in cross section, b) drum with triangular internals in side view.
  • Fig. 1 shows schematically the drum 1 of a device for painting lumpy products from obliquely above.
  • the drum 1 comprises a drum wall 2 with the internals 3 according to the invention.
  • Fig. 2 shows schematically the drum 1 of a device for painting with rectangular internals 23 in cross section.
  • the drum 1 comprises a drum wall 2 with the rectangular internals 23.
  • 3 a shows schematically the drum 1 of a device for painting with triangular internals 33 in cross section.
  • the top edges of the triangular internals can also be rounded.
  • FIG. 3b schematically shows the drum 1 of a device for painting with triangular internals 33 in a side view parallel to the axis of rotation 36.
  • the front edges 34 and rear edges 35 of the internals 33 can also be beveled, as in FIG.
  • Tables 2 and 3 show the result of comparative tests with 350 mg tablets of oblong form. Each tablet was 15 mm long and 3 mm in diameter. The same drum coater with a diameter of 1250 mm and the various internals was used for the comparative tests
  • Table la gives the number of permissible tablets in the individual error classes depending on the batch size and table lb the assignment of
  • error classes have the following meaning: Error class I critical error, product unusable Error class II main error, usability greatly reduced
  • the drum coater had 6 internals, each of which was arranged on the inside of the drum at an angle of approximately 30 ° to the axis of rotation of the drum.
  • the height of the internals is 200 mm and the width is 500 mm.
  • the internals had a rectangular cross section.
  • the batch size was approximately 100 kg of tablets. According to Table la, 1250 pieces were taken as a sample.
  • the drum coater had 24 internals, which were arranged at equal intervals parallel to the drum axis of rotation on the inside of the drum.
  • the internals had a rectangular cross section, a height of 10 mm and a width of 15 mm.
  • the batch size was again about 100 kg and 1250 pieces were taken as a line sample according to Table la.
  • Table la The number of tablets listed in the individual error classes in Table la corresponds to the maximum permissible number of defective tablets for which the batch may still be sold without individual reading.
  • Table 2 State-of-the-art installations in the drum coater with a diameter of 1250 mm, sample size 1250 each
  • Table 3 Installations according to the invention in the drum coater with a diameter of 1250 mm, sample size in each case 1250

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif (1) servant au revêtement de produits en morceaux et comprenant un tambour logé rotatif (2), des moyens pour insuffler de l'air dans la zone intérieure du tambour, des moyens pour aspirer l'air hors de la zone intérieure du tambour, ainsi que des buses qui aspergent le produit de mélange situé dans la zone intérieure du tambour. Le dispositif selon l'invention est caractérisé en ce que, sur la paroi intérieure du tambour, se trouvent des éléments encastrés (23) qui sont placés parallèlement ou au plus à un angle de 10° par rapport à l'axe de rotation du tambour et ont une hauteur correspondant à une à deux couches du produit.
PCT/EP2002/006236 2001-06-20 2002-06-07 Elements encastres dans un dispositif pour le revetement de produits en morceaux Ceased WO2003008081A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001129673 DE10129673C1 (de) 2001-06-20 2001-06-20 Einbauten in eine Vorrichtung zum Lackieren von stückigen Produkten
DE10129673.8 2001-06-20

Publications (1)

Publication Number Publication Date
WO2003008081A1 true WO2003008081A1 (fr) 2003-01-30

Family

ID=7688787

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006236 Ceased WO2003008081A1 (fr) 2001-06-20 2002-06-07 Elements encastres dans un dispositif pour le revetement de produits en morceaux

Country Status (2)

Country Link
DE (1) DE10129673C1 (fr)
WO (1) WO2003008081A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008058073A3 (fr) * 2006-11-07 2008-07-10 Wyeth Corp Processus d'enrobage de sucre et chicanes correspondantes
EP4039369A1 (fr) * 2021-02-05 2022-08-10 WMV Apparatebau GmbH Panier de centrifugeuse

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126423A (en) * 1976-04-27 1978-11-21 Elkem-Spigerverket A/S Method of increasing the bulk density of silica dust
EP0056573A2 (fr) * 1981-01-06 1982-07-28 G.S. DI SCIPIONI & GIOGOLI S.n.c. Dispositif à tambour tournant pour enrober des produits pulvérulents
US4799449A (en) * 1983-12-21 1989-01-24 Takeda Chemical Industries, Ltd. Coating apparatus
US4842790A (en) * 1988-02-22 1989-06-27 Tennessee Valley Authority Method and apparatus for producing high-strength grannular particulates from low-strength prills
EP0545044A2 (fr) 1991-11-27 1993-06-09 Lorenz B. Dipl.-Ing. Bohle Machine de dragéification de produits en morceaux, en particulier de pilules et comprimés
US5534349A (en) * 1993-06-29 1996-07-09 Bacardi; Jean M. Granulation of phosphorus pentasulfide with a predetermined reactivity
EP0890353A2 (fr) * 1997-04-23 1999-01-13 BWI plc Appareil d'enrobage de comprimés

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915120A (en) * 1974-08-06 1975-10-28 American Home Prod Contoured belt coater
IT1149716B (it) * 1982-02-02 1986-12-10 Edt Spa Procedimento ed apparecchio per l'applicazione elettrostatica di liquidi o polveri su sostanze ed oggetti
JPS6025181B2 (ja) * 1982-10-04 1985-06-17 フロイント産業株式会社 パンコ−チング装置
DE4411058C2 (de) * 1994-03-30 1997-04-03 Niklas Willy Gmbh Vorrichtung zum Beschichten von körnigem Gut
DE19518721A1 (de) * 1995-05-24 1996-11-28 Bohle L B Pharmatech Gmbh Trommelcoater
DE19543869A1 (de) * 1995-11-24 1997-05-28 Seidenader Maschinenbau Gmbh Verfahren und Vorrichtung zur kontinuierlichen Überwachung der Flüssigkeitszugabe
WO1999026484A1 (fr) * 1997-11-26 1999-06-03 Wm. Wrigley Jr. Company Dispositif et procede d'enrobage de produits

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126423A (en) * 1976-04-27 1978-11-21 Elkem-Spigerverket A/S Method of increasing the bulk density of silica dust
EP0056573A2 (fr) * 1981-01-06 1982-07-28 G.S. DI SCIPIONI & GIOGOLI S.n.c. Dispositif à tambour tournant pour enrober des produits pulvérulents
US4799449A (en) * 1983-12-21 1989-01-24 Takeda Chemical Industries, Ltd. Coating apparatus
US4842790A (en) * 1988-02-22 1989-06-27 Tennessee Valley Authority Method and apparatus for producing high-strength grannular particulates from low-strength prills
EP0545044A2 (fr) 1991-11-27 1993-06-09 Lorenz B. Dipl.-Ing. Bohle Machine de dragéification de produits en morceaux, en particulier de pilules et comprimés
US5534349A (en) * 1993-06-29 1996-07-09 Bacardi; Jean M. Granulation of phosphorus pentasulfide with a predetermined reactivity
EP0890353A2 (fr) * 1997-04-23 1999-01-13 BWI plc Appareil d'enrobage de comprimés

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008058073A3 (fr) * 2006-11-07 2008-07-10 Wyeth Corp Processus d'enrobage de sucre et chicanes correspondantes
EP4039369A1 (fr) * 2021-02-05 2022-08-10 WMV Apparatebau GmbH Panier de centrifugeuse
US12251715B2 (en) 2021-02-05 2025-03-18 Wmv Apparatebau Gmbh Centrifuge basket

Also Published As

Publication number Publication date
DE10129673C1 (de) 2003-03-20

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