WO2003008081A1 - Enclosed components in a device for coating pieced products - Google Patents
Enclosed components in a device for coating pieced products Download PDFInfo
- Publication number
- WO2003008081A1 WO2003008081A1 PCT/EP2002/006236 EP0206236W WO03008081A1 WO 2003008081 A1 WO2003008081 A1 WO 2003008081A1 EP 0206236 W EP0206236 W EP 0206236W WO 03008081 A1 WO03008081 A1 WO 03008081A1
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- WIPO (PCT)
- Prior art keywords
- drum
- internals
- products
- height
- mix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/20—Apparatus for coating or filling sweetmeats or confectionery
- A23G3/26—Apparatus for coating by tumbling with a liquid or powder, spraying device-associated, drum, rotating pan
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/12—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating drums
Definitions
- the invention relates to installations in a device for painting lumpy products, in particular solid dosage forms (e.g. coated tablets, tablets or
- drum coaters Conventional devices for painting lumpy products, also called drum coaters, comprise a rotatably mounted drum with means for blowing air into the interior of the drum and means for extracting air from the interior of the drum.
- nozzles In the interior of the drum there are nozzles that spray the mix (e.g. solid dosage forms). Often these nozzles are arranged in the axis of rotation of the drum and spray radially outwards.
- Such a device is disclosed for example in EP 0 545 044 A2.
- drums known from the prior art have internals which are arranged on the inside of the rotatable drum wall. From EP 0 545 044 A2 it is known to design the exhaust air ducts in such a way that they simultaneously
- the exhaust air ducts known from EP 0 545 044 A2 have a square, triangular or polygonal cross section. They are preferably arranged as a chicane in a herringbone pattern, i.e. at an angle to the running direction of the drum wall.
- the internals for mixing the material usually protrude radially from the inner wall of the drum into the interior of the drum. They are arranged obliquely with respect to the axis of rotation of the drum, for example in a herringbone pattern, in order to achieve transverse mixing of the lumpy mix.
- the height of the internals will chosen between 50 to 300 mm in order to achieve a strong forced mixing, especially in the horizontal direction.
- the object of the invention is therefore to design internals for a device for painting lumpy products which, on the one hand, ensure good mixing and uniform painting of the material to be mixed and, on the other hand, are gentle on the product.
- the solution to the problem according to the invention consists of internals on the inside wall of the drum which are parallel or at most at an angle of 20 °, preferably of are arranged at most 10 ° to the drum axis of rotation and have a height which corresponds to one or two product layers of the lumpy products, for example tablet layers, and is preferably in the range from 5 to 40 mm, particularly preferably in the range from 7 to 15 mm.
- the height is independent of the drum diameter and remains constant for every mix quantity.
- the internals can have, for example, a triangular, rectangular, semicircular or semi-conical profile.
- the internals have an average width in the range from 5 to 40 mm, preferably in the range from 10 to 20 mm.
- the internals on the inside wall of the drum are preferably at a distance from one another in the range from 100 to 200 mm.
- the internals can also be perforated for cleaning purposes.
- the advantage of the device according to the invention is that a very calm and uniform tablet bed is produced during the coating process.
- the mix is constantly in motion in all areas so that twin formation is avoided. It does not hit the drum base due to the low height of the internals.
- the internals with a semicircular or semi-conical profile prevent damage to the lower product layer if the mix slides over the internals due to gravity.
- the coating result particularly of sensitive tablet shapes, can be significantly improved.
- the tablets are significantly less damaged and coated more evenly.
- the device for coating tablets with the internals according to the invention leads to one despite the low internals good longitudinal and transverse mixing of the mixed bed. Mixing in both the horizontal and vertical directions is comparable to conventional internals.
- FIG. 1 drum with the internals of the invention.
- FIG. 1 drum with rectangular internals in cross section.
- Figure 3 a) drum with triangular internals in cross section, b) drum with triangular internals in side view.
- Fig. 1 shows schematically the drum 1 of a device for painting lumpy products from obliquely above.
- the drum 1 comprises a drum wall 2 with the internals 3 according to the invention.
- Fig. 2 shows schematically the drum 1 of a device for painting with rectangular internals 23 in cross section.
- the drum 1 comprises a drum wall 2 with the rectangular internals 23.
- 3 a shows schematically the drum 1 of a device for painting with triangular internals 33 in cross section.
- the top edges of the triangular internals can also be rounded.
- FIG. 3b schematically shows the drum 1 of a device for painting with triangular internals 33 in a side view parallel to the axis of rotation 36.
- the front edges 34 and rear edges 35 of the internals 33 can also be beveled, as in FIG.
- Tables 2 and 3 show the result of comparative tests with 350 mg tablets of oblong form. Each tablet was 15 mm long and 3 mm in diameter. The same drum coater with a diameter of 1250 mm and the various internals was used for the comparative tests
- Table la gives the number of permissible tablets in the individual error classes depending on the batch size and table lb the assignment of
- error classes have the following meaning: Error class I critical error, product unusable Error class II main error, usability greatly reduced
- the drum coater had 6 internals, each of which was arranged on the inside of the drum at an angle of approximately 30 ° to the axis of rotation of the drum.
- the height of the internals is 200 mm and the width is 500 mm.
- the internals had a rectangular cross section.
- the batch size was approximately 100 kg of tablets. According to Table la, 1250 pieces were taken as a sample.
- the drum coater had 24 internals, which were arranged at equal intervals parallel to the drum axis of rotation on the inside of the drum.
- the internals had a rectangular cross section, a height of 10 mm and a width of 15 mm.
- the batch size was again about 100 kg and 1250 pieces were taken as a line sample according to Table la.
- Table la The number of tablets listed in the individual error classes in Table la corresponds to the maximum permissible number of defective tablets for which the batch may still be sold without individual reading.
- Table 2 State-of-the-art installations in the drum coater with a diameter of 1250 mm, sample size 1250 each
- Table 3 Installations according to the invention in the drum coater with a diameter of 1250 mm, sample size in each case 1250
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Einbauten in eine Vorrichtung zum Lackieren von stückigen ProduktenInstallation in a device for painting lumpy products
Die Erfindung betrifft Einbauten in eine Vorrichtung zum Lackieren von stückigen Produkten, insbesondere von festen Arzneiformen (z.B. Dragees, Tabletten oderThe invention relates to installations in a device for painting lumpy products, in particular solid dosage forms (e.g. coated tablets, tablets or
Pellets).Pellets).
Übliche Vorrichtungen zum Lackieren von stückigen Produkten, auch Trommel- coater genannt, umfassen eine drehbar gelagerte Trommel mit Mitteln zum Einblasen von Luft in den Innenbereich der Trommel und Mitteln zum Absaugen der Luft aus dem Innenbereich der Trommel. Im Innenbereich der Trommel befinden sich Düsen, die das Mischgut (z.B. feste Arzneiformen) besprühen. Häufig sind diese Düsen in der Drehachse der Trommel angeordnet und sprühen radial nach außen. Eine solche Vorrichtung ist zum Beispiel in EP 0 545 044 A2 offenbart.Conventional devices for painting lumpy products, also called drum coaters, comprise a rotatably mounted drum with means for blowing air into the interior of the drum and means for extracting air from the interior of the drum. In the interior of the drum there are nozzles that spray the mix (e.g. solid dosage forms). Often these nozzles are arranged in the axis of rotation of the drum and spray radially outwards. Such a device is disclosed for example in EP 0 545 044 A2.
Um eine gleichmäßige Lackierung des in der Trommel befindlichen Mischgutes zu gewährleisten, muss dieses während des Besprühens gleichmäßig durchmischt werden. Die aus dem Stand der Technik bekannten Trommeln weisen hierzu Einbauten auf, die innen an der rotierbaren Trommelwand angeordnet sind. Aus EP 0 545 044 A2 ist bekannt die Abluftkanäle so zu gestalten, dass sie gleichzeitig denIn order to ensure a uniform coating of the mix in the drum, it must be mixed evenly during spraying. For this purpose, the drums known from the prior art have internals which are arranged on the inside of the rotatable drum wall. From EP 0 545 044 A2 it is known to design the exhaust air ducts in such a way that they simultaneously
Zweck von Einbauten für die gute Durchmischung des Mischgutes erfüllen. Die aus EP 0 545 044 A2 bekannten Abluftkanäle haben einen viereckigen, dreieckigen oder mehreckigen Querschnitt. Sie werden bevorzugt als Schikane im Fischgrätenmuster, also schräg zur Laufrichtung der Trommelwand angeordnet.Meet the purpose of internals for the thorough mixing of the mix. The exhaust air ducts known from EP 0 545 044 A2 have a square, triangular or polygonal cross section. They are preferably arranged as a chicane in a herringbone pattern, i.e. at an angle to the running direction of the drum wall.
Üblicherweise ragen die Einbauten zur Durchmischung des Mischgutes je nach Trommeldurchmesser und Menge an Mischgut 50 bis 300 mm radial von der Trommelinnenwand in den Trommelinnenraum. Sie werden schräg bezüglich der Drehachse der Trommel angeordnet z.B. im Fischgrätenmuster, um eine Querdurch- mischung des stückigen Mischgutes zu erreichen. Die Höhe der Einbauten wird zwischen 50 bis 300 mm gewählt, um eine starke Zwangsdurchmischung insbesondere in horizontaler Richtung zu erreichen.Depending on the drum diameter and the amount of material to be mixed, the internals for mixing the material usually protrude radially from the inner wall of the drum into the interior of the drum. They are arranged obliquely with respect to the axis of rotation of the drum, for example in a herringbone pattern, in order to achieve transverse mixing of the lumpy mix. The height of the internals will chosen between 50 to 300 mm in order to achieve a strong forced mixing, especially in the horizontal direction.
Der Nachteil der bekannten Einbauten besteht darin, dass es durch die enorme Höhe der Einbauten im Verhältnis zur Größe der stückigen Produkte zu einer sehr starkenThe disadvantage of the known internals is that due to the enormous height of the internals in relation to the size of the lumpy products it becomes a very strong one
Bettbewegung und damit Reibung im Mischguts kommt, die zu Beschädigungen der Produkte führen kann. Durch die starke Bettbewegung ändert sich auch der Abstand zwischen den stückigen Produkten und den Sprühdüsen ständig, was zu einer ungleichmäßigen Lackierang führen kann. Hinter den hohen Einbauten bilden sich jeweils Ruhezonen, was zu einer unzureichenden Trocknung und zu einem Zusammenkleben der lackierten Produkte (Zwillingsbildung) führen kann. An anderen Stellen des Mischbettes kommt es wiederum zu starker Turbulenz, so dass einzelne stückige Produkte springen und beim Zusammenprall mit anderen stückigen Produkten beschädigt werden können. Insbesondere springen sie über die hohen Einbauten, wenn die Trommelwand sich soweit gedreht hat, dass die Schwerkraft zu hoch wird und schlagen dann hinter den Einbauten auf die Trommelwand auf. Dies führt zu einer extrem hohen Belastung der Produkte und zu Produktbrach oder Absplitterungen. Insbesondere Oblong- Arzneiformen sind anfällig für Beschädigungen.Bed movement and thus friction in the mix comes, which can damage the products. Due to the strong bed movement, the distance between the lumpy products and the spray nozzles is constantly changing, which can lead to uneven painting. Quiet zones form behind the high internals, which can lead to inadequate drying and sticking of the painted products (twin formation). At other points in the mixed bed, there is again strong turbulence, so that individual lumpy products can jump and be damaged when they collide with other lumpy products. In particular, they jump over the high internals when the drum wall has turned so far that gravity becomes too high and then hit the drum wall behind the internals. This leads to an extremely high load on the products and to product breakage or chipping. Oblong dosage forms in particular are susceptible to damage.
Nach dem Stand der Technik werden für verschiedene Trommelgrößen und Mischgutmengen unterschiedlich hohe Einbauten verwendet, was zusätzlichen Aufwand beim Wechsel der Mischgutmenge und die Bereitstellung unterschiedlich dimensionierter Einbauten erfordert.According to the state of the art, internals of different heights are used for different drum sizes and quantities of mix, which requires additional effort when changing the quantity of mix and the provision of internally dimensioned internals.
Die erfindungsgemäße Aufgabe besteht deshalb darin, Einbauten für eine Vorrichtungen zum Lackieren von stückigen Produkten zu konzipieren, die einerseits eine gute Durchmischung und gleichmäßige Lackierung des Mischgutes gewährleisten und andererseits produktschonend sind.The object of the invention is therefore to design internals for a device for painting lumpy products which, on the one hand, ensure good mixing and uniform painting of the material to be mixed and, on the other hand, are gentle on the product.
Die Lösung der erfindungsgemäßen Aufgabe besteht in Einbauten an der Trommelinnenwand, die parallel oder höchstens in einem Winkel von 20°, bevorzugt von höchstens 10° zur Trommeldrehachse angeordnet sind und eine Höhe haben, die ein bis zwei Produktlagen der stückigen Produkte, z.B. Tablettenlagen, entspricht und bevorzugt im Bereich von 5 bis 40 mm, besonders bevorzugt im Bereich von 7 bis 15 mm liegt. Die Höhe ist unabhängig vom Trommeldurchmesser und bleibt auch für jede Mischgutmenge konstant.The solution to the problem according to the invention consists of internals on the inside wall of the drum which are parallel or at most at an angle of 20 °, preferably of are arranged at most 10 ° to the drum axis of rotation and have a height which corresponds to one or two product layers of the lumpy products, for example tablet layers, and is preferably in the range from 5 to 40 mm, particularly preferably in the range from 7 to 15 mm. The height is independent of the drum diameter and remains constant for every mix quantity.
Die Einbauten können beispielsweise ein dreieckiges, rechteckiges, halbrundes oder halbkegelschnittformiges Profil haben. Die Einbauten haben eine mittlere Breite im Bereich von 5 bis 40 mm, bevorzugt im Bereich von 10 bis 20 mm.The internals can have, for example, a triangular, rectangular, semicircular or semi-conical profile. The internals have an average width in the range from 5 to 40 mm, preferably in the range from 10 to 20 mm.
In einer Trommel befinden sich mindestens drei Einbauten. Bevorzugt haben die Einbauten auf der Trommelinnenwand einen Abstand voneinander im Bereich von 100 bis 200 mm.There are at least three internals in a drum. The internals on the inside wall of the drum are preferably at a distance from one another in the range from 100 to 200 mm.
Die Einbauten können auch zu Reinigungszwecken perforiert sein.The internals can also be perforated for cleaning purposes.
Der Vorteil der erfindungsgemäßen Vorrichtung ist, dass während der Lackierung ein sehr ruhiges und gleichmäßiges Tablettenbett entsteht. Das Mischgut ist in allen Bereichen ständig in Bewegung, so dass eine Zwillingsbildung vermieden wird. Auf- schlagen auf den Trommelboden findet wegen der geringen Höhe der Einbauten nicht statt. Neben der geringen Höhe der Einbauten verhindern auch die Einbauten mit halbrunden oder halbkegelschnittförmigem Profil Beschädigungen der unteren Produktlage, wenn das Mischgut aufgrund der Schwerkraft über die Einbauten rutscht.The advantage of the device according to the invention is that a very calm and uniform tablet bed is produced during the coating process. The mix is constantly in motion in all areas so that twin formation is avoided. It does not hit the drum base due to the low height of the internals. In addition to the low height of the internals, the internals with a semicircular or semi-conical profile prevent damage to the lower product layer if the mix slides over the internals due to gravity.
Das Lackierergebnis insbesondere empfindlicher Tablettenformen kann wesentlich verbessert werden. Die Tabletten werden deutlich weniger beschädigt und gleichmäßiger lackiert.The coating result, particularly of sensitive tablet shapes, can be significantly improved. The tablets are significantly less damaged and coated more evenly.
Die Vorrichtung zum Lackieren von Tabletten mit den erfindungsgemäßen Einbauten führt entgegen der allgemeinen Annahme trotz der niedrigen Einbauten zu einer guten Längs- und Querdurchmischung des Mischbettes. Die Durchmischung sowohl in horizontaler als auch in vertikaler Richtung ist vergleichbar mit herkömmlichen Einbauten. Contrary to the general assumption, the device for coating tablets with the internals according to the invention leads to one despite the low internals good longitudinal and transverse mixing of the mixed bed. Mixing in both the horizontal and vertical directions is comparable to conventional internals.
Figuren und BeispieleFigures and examples
Es zeigenShow it
Figuren und BeispieleFigures and examples
Figur 1 Trommel mit den erfindungsgemäßen Einbauten.Figure 1 drum with the internals of the invention.
Figur 2 Trommel mit rechteckigen Einbauten im Querschnitt.Figure 2 drum with rectangular internals in cross section.
Figur 3 a) Trommel mit dreieckigen Einbauten im Querschnitt, b) Trommel mit dreieckigen Einbauten in Seitenansicht.Figure 3 a) drum with triangular internals in cross section, b) drum with triangular internals in side view.
Die Fig. 1 zeigt schematisch die Trommel 1 einer Vorrichtung zum Lackieren von stückigen Produkten von schräg oben. Die Trommel 1 umfasst eine Trommelwand 2 mit den erfindungsgemäßen Einbauten 3.Fig. 1 shows schematically the drum 1 of a device for painting lumpy products from obliquely above. The drum 1 comprises a drum wall 2 with the internals 3 according to the invention.
Fig. 2 zeigt schematisch die Trommel 1 einer Vorrichtung zum Lackieren mit rechteckigen Einbauten 23 im Querschnitt. Die Trommel 1 umfasst eine Trommelwand 2 mit den rechteckigen Einbauten 23.Fig. 2 shows schematically the drum 1 of a device for painting with rectangular internals 23 in cross section. The drum 1 comprises a drum wall 2 with the rectangular internals 23.
Fig. 3 a zeigt schematisch die Trommel 1 einer Vorrichtung zum Lackieren mit dreieckigen Einbauten 33 im Querschnitt. Die oberen Kanten der dreieckigen Einbauten können auch abgerundet sein.3 a shows schematically the drum 1 of a device for painting with triangular internals 33 in cross section. The top edges of the triangular internals can also be rounded.
Fig. 3b zeigt schematisch die Trommel 1 einer Vorrichtung zum Lackieren mit dreieckigen Einbauten 33 in Seitenansicht parallel zur Drehachse 36. Die Vorderkanten 34 und Hinterkanten 35 der Einbauten 33 können auch angeschrägt sein wie in Fig.3b schematically shows the drum 1 of a device for painting with triangular internals 33 in a side view parallel to the axis of rotation 36. The front edges 34 and rear edges 35 of the internals 33 can also be beveled, as in FIG.
3b dargestellt.3b shown.
Die Tabellen 2 und 3 zeigen das Ergebnis von Vergleichsversuchen mit 350 mg Tabletten von oblonger Form. Jede Tablette hatte eine Länge von 15 mm und einen Durchmesser von 3 mm. Für die Vergleichsversuche wurde jeweils derselbe Trommelcoater mit 1250 mm Durchmesser mit den verschiedenen Einbauten verwendetTables 2 and 3 show the result of comparative tests with 350 mg tablets of oblong form. Each tablet was 15 mm long and 3 mm in diameter. The same drum coater with a diameter of 1250 mm and the various internals was used for the comparative tests
Die Tabelle la gibt die Anzahl der zulässigen Tabletten in den einzelnen Fehler- klassen in Abhängigkeit von der Chargengröße und Tabelle lb die Zuordnung vonTable la gives the number of permissible tablets in the individual error classes depending on the batch size and table lb the assignment of
Fehlern zu den Fehlerklassen an.Errors to the error classes.
Die Fehlerklassen haben folgende Bedeutung: Fehlerklasse I kritischer Fehler, Produkt unbrauchbar Fehlerklasse II Hauptfehler, Brauchbarkeit stark vermindertThe error classes have the following meaning: Error class I critical error, product unusable Error class II main error, usability greatly reduced
Fehlerklasse III Nebenfehler, Brauchbarkeit vermindertError class III minor errors, usability reduced
Fehlerklasse IV NebenfehlerError class IV secondary errors
Fehlerklasse V SchönheitsfehlerDefect class V blemishes
Es wurden 3 Versuche mit dem Trommelcoater mit Einbauten nach dem Stand derThere were 3 experiments with the drum coater with internals according to the
Technik vorgenommen (Tabelle 2). Der Trommelcoater hatte 6 Einbauten, die fischgrätenartig jeweils in einem Winkel von etwa 30° zur Trommeldrehachse an der Trommelinnenwand angeordnet waren. Die Höhe der Einbauten betrag 200 mm und die Breite 500 mm. Die Einbauten hatten einen rechteckigem Querschnitt. Die Chargengröße betrug ca. 100 kg Tabletten. Es wurden gemäß Tabelle la 1250 Stück als Strichprobe entnommen.Technique made (Table 2). The drum coater had 6 internals, each of which was arranged on the inside of the drum at an angle of approximately 30 ° to the axis of rotation of the drum. The height of the internals is 200 mm and the width is 500 mm. The internals had a rectangular cross section. The batch size was approximately 100 kg of tablets. According to Table la, 1250 pieces were taken as a sample.
Es wurden 2 Versuche mit einem Trommelcoater mit den erfindungsgemäßen Einbauten vorgenommen (Tabelle 3). Der Trommelcoater hatte 24 Einbauten, die in gleichen Abständen parallel zur Trommeldrehachse an der Trommelinnenwand angeordnet waren. Die Einbauten hatten einen rechteckigen Querschnitt, eine Höhe von 10 mm und eine Breite von 15 mm. Die Chargengröße betrug wiederum ca. 100 kg und es wurden gemäß Tabelle la 1250 Stück als Strichprobe entnommen.Two tests were carried out using a drum coater with the internals according to the invention (Table 3). The drum coater had 24 internals, which were arranged at equal intervals parallel to the drum axis of rotation on the inside of the drum. The internals had a rectangular cross section, a height of 10 mm and a width of 15 mm. The batch size was again about 100 kg and 1250 pieces were taken as a line sample according to Table la.
Die Fehlerbewertung, wie sie in den Tabellen 2 und 3 wiedergegeben ist, zeigt deutlich mehr Beschädigungen an den Tabletten, die mit den Trommelcoatern mit den Einbauten nach dem Stand der Technik lackiert worden sind. Insbesondere hätten diese Chargen die Sollvorgaben nach Tabelle la bei weitem verfehlt.The error evaluation, as shown in Tables 2 and 3, shows significantly more damage to the tablets that with the drum coats with the Internals have been painted according to the state of the art. In particular, these batches would have by far failed to meet the target specifications in Table la.
Tabelle la; SollvorgabenTable la; target specifications
Tabelle lb: FehlerartenTable lb: Types of errors
Die in den einzelnen Fehlerklassen in Tabelle la genannten Tablettenzahlen entsprechen der maximal zulässigen Anzahl fehlerhafter Tabletten, bei denen die Charge ohne Einzelverlesung noch vertrieben werden darf. Tabelle 2: Einbauten nach dem Stand der Technik in den Trommelcoater mit 1250 mm Durchmesser, Stichprobengröße jeweils 1250The number of tablets listed in the individual error classes in Table la corresponds to the maximum permissible number of defective tablets for which the batch may still be sold without individual reading. Table 2: State-of-the-art installations in the drum coater with a diameter of 1250 mm, sample size 1250 each
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129673.8 | 2001-06-20 | ||
| DE2001129673 DE10129673C1 (en) | 2001-06-20 | 2001-06-20 | Installation in a device for painting lumpy products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003008081A1 true WO2003008081A1 (en) | 2003-01-30 |
Family
ID=7688787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2002/006236 Ceased WO2003008081A1 (en) | 2001-06-20 | 2002-06-07 | Enclosed components in a device for coating pieced products |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE10129673C1 (en) |
| WO (1) | WO2003008081A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008058073A3 (en) * | 2006-11-07 | 2008-07-10 | Wyeth Corp | Sugar-coating process and baffles therefor |
| EP4039369A1 (en) * | 2021-02-05 | 2022-08-10 | WMV Apparatebau GmbH | Centrifuge basket |
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| EP0056573A2 (en) * | 1981-01-06 | 1982-07-28 | G.S. DI SCIPIONI & GIOGOLI S.n.c. | Rotary drum device for coating a loose product |
| US4799449A (en) * | 1983-12-21 | 1989-01-24 | Takeda Chemical Industries, Ltd. | Coating apparatus |
| US4842790A (en) * | 1988-02-22 | 1989-06-27 | Tennessee Valley Authority | Method and apparatus for producing high-strength grannular particulates from low-strength prills |
| EP0545044A2 (en) | 1991-11-27 | 1993-06-09 | Lorenz B. Dipl.-Ing. Bohle | Coating apparatus for lump products, particularly pills and tablets |
| US5534349A (en) * | 1993-06-29 | 1996-07-09 | Bacardi; Jean M. | Granulation of phosphorus pentasulfide with a predetermined reactivity |
| EP0890353A2 (en) * | 1997-04-23 | 1999-01-13 | BWI plc | Tablet coating machine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3915120A (en) * | 1974-08-06 | 1975-10-28 | American Home Prod | Contoured belt coater |
| IT1149716B (en) * | 1982-02-02 | 1986-12-10 | Edt Spa | PROCEDURE AND APPARATUS FOR THE ELECTROSTATIC APPLICATION OF LIQUIDS OR POWDERS ON SUBSTANCES AND OBJECTS |
| JPS6025181B2 (en) * | 1982-10-04 | 1985-06-17 | フロイント産業株式会社 | Pan coaching device |
| DE4411058C2 (en) * | 1994-03-30 | 1997-04-03 | Niklas Willy Gmbh | Device for coating granular material |
| DE19518721A1 (en) * | 1995-05-24 | 1996-11-28 | Bohle L B Pharmatech Gmbh | Drum coater for nuclei, esp. pharmaceutical tablets and capsules |
| DE19543869A1 (en) * | 1995-11-24 | 1997-05-28 | Seidenader Maschinenbau Gmbh | Method and device for continuously monitoring the addition of liquid |
| WO1999026484A1 (en) * | 1997-11-26 | 1999-06-03 | Wm. Wrigley Jr. Company | Device and method for coating products |
-
2001
- 2001-06-20 DE DE2001129673 patent/DE10129673C1/en not_active Expired - Fee Related
-
2002
- 2002-06-07 WO PCT/EP2002/006236 patent/WO2003008081A1/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4126423A (en) * | 1976-04-27 | 1978-11-21 | Elkem-Spigerverket A/S | Method of increasing the bulk density of silica dust |
| EP0056573A2 (en) * | 1981-01-06 | 1982-07-28 | G.S. DI SCIPIONI & GIOGOLI S.n.c. | Rotary drum device for coating a loose product |
| US4799449A (en) * | 1983-12-21 | 1989-01-24 | Takeda Chemical Industries, Ltd. | Coating apparatus |
| US4842790A (en) * | 1988-02-22 | 1989-06-27 | Tennessee Valley Authority | Method and apparatus for producing high-strength grannular particulates from low-strength prills |
| EP0545044A2 (en) | 1991-11-27 | 1993-06-09 | Lorenz B. Dipl.-Ing. Bohle | Coating apparatus for lump products, particularly pills and tablets |
| US5534349A (en) * | 1993-06-29 | 1996-07-09 | Bacardi; Jean M. | Granulation of phosphorus pentasulfide with a predetermined reactivity |
| EP0890353A2 (en) * | 1997-04-23 | 1999-01-13 | BWI plc | Tablet coating machine |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008058073A3 (en) * | 2006-11-07 | 2008-07-10 | Wyeth Corp | Sugar-coating process and baffles therefor |
| EP4039369A1 (en) * | 2021-02-05 | 2022-08-10 | WMV Apparatebau GmbH | Centrifuge basket |
| US12251715B2 (en) | 2021-02-05 | 2025-03-18 | Wmv Apparatebau Gmbh | Centrifuge basket |
Also Published As
| Publication number | Publication date |
|---|---|
| DE10129673C1 (en) | 2003-03-20 |
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