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WO2003007948A1 - Antipaludique contenant un compose de rhodacyanine - Google Patents

Antipaludique contenant un compose de rhodacyanine Download PDF

Info

Publication number
WO2003007948A1
WO2003007948A1 PCT/JP2002/007255 JP0207255W WO03007948A1 WO 2003007948 A1 WO2003007948 A1 WO 2003007948A1 JP 0207255 W JP0207255 W JP 0207255W WO 03007948 A1 WO03007948 A1 WO 03007948A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
ion
methyl
antimalarial
dye compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/007255
Other languages
English (en)
Japanese (ja)
Inventor
Masataka Ihara
Kiyosei Takasu
Hiroshi Inoue
Yusuke Wataya
Hye-Sook Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp
Publication of WO2003007948A1 publication Critical patent/WO2003007948A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the F28-7 strain a wild strain of mouse breast cancer-derived FM3A cells, was used.
  • Medium was added to a 2% fetal calf serum inactivated in ES medium, C ⁇ 2 concentration of 5% were cultured at 3 7 ° C.
  • the doubling time of FM3A cells under these conditions was about 12 hours.
  • Preculture was performed, and cells that had entered the logarithmic growth phase were diluted with a medium so as to have a concentration of 5 ⁇ 10 4 ce 11 s ZmL, and a sample prepared at the time of measuring the malaria activity was used.
  • the sample solution prepared in Example 7 was added to a 24-well culture plate in an amount of 5 to 10 ⁇ L each. Two to three tests were performed for each test sample.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un antipaludique efficace contre le plasmode paludéen présentant une résistance a divers antipaludiques et ayant des effets secondaires réduits. L'antipaludique contient en tant que principe actif un composé de rhodacyanine de formule (I), dans laquelle: R1 et R2 représentent indépendamment hydrogène, alkyle en C¿1?-C8 substitué ou non substitué, ou aryle en C6-C8 ou R?1 et R2¿ sont liés l'un à l'autre pour former un noyau à six chaînons substitué ou non substitué; B représente un système conjugué; n est 0, 1 ou 2; A représente un groupe nécessaire à la formation d'un hétérocycle à cinq ou six chaînons, pouvant être non substitué ou ayant un ou des substituants, qui peuvent être liés l'un à l'autre; et Q représente un anion pharmaceutiqement acceptable.
PCT/JP2002/007255 2001-07-19 2002-07-17 Antipaludique contenant un compose de rhodacyanine Ceased WO2003007948A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-220579 2001-07-19
JP2001220579A JP2003034641A (ja) 2001-07-19 2001-07-19 ロダシアニン系色素化合物を含有する抗マラリア剤

Publications (1)

Publication Number Publication Date
WO2003007948A1 true WO2003007948A1 (fr) 2003-01-30

Family

ID=19054378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007255 Ceased WO2003007948A1 (fr) 2001-07-19 2002-07-17 Antipaludique contenant un compose de rhodacyanine

Country Status (2)

Country Link
JP (1) JP2003034641A (fr)
WO (1) WO2003007948A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1800682A4 (fr) * 2004-10-04 2010-06-30 Masataka Ihara Préparation médicamenteuse pour le traitement prophylactique ou thérapeutique d une infection protozoaire parasitaire

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004331545A (ja) * 2003-05-06 2004-11-25 Japan Science & Technology Agency 抗リーシュマニア剤
JP4553354B2 (ja) * 2004-10-04 2010-09-29 正隆 井原 抗トリパノソーマ剤
JPWO2006137258A1 (ja) * 2005-06-24 2009-01-08 独立行政法人科学技術振興機構 アザロダシアニン化合物を有効成分として含有する医薬組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360803A (en) * 1991-08-13 1994-11-01 Dan Farber Cancer Institute Composition and method for treating cancer
JPH0859467A (ja) * 1994-08-18 1996-03-05 Fuji Photo Film Co Ltd 皮膚疾患治療薬
JP2000191531A (ja) * 1998-12-28 2000-07-11 Fuji Photo Film Co Ltd 抗マラリア剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360803A (en) * 1991-08-13 1994-11-01 Dan Farber Cancer Institute Composition and method for treating cancer
JPH0859467A (ja) * 1994-08-18 1996-03-05 Fuji Photo Film Co Ltd 皮膚疾患治療薬
JP2000191531A (ja) * 1998-12-28 2000-07-11 Fuji Photo Film Co Ltd 抗マラリア剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIYOSEI TAKASU ET AL.: "Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity", J. MED. CHEM., vol. 45, no. 5, 2002, pages 995 - 998, XP002957612 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1800682A4 (fr) * 2004-10-04 2010-06-30 Masataka Ihara Préparation médicamenteuse pour le traitement prophylactique ou thérapeutique d une infection protozoaire parasitaire
US8193224B2 (en) 2004-10-04 2012-06-05 Fujifilm Corporation Medicinal composition for prevention or treatment of parasitic protozoan infection

Also Published As

Publication number Publication date
JP2003034641A (ja) 2003-02-07

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