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WO2003006489A3 - Prodrugs of excitatory amino acids - Google Patents

Prodrugs of excitatory amino acids Download PDF

Info

Publication number
WO2003006489A3
WO2003006489A3 PCT/US2002/019825 US0219825W WO03006489A3 WO 2003006489 A3 WO2003006489 A3 WO 2003006489A3 US 0219825 W US0219825 W US 0219825W WO 03006489 A3 WO03006489 A3 WO 03006489A3
Authority
WO
WIPO (PCT)
Prior art keywords
prodrugs
excitatory amino
amino acids
relates
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/019825
Other languages
French (fr)
Other versions
WO2003006489A2 (en
Inventor
Melendo Ana Belen Bueno
Dios Alfonso De
Carmen Dominguez-Fernandez
Crespo Rafael Ferritto
Marc Herin
Jose Alfredo Martin
Luisa Maria Martin-Cabrejas
Maria Angeles Martinez-Grau
Steven Marc Massey
James Allen Monn
Salgado Carlos Montero
Concepcion Pedregal-Tercero
Matthew John Valli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to EP02744537A priority Critical patent/EP1423411A2/en
Priority to US10/480,517 priority patent/US20040176459A1/en
Publication of WO2003006489A2 publication Critical patent/WO2003006489A2/en
Publication of WO2003006489A3 publication Critical patent/WO2003006489A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/40—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psychiatric disorders.
PCT/US2002/019825 2001-07-09 2002-07-02 Prodrugs of excitatory amino acids Ceased WO2003006489A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02744537A EP1423411A2 (en) 2001-07-09 2002-07-02 Prodrugs of excitatory amino acids
US10/480,517 US20040176459A1 (en) 2001-07-09 2002-07-02 Prodrugs of excitatory amino acids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01500175 2001-07-09
GB01500175.3 2001-07-09
EP01500275 2001-11-23
GB01500275.1 2001-11-23

Publications (2)

Publication Number Publication Date
WO2003006489A2 WO2003006489A2 (en) 2003-01-23
WO2003006489A3 true WO2003006489A3 (en) 2003-09-25

Family

ID=26077296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019825 Ceased WO2003006489A2 (en) 2001-07-09 2002-07-02 Prodrugs of excitatory amino acids

Country Status (2)

Country Link
EP (1) EP1423411A2 (en)
WO (1) WO2003006489A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256217B2 (en) 2001-01-11 2007-08-14 Eli Lilly And Company Prodrugs of excitatory amino acids
WO2002055485A1 (en) 2001-01-11 2002-07-18 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004010A1 (en) * 1998-07-17 2000-01-27 Eli Lilly And Company Limited Bicyclohexane derivatives
WO2000012464A1 (en) * 1998-08-31 2000-03-09 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3. 1.0]hexane derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004010A1 (en) * 1998-07-17 2000-01-27 Eli Lilly And Company Limited Bicyclohexane derivatives
WO2000012464A1 (en) * 1998-08-31 2000-03-09 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3. 1.0]hexane derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COSTANTINO G ET AL.: "Pharmacorephore Models of Group I and Group II Metabotropic Glutamate Receptor Agonists. Analysis of Conformational, Steric, and Topological Parameters Affecting Potency and Selectivity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, 1999, pages 2816 - 2827, XP002231618 *
NAKAZATO A ET AL.: "Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 2000, pages 4893 - 4909, XP001093883 *

Also Published As

Publication number Publication date
WO2003006489A2 (en) 2003-01-23
EP1423411A2 (en) 2004-06-02

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