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WO2005021005A3 - Process for the preparation of 1,4-benzodiazepine derivatives - Google Patents

Process for the preparation of 1,4-benzodiazepine derivatives Download PDF

Info

Publication number
WO2005021005A3
WO2005021005A3 PCT/IB2004/002775 IB2004002775W WO2005021005A3 WO 2005021005 A3 WO2005021005 A3 WO 2005021005A3 IB 2004002775 W IB2004002775 W IB 2004002775W WO 2005021005 A3 WO2005021005 A3 WO 2005021005A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
benzodiazepine derivatives
relates
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/002775
Other languages
French (fr)
Other versions
WO2005021005A2 (en
Inventor
Yatendra Kumar
Chandra Has Khanduri
Mukesh Kumar Sharma
Atulya Kumar Panda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2005021005A2 publication Critical patent/WO2005021005A2/en
Publication of WO2005021005A3 publication Critical patent/WO2005021005A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The field of the invention relates to a process for the preparation of 1,4-benzodiazepine derivatives. It also relates to pharmaceutical compositions that include the 1,4- benzodiazepine derivatives.
PCT/IB2004/002775 2003-08-28 2004-08-27 Process for the preparation of 1,4-benzodiazepine derivatives Ceased WO2005021005A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1048/DEL/2003 2003-08-28
IN1048DE2003 2003-08-28

Publications (2)

Publication Number Publication Date
WO2005021005A2 WO2005021005A2 (en) 2005-03-10
WO2005021005A3 true WO2005021005A3 (en) 2005-04-14

Family

ID=34259933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002775 Ceased WO2005021005A2 (en) 2003-08-28 2004-08-27 Process for the preparation of 1,4-benzodiazepine derivatives

Country Status (1)

Country Link
WO (1) WO2005021005A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR123593A1 (en) * 2020-09-26 2022-12-21 Pi Industries Ltd A PROCESS FOR THE SYNTHESIS OF ANTHRANILIC ACID/AMIDE COMPOUNDS AND INTERMEDIATES THEREOF

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405123A (en) * 1965-02-08 1968-10-08 Hoffmann La Roche Process for preparing 1, 4-benzodiazepin-2-ones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405123A (en) * 1965-02-08 1968-10-08 Hoffmann La Roche Process for preparing 1, 4-benzodiazepin-2-ones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WALSER A ET AL: "CYCLIZATION PRODUCTS DERIVED FROM O-BENZOYL MALONANILATES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 38, no. 3, 1973, pages 449 - 456, XP001026819, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
WO2005021005A2 (en) 2005-03-10

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