WO2003079794A1 - Use of olive tree extracts in detergents, rinsing agents and cleaning agents - Google Patents

Abstract

The invention relates to the use of olive tree extracts as an antimicrobial active ingredient in detergents, rinsing and cleaning agents. Extracts from the olive tree, especially from the leaves of the olive tree and/or from waste water produced during the production of olive oil have an antimicrobial effect against aerobic, anaerobic germs, yeast and mould.

Description

Use of extracts from the olive tree in detergents, dishwashing detergents and cleaning agents

The invention is in the field of cleaning agents and relates to the use of extracts from the olive tree as an antimicrobial active ingredient in detergents, dishwashing detergents and cleaning agents.

State of the art

The use of antimicrobial agents in washing, rinsing and cleaning agents has been known for many years. However, their use always leads to problems.

Users of detergents in particular, with which there is skin contact, complain about the poor dermatological tolerance of the antimicrobial agents used. The number of allergies and skin diseases is increasing steadily. The developers and formulators criticize the lack of compatibility with other auxiliaries. While on the one hand the substances should have sufficient water solubility, on the other hand they must be sufficiently lipophilic to be able to penetrate the bacterial wall. The microbiologists complain about the diminishing antimicrobial effectiveness of these active substances in combination with other auxiliary substances in detergents and cleaning agents. The increasing development of resistance also poses another problem for science. The profile of requirements for antimicrobial agents in detergents, dishwashing detergents and cleaning agents is therefore very high, so that new agents are constantly being sought that can optimally fulfill them.

The object of the present invention is therefore to provide new antimicrobial active ingredients which on the one hand are notable for good activity, but on the other hand also have excellent dermatological tolerance and a low risk of allergy. These active ingredients should be easy to process in washing formulations and should have good compatibility with other auxiliaries. Description of the invention

The invention relates to the use of extracts from the olive tree as an antimicrobial active ingredient in detergents, dishwashing detergents and cleaning agents.

It has been found that extracts from the olive tree, in particular from the leaves of the olive tree and / or from the wastewater from olive oil production, have an antimicrobial action against aerobic, anaerobic germs, yeasts and molds. They can be easily incorporated into formulations with a high proportion of surfactants without losing their effectiveness and are characterized by very good dermatological compatibility.

These properties make them particularly suitable for use in detergents, dishwashing detergents and cleaning agents. Their good skin tolerance leads to their preferred use in body detergents or cleaning agents, the use of which is associated with direct contact with the skin, such as hand dishwashing detergents.

Extracts of the olive tree

The extracts to be used according to the invention are prepared by customary extraction methods. Regarding the suitable conventional extraction methods such as maceration, remaceration, digestion, movement maceration, vortex extraction, ultrasound extraction, countercurrent extraction, percolation, repercolation, evacolation (extraction under reduced pressure), diacolation and solid-liquid extraction under continuous reflux , which is carried out in a Soxhiet extractor, which is familiar to a person skilled in the art and in principle all can be used, is exemplary of Hager's Handbook of Pharmaceutical Practice, (5th edition, vol. 2, pp. 1026-1030, Springer Verlag, Berlin- Heidelberg-New-York 1991). Fresh or dried parts of the olive tree can be used as the starting material, but usually leaves are used which are mechanically shredded before extraction. All grinding methods known to the person skilled in the art are suitable here, for example crushing with a mortar.

Water, organic solvents or mixtures of organic solvents and water, in particular low molecular weight alcohols, hydrocarbons, ketones, esters or halogen-containing hydrocarbons with more or less high water contents (distilled or not distilled), preferably aqueous, alcoholic solutions, can preferably be used as solvents for carrying out the extractions a temperature of greater than or equal to 20 ° C can be used. Extraction with water, methanol, ethanol, hexane, cyclohexane, pentane, acetone, propylene glycols, polyethylene glycols, ethyl acetate, dichloromethane, trichloromethane and mixtures thereof is particularly preferred. out. The extraction is usually carried out at 20 to 100 ° C, preferably at 20 to 85 ° C, in particular either at the boiling point of the solvent used or at room temperature. In one possible embodiment, the extraction takes place under an inert gas atmosphere to avoid oxidation of the ingredients of the extract. The extraction times are set by the person skilled in the art depending on the starting material, the extraction process, the extraction temperature, the ratio of solvent to raw material, etc. After the extraction, the crude extracts obtained can optionally be subjected to further customary steps, such as purification, concentration and / or decolorization. If desired, the extracts produced in this way can, for example, be subjected to a selective separation of individual undesirable ingredients. The extraction can be carried out to any desired degree of extraction, but is usually carried out until exhaustion. The present invention includes the knowledge that the extraction conditions and the yields of the final extracts can be selected depending on the desired field of use. If desired, the extracts can then be subjected to spray drying or freeze drying, for example.

The amount of the extracts used in the preparations mentioned depends on the type of application of the extracts and on the concentration of the individual ingredients. The total amount of the olive tree leaf extract which is contained in the preparations according to the invention is generally 0.01 to 15% by weight, preferably 0.05 to 5% by weight, in particular 0.1 to 3% by weight, based on the final preparation, with the proviso that the quantities with water and possibly other auxiliary substances and additives add up to 100% by weight.

Olive tree leaf extracts are preferably used, which are standardized with regard to their main ingredient oleuropein. They contain 1 to 40% by weight, preferably 5 to 30% by weight, particularly preferably 10 to 25% by weight and especially 18 to 22% by weight oleuropein, based on the dry extract.

Extracts from the wastewater of olive tree production are produced by drying the water, preferably by spray drying, after addition of auxiliaries such as mannitol or sodium caseinate. They are adjusted to a content of polyphenols, preferably hydroxytyrosol and tyrosol, which is at least 0.5% by weight, preferably at least 1% by weight and particularly preferably at least 2% by weight, based on the dry extract.

Active substance in the sense of the invention relates to the proportion of substances and auxiliaries and additives which are contained in the preparations, with the exception of the additionally added water. Detergent, dishwashing detergent or cleaning agent

Another object of the invention are washing, rinsing or cleaning agent preparations containing extracts from the leaves of the olive tree and / or from the wastewater of olive oil production and at least 10% by weight, preferably at least 15% by weight and particularly preferably at least 20% by weight .% of active substance of an anionic and / or cationic and / or amphoteric and / or nonionic surfactant - based on the preparation.

The present invention also relates to the use of the olive tree extracts for the production of washing, rinsing and cleaning agents.

Common detergents, dishwashing detergents and cleaning agents contain - based on the preparation - for example 0.01 to 15% by weight of extracts from the leaves of the olive tree and / or from the wastewater of olive oil production and at least 10% by weight of active substance of an anionic and / or cationic and / or amphoteric and / or nonionic surfactants, preferably they contain 0.05 to 5% by weight of extracts from the leaves of the olive tree and / or from the wastewater from olive oil production and at least 15% by weight of active substance of an anionic and / or cationic and / or amphoteric and / or nonionic surfactants, and particularly preferably 0.1 to 3% by weight of extracts from the leaves of the olive tree and / or from the waste water from olive oil production and at least 20% by weight of active substance of an anionic and / or cationic and / or amphoteric and / or nonionic surfactants.

It is also possible to use the extracts with high amounts of surfactants. The cleaning capacity and the foam quality of the preparations are not reduced by the addition of extracts from the olive tree.

Depending on the area of application, strongly foaming or mild, nourishing surfactants are added to the preparations. Because of their good skin tolerance, the extracts are preferably used in hand dishwashing detergents and body detergents.

Hand dishwashing detergents

The hand dishwashing detergents according to the invention preferably contain alk (en) yl oligoglycosides as surfactants.

Alkyl and Alkenyloligoαlvkoside

The alkyl and alkenyl oligoglycosides preferably contained in the hand dishwashing detergents follow the formula (I) R 0- [G] _P (I)

in which R ^{1 is} an alkyl and / or alkenyl radical having 4 to 22 carbon atoms, G is a sugar radical having 5 or 6 carbon atoms and p is a number from 1 to 10. They can be obtained according to the relevant procedures in preparative organic chemistry.

The alkyl and / or alkenyl oligoglycosides can be derived from aldoses or ketoses with 5 or 6 carbon atoms, preferably glucose. The preferred alkyl and / or alkenyl oligoglycosides are thus alkyl and / or alkenyl oligoglucosides. The index number p in the general formula (I) indicates the degree of olomerization (DP), ie the distribution of mono- and oligoglycosides, and stands for a number between 1 and 10. While p in a given compound must always be an integer, and especially here can assume the values p = 1 to 6, the value p for a certain alkyl oligoglycoside is an analytically determined arithmetic parameter, which usually represents a fractional number. Alkyl and / or alkenyl oligoglycosides with an average degree of oligomerization p of 1.1 to 3.0 are preferably used. From an application point of view, preference is given to those alkyl and / or alkenyl oligoglycosides whose degree of oligomerization is less than 1.7 and is in particular between 1.2 and 1.4. The alkyl or alkenyl radical R ¹ can be derived from primary alcohols having 4 to 11, preferably 8 to 10, carbon atoms. Typical examples are butanol, capronic alcohol, caprylic alcohol, capric alcohol and undecyl alcohol and their technical mixtures, such as are obtained, for example, in the hydrogenation of technical fatty acid methyl esters or in the course of the hydrogenation of aldehydes from Roelen's oxosynthesis. Alkyl oligoglucosides of chain length Cβ-Cio (DP = 1 to 3) are preferred, which are obtained as a preliminary step in the separation of technical Cs-Cis-coconut fatty alcohol by distillation and are contaminated with a proportion of less than 6% by weight of C12 alcohol can as well as alkyl oligoglucosides based on technical Cg / n-oxo alcohols (DP = 1 to 3). The alkyl or alkenyl radical R ¹ can also be derived from primary alcohols having 12 to 22, preferably 12 to 14, carbon atoms. Typical examples are lauryl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, alaidyl alcohol, petroselinyl alcohol, arachyl alcohol, gadoleyl alcohol, behenyl alcohol, erucyl alcohol, brassidyl alcohol and their technical mixtures, which can be obtained as well as their technical mixtures. Alkyl oligoglucosides based on hydrogenated Ci2 / i4 coconut alcohol with a DP of 1 to 3 are preferred.

Other non-ionic surfactants

Apart from the alkyl and alkenyl oligoglycosides, the hand dishwashing detergents according to the invention can contain further nonionic surfactants. Typical examples of nonionic surfactants are alkoxylated carboxylic acid esters, hydroxy mixed ethers, fatty alcohol polyglycol ethers, alkylphenol polyglycol ether, fatty acid amide polyglycol ether, fatty amine polyglycol ether, alkoxylated triglycerides, fatty acid N-alkyl-glucamides, protein hydrolysates (especially vegetable products based on wheat), polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. If the nonionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution.

Other nonionic surfactants are preferably selected from the group formed by alkoxylated carboxylic acid esters, hydroxy mixed ethers, fatty alcohol polyglycol ethers, end group-capped fatty alcohol polyglycol ethers, amine oxides and fatty acid N-alkyl glucamides.

anionic surfactants

The agents according to the invention can contain anionic surfactants. Typical examples of anionic surfactants are soaps, alkyl benzene sulfonates, alkane sulfonates, olefin sulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfo fatty acids, alkyl and / or alkenyl sulfates, alkyl ether sulfates, glycerol ether sulfates, fatty acid monoglyid sulfate (ether sulfate amide), monoglyid sulfate (ether) ether) sulfates, mono- and dialkylsulfosuccinates, mono- and dialkylsulfosuccinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid retaurides, N-acylamino acids such as acyl lactylates, acyl glutolate glucate, acyl glolate glycate, acyl glolate glycate, acyl glolate glucosate, especially vegetable products based on wheat) and alkyl (ether) phosphates. If the anionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution.

Alkyl and / or alkenyl sulfates, alkyl ether sulfates, alkane sulfonates, monoglyceride (ether) sulfates, alkyl benzene sulfonates, sulfosuccinates and / or fatty acid polyglycol ester sulfates, in particular fatty alcohol sulfates, fatty alcohol ether sulfates, are preferably used.

Amphoteric or zwitterionic surfactants

In a further embodiment, the hand dishwashing detergents according to the invention contain amphoteric or zwitterionic surfactants. Typical examples of amphoteric or zwitterionic surfactants are alkyl betaines, alkyl amido betaines, aminopropionates, imidazolinium betaines and sulfobetaines.

Betaines are known surfactants which are predominantly produced by carboxyalkylation, preferably carboxymethylation, of aminic compounds. The starting materials are preferably contacted with halocarboxylic acids or their salts, in particular with sodium chloroacetate. dense, forming one mole of salt per mole of betaine. The addition of unsaturated carboxylic acids, such as acrylic acid, is also possible.

Other auxiliaries and additives

Optional auxiliary agents such as builders, e.g. Glutaric acid, succinic acid, adipic acid, tartaric acid, gluconic acid, trisodium citrate, solvents, e.g. Acetone or ethanol, hydrotrope e.g. Cumene sulfonate, butyl glucoside, butylene glycol, viscosity regulators such as Fatty acid alkanolamides, pH regulators, e.g. Citric acid, caustic soda and potassium hydroxide, pearlescent agents such as Stearic acid derivatives. It can also contain dyes and fragrances.

The hand dishwashing detergents can of course contain other antimicrobial active ingredients. Quaternized ammonium compounds, quaternized fatty acid triethanolamine ester salts (esterquats) and / or aromatic alcohols are preferably used for this purpose.

fragrances

Individual fragrance compounds, for example the synthetic products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type, can be used as perfume oils or fragrances. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert.-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenylglycinate, allylcyclohexyl benzylatepylpropionate, stally. The ethers include, for example, benzyl ethyl ether, the aldehydes, for example, the linear alkanals with 8-18 C atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, and the ketones include, for example, the jonones, α-isomethylionone and methylcedrylke - clay, the alcohols anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol and terpinol, the hydrocarbons mainly include the terpenes such as limonene and pinene. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance. Perfume oils of this type can also contain natural fragrance mixtures such as are obtainable from plant sources, for example pine, citrus, jasmine, patchouly, rose or ylang-ylang oil. Also suitable are muscatel, sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, olibanum oil, galbanum oil and labdanum oil as well as orange blossom oil, neroliol, orange peel oil and sandalwood oil. body wash

The body detergents according to the invention can be present as hair shampoos, foam baths, shower baths, washing lotions or bars of soap. These agents can also be used as further auxiliaries and additives, mild surfactants, oil bodies, emulators, pearlescent waxes, consistency agents, thickeners, superfatting agents, stabilizers, polymers, silicone compounds, fats, waxes, lecithins, phospholipids, biogenic active ingredients, antidandruff agents, film formers, hydrotropes, Contain solubilizers, preservatives, perfume oils, dyes and the like.

surfactants

Anionic, nonionic, cationic and / or amphoteric or zwitterionic surfactants may be present as surface-active substances, the proportion of which in the compositions is usually about 1 to 70, preferably 5 to 50 and in particular 10 to 30% by weight. Typical examples of anionic surfactants are soaps, alkyl benzene sulfonates, alkane sulfonates, olefin sulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfo fatty acids, alkyl sulfates, fatty alcohol ether sulfates, glycerol ether sulfates, fatty acid ether sulfates, ether ether sulfates (mono) ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, mono ether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, hydroxymether ether sulfates, mono ether sulfates, sulfates, mono- and dialkylsulfosuccinates, mono- and dialkylsulfosuccinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosines, fatty acid taurides, N-acylamino acids, such as acyl lactylates, acyl sulfate fucylate, acyl acylate fate (especially vegetable products based on wheat) and alkyl (ether) phosphates. If the anionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution. Typical examples of nonionic surfactants are fatty alcohol polyglycol ethers, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty acid amide polyglycol ethers, fatty amine polyglycol ethers, alkoxylated triglycerides, mixed ethers or mixed formals, optionally partially oxidized alk (en) yl oligoglycosides or alkyl glucoramide acid derivatives (especially glucoronic acid derivatives) Wheat-based products), polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. If the nonionic surfactants contain polyglycol ether chains, they can have a conventional, but preferably a narrow, homolog distribution. Typical examples of cationic surfactants are quaternary ammonium compounds, such as, for example, dimethyldistearylammonium chloride, and esterquats, in particular quaternized fatty acid trialkanolamine ester salts. Typical examples of amphoteric or zwitterionic surfactants are alkyl betaines, alkyl amido betaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfobetaines. The surfactants mentioned are exclusively known compounds. Typical examples of particularly suitable mild, ie particularly skin-compatible surfactants are fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono- and / or dialkyl sulfosuccinates, fatty acid isethio nates, fatty acid sarcosinates, fatty acid taurides, fatty acid glutamates, α-olefin sulfonates, ether carboxylic acids, alkyl oligoglucosides, fatty acid glucamides, alkyl amido betaines, amphoacetals and / or protein fatty acid condensates, the latter preferably based on wheat proteins.

oil body

Guerbet alcohols based on fatty alcohols with 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C6-C22 fatty acids with linear or branched C6-C22 fatty alcohols or esters of branched C6-Ci3 carboxylic acids with linear or branched C6-C22-fatty alcohols, such as myristyl myristate, myristyl palmitate sostearat, myristyl stearate, Myristyli-, myristyl, Myristylbehenat, Myristylerucat, cetyl myristate, cetyl palmitate, cetyl stearate, Ce tylisostearat, cetyl oleate, cetyl behenate, Cetylerucat, Stearylmyristat, stearyl palmitate, stearyl stearate, Stearylisostearat, stearyl oleate , stearyl behenate, Stearylerucat, isostearyl, isostearyl palmitate, Isostearylstearat, isostearyl isostearate, Isostearyloleat, isostearyl behenate, Isostearyloleat, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, Oleylbehenat, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl, Behenylisostearat, behenyl oleate, Behenylbehen at, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate and erucyl rucate. In addition, esters of linear C6-C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of Ci8-C38 alkylhydroxycarboxylic acids with linear or branched C6-C22 fatty alcohols, in particular dioctyl malates, esters of linear and / or branched fatty acids are also suitable polyhydric alcohols (such as propylene glycol, dimer diol or trimer triol) and / or Guerbet alcohols, triglycerides based on C6-Cιo fatty acids, liquid mono- / di- / triglyceride mixtures based on Cθ-Cis fatty acids, esters of C6-C22- Fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid, esters of C2-Ci2-dicarboxylic acids with linear or branched alcohols with 1 to 22 carbon atoms or polyols with 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols Cyclohexanes, linear and branched C6-C22 fatty alcohol carbonates, such as, for example, dicaprylyl carbonates (Cetiol® CC), Guerbetcarbona te based on fatty alcohols with 6 to 18, preferably 8 to 10 C atoms, esters of benzoic acid with linear and / or branched C6-C22 alcohols (e.g. Finsolv® TN), linear or branched, symmetrical or asymmetrical dialkyl ethers with 6 to 22 Carbon atoms per alkyl group, such as dicaprylyl ether (Cetiol® OE), ring opening products of epoxidized fatty acid esters with polyols, silicone oils (cyclomethicones, silicon methicone types, etc.) and / or aliphatic or naphthenic hydrocarbons, such as squalane, squalene or dialkylcyclohexanes. emulators

Examples of suitable emulsifiers are nonionic surfactants from at least one of the following groups:

> Addition products of 2 to 30 mol ethylene oxide and / or 0 to 5 mol propylene oxide on linear

Fatty alcohols with 8 to 22 carbon atoms, fatty acids with 12 to 22 carbon atoms, alkylphenols with 8 to 15 carbon atoms in the alkyl group and alkylamines with 8 to 22 carbon atoms in the alkyl radical;

> Alkyl and / or alkenyl oligoglycosides with 8 to 22 carbon atoms in the alk (en) yl radical and their ethoxylated analogs;

> Adducts of 1 to 15 moles of ethylene oxide with castor oil and / or hardened castor oil;

> Adducts of 15 to 60 moles of ethylene oxide with castor oil and / or hardened castor oil;

> Partial esters of glycerol and / or sorbitan with unsaturated, linear or saturated, branched fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 moles of ethylene oxide;

> Partial esters of polyglycerol (average degree of self-condensation 2 to 8), polyethylene glycol (molecular weight 400 to 5000), trimethylolpropane, pentaerythritol, sugar alcohols (e.g. sorbitol), alkyl glucosides (e.g. methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g. cellulose) / or unsaturated, linear or branched fatty acids with 12 to 22 carbon atoms and / or hydroxycarboxylic acids with 3 to 18 carbon atoms and their adducts with 1 to 30 moles of ethylene oxide;

> Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol and / or mixed esters of fatty acids with 6 to 22 carbon atoms, methyl glucose and polyols, preferably glycerol or polyglycerol.

> Mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts;

> Wool wax alcohols;

> Polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives;

> Block copolymers e.g. Polyethylene glycol-30 dipolyhydroxystearate; Polymer emulsifiers, e.g. Pemulen types (TR-1, TR-2) from Goodrich;

> Polyalkylene glycols as well

> Glycerine carbonate.

> Ethylene oxide addition products

The adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols or with castor oil are known, commercially available products are homolog mixtures whose average degree of alkoxylation corresponds to the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate with which the addition reaction is carried out. Ci2 / ιs fatty acid monoesters and diesters of adducts of ethylene oxide with glycerol are known as refatting agents for cosmetic preparations.

Alkyl and / or alkenyl oligoglycosides

Alkyl and / or alkenylollgoglycosides, their preparation and their use are known from the prior art. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms. With regard to the glycoside residue, both monoglycosides in which a cyclic sugar residue is glycosidically bound to the fatty alcohol and oligomeric glycosides with a degree of oligomerization of up to about 8 are suitable. The degree of olomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.

Partialglvceride

Typical examples of suitable partial glycerides are hydroxystearic acid monoglyceride, stearic acid diglyceride hydroxy, isostearic acid, Isostearinsäurediglycerid, Ölsäuremonogly- cerid, oleic acid diglyceride, Ricinolsäuremoglycerid, Ricinolsäurediglycerid, Linolsäuremonoglycerid, Linolsäurediglycerid, Linolensäuremonoglycerid, Linolensäurediglycerid, Erucasäuremonoglycerid, Erucasäurediglycerid, Weinsäuremonoglycerid, Weinsäurediglycerid, Citronensäuremonoglycerid, Citronendiglycerid, Äpfelsäuremonoglycerid, malic acid diglyceride and their technical mixtures, which may still contain small amounts of triglyceride from the manufacturing process. Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto the partial glycerides mentioned are also suitable.

sorbitan

As sorbitan sorbitan, sorbitan sesquiisostearate, sorbitan come diisostearate, sorbitan triisostearate, sorbitan monooleate, sorbitan dioleate, bitantrioleat sorting, Sorbitanmonoerucat, Sorbitansesquierucat, Sorbitandierucat, Sorbitantrierucat, sorting bitanmonoricinoleat, Sorbitansesquiricinoleat, Sorbitandiricinoleat, Sorbitantriricinoleat, sorbitan monohydroxystearat, Sorbitansesquihydroxystearat, Sorbitandihydroxystearat , Sorbitan trihydroxystearate, sorbitan monotartrate, sorbitan sesq u i-tartrate, sorbitan ditartrate, sorbitan tritartrate, sorbi- Tan monocitrate, sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate, sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate, sorbitan trimaleate and their technical mixtures. Addition products of 1 to 30, preferably 5 to 10, mol of ethylene oxide onto the sorbitan esters mentioned are also suitable.

> Polyglycerol esters

Typical examples of suitable polyglycerol esters are polyglyceryl-2 dipolyhydroxystearates (Dehymuls® PGPH), polyglycerol-3-diisostearates (Lameform® TGI), polyglyceryl-4 isostearates (Isolan® Gl 34), polyglyceryl-3 oleates, diisostearoyl polyglyceryl polyglyceryl 3 diisostearates (Isolan® PDI), polyglyceryl-3 methylglucose distearate (Tego Care® 450), polyglyceryl-3 beeswax (Gera Bellina®), polyglyceryl-4 caprate (polyglycerol caprate T2010 / 90), polyglyceryl-3 cetyl ether ( Chimexane® NL), Polyglyceryl-3 Distearate (Cremophor® GS 32) and Polyglyceryl Polyricinoleate (Admul® WOL 1403) Polyglyceryl Dimerate Isostearate and their mixtures. Examples of other suitable polyol esters are the mono-, di- and triesters of trimethylolpropane or pentaerythritol with lauric acid, coconut fatty acid, taig fatty acid, palmitic acid, stearic acid, oleic acid, behenic acid and the like which are optionally reacted with 1 to 30 mol of ethylene oxide.

> Anionic emulsifiers

Typical anionic emulsifiers are aliphatic fatty acids with 12 to 22 carbon atoms, such as, for example, palmitic acid, stearic acid or behenic acid, and dicarboxylic acids with 12 to 22 carbon atoms, such as, for example, azelaic acid or sebacic acid.

Amphoteric and cationic emulsifiers

Zwitterionic surfactants can also be used as emulsifiers. Zwitterionic surfactants are surface-active compounds that contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example coconut alkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinate, for example coconut acylaminopropyldimethylammonium glycinate, and 2-alkyl-3 -carboxylmethyl-3-hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the coconut acylaminoethyl hydroxyethylcarboxymethylglycinate. This is particularly preferred under the CTFA name Cocamidopropyl betaine known fatty acid amide derivative. Suitable emulsifiers are ampholytic surfactants. Ampholytic surfactants are surface-active compounds which, in addition to a Cs-alkyl or acyl group, contain at least one free amino group and at least one -COOH or -Sθ3H group in the molecule and are capable of forming internal salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids, each with about 8 to 18 carbon atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocacylaminoethylaminopropionate and Ci2 / i8-acylsarcosine. Finally, cationic surfactants are also suitable as emulsifiers, those of the esterquat type, preferably methyl-quaternized difatty acid triethanolamine ester salts, being particularly preferred.

Fats and waxes

Typical examples of fats are glycerides, i.e. Solid or liquid vegetable or animal products, which consist essentially of mixed glycerol esters of higher fatty acids, come as waxes, among others. natural waxes, e.g. Candelilla wax, carnauba wax, japan wax, esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax, walnut, lanolin (wool wax), pretzel fat, ceresin, ozokerite (earth wax), petrolatum, paraffin waxes, micro waxes chemically modified waxes (hard waxes), e.g. Montanester waxes, Sasol waxes, hydrogenated jojoba waxes and synthetic waxes, such as Polyalkylene waxes and polyethylene glycol waxes in question. In addition to fats, fat-like substances such as lecithins and phospholipids can also be used as additives. The term “lecithins” is understood by the person skilled in the art to mean those glycerophospholipids which form from fatty acids, glycerol, phosphoric acid and choline by esterification. Lecithins are therefore often used in the professional world as phosphatidylcholines (PC). Examples of natural lecithins are the cephalins, which are also referred to as phosphatidic acids and are derivatives of 1,2-diacyl-sn-glycerol-3-phosphoric acids. In contrast, phospholipids are usually understood to be mono- and preferably diesters of phosphoric acid with glycerol (glycerol phosphates), which are generally classed as fats. In addition, sphingosines or sphingolipids are also suitable.

pearlescent

Pearlescent waxes that can be used are, for example: Al ky leng lycolester, especially ethylene glycol distearate; Fatty acid alkanolamides, especially coconut fatty acid diethanolamide; Partial glycerides, especially steak rinsäuremonoglycerid; Esters of polyvalent, optionally hydroxy-substituted carboxylic acids with fatty alcohols having 6 to 22 carbon atoms, especially long-chain esters of tartaric acid; Fatty substances, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which have a total of at least 24 carbon atoms, especially lauron and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring opening products of olefin epoxides with 12 to 22 carbon atoms with fatty alcohols with 12 to 22 carbon atoms and / or polyols with 2 to 15 carbon atoms and 2 to 10 hydroxyl groups and mixtures thereof.

Consistency agents and thickeners

Suitable consistency agents are primarily fatty alcohols or hydroxyfatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms and also partial glycerides, fatty acids or hydroxyfatty acids. A combination of these substances with alkylollgoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates is preferred. Suitable thickeners are, for example, Aerosil types (hydrophilic silicas), polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl and hydroxypropyl cellulose, and also higher molecular weight polyethylene glycol mono- and - diesters of fatty acids, polyacrylates, (eg Carbopole® and Pemulen types from Goodrich; Synthalene® from Sigma; Keltrol types from Kelco; Sepigel types from Seppic; Salcare types from Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and Poly vinyl pyrrolidone. Bentonites, such as e.g. Bentone® Gel VS-5PC (Rheox), which is a mixture of cyclopentasiloxane, disteardimonium hectorite and propylene carbonate. Surfactants such as ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as pentaerythritol or trimethylolpropane, fatty alcohol ethoxylates with a narrow homolog distribution or alkyl oligoglucosides as well as electrolytes such as table salt and ammonium chloride are also suitable.

superfatting

Substances such as, for example, lanolin and lecithin, and also polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and fatty acid alkanolamides can be used as superfatting agents, the latter simultaneously serving as foam stabilizers. stabilizers

Metal salts of fatty acids, such as e.g. Magnesium, aluminum and / or zinc stearate or ricinoleate are used.

polymers

Suitable cationic polymers are, for example, cationic cellulose derivatives, e.g. a quaternized hydroxyethyl cellulose available under the name Polymer JR 400® from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / vinylimidazole polymers such as e.g. Luviquat® (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides, such as lauryldimonium hydroxypropyl hydrolyzed collagen (Lamequat®L / Grünau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone polymers, such as e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine® / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat® 550 / Chemviron), polyaminopolyamides, as well as their crosslinked water-soluble polymers, cationic chitin derivatives, such as quanernized, optionally quaternized, Condensation products from dihaloalkylene, such as Dibromobutane with bisdialkylamines, e.g. Bis-dimethylamino-1,3-propane, cationic guar gum, e.g. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol.

Anionic, zwitterionic, amphoteric and nonionic polymers include, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobomylacrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their crosslinked polyols and their esters, polyols and their polyols , Acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate / tert.butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylamino-methyl-acrylate and acrylate-vinylamine / vinyl acrylate-methacrylate, if appropriate, and also vinyl-pyridolidate / dimethylamino-methyl-methacrylate ,

silicone compounds

Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, cyclic silicones and amino-, fatty acid-, alcohol-, polyether-, epoxy-, fluorine-, glycoside- and / or alkyl-modified silicone compounds which are both liquid and resinous at room temperature. can lie. Simethicones, which are mixtures of dimethicones with an average chain length of 200 to 300 dimethylsiloxane units and hydrogenated silicates, are also suitable.

Biogenic agents

Examples of biogenic active substances are tocopherol, tocopherol acetate, tocopherol palmitate, ascorbic acid, (deoxy) ribonucleic acid and its fragmentation products, ß-glucans, retinol, bisabolol, allantoin, phytantriol, panthenol, AHA acids, amino acids, ceramides, pseudo-leeroceramides, essential extracts, plant extracts Understand vitamin complexes.

hydrotropes

Hydrotropes, such as ethanol, isopropyl alcohol, or polyols can also be used to improve the flow behavior. Polyols that come into consideration here preferably have 2 to 15 carbon atoms and at least two hydroxyl groups. The polyols can also contain further functional groups, in particular amino groups, or be modified with nitrogen. Typical examples are

> Glycerin;

> Alkylene glycols, such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, hexylene glycol and polyethylene glycols with an average molecular weight of 100 to 1,000 daltons;

> technical oligoglycerol mixtures with a degree of self-condensation of 1.5 to 10 such as technical diglycerol mixtures with a diglycerol content of 40 to 50% by weight;

> Methyl compounds, such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol;

> Lower alkyl glucosides, especially those with 1 to 8 carbons in the alkyl radical, such as methyl and butyl glucoside;

> Sugar alcohols with 5 to 12 carbon atoms, such as sorbitol or mannitol,

> Sugar with 5 to 12 carbon atoms, such as glucose or sucrose;

> Aminosugars such as glucamine;

> Dialcohol amines, such as diethanolamine or 2-amino-1, 3-propanediol. preservative

Suitable preservatives are, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid, as well as the silver complexes known under the name Surfacine® and the other classes of substances listed in Appendix 6, Parts A and B of the Cosmetics Regulation.

Perfume oils and flavors

Perfume oils include mixtures of natural and synthetic fragrances. Natural fragrances are extracts of flowers (lily, lavender, roses, jasmine, neroli, ylang-ylang), stems and leaves (geranium, patchouli, petitgrain), fruits (anise, coriander, caraway, juniper), fruit peel (bergamot, lemon, Oranges), roots (mace, angelica, celery, cardamom, costus, iris, calmus), wood (pine, sandal, guaiac, cedar, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), Needles and twigs (spruce, fir, pine, mountain pine), resins and balms (galbanum, elemi, benzoin, myrrh, olibanum, opoponax). Animal raw materials, such as civet and castoreum, are also suitable. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenylglycinate, allylcyclohexyl benzylatepylpropionate, allyl cyclohexyl propyl pionate. The ethers include, for example, benzyl ethyl ether, the aldehydes include, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, and the ketones include, for example, the jonones, α-isomethylionone and methylcedryl ketone the alcohols anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol, the hydrocarbons mainly include the terpenes and balsams. However, preference is given to using mixtures of different fragrances which together produce an appealing fragrance. Essential oils of lower volatility, which are mostly used as aroma components, are also suitable as perfume oils, for example sage oil, chamomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil. Bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α-hexyl cinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, boisambrene forte, ambroxan, indole, hedione, sandelice, lemon oil, mandarin oil, lavender oil, orange glycolate, almond glycol, alanol glycol, alanol oil, alanol glycolate, alanol glycolate, alanol glycolate, alanol glycolate, alanol glycolate, alanol glycolate, alanol glycolate, alanecalcolate, orange oil, alanol glycolate, alanol glycolate, alanecalcolate, orange oil, alanol glycolate, alanol glycolate, alanecalcolate, orange oil, alanecalcolate, orange oil, aldolate, lamellar oil, orange oil, orange oil, orange oil, aldolate, lemon oil, orange oil, orange oil oil, orange oil oil, alanecalcone oil, orange oil, alanecalcone oil Sage oil, ß-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, romilllate, irotyl and floramate alone or in mixtures. Suitable flavors are, for example, peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, lemon oil, wintergreen oil, clove oil, menthol and the like.

dyes

The dyes which can be used are those which are suitable and approved for cosmetic purposes. Examples are Kochillerot A (Cl 16255), patent blue V (C.1.42051), indigotine (C.1.73015), chlorophylline (C.1.75810), quinoline yellow (CI47005), titanium dioxide (C.1.77891), indanthrene blue RS (Cl 69800) and madder varnish (CI58000). Luminol may also be present as the luminescent dye. These dyes are usually used in concentrations of 0.001 to 0.1% by weight, based on the mixture as a whole.

The total proportion of auxiliaries and additives can be 1 to 50, preferably 5 to 40,% by weight, based on the composition. The agents can be produced by customary cold or hot processes; the phase inversion temperature method is preferably used.

Examples

Leaves of the olive tree (Olea europaea) were collected, dried, ground and extracted by a 55-60 vol.% Ethanol / water mixture at 60 ° C. for 4 hours. The eluate was dried, ground and sieved and adjusted to a content of approximately 20% by weight oleuropein.

An agar diffusion test was carried out to determine the antimicrobial activity.

agar diffusion test

Test germs:

1. Corynebacterium (C.) minutissimum ATCC 23348 1, 5 x 10 ³ CFU / ml

2. Staphylococcus (S.) epidermidis ATCC 12228 2.5 x 10 ³ CFU / ml

3. Propionibacterium (P.) acnes ATCC 11829 3.1 x 103 "BE / ml

4. Malassezia (M.) furfur DSM 6171 1.9 x 103 CFU / ml

Production of test germ suspensions (aerobic bacteria):

The test germs were subcultured on Columbia blood agar (bioMerieux Art. 43049). Sufficient colonies were homogenized in NaCl peptone buffer using a swab so that the turbidity corresponded to the McFarland Standard 1.0.

Production of test germ suspensions (anaerobic bacteria):

The test germs were subcultured on Schaedler agar (bioMerieux Art. 43273). Sufficient colonies were homogenized in NaCl peptone buffer using a swab so that the turbidity corresponded to the McFarland Standard 1.0.

Production of test germ suspensions (yeast and mold):

The test germs were subcultured on Sabouraud agar HLT (Merck, Art. 18364). Sufficient colonies were homogenized in NaCl peptone buffer using a swab so that the turbidity corresponded to the McFarland Standard 1.0.

Sample preparation:

A test concentration of 5% by weight of olive tree leaf extract (Herbalia®Olive - Cognis Iberia SL, Poligono San Vicente, 08755 Castellbisbal, Barcelona (Spain)) was obtained by weighing out 0.5 g of dry extract and dissolving to 10 ml with 15% by volume of ethanol ( Merck, Art. 100971). controls:

K1 test leaves unvaccinated

K2 test papers + 10 resp. 20 ul 15 vol% ethanol

incubation Conditions:

3 test plates were created for each batch. The agar plates were

18 h at 36 ° C germ 1, 2

72 h at 36 ° C anaerobic germ 3

Incubated for 72 h at 30 ° C germ 4.

Test procedure

The test germs were homogenized 2% with the appropriate test medium (see below). 15 ml of this was poured into petri dishes.

Müller Hinton-Agar Merck, Art. 5437 Germ 1, 2

Wilkens Chalgren Oxoid, Art. CM 643 Germ 3

PIT - medium germ 4

(Malt Agar Merck Art. 5398, Ochsengalle 3756, Tween 40822185 and Monoolein Fluka Art. 49960)

After solidification and drying of the plates, 5 sterile test plates (6mm diameter, BioMerieux, Art. 54991) were laid out (3 x sample, 2 x control). Two batches were carried out for each sample: batch 1 with 10 μl, batch 2 with 20 μl. After incubation, the inhibition zone diameters [mm] were measured.

Results

Table 1: Antimicrobial activity of olive tree leaf extract

Insbesondere bei einer Ansatzgröße von 20 μl werden die Mikroorganismen vom Olivenbaumblätter- extrakt deutlich gehemmt. Staphylococcus epidermidis unterliegt der Hemmung bereits bei sehr geringen Probekonzentrationen.

Especially with a batch size of 20 μl, the microorganisms from the olive tree leaf extract are significantly inhibited. Staphylococcus epidermidis is subject to inhibition even at very low sample concentrations.

Table 2 below contains a number of formulation examples with olive tree leaf extract as an antimicrobial agent.

Table 2:

Hand dishwashing liquid - formulation examples

Table 3: Model formulation - hand dishwashing liquid

Claims

claims 1. Use of extracts from the olive tree as an antimicrobial active ingredient in detergents, dishwashing detergents and cleaning agents. 2. Use according to claim 1, characterized in that extracts from the leaves of the olive tree and / or from the wastewater of olive oil production are used. 3. Use according to claims 1 and / or 2, characterized in that the extracts are used in concentrations of 0.01 to 15% by weight. 4. Use according to at least one of claims 1 to 3, characterized in that the extracts contain at least 1% by weight of oleuropein. 5. Use according to at least one of claims 1 to 4, characterized in that the extracts contain at least 1% by weight of polyphenols. 6. Use of extracts from the olive tree to inhibit aerobic and / or anaerobic germs and / or to inhibit yeasts and molds of the microflora on the skin and scalp. 7. washing, rinsing and cleaning agent preparations, containing extracts from the leaves of the olive tree and / or from the wastewater of olive oil production and at least 10% by weight of an anionic and / or cationic and / or amphoteric and / or nonionic surfactant.