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WO2003070182A3 - Bloqueurs de canaux sodium - Google Patents

Bloqueurs de canaux sodium Download PDF

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Publication number
WO2003070182A3
WO2003070182A3 PCT/US2003/004817 US0304817W WO03070182A3 WO 2003070182 A3 WO2003070182 A3 WO 2003070182A3 US 0304817 W US0304817 W US 0304817W WO 03070182 A3 WO03070182 A3 WO 03070182A3
Authority
WO
WIPO (PCT)
Prior art keywords
sodium channel
channel blockers
present
variety
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/004817
Other languages
English (en)
Other versions
WO2003070182A2 (fr
Inventor
Michael R Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27752677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003070182(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020107027168A priority Critical patent/KR101225201B1/ko
Priority to EP03742810A priority patent/EP1485360B1/fr
Priority to US10/532,110 priority patent/US20060142306A1/en
Priority to AU2003211135A priority patent/AU2003211135B2/en
Priority to HK05103365.6A priority patent/HK1070369B/en
Priority to KR1020107027167A priority patent/KR101183274B1/ko
Application filed by Individual filed Critical Individual
Priority to JP2003569142A priority patent/JP4557550B2/ja
Priority to SI200332076T priority patent/SI1485360T1/sl
Priority to DK03742810.9T priority patent/DK1485360T3/da
Priority to ES03742810T priority patent/ES2374130T3/es
Priority to KR1020047012934A priority patent/KR101008728B1/ko
Priority to CA2476430A priority patent/CA2476430C/fr
Priority to AT03742810T priority patent/ATE520674T1/de
Publication of WO2003070182A2 publication Critical patent/WO2003070182A2/fr
Publication of WO2003070182A3 publication Critical patent/WO2003070182A3/fr
Anticipated expiration legal-status Critical
Priority to US12/179,353 priority patent/US8198286B2/en
Priority to US13/492,711 priority patent/US8846688B2/en
Priority to US14/158,441 priority patent/US20140179625A1/en
Priority to US14/727,189 priority patent/US20150376146A1/en
Priority to US15/336,574 priority patent/US10167266B2/en
Priority to US16/181,230 priority patent/US20190241528A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C07D241/30—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms in which said hetero-bound carbon atoms are part of a substructure —C(=X)—X—C(=X)—X— in which X is an oxygen or sulphur atom or an imino radical, e.g. imidoylguanidines
    • C07D241/32—(Amino-pyrazinoyl) guanidines
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des bloqueurs de canaux sodium ainsi qu'une pluralité de méthodes de traitement utilisant lesdits bloqueurs de canaux de sodium de l'invention.
PCT/US2003/004817 2002-02-19 2003-02-19 Bloqueurs de canaux sodium Ceased WO2003070182A2 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CA2476430A CA2476430C (fr) 2002-02-19 2003-02-19 Bloqueurs de canaux sodium
ES03742810T ES2374130T3 (es) 2002-02-19 2003-02-19 Bloqueantes de los canales de sodio.
US10/532,110 US20060142306A1 (en) 2002-02-19 2003-02-19 Sodium channel blockers
AU2003211135A AU2003211135B2 (en) 2002-02-19 2003-02-19 Sodium channel blockers
HK05103365.6A HK1070369B (en) 2002-02-19 2003-02-19 Sodium channel blockers
KR1020107027167A KR101183274B1 (ko) 2002-02-19 2003-02-19 나트륨 채널 차단제
EP03742810A EP1485360B1 (fr) 2002-02-19 2003-02-19 Bloqueurs de canaux sodium
JP2003569142A JP4557550B2 (ja) 2002-02-19 2003-02-19 ナトリウムチャネル遮断薬
SI200332076T SI1485360T1 (sl) 2002-02-19 2003-02-19 Blokatorji natrijevih kanalov
DK03742810.9T DK1485360T3 (da) 2002-02-19 2003-02-19 Natriumkanalblokkere
KR1020047012934A KR101008728B1 (ko) 2002-02-19 2003-02-19 나트륨 채널 차단제
KR1020107027168A KR101225201B1 (ko) 2002-02-19 2003-02-19 나트륨 채널 차단제
AT03742810T ATE520674T1 (de) 2002-02-19 2003-02-19 Natriumkanalblocker
US12/179,353 US8198286B2 (en) 2002-02-19 2008-07-24 Sodium channel blockers
US13/492,711 US8846688B2 (en) 2002-02-19 2012-06-08 Sodium channel blockers
US14/158,441 US20140179625A1 (en) 2002-02-19 2014-01-17 Sodium channel blockers
US14/727,189 US20150376146A1 (en) 2002-02-19 2015-06-01 Sodium channel blockers
US15/336,574 US10167266B2 (en) 2002-02-19 2016-10-27 Sodium channel blockers
US16/181,230 US20190241528A1 (en) 2002-02-19 2018-11-05 Sodium channel blockers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/076,571 US6858615B2 (en) 2002-02-19 2002-02-19 Phenyl guanidine sodium channel blockers
US10/076,571 2002-02-19

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US10/076,571 Continuation-In-Part US6858615B2 (en) 2002-02-19 2002-02-19 Phenyl guanidine sodium channel blockers
US10/076,571 Continuation US6858615B2 (en) 2002-02-19 2002-02-19 Phenyl guanidine sodium channel blockers

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10532110 A-371-Of-International 2003-02-19
US10/532,110 A-371-Of-International US20060142306A1 (en) 2002-02-19 2003-02-19 Sodium channel blockers
US12/179,353 Continuation US8198286B2 (en) 2002-02-19 2008-07-24 Sodium channel blockers

Publications (2)

Publication Number Publication Date
WO2003070182A2 WO2003070182A2 (fr) 2003-08-28
WO2003070182A3 true WO2003070182A3 (fr) 2003-12-24

Family

ID=27752677

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004817 Ceased WO2003070182A2 (fr) 2002-02-19 2003-02-19 Bloqueurs de canaux sodium

Country Status (13)

Country Link
US (15) US6858615B2 (fr)
EP (1) EP1485360B1 (fr)
JP (2) JP4557550B2 (fr)
KR (3) KR101183274B1 (fr)
AT (1) ATE520674T1 (fr)
AU (2) AU2003211135B2 (fr)
CA (1) CA2476430C (fr)
CY (1) CY1112906T1 (fr)
DK (1) DK1485360T3 (fr)
ES (1) ES2374130T3 (fr)
PT (1) PT1485360E (fr)
SI (1) SI1485360T1 (fr)
WO (1) WO2003070182A2 (fr)

Cited By (7)

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