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WO2003059865A1 - Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes - Google Patents

Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes Download PDF

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Publication number
WO2003059865A1
WO2003059865A1 PCT/JP2002/012473 JP0212473W WO03059865A1 WO 2003059865 A1 WO2003059865 A1 WO 2003059865A1 JP 0212473 W JP0212473 W JP 0212473W WO 03059865 A1 WO03059865 A1 WO 03059865A1
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
intermediates
processes
glutamic acid
acid compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/012473
Other languages
English (en)
French (fr)
Inventor
Shigeru Kawahara
Yusuke Amino
Kenichi Mori
Nao Funakoshi
Tadashi Takemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27482750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003059865(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES02783682T priority Critical patent/ES2383518T3/es
Priority to KR1020047010083A priority patent/KR100906947B1/ko
Priority to AU2002349606A priority patent/AU2002349606A1/en
Priority to CA2471847A priority patent/CA2471847C/en
Priority to AT02783682T priority patent/ATE552242T1/de
Priority to JP2003559970A priority patent/JP4196832B2/ja
Priority to EP02783682A priority patent/EP1466890B1/en
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2003059865A1 publication Critical patent/WO2003059865A1/ja
Priority to US10/872,573 priority patent/US7064219B2/en
Anticipated expiration legal-status Critical
Priority to US11/283,943 priority patent/US7390909B2/en
Priority to US11/951,395 priority patent/US7678925B2/en
Priority to US12/490,024 priority patent/US7868187B2/en
Priority to US12/613,713 priority patent/US20100105924A1/en
Priority to US13/273,290 priority patent/US20120035373A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PCT/JP2002/012473 2001-12-27 2002-11-29 Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes Ceased WO2003059865A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES02783682T ES2383518T3 (es) 2001-12-27 2002-11-29 Procedimientos para la preparación de compuestos de ácido glutámico e intermedios de los mismos y nuevos intermedios usados en los procedimientos
KR1020047010083A KR100906947B1 (ko) 2001-12-27 2002-11-29 글루탐산 화합물 및 이의 제조 중간체의 제조방법 및 이를 위한 신규 중간체
AU2002349606A AU2002349606A1 (en) 2001-12-27 2002-11-29 Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes
CA2471847A CA2471847C (en) 2001-12-27 2002-11-29 Processes of producing glutamic acid compounds and production intermediates therefor and novel intermediate for the processes
AT02783682T ATE552242T1 (de) 2001-12-27 2002-11-29 ßVERFAHREN ZUR HERSTELLUNG VON GLUTAMINSÄUREVERBINDUNGEN UND ZWISCHENPRODUKTEN DAVON, UND IN DEN VERFAHREN VERWENDETE NEUE ZWISCHENPRODUKTEß
JP2003559970A JP4196832B2 (ja) 2001-12-27 2002-11-29 グルタミン酸化合物及びそれらの製造中間体の製造方法並びにそのための新規中間体
EP02783682A EP1466890B1 (en) 2001-12-27 2002-11-29 Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes
US10/872,573 US7064219B2 (en) 2001-12-27 2004-06-22 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US11/283,943 US7390909B2 (en) 2001-12-27 2005-11-22 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US11/951,395 US7678925B2 (en) 2001-12-27 2007-12-06 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US12/490,024 US7868187B2 (en) 2001-12-27 2009-06-23 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US12/613,713 US20100105924A1 (en) 2001-12-27 2009-11-06 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US13/273,290 US20120035373A1 (en) 2001-12-27 2011-10-14 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2001396300 2001-12-27
JP2001-396300 2001-12-27
JP2002-149078 2002-05-23
JP2002149069 2002-05-23
JP2002-149069 2002-05-23
JP2002149078 2002-05-23
JP2002-182032 2002-06-21
JP2002182032 2002-06-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/872,573 Continuation US7064219B2 (en) 2001-12-27 2004-06-22 Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

Publications (1)

Publication Number Publication Date
WO2003059865A1 true WO2003059865A1 (en) 2003-07-24

Family

ID=27482750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/012473 Ceased WO2003059865A1 (en) 2001-12-27 2002-11-29 Processes for the preparation of glutamic acid compounds and intermediates thereof and novel intermediates used in the processes

Country Status (10)

Country Link
US (6) US7064219B2 (ja)
EP (1) EP1466890B1 (ja)
JP (2) JP4196832B2 (ja)
KR (1) KR100906947B1 (ja)
CN (2) CN101450907B (ja)
AT (1) ATE552242T1 (ja)
AU (1) AU2002349606A1 (ja)
CA (1) CA2471847C (ja)
ES (1) ES2383518T3 (ja)
WO (1) WO2003059865A1 (ja)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1533300A1 (en) * 2003-11-21 2005-05-25 Ajinomoto Co., Inc. Organic amine salts of glutamic acid derivatives and their application
WO2005082850A1 (ja) * 2004-02-27 2005-09-09 Ajinomoto Co., Inc. モナティンの製造方法
WO2006038520A1 (ja) * 2004-10-05 2006-04-13 Ajinomoto Co., Inc. ヒドロキシイミノ酸からのアミノ酸誘導体製造方法
US7064219B2 (en) 2001-12-27 2006-06-20 Ajinomoto Co., Inc. Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes
US7241599B2 (en) 2004-06-07 2007-07-10 Ajinomoto Co., Inc. Aldolase, and method for producing optically active IHOG and monatin
EP1956003A2 (en) 2007-02-08 2008-08-13 Ajinomoto Co., Inc. Process for producing an optically active compound
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2107053A1 (en) 2008-03-11 2009-10-07 Ajinomoto Co., Inc. Hydrate crystals of (2R,4R)-Monatin monosodium salt
US7781005B2 (en) 2004-10-15 2010-08-24 Ajinomoto Co., Inc. Sweetener composition
US7888081B2 (en) 2006-05-24 2011-02-15 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8043837B2 (en) 2006-03-07 2011-10-25 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
US8058038B2 (en) 2002-08-26 2011-11-15 Ajinomoto Co., Inc. Aldolase and production process of substituted α-keto acids
US8058034B2 (en) 2002-12-09 2011-11-15 Ajinomoto Co., Inc. Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076107B2 (en) 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8153405B2 (en) 2005-04-20 2012-04-10 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
WO2012050125A1 (ja) 2010-10-14 2012-04-19 味の素株式会社 モナティンの製造方法
US8206955B2 (en) 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
CN115806481A (zh) * 2022-12-05 2023-03-17 安徽丰乐香料有限责任公司 L-薄荷基甲酸的分离提纯方法

Families Citing this family (13)

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CN1319943C (zh) * 2001-11-30 2007-06-06 味之素株式会社 莫那特因的非天然型立体异构体盐的结晶及其使用
CN101671707A (zh) * 2001-12-27 2010-03-17 味之素株式会社 谷氨酸衍生物的制备方法
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
KR101160473B1 (ko) * 2003-01-09 2012-06-28 아지노모토 가부시키가이샤 글루탐산 유도체 및 피로글루탐산 유도체의 제조 방법 및신규 제조 중간체
JP2007501004A (ja) * 2003-08-01 2007-01-25 カーギル，インコーポレイティド モナチン卓上甘味料組成物およびその製造方法
KR101191542B1 (ko) * 2003-08-25 2012-10-15 카아길, 인코포레이팃드 모나틴을 포함하는 음료 조성물 및 이의 제조 방법
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
KR101216575B1 (ko) * 2004-07-14 2012-12-31 아지노모토 가부시키가이샤 (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물
US7180370B2 (en) * 2004-09-01 2007-02-20 Micron Technology, Inc. CMOS amplifiers with frequency compensating capacitors
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN119775157B (zh) * 2024-12-11 2025-09-19 西安味品荟食品科技有限公司 一种呈味化合物及其制备方法及应用

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US4975298A (en) * 1987-06-15 1990-12-04 South African Inventions Development Corporation 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds
EP0438314A1 (en) * 1990-01-19 1991-07-24 Technology Finance Corporation (Proprietary) Limited Process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole

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ATE552242T1 (de) * 2001-12-27 2012-04-15 Ajinomoto Kk ßVERFAHREN ZUR HERSTELLUNG VON GLUTAMINSÄUREVERBINDUNGEN UND ZWISCHENPRODUKTEN DAVON, UND IN DEN VERFAHREN VERWENDETE NEUE ZWISCHENPRODUKTEß
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CA2506247C (en) * 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CA2471847A1 (en) 2003-07-24
CN100465156C (zh) 2009-03-04
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ATE552242T1 (de) 2012-04-15
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US7868187B2 (en) 2011-01-11
US20090259052A1 (en) 2009-10-15
JP4196832B2 (ja) 2008-12-17
US20080091032A1 (en) 2008-04-17
US20060074249A1 (en) 2006-04-06
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CN1610658A (zh) 2005-04-27
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KR20040076269A (ko) 2004-08-31
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US20100105924A1 (en) 2010-04-29
US7678925B2 (en) 2010-03-16
CN101450907B (zh) 2013-07-17
US7064219B2 (en) 2006-06-20
US20050004394A1 (en) 2005-01-06
US7390909B2 (en) 2008-06-24
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CA2471847C (en) 2012-05-15

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