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WO2003059338A1 - Procede de production d'une preparation liquide contenant des acides amines ramifies - Google Patents

Procede de production d'une preparation liquide contenant des acides amines ramifies Download PDF

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Publication number
WO2003059338A1
WO2003059338A1 PCT/JP2003/000218 JP0300218W WO03059338A1 WO 2003059338 A1 WO2003059338 A1 WO 2003059338A1 JP 0300218 W JP0300218 W JP 0300218W WO 03059338 A1 WO03059338 A1 WO 03059338A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
liquid preparation
leucine
branched
isoleucine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/000218
Other languages
English (en)
Japanese (ja)
Inventor
Akira Yabuki
Hiroyuki Higuchi
Mitsuyasu Ida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to AU2003203159A priority Critical patent/AU2003203159A1/en
Publication of WO2003059338A1 publication Critical patent/WO2003059338A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a liquid preparation for a pharmaceutical or health drink containing only three kinds of branched chain amino acids of isoleucine, leucine and palline as an amino acid component as an active ingredient, and a method for producing the same.
  • the present invention is a solution containing three types of branched chain amino acids consisting of isoleucine, leucine, and valine, which have strong bitterness, as active ingredients in a high concentration, and the dose per dose is reduced.
  • the present invention relates to a solution capable of producing a liquid or syrup for a health drink or a medicine and a method for producing the same.
  • Preparations containing three types of branched-chain amino acids consisting of isoleucine, leucine and palin as active ingredients are effective remedies for liver diseases, but currently marketed preparations mainly consist of granules.
  • the single dose is about 5 g, which is significantly higher than that of general preparations, and is difficult to take due to the strong bitterness. is there.
  • the liquid volume is small in terms of ease of taking and portability, and many liquids have a single dose of 10 OmL or less.
  • the solubility in water in the neutral region is low.
  • the solubility of leucine is 2.3 g at 10 ° C, 2.4 g of ZdL and 20 ° C. / dL, which is extremely low, when preparing a liquid preparation of 10 OmL or less containing 4 g of branched-chain amino acids, there were problems such as crystallization during the distribution process or during refrigerated storage.
  • the present invention relates to the use of three types of branched-chain amino acids consisting of isoleucine, leucine, and valine, which are effective therapeutic agents for liver diseases, as an active ingredient in a liquid medicine or health drink for each dose.
  • the aim is to reduce the volume and improve the ingestibility.
  • the inventors of the present invention have conducted intensive studies and found that, in the step of dissolving the raw material in the production process of the branched chain amino acid-containing liquid preparation, the addition of an organic acid and / or an inorganic acid results in a branched chain
  • a high-concentration solution can be prepared by improving the solubility of amino acids, and the prepared solution masks the bitterness peculiar to branched-chain amino acids by the added acid, making it easy to take.
  • the present invention includes the following inventions.
  • the total amount of the three types of branched-chain amino acids of isoleucine, leucine and palline dissolved per 10 OmL of the liquid preparation is not less than 4. Og, any one of (1) to (3).
  • the liquid preparation for pharmaceuticals or health drinks of the present invention is a liquid preparation prepared as an aqueous solution in which three kinds of branched-chain amino acids consisting of isoleucine, oral isine and valine as active ingredients are dissolved at a high concentration.
  • Examples of the inorganic acid used for producing the liquid preparation for medical or health drinks of the present invention include carbonic acid, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid and boric acid. Acids are preferred.
  • the organic acids include cunic acid, cunic anhydride, d-monomalic acid, tartaric acid, d-tartaric acid, ascorbic acid, acetic acid, lactic acid, succinic acid, Maleic acid, malonic acid, 1-glutamic acid hydrochloride and the like can be mentioned, and particularly, citric acid, citric anhydride, dl-malic acid, tartaric acid, d-tartaric acid, ascorbic acid, acetic acid and the like are preferable.
  • a sweetener / flavoring agent may be added to the pharmaceutical or health drink solution of the present invention.
  • sweeteners / flavors include aspartame, saccharin, sodium saccharin, glycyrrhizic acid, monoammonium glycyrrhizinate, diammonium darityl ritinate, dipotassium glycyrrhizinate, ninatrium glycyrrhizinate, trisodium glycyrrhizinate, acesulfame K, acesulfame K Erythritol, sorbitol, xylitol and trehalose.
  • Particularly preferred are aspartame, saccharin, saccharin sodium, mannitol and the like.
  • Flavoring agents can be used in the liquid preparation for medicine or health drink of the present invention.
  • Various flavors can be used as such a flavoring agent, and examples thereof include lemon flavor, orange flavor, grapefruit flavor, chocolate flavor, dl-menthol, and 1-menthol.
  • the isoleucine raw material, leucine raw material and palin raw material as active ingredients are generally produced by a fermentation method and crushed into particles having a particle size of 1 mm or less. There are no particular restrictions on the particle size and the like as long as they can be dissolved in water according to the method of the present invention.
  • the liquid preparation containing only the above three kinds of branched-chain amino acids as the amino acid component in the liquid preparation for medical use or health food of the present invention can also be produced by using equipment such as a dissolving tank having a stirring blade, a high-speed homogenizer and the like. . In addition, by heating during dissolution, the preparation time can be reduced.
  • Example 1 After pouring 900 g of heated distilled water into a glass beaker (capacity: 2 liters), add 19.04 g of isine, 9.52 g of isoleucine, 1.44 g of phosphorus, and 1.44 g of citric acid monohydrate. 7 g, aspartame 30 g and d-mannitol 7.50 g were weighed, added and dissolved with stirring (equivalent to 10 doses). The solution was cooled to room temperature, and the pH was measured to be 3.4. From this solution, a liquid preparation in which 4.0 g of the branched-chain amino acid was dissolved in about 94 mL of the liquid per dose could be prepared. No precipitate was observed when the obtained solution was cooled in a refrigerator (about 418) for 24 hours.
  • Example 2 After pouring 900 g of heated distilled water into a glass beaker (capacity: 2 liters), add 19.04 g of isine, 9.52 g of isoleucine, 1.44
  • the liquid formulation consisting of a branched-chain amino acid solution whose pH has been acidified by an acid such as an organic acid is one in which the bitterness inherent in branched-chain amino acids is effectively reduced.
  • the method of the present invention can produce a solution in which only three kinds of branched-chain amino acids consisting of isoleucine, leucine, and valine are dissolved at a high concentration as amino acid components as active ingredients. It is possible to prepare the branched-chain amino acid-containing liquid preparation in which the amount is reduced to 10 OmL or less, and the bitterness of the raw material branched-chain amino acid due to the acid added at the time of preparing the solution. With the addition of the drug effect, it has become possible to provide a liquid preparation with further improved takeability.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

L'invention concerne une préparation liquide contenant, en tant que principes actifs, trois acides aminés ramifiés, notamment l'isoleucine, la leucine et la valine, à des concentrations élevées, et un procédé de production de ceux-ci. L'invention concerne une préparation liquide pour des boissons médicinales ou diététiques contenant, en tant que principes actifs, trois acides aminés ramifiés, notamment l'isoleucine, la leucine et la valine, à des concentrations élevées, et un procédé de production de ceux-ci, caractérisé en ce que les trois acides aminés ramifiés, sont dissous dans de l'eau en présence d'un acide organique et/ou d'un acide inorganique tel que l'acide citrique, l'acide tartrique, l'acide malique, l'acide succinique, l'acide phosphorique, l'acide carbonique et l'acide hydrochloridrique.
PCT/JP2003/000218 2002-01-15 2003-01-14 Procede de production d'une preparation liquide contenant des acides amines ramifies Ceased WO2003059338A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003203159A AU2003203159A1 (en) 2002-01-15 2003-01-14 Process for producing liquid preparation containing branched amino acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-006129 2002-01-15
JP2002006129A JP3368897B1 (ja) 2002-01-15 2002-01-15 分岐鎖アミノ酸含有液剤の製造方法

Publications (1)

Publication Number Publication Date
WO2003059338A1 true WO2003059338A1 (fr) 2003-07-24

Family

ID=19191188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/000218 Ceased WO2003059338A1 (fr) 2002-01-15 2003-01-14 Procede de production d'une preparation liquide contenant des acides amines ramifies

Country Status (3)

Country Link
JP (1) JP3368897B1 (fr)
AU (1) AU2003203159A1 (fr)
WO (1) WO2003059338A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007023999A1 (fr) * 2005-08-24 2007-03-01 Ajinomoto Co., Inc. Boisson acide contenant un acide aminé et son procédé de production
WO2008117786A1 (fr) * 2007-03-26 2008-10-02 Ajinomoto Co., Inc. Aliment conditionné contenant de l'isoleucine
JP5295073B2 (ja) * 2009-10-30 2013-09-18 株式会社ゼロベース 健康補助食品
WO2014136944A1 (fr) 2013-03-07 2014-09-12 味の素株式会社 Composition liquide aqueuse comprenant une concentration élevée en l-histidine
JP2013208128A (ja) * 2013-06-10 2013-10-10 Zero Base:Kk 健康補助食品
JP6802627B2 (ja) * 2014-12-19 2020-12-16 ハウス食品株式会社 ロイシンの苦味低減剤及びロイシンの苦味低減方法
WO2019009251A1 (fr) * 2017-07-03 2019-01-10 味の素株式会社 Boisson
JP7000877B2 (ja) * 2018-01-25 2022-01-19 味の素株式会社 アミノ酸を含有する食品の製造方法
JP7597028B2 (ja) 2019-06-25 2024-12-10 味の素株式会社 共非晶質構造を有するアミノ酸混合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05148149A (ja) * 1991-07-26 1993-06-15 Green Cross Corp:The 輸液製剤
JPH0624971A (ja) * 1992-03-20 1994-02-01 Clintec Nutrition Co 高度に濃縮されたアミノ酸溶液
JPH0725838A (ja) * 1993-05-13 1995-01-27 Yotsuba Yuka Kk 疲労の予防または回復のための経口投与剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05148149A (ja) * 1991-07-26 1993-06-15 Green Cross Corp:The 輸液製剤
JPH0624971A (ja) * 1992-03-20 1994-02-01 Clintec Nutrition Co 高度に濃縮されたアミノ酸溶液
JPH0725838A (ja) * 1993-05-13 1995-01-27 Yotsuba Yuka Kk 疲労の予防または回復のための経口投与剤

Also Published As

Publication number Publication date
AU2003203159A1 (en) 2003-07-30
JP2003212766A (ja) 2003-07-30
JP3368897B1 (ja) 2003-01-20

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