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WO2003049714A1 - Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire - Google Patents

Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire Download PDF

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Publication number
WO2003049714A1
WO2003049714A1 PCT/EP2001/013201 EP0113201W WO03049714A1 WO 2003049714 A1 WO2003049714 A1 WO 2003049714A1 EP 0113201 W EP0113201 W EP 0113201W WO 03049714 A1 WO03049714 A1 WO 03049714A1
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
skin
sun
astringent
sunlight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/013201
Other languages
German (de)
English (en)
Inventor
Gerhard Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/EP2001/013201 priority Critical patent/WO2003049714A1/fr
Priority to EP01274941A priority patent/EP1482906A1/fr
Priority to AU2002218299A priority patent/AU2002218299A1/en
Publication of WO2003049714A1 publication Critical patent/WO2003049714A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof

Definitions

  • Astringent substances as sunscreens especially against UV radiation and infrared radiation from sunlight
  • the invention relates to the use of astringent substances as sunscreens.
  • Sunscreens in general serve to protect human skin against the pathological effects of sun rays.
  • Chemical sunscreens are derived from p-aminobenzoic acid and its derivatives, but cinnamic acid derivatives and benzophenone are also used.
  • the market volume of chemical sunblockers in Germany has been in the hundreds of millions for years, which indicates their spread among the population.
  • the “sunscreens” have in common the absorption of UVA and / or UVB in different intensities. Their protective effect is determined and specified using the standard term "protection factor” or SPF (Colipa, "SPF Test Method", The Europe Cosm. Toilt. A Perfume Ass., Brussels, Belgium 1989; Rohr, M., Schrader, K., “The Determination of the Sun Protection Factor According to COLIPA, Perfume and Cosmetics, 1998, 5: 5 - 12).
  • SPF protection factor
  • compositions for protecting and treating sun-damaged skin which contain at least one anti-oxidant, at least one anti-inflammatory agent and at least one immune-promoting component. It is further disclosed that these compositions can contain one or more plant extracts in a small proportion.
  • a ginkgo biloba extract is mentioned as a component of the compositions, which contains, among other things, tannin.
  • the therapeutic dose of the composition for preventing or treating UV damage to the skin is disclosed to range from 1 mg to about 2000 mg when administered orally.
  • topical administration is generally disclosed, the proportion of the active ingredient composition in a composition for topical application is not disclosed.
  • EP 0 699 443 discloses an elder bark infusion for the treatment of burns and erythema caused by the sun.
  • One of the more important components of the bark is tannin, among others.
  • EP 0 699 443 relates only to the treatment of corresponding skin damage and contains no reference to the prevention of skin damage caused by sunlight.
  • JP 10 087469 describes the use of tannin in combinations with titanium dioxide, mica coated with titanium dioxide and zinc oxide, each component being in a ratio of 0.025 to 0.05 parts by weight per 1 part by weight of the component consisting of the aforementioned metal compounds.
  • the absolute amount of the aforementioned components in a usable preparation is disclosed.
  • the disclosure also focuses solely on the protective effect against UV rays by light scattering.
  • Bangha E. and Eisner P . Skin Problems in sugar artists.
  • British Journal of Dermatology, 1996, Vol. 135, No. 5, pages 772-74 disclose the treatment of, among other things, erythema with a preparation which contains 10% aluminum chloride hexahydrate.
  • This has been the case Thermally induced erythema was reduced in only 7% of the test persons.
  • This article also does not indicate any preventive effects of aluminum chloride hexahydrate or another astringent substance.Furthermore, this article contains no indication of damage prevention.
  • the invention is therefore based on the object of providing light protection which develops an effective local prophylaxis against the effect of light and the pathogenic effect of light on human skin and at the location of its application a preventive protection against the pathological provides solar radiation.
  • astringents are substances that, when exposed to mucous membranes (and wounds), cause a seal and slight shrinkage of the tissue due to protein falling on very superficial layers. They are indicated for the local treatment of inflammatory mucous membranes "(Kuschinsky, G. et al., Pharmacology and Toxicology, Georg Thieme Verlag, Stuttgart, New York, 1981). A distinction is made between two groups: tannin-based, vegetable extracts on the one hand and dilute solutions of metal salts (e.g. AgN0 3 ) on the other.
  • metal salts e.g. AgN0 3
  • astringent substances according to the invention does not affect the mucous membrane or wounds and is not a therapeutic agent.
  • the application of astringent copies according to the invention has the task of preventing penetration, e.g. B. to reduce the heat radiation of the sun in the layer of the human skin so that it results in a sunscreen against the penetration of solar radiation into the germinative epidermis.
  • penetration e.g. B. to reduce the heat radiation of the sun in the layer of the human skin so that it results in a sunscreen against the penetration of solar radiation into the germinative epidermis.
  • FIG. 1 shows a schematic representation of processes on the skin surface which take place when irradiated with electromagnetic waves
  • Fig. 2 reflectance spectra of the skin
  • Fig. 3 reflectance spectra similar to Fig. 2;
  • FIG. 4 reflectance spectra similar to FIGS. 2 and 3;
  • Fig. 6 is a schematic representation of the regression of a radiation erythema.
  • Two xenon short-arc lamps (model LPS 220) for excitation and irradiation with UV, visible and IR radiation (800 - 2500 ⁇ m) with a maximum output of 75 watts generate a continuous spectrum of UV over visible light and IR.
  • the radiation from one xenon lamp is spectrally broken down in the double-grating monochromator (model 102).
  • the radiation from the second xenon lamp is divided into two beams by means of an Indo-1 dichroic (mirror 455 nm, bandpass filter 485/10 nm and 405/10).
  • a BaS0 spectrum is recorded as a measure of 100% skin remission, with which all remission spectra are corrected.
  • the remission effect consists of absorption and remission of the incident radiation.
  • the SPF is determined according to Colipa (ibid.).
  • the subjects were selected according to Fitzpatrick (ibid.).
  • the The task of determining the IR according to the invention using the second xenon arc lamp compared the radiation effect of UV, visible light and IR.
  • astringent substances had the task of showing what light-protecting properties they have using the example of tannin and tamol (synthetic tannins) for comparison with aluminum lactate, aluminum chlorohydrate and Colipa standard.
  • Fig. 2. shows the reflectance spectra of the skin before and after application of the standard and 5%
  • Tannin. 3 and 4. show that the tannin alone causes an increase in absorption at about 320 nm and in the IR. In contrast to placebo and tamol, the use of a tannin solution for 14 days shows a constant increase in absorption, but no strengthening (FIG. 5).
  • This basic formulation was used as a placebo, while comparisons were carried out with model formulations which additionally contained 3 or 5% by weight of tannin as an astringent substance.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de substances astringentes pour la prévention des effets néfastes de la lumière solaire, et en tant que protection solaire destinée à la peau humaine.
PCT/EP2001/013201 2001-11-15 2001-11-15 Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire Ceased WO2003049714A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/EP2001/013201 WO2003049714A1 (fr) 2001-11-15 2001-11-15 Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire
EP01274941A EP1482906A1 (fr) 2001-11-15 2001-11-15 Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire
AU2002218299A AU2002218299A1 (en) 2001-11-15 2001-11-15 Astringent substances as sun protection products, especially for protecting against the uv radiation and infrared radiation of sunlight

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/013201 WO2003049714A1 (fr) 2001-11-15 2001-11-15 Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire

Publications (1)

Publication Number Publication Date
WO2003049714A1 true WO2003049714A1 (fr) 2003-06-19

Family

ID=8164674

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013201 Ceased WO2003049714A1 (fr) 2001-11-15 2001-11-15 Substances astringentes servant de protection solaire, en particulier contre les rayonnements ultraviolets et infrarouges de la lumiere solaire

Country Status (3)

Country Link
EP (1) EP1482906A1 (fr)
AU (1) AU2002218299A1 (fr)
WO (1) WO2003049714A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61109708A (ja) * 1984-10-31 1986-05-28 Kobayashi Kooc:Kk 化粧料
US5169624A (en) * 1991-02-23 1992-12-08 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Waterproof sunblock compositions
JPH1087469A (ja) * 1996-09-13 1998-04-07 Ichimaru Pharcos Co Ltd 紫外線防御剤
US5747010A (en) * 1996-06-12 1998-05-05 Johnson & Johnson Consumer Products, Inc. Photoprotective lipophilic antioxidant compounds and their use to prevent UVA-mediated lipid peroxidation
US5804168A (en) * 1997-01-29 1998-09-08 Murad; Howard Pharmaceutical compositions and methods for protecting and treating sun damaged skin
DE10026571A1 (de) * 2000-05-30 2001-12-13 Weber Gerhard Adstringierende Substanzen als Sonnenschutzmittel insbesondere gegen UV-Strahlung und Infrarotstrahlung des Sonnenlichtes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61109708A (ja) * 1984-10-31 1986-05-28 Kobayashi Kooc:Kk 化粧料
US5169624A (en) * 1991-02-23 1992-12-08 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Waterproof sunblock compositions
US5747010A (en) * 1996-06-12 1998-05-05 Johnson & Johnson Consumer Products, Inc. Photoprotective lipophilic antioxidant compounds and their use to prevent UVA-mediated lipid peroxidation
JPH1087469A (ja) * 1996-09-13 1998-04-07 Ichimaru Pharcos Co Ltd 紫外線防御剤
US5804168A (en) * 1997-01-29 1998-09-08 Murad; Howard Pharmaceutical compositions and methods for protecting and treating sun damaged skin
DE10026571A1 (de) * 2000-05-30 2001-12-13 Weber Gerhard Adstringierende Substanzen als Sonnenschutzmittel insbesondere gegen UV-Strahlung und Infrarotstrahlung des Sonnenlichtes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 010, no. 292 (C - 376) 3 October 1986 (1986-10-03) *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 09 31 July 1998 (1998-07-31) *

Also Published As

Publication number Publication date
EP1482906A1 (fr) 2004-12-08
AU2002218299A1 (en) 2003-06-23

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