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WO2002014469A3 - Utilisation de cellules souches totipotentes pour reprogrammer des cellules de façon à renforcer l'aptitude à la différentiation - Google Patents

Utilisation de cellules souches totipotentes pour reprogrammer des cellules de façon à renforcer l'aptitude à la différentiation Download PDF

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Publication number
WO2002014469A3
WO2002014469A3 PCT/US2001/025493 US0125493W WO0214469A3 WO 2002014469 A3 WO2002014469 A3 WO 2002014469A3 US 0125493 W US0125493 W US 0125493W WO 0214469 A3 WO0214469 A3 WO 0214469A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
pluripotent stem
reprogrammed
tissue type
stem cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/025493
Other languages
English (en)
Other versions
WO2002014469A2 (fr
Inventor
David J Earp
Melissa K Carpenter
Joseph D Gold
Jane S Lebkowski
J Michael Schiff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Priority to AU2001284923A priority Critical patent/AU2001284923A1/en
Priority to US10/344,680 priority patent/US20030211603A1/en
Publication of WO2002014469A2 publication Critical patent/WO2002014469A2/fr
Publication of WO2002014469A3 publication Critical patent/WO2002014469A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé permettant de reprogrammer des cellules d'un type de tissu de façon à produire des cellules d'un autre type de tissu. A cet effet, on prend des cellules d'un donneur humain, et, pour les reprogrammer, on les cultive au voisinage immédiat de cellules souches totipotentes de primates (à l'état indifférencié ou récemment différencié) ou dans un environnement complété par des composants provenant de cellules souches totipotentes de primates. Simultanément ou lors d'une étape ultérieure, les cellules du donneur pourront être traitées de façon à renforcer une différenciation les rapprochant d'un autre type de tissu. Ce procédé permet de traiter des patients nécessitant une régénération tissulaire, et ce, en utilisant des cellules différenciées puis reprogrammées mais à partir de leur propre donation cellulaire autologue.
PCT/US2001/025493 2000-08-15 2001-08-14 Utilisation de cellules souches totipotentes pour reprogrammer des cellules de façon à renforcer l'aptitude à la différentiation Ceased WO2002014469A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001284923A AU2001284923A1 (en) 2000-08-15 2001-08-14 Reprogramming cells for enhanced differentiation capacity using pluripotent stemcells
US10/344,680 US20030211603A1 (en) 2001-08-14 2001-08-14 Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US22562200P 2000-08-15 2000-08-15
US22551000P 2000-08-15 2000-08-15
US22550300P 2000-08-15 2000-08-15
US22621000P 2000-08-15 2000-08-15
US22550900P 2000-08-15 2000-08-15
US22551100P 2000-08-15 2000-08-15
US60/225,503 2000-08-15
US60/225,622 2000-08-15
US60/226,210 2000-08-15
US60/225,509 2000-08-15
US60/225,510 2000-08-15
US60/225,511 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002014469A2 WO2002014469A2 (fr) 2002-02-21
WO2002014469A3 true WO2002014469A3 (fr) 2002-06-13

Family

ID=27559177

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025493 Ceased WO2002014469A2 (fr) 2000-08-15 2001-08-14 Utilisation de cellules souches totipotentes pour reprogrammer des cellules de façon à renforcer l'aptitude à la différentiation

Country Status (2)

Country Link
AU (1) AU2001284923A1 (fr)
WO (1) WO2002014469A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7253334B2 (en) 2000-12-22 2007-08-07 Aurox, Llc Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
RU2333243C2 (ru) * 2002-03-28 2008-09-10 Бластикон Биотехнологише Форшунг Гмбх Дедифференцированные программируемые стволовые клетки моноцитарного происхождения и их получение и применение
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2394958B (en) * 2001-07-24 2006-03-01 Es Cell Int Pte Ltd Methods of inducing differentiation of stem cells
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
DE10326750B4 (de) * 2003-06-13 2006-07-27 Gerlach, Jörg, Dr.med. Verfahren zur Herstellung einer Zellpräparation und derart hergestellte Zellpräparationen
CA2569242A1 (fr) * 2004-06-01 2005-12-15 Es Cell International Pte Ltd Differenciation en cardiomyocytes amelioree
WO2006084229A2 (fr) * 2004-07-15 2006-08-10 Primegen Biotech, Llc Utilisation de substance nucleaire aux fins de reprogrammation therapeutique de cellules differenciees
CN102021143B (zh) * 2010-11-24 2012-07-25 浙江大学 一种提高间充质干细胞迁移能力的预处理方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6090622A (en) * 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6093531A (en) * 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
US6090622A (en) * 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6093531A (en) * 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ASAHARA ET AL.: "Stem cell therapy and gene transfer for regeneration", GENE THERAPY, vol. 7, no. 6, March 2000 (2000-03-01), pages 451 - 457, XP000916745 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7253334B2 (en) 2000-12-22 2007-08-07 Aurox, Llc Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
RU2333243C2 (ru) * 2002-03-28 2008-09-10 Бластикон Биотехнологише Форшунг Гмбх Дедифференцированные программируемые стволовые клетки моноцитарного происхождения и их получение и применение

Also Published As

Publication number Publication date
WO2002014469A2 (fr) 2002-02-21
AU2001284923A1 (en) 2002-02-25

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