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WO2002012471A3 - Homologue de l'enzyme de conversion de l'angiotensine et utilisations - Google Patents

Homologue de l'enzyme de conversion de l'angiotensine et utilisations Download PDF

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Publication number
WO2002012471A3
WO2002012471A3 PCT/US2001/025059 US0125059W WO0212471A3 WO 2002012471 A3 WO2002012471 A3 WO 2002012471A3 US 0125059 W US0125059 W US 0125059W WO 0212471 A3 WO0212471 A3 WO 0212471A3
Authority
WO
WIPO (PCT)
Prior art keywords
converting enzyme
angiotensin converting
uses therefor
enzyme homolog
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/025059
Other languages
English (en)
Other versions
WO2002012471A2 (fr
Inventor
Susan Acton
Keith E Robison
Frank Y Hsieh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/635,501 external-priority patent/US6884771B1/en
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to AU2001284794A priority Critical patent/AU2001284794A1/en
Publication of WO2002012471A2 publication Critical patent/WO2002012471A2/fr
Publication of WO2002012471A3 publication Critical patent/WO2002012471A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/15—Peptidyl-dipeptidases (3.4.15)
    • C12Y304/15001—Peptidyl-dipeptidase A (3.4.15.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne la découverte de nouveaux gènes codant pour une enzyme de conversion de l'angiotensine, l'enzyme 2 de conversion de l'angiotensine (ACE-2). L'invention concerne également des méthodes thérapeutiques, de pronostic et de diagnostic permettant de traiter les troubles associés à la pression sanguine ainsi que divers types de conditions allergiques, entre autres. L'invention concerne en outre des analyses de criblage visant à identifier des composés permettant de traiter et de prévenir ces conditions.
PCT/US2001/025059 2000-08-09 2001-08-09 Homologue de l'enzyme de conversion de l'angiotensine et utilisations Ceased WO2002012471A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001284794A AU2001284794A1 (en) 2000-08-09 2001-08-09 Angiotensin converting enzyme homolog and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/635,501 2000-08-09
US09/635,501 US6884771B1 (en) 1997-12-11 2000-08-09 Angiotensin converting enzyme homolog and uses therefor

Publications (2)

Publication Number Publication Date
WO2002012471A2 WO2002012471A2 (fr) 2002-02-14
WO2002012471A3 true WO2002012471A3 (fr) 2003-01-03

Family

ID=24548043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025059 Ceased WO2002012471A2 (fr) 2000-08-09 2001-08-09 Homologue de l'enzyme de conversion de l'angiotensine et utilisations

Country Status (2)

Country Link
AU (1) AU2001284794A1 (fr)
WO (1) WO2002012471A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2448051A1 (fr) 2001-06-04 2002-12-12 Human Genome Sciences, Inc. Procedes et compositions permettant la modulation de l'activite de l'enzyme de conversion de l'angiotensine-2
US6900033B2 (en) 2001-06-04 2005-05-31 Human Genome Sciences, Inc. Methods and compositions for modulating ACE-2 activity
ES2318137T3 (es) * 2002-06-19 2009-05-01 University Health Network Activacion de ace2 para el tratamiento de enfermedades cardiacas, pulmonares y renales e hipertension.
EP1570854A4 (fr) * 2002-10-29 2008-07-30 Gen Kondoh Medicament contenant une angiotensine convertase
EP1723962A1 (fr) 2005-05-19 2006-11-22 IMBA-Institut für Molekulare Biotechnologie GmbH Utilisation des inhibiteurs du système de rénine-angiotensine pour le traitement des lesions poumonaires.
WO2009049022A1 (fr) * 2007-10-10 2009-04-16 Ore Pharmaceuticals Inc. Procédé de traitement de la pancréatite
JP2011513491A (ja) * 2008-03-10 2011-04-28 オレ・ファーマシューティカルズ・インコーポレーテッド 近位消化管の障害の治療
CA2743736A1 (fr) * 2008-12-02 2010-06-10 F. Hoffmann-La Roche Ag Dosages de criblage pour l'identification d'inhibiteurs bace2
US20210238229A1 (en) * 2018-06-14 2021-08-05 University College Cork - National University Of Ireland, Cork Peptide for disease treatment
WO2021217120A2 (fr) * 2020-04-24 2021-10-28 Administrators Of The Tulane Educational Fund Compositions et procédés visant à prévenir ou réduire les effets d'infections par des coronavirus qui se lient au domaine extracellulaire du récepteur ace2
CN116368224A (zh) * 2020-05-20 2023-06-30 壹鸣生物公司 Ace2突变蛋白及其使用方法
CA3216329A1 (fr) * 2021-04-20 2022-10-27 The Council Of The Queensland Institute Of Medical Research Nouvelles compositions et nouvelles methodes de traitement d'infections a coronavirus
EP4147702A1 (fr) 2021-09-13 2023-03-15 Medizinische Universität Graz Nouvelle combinaison d'héparine et de leurres ace2 pour le traitement de la covid-19

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974644A1 (fr) * 1998-07-23 2000-01-26 Ajinomoto Co., Inc. Méthode pur la prodution de levure résistant à la congelation
EP0974664A2 (fr) * 1998-05-13 2000-01-26 Smithkline Beecham Plc Polypeptides et polynucleotides humains ayant une homologie avec l'enzyme de conversion de l'angiotensine spécifique des testicules
WO2000018899A2 (fr) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Homologue d'enzyme de conversion d'angiotensine et son utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974664A2 (fr) * 1998-05-13 2000-01-26 Smithkline Beecham Plc Polypeptides et polynucleotides humains ayant une homologie avec l'enzyme de conversion de l'angiotensine spécifique des testicules
EP0974644A1 (fr) * 1998-07-23 2000-01-26 Ajinomoto Co., Inc. Méthode pur la prodution de levure résistant à la congelation
WO2000018899A2 (fr) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Homologue d'enzyme de conversion d'angiotensine et son utilisation

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BERNSTEIN: "Two ACEs and a heart", NATURE, vol. 417, 20 June 2002 (2002-06-20), pages 799 - 802, XP002207554 *
DATABASE EMBL [online] 1 July 2000 (2000-07-01), "Homo sapiens angiotensin converting enzyme-like protein mRNA, complete cds", XP002207559, Database accession no. AF241254 *
DATABASE GENESEQ [online] 11 April 2000 (2000-04-11), "Human MPROT15 amino acid sequence #1", XP002207557, Database accession no. AAY67310 *
DATABASE GENESEQ [online] 11 April 2000 (2000-04-11), "Human MPROT15 coding sequence", XP002207558, Database accession no. AAZ59465 *
DATABASE GENESEQ [online] 25 July 2000 (2000-07-25), "A human angiotensin converting enzyme-2 (ACE-2) protein", XP002207555, Database accession no. AAY84562 *
DATABASE GENESEQ [online] 25 July 2000 (2000-07-25), "cDNA encoding a human angiotensin converting enzyme-2 (ACE-2)", XP002207556, Database accession no. AAA12764 *
DATABASE SWALL [online] 1 October 2000 (2000-10-01), "Angiotensin converting enzyme-like protein (ACE-related carboxypeptidase ACE2)", XP002207560, Database accession no. Q9NRA7 *
DONOGHUE MARY ET AL: "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.", CIRCULATION RESEARCH, vol. 87, no. 5, 1 September 2000 (2000-09-01), pages e1 - e9, XP002207553, ISSN: 0009-7330 *
TIPNIS ET AL.: "A human homolog of Angiotensin-converting enzyme", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 43, 27 October 2000 (2000-10-27), pages 33238 - 33243, XP002207551 *

Also Published As

Publication number Publication date
WO2002012471A2 (fr) 2002-02-14
AU2001284794A1 (en) 2002-02-18

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