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WO2002003848A3 - Method for opening the blood-brain barrier - Google Patents

Method for opening the blood-brain barrier Download PDF

Info

Publication number
WO2002003848A3
WO2002003848A3 PCT/US2001/019654 US0119654W WO0203848A3 WO 2002003848 A3 WO2002003848 A3 WO 2002003848A3 US 0119654 W US0119654 W US 0119654W WO 0203848 A3 WO0203848 A3 WO 0203848A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
brain barrier
opening
sugar
nervous system
Prior art date
Application number
PCT/US2001/019654
Other languages
French (fr)
Other versions
WO2002003848A8 (en
WO2002003848A2 (en
Inventor
Albert T Naito
Original Assignee
Albert T Naito
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert T Naito filed Critical Albert T Naito
Priority to JP2002508310A priority Critical patent/JP2004502706A/en
Priority to AU2001271345A priority patent/AU2001271345A1/en
Priority to EP01950344A priority patent/EP1298994A2/en
Publication of WO2002003848A2 publication Critical patent/WO2002003848A2/en
Publication of WO2002003848A3 publication Critical patent/WO2002003848A3/en
Publication of WO2002003848A8 publication Critical patent/WO2002003848A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oral administritration of sugar opens the blood-brain barrier and permits a co-administered chemical compound to enter the central nervous system in a higher amount than occurs without co-administration of the sugar. The increased amount that enters the central nervous system results in an increased biologic effect of the chemical compound.
PCT/US2001/019654 2000-07-10 2001-06-19 Method for opening the blood-brain barrier WO2002003848A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002508310A JP2004502706A (en) 2000-07-10 2001-06-19 How to open the blood-brain barrier
AU2001271345A AU2001271345A1 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier
EP01950344A EP1298994A2 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61321200A 2000-07-10 2000-07-10
US09/613,212 2000-07-10

Publications (3)

Publication Number Publication Date
WO2002003848A2 WO2002003848A2 (en) 2002-01-17
WO2002003848A3 true WO2002003848A3 (en) 2002-08-15
WO2002003848A8 WO2002003848A8 (en) 2003-11-06

Family

ID=24456335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019654 WO2002003848A2 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier

Country Status (4)

Country Link
EP (1) EP1298994A2 (en)
JP (1) JP2004502706A (en)
AU (1) AU2001271345A1 (en)
WO (1) WO2002003848A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003327528A (en) * 2002-03-04 2003-11-19 Pharmafoods Kenkyusho:Kk Immunocompetence-improving composition
EP1576141A4 (en) * 2002-05-14 2006-03-22 Bristol Myers Squibb Co Polynucleotide encoding novel human g-protein coupled receptors, and splice variants thereof
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US20070072795A1 (en) * 2005-09-28 2007-03-29 Anton Haselbeck Treatment of neurodegenerative disorders
CA2948844C (en) * 2014-05-12 2020-06-30 The Johns Hopkins University Engineering synthetic brain penetrating gene vectors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643773A (en) * 1984-03-09 1987-02-17 A. E. Staley Manufacturing Company Crystallization of fructose utilizing a mixture of alcohols
US4897380A (en) * 1985-08-30 1990-01-30 Pollack Robert L Method and composition for relieving dietary-related disorders
JPH0352810A (en) * 1989-07-20 1991-03-07 T Knight Albert Substance passing through blood- brain barrier
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643773A (en) * 1984-03-09 1987-02-17 A. E. Staley Manufacturing Company Crystallization of fructose utilizing a mixture of alcohols
US4897380A (en) * 1985-08-30 1990-01-30 Pollack Robert L Method and composition for relieving dietary-related disorders
JPH0352810A (en) * 1989-07-20 1991-03-07 T Knight Albert Substance passing through blood- brain barrier
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE (COLUMBUS, OHIO, USA); KNIGHT A.T.: "Sugars and amino acids as carriers of therapeutic agents in blood-brain carriers", XP002950325, accession no. STN Database accession no. 1991:614851 *

Also Published As

Publication number Publication date
JP2004502706A (en) 2004-01-29
WO2002003848A8 (en) 2003-11-06
EP1298994A2 (en) 2003-04-09
WO2002003848A2 (en) 2002-01-17
AU2001271345A1 (en) 2002-01-21

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