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WO2002088189A3 - Photoaktivierbare polysaccharidderivate für die immobilisierung von biomolekülen - Google Patents

Photoaktivierbare polysaccharidderivate für die immobilisierung von biomolekülen Download PDF

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Publication number
WO2002088189A3
WO2002088189A3 PCT/EP2002/004527 EP0204527W WO02088189A3 WO 2002088189 A3 WO2002088189 A3 WO 2002088189A3 EP 0204527 W EP0204527 W EP 0204527W WO 02088189 A3 WO02088189 A3 WO 02088189A3
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WO
WIPO (PCT)
Prior art keywords
group
immobilising
bio
photo
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/004527
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English (en)
French (fr)
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WO2002088189A2 (de
Inventor
Frank Loescher
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Molecular Machines and Industries GmbH
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Molecular Machines and Industries GmbH
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Publication date
Application filed by Molecular Machines and Industries GmbH filed Critical Molecular Machines and Industries GmbH
Publication of WO2002088189A2 publication Critical patent/WO2002088189A2/de
Publication of WO2002088189A3 publication Critical patent/WO2002088189A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3289—Coatings involving more than one layer of same or different nature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
    • C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)

Abstract

Die Erfindung betrifft neue Polysaccharidderivate der Formel (I), wobei p eine Zahl von 5 - 100000 ist; A1, A2 bzw. A3 u.a. ein Sauerstoffatom oder eine NH-Gruppe darstellt, D eine photoaktivierbare Gruppe Da oder eine Gruppe Db darstellt, wobei die Gruppe Db ein Wasserstoffatom, eine Alkyl- und/oder Alkylengruppe oder eine Silylgruppe darstellt, die jeweils substituiert sein können, der Substitutionsgrad DSa von Da pro Anhydroseeinheit 0,001 - 2 und der Substitutionsgrad DSb von Db pro Anhydroseeinheit 1 - 2,999 beträgt, wobei gilt DSa + DSb = 3; und wobei die Anhydroseeinheiten beliebig glykosidisch verknüpft sein können, und das Polysaccharidderivat in Chloroform oder Hexan löslich ist. Die Erfindung stellt zudem ein Beschichtungsverfahren mit dem erfindungsgemäßen Polysaccharid, ein entsprechend beschichtetes Substrat und ein Verfahren zur Immobilisierung von Biomolekülen an dieses Substrat bereit.
PCT/EP2002/004527 2001-04-30 2002-04-24 Photoaktivierbare polysaccharidderivate für die immobilisierung von biomolekülen Ceased WO2002088189A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10121201.1 2001-04-30
DE10121201A DE10121201B4 (de) 2001-04-30 2001-04-30 Photoaktivierbare Polysaccharidderivate für die Immobilisierung von Biomolekülen

Publications (2)

Publication Number Publication Date
WO2002088189A2 WO2002088189A2 (de) 2002-11-07
WO2002088189A3 true WO2002088189A3 (de) 2002-12-27

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PCT/EP2002/004527 Ceased WO2002088189A2 (de) 2001-04-30 2002-04-24 Photoaktivierbare polysaccharidderivate für die immobilisierung von biomolekülen

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DE (1) DE10121201B4 (de)
WO (1) WO2002088189A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409526B2 (en) * 2010-12-09 2013-04-02 General Electric Company Cellulose substrates, compositions and methods for storage and analysis of biological materials
FR3029784B1 (fr) 2014-12-16 2016-12-30 Oreal Procede cosmetique pour attenuer les rides
FR3029788B1 (fr) 2014-12-16 2018-03-02 L'oreal Procede cosmetique pour attenuer les odeurs

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959078A (en) * 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
EP0130523A2 (de) * 1983-07-05 1985-01-09 Molecular Diagnostics, Inc. Immobilisierte Nukleinsäure-Sonde und fester Träger fur Nukleinsäuren
EP0354543A1 (de) * 1988-08-08 1990-02-14 Biomira, Inc. Photochemische Verknüpfung von Chelatgruppen mit Biomolekülen
US5034428A (en) * 1986-06-19 1991-07-23 Board Of Regents Of The University Of Washington Immobilized biomolecules and method of making same
WO1991016425A1 (de) * 1990-04-12 1991-10-31 Hans Sigrist Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch 'inerten' oberflächen
US5847019A (en) * 1995-04-25 1998-12-08 The United States Of America As Represented By The Secretary Of The Navy Photoactivatable polymers for producing patterned biomolecular assemblies
WO1999010383A1 (de) * 1997-08-23 1999-03-04 Stefan Seeger Aminoalkyltrialkylsilylcellulosen und ein verfahren zur beschichtung von oberflächen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4015158A1 (de) * 1990-05-11 1991-11-14 Wolff Walsrode Ag Alkenylmethylhydroxypropylcelluloseether und ein verfahren zu ihrer herstellung
DE4133677A1 (de) * 1991-10-11 1993-04-15 Wolff Walsrode Ag 3-allyloxy-2-hydroxypropylether
DE19544091C1 (de) * 1995-11-27 1997-04-03 Daimler Benz Ag Flüssigkristalline, photovernetzbare Cellulosemischether als interferentiell wirksame, farbgebende Substanz für farbige Lacke, in denen die Hauptgruppen-Mesogene zumindest näherungsweise chiral-nematisch geordnet sind, Verfahren zu ihrer Herstellung, sie enthaltende Interferenzpigmente, Verfahren zur Herstellung plättchenförmiger Interferenzpigmente , diese Interferenzpigmente enthaltende Effektlacke und die Verwendung dieser Effektlacke beim Lackieren von Gebrauchsgegenständen

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959078A (en) * 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
EP0130523A2 (de) * 1983-07-05 1985-01-09 Molecular Diagnostics, Inc. Immobilisierte Nukleinsäure-Sonde und fester Träger fur Nukleinsäuren
US5034428A (en) * 1986-06-19 1991-07-23 Board Of Regents Of The University Of Washington Immobilized biomolecules and method of making same
EP0354543A1 (de) * 1988-08-08 1990-02-14 Biomira, Inc. Photochemische Verknüpfung von Chelatgruppen mit Biomolekülen
WO1991016425A1 (de) * 1990-04-12 1991-10-31 Hans Sigrist Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch 'inerten' oberflächen
US5847019A (en) * 1995-04-25 1998-12-08 The United States Of America As Represented By The Secretary Of The Navy Photoactivatable polymers for producing patterned biomolecular assemblies
WO1999010383A1 (de) * 1997-08-23 1999-03-04 Stefan Seeger Aminoalkyltrialkylsilylcellulosen und ein verfahren zur beschichtung von oberflächen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; "Protein photoimmobilization onphotosensitive derivatives of carboxymethylcellulose. Sensitivity and signal/background ratio in determination of immobilized proteins by chemical and biospecific intercations", XP002215669, retrieved from STN Database accession no. 111:149975 *
DOBRIKOV M I ET AL., IZV. SIB. OTD. AKAD. NAUK SSSR, SER. KHIM. NAUK, no. 3, 1989, pages 133 - 138 *

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Publication number Publication date
WO2002088189A2 (de) 2002-11-07
DE10121201B4 (de) 2007-07-12
DE10121201A1 (de) 2002-11-07

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