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WO2002066025A3 - Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol - Google Patents

Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol Download PDF

Info

Publication number
WO2002066025A3
WO2002066025A3 PCT/EP2002/001762 EP0201762W WO02066025A3 WO 2002066025 A3 WO2002066025 A3 WO 2002066025A3 EP 0201762 W EP0201762 W EP 0201762W WO 02066025 A3 WO02066025 A3 WO 02066025A3
Authority
WO
WIPO (PCT)
Prior art keywords
combination
active ingredients
desmethyltramadol
tramadol
racemate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/001762
Other languages
English (en)
French (fr)
Other versions
WO2002066025A2 (de
Inventor
Elmar Friderichs
Johannes Bartholomaeus
Stephan Wnendt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to AU2002250977A priority Critical patent/AU2002250977A1/en
Publication of WO2002066025A2 publication Critical patent/WO2002066025A2/de
Publication of WO2002066025A3 publication Critical patent/WO2002066025A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die vorliegende Erfindung betrifft eine Wirkstoffkombination aus dem Racemat des Tramadols und dem (+)-O-Desmethyltramadol, Arzneimittel enthaltend diese Wirkstoffkombination sowie die Verwendung dieser Wirkstoffkombination zur Herstellung eines Arzneimittels.
PCT/EP2002/001762 2001-02-21 2002-02-20 Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol Ceased WO2002066025A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250977A AU2002250977A1 (en) 2001-02-21 2002-02-20 Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10108123.5 2001-02-21
DE10108123A DE10108123A1 (de) 2001-02-21 2001-02-21 Wirkstoffkombination

Publications (2)

Publication Number Publication Date
WO2002066025A2 WO2002066025A2 (de) 2002-08-29
WO2002066025A3 true WO2002066025A3 (de) 2003-04-24

Family

ID=7674848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001762 Ceased WO2002066025A2 (de) 2001-02-21 2002-02-20 Wirkstoffkombination aus dem racemat des tramadols und dem (+)-o-desmethyltramadol

Country Status (3)

Country Link
AU (1) AU2002250977A1 (de)
DE (1) DE10108123A1 (de)
WO (1) WO2002066025A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9717701B2 (en) 2011-07-09 2017-08-01 Syntrix Biosystems Inc. Compositions for overcoming resistance to tramadol

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10225315A1 (de) * 2002-06-06 2003-12-24 Gruenenthal Gmbh Wirkstoffsalze und Ester von 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl- pentan-3-ol und 3-(3-Dimethylamino-1-ethyl-1-hydroxy-2-methyl- propyl)-phenol
DE102006006532B4 (de) * 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
EP2022778A1 (de) * 2007-08-07 2009-02-11 Laboratorios del Dr. Esteve S.A. Kristalline Form von (R,R)-Tramadol-(S)-Naproxensalz

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601744A1 (de) * 1996-01-19 1997-07-31 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601744A1 (de) * 1996-01-19 1997-07-31 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GROND S ET AL: "ANALGESIC EFFICACY AND SAFETY OF TRAMADOL ENANTIOMERS IN COMPARISON WITH THE RACEMATE: A RANDOMISED, DOUBLE-BLIND STUDY WITH GYNAECOLOGICAL PATIENTS USING INTRAVENOUS PATIENT-CONTROLLED ANALGESIA", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 62, no. 3, September 1995 (1995-09-01), pages 313 - 320, XP000891573, ISSN: 0304-3959 *
RAFFA R B: "A NOVEL APPROACH TO THE PARMACOLOGY OF ANALGESICS", AMERICAN JOURNAL OF MEDICINE, XX, XX, vol. 101, 1996, pages 40S - 46S, XP000920591, ISSN: 0002-9343 *
SINDRUP S H ET AL: "THE EFFECT OF TRAMADOL IN PAINFUL POLYNEUROPATHY IN RELATION TO SERUM DRUG AND METABOLIC LEVELS", CLINICAL PHARMACOLOGY & THERAPEUTICS, MOSBY-YEAR BOOK, ST LOUIS, MO, US, vol. 66, no. 6, 1999, pages 636, XP000909291, ISSN: 0009-9236 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9717701B2 (en) 2011-07-09 2017-08-01 Syntrix Biosystems Inc. Compositions for overcoming resistance to tramadol
US9717700B2 (en) 2011-07-09 2017-08-01 Syntrix Biosystems Inc. Methods for overcoming resistance to tramadol
US9808432B2 (en) 2011-07-09 2017-11-07 Syntrix Biosystems Inc. Methods for overcoming resistance to tramadol
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol

Also Published As

Publication number Publication date
DE10108123A1 (de) 2002-10-02
AU2002250977A1 (en) 2002-09-04
WO2002066025A2 (de) 2002-08-29

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