AU2002250977A1 - Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadol - Google Patents
Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadolInfo
- Publication number
- AU2002250977A1 AU2002250977A1 AU2002250977A AU2002250977A AU2002250977A1 AU 2002250977 A1 AU2002250977 A1 AU 2002250977A1 AU 2002250977 A AU2002250977 A AU 2002250977A AU 2002250977 A AU2002250977 A AU 2002250977A AU 2002250977 A1 AU2002250977 A1 AU 2002250977A1
- Authority
- AU
- Australia
- Prior art keywords
- desmethyltramadol
- tramadol
- racemate
- combination
- active ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title 1
- UWJUQVWARXYRCG-HIFRSBDPSA-N O-Desmethyltramadol Chemical compound CN(C)C[C@H]1CCCC[C@]1(O)C1=CC=CC(O)=C1 UWJUQVWARXYRCG-HIFRSBDPSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 229960004380 tramadol Drugs 0.000 title 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108123A DE10108123A1 (en) | 2001-02-21 | 2001-02-21 | drug combination |
| DE10108123.5 | 2001-02-21 | ||
| PCT/EP2002/001762 WO2002066025A2 (en) | 2001-02-21 | 2002-02-20 | Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002250977A1 true AU2002250977A1 (en) | 2002-09-04 |
Family
ID=7674848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002250977A Abandoned AU2002250977A1 (en) | 2001-02-21 | 2002-02-20 | Combination of active ingredients consisting of the racemate of tramadol and of (+)-o-desmethyltramadol |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002250977A1 (en) |
| DE (1) | DE10108123A1 (en) |
| WO (1) | WO2002066025A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10225315A1 (en) * | 2002-06-06 | 2003-12-24 | Gruenenthal Gmbh | Active substance salts and esters of 1-dimethylamino-3- (3-methoxyphenyl) -2-methylpentan-3-ol and 3- (3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl) - phenol |
| DE102006006532B4 (en) * | 2006-02-10 | 2007-11-08 | Biogenerics Pharma Gmbh | Pharmaceutical preparation |
| EP2022778A1 (en) * | 2007-08-07 | 2009-02-11 | Laboratorios del Dr. Esteve S.A. | A crystalline form of (R,R)-tramadol-(S)-naproxene salt |
| US10702485B2 (en) * | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19601744C2 (en) * | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Process for the preparation of the enantiomers of O-demethyltramadol |
| DE19712398A1 (en) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Oral use of (+) - 0-demethyltramadol as a pain reliever |
-
2001
- 2001-02-21 DE DE10108123A patent/DE10108123A1/en not_active Withdrawn
-
2002
- 2002-02-20 WO PCT/EP2002/001762 patent/WO2002066025A2/en not_active Ceased
- 2002-02-20 AU AU2002250977A patent/AU2002250977A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002066025A2 (en) | 2002-08-29 |
| WO2002066025A3 (en) | 2003-04-24 |
| DE10108123A1 (en) | 2002-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |