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WO2002065515A3 - Dispositifs nanostructures de separation et d'analyse - Google Patents

Dispositifs nanostructures de separation et d'analyse Download PDF

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Publication number
WO2002065515A3
WO2002065515A3 PCT/US2002/004381 US0204381W WO02065515A3 WO 2002065515 A3 WO2002065515 A3 WO 2002065515A3 US 0204381 W US0204381 W US 0204381W WO 02065515 A3 WO02065515 A3 WO 02065515A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
separation
matrix
gradient
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/004381
Other languages
English (en)
Other versions
WO2002065515A2 (fr
Inventor
Gabriel P Lopez
Steven R J Brueck
Linnea K Ista
Michael J O'brien
Stephen D Hersee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNM Rainforest Innovations
Original Assignee
STC UNM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STC UNM filed Critical STC UNM
Priority to AU2002251946A priority Critical patent/AU2002251946A1/en
Publication of WO2002065515A2 publication Critical patent/WO2002065515A2/fr
Publication of WO2002065515A3 publication Critical patent/WO2002065515A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6065—Construction of the column body with varying cross section
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/524—Physical parameters structural properties
    • G01N2030/525—Physical parameters structural properties surface properties, e.g. porosity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249961—With gradual property change within a component
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Electrochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une matrice comprenant un réseau de nanostructures qui présente une variation (gradient) dans ses propriétés physiques (telles que la taille ou le pas) dans au moins une direction du plan contenant ce réseau. L'invention concerne également un procédé de formation d'un réseau possédant une propriété de gradient, ainsi qu'un procédé de séparation qui comprend les étapes consistant : à produire une matrice comprenant un réseau de nanostructures disposées de sorte que le réseau ait la propriété du gradient, et à effectuer au moins un procédé de séparation de biomolécules en vue de séparer à l'aide d'une matrice des biomolécules contenues dans une composition.
PCT/US2002/004381 2001-02-14 2002-02-14 Dispositifs nanostructures de separation et d'analyse Ceased WO2002065515A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002251946A AU2002251946A1 (en) 2001-02-14 2002-02-14 Nanostructured devices for separation and analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26836501P 2001-02-14 2001-02-14
US60/268,365 2001-02-14

Publications (2)

Publication Number Publication Date
WO2002065515A2 WO2002065515A2 (fr) 2002-08-22
WO2002065515A3 true WO2002065515A3 (fr) 2003-03-06

Family

ID=23022660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004381 Ceased WO2002065515A2 (fr) 2001-02-14 2002-02-14 Dispositifs nanostructures de separation et d'analyse

Country Status (3)

Country Link
US (1) US6685841B2 (fr)
AU (1) AU2002251946A1 (fr)
WO (1) WO2002065515A2 (fr)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060128006A1 (en) * 1999-11-10 2006-06-15 Gerhardt Antimony L Hydrodynamic capture and release mechanisms for particle manipulation
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US7419574B2 (en) * 2001-06-20 2008-09-02 Cummings Eric B Dielectrophoresis device and method having non-uniform arrays for manipulating particles
US6848462B2 (en) * 2001-12-06 2005-02-01 Nanostream, Inc. Adhesiveless microfluidic device fabrication
AU2003216175A1 (en) * 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
US6872645B2 (en) * 2002-04-02 2005-03-29 Nanosys, Inc. Methods of positioning and/or orienting nanostructures
US7652574B2 (en) * 2002-04-08 2010-01-26 Sayegh Adel O Article surveillance tag having a vial
US7217562B2 (en) 2002-04-16 2007-05-15 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US7122640B2 (en) * 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
WO2003103836A1 (fr) * 2002-06-11 2003-12-18 Kionix, Inc. Procedes et dispositifs d'extraction de microfluides
WO2004029221A2 (fr) 2002-09-27 2004-04-08 The General Hospital Corporation Dispositif microfluidique pour la separation de cellules et utilisations de ce dispositif
EP1604184A4 (fr) * 2003-02-27 2010-10-27 Stephen A Lesko Evaluation normalisee de l'efficacite therapeutique fondee sur des marqueurs biologiques cellulaires
US20040191127A1 (en) * 2003-03-31 2004-09-30 Avinoam Kornblit Method and apparatus for controlling the movement of a liquid on a nanostructured or microstructured surface
US20040241721A1 (en) * 2003-05-08 2004-12-02 Gjerde Douglas T. Open channel solid phase extraction systems and methods
AU2004250131A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US7347923B2 (en) * 2003-10-03 2008-03-25 Sandia Corporation Dielectrophoresis device and method having insulating ridges for manipulating particles
WO2005047851A2 (fr) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Dispositif de mesure des reactions de liaison en fonction des marques de niveau du nanometre
US20050133437A1 (en) * 2003-12-17 2005-06-23 Intel Corporation Sieving media from planar arrays of nanoscale grooves, method of making and method of using the same
JP4237610B2 (ja) * 2003-12-19 2009-03-11 株式会社東芝 保守支援方法及びプログラム
US7465381B2 (en) * 2004-01-22 2008-12-16 Stc.Unm Electrokinetic molecular separation in nanoscale fluidic channels
US20110039690A1 (en) * 2004-02-02 2011-02-17 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US7553371B2 (en) * 2004-02-02 2009-06-30 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US8025960B2 (en) 2004-02-02 2011-09-27 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US20060065528A1 (en) * 2004-02-03 2006-03-30 Gabriel Lopez Nanostructured devices for separation and analysis
AU2005218622A1 (en) * 2004-03-03 2005-09-15 Living Microsystems Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US7048889B2 (en) * 2004-03-23 2006-05-23 Lucent Technologies Inc. Dynamically controllable biological/chemical detectors having nanostructured surfaces
EP1747577A2 (fr) * 2004-04-30 2007-01-31 Nanosys, Inc. Systemes et procedes de croissance et de culture de nanofils
US20050279274A1 (en) * 2004-04-30 2005-12-22 Chunming Niu Systems and methods for nanowire growth and manufacturing
US7785922B2 (en) 2004-04-30 2010-08-31 Nanosys, Inc. Methods for oriented growth of nanowires on patterned substrates
JP2007536101A (ja) * 2004-05-05 2007-12-13 カリフォルニア インスティテュート オブ テクノロジー ナノ繊維配列（ａｒｒａｙ）のキャピラリーリソグラフィー
AU2005325265A1 (en) * 2004-07-07 2006-07-27 Nanosys, Inc. Systems and methods for harvesting and integrating nanowires
US7608446B2 (en) * 2004-09-30 2009-10-27 Alcatel-Lucent Usa Inc. Nanostructured surface for microparticle analysis and manipulation
US8021967B2 (en) * 2004-11-01 2011-09-20 California Institute Of Technology Nanoscale wicking methods and devices
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
ES2437845T3 (es) 2005-01-18 2014-01-14 Biocept, Inc. Separación de células usando un microcanal que tiene pilares con una configuración
US8158410B2 (en) * 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US7579149B2 (en) * 2005-01-31 2009-08-25 International Business Machines Corporation Method and apparatus to separate molecules according to their mobilities
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070017808A1 (en) * 2005-05-27 2007-01-25 Intel Corporation Linear valve-coupled two-dimensional separation device and separation matrix and method
US8628055B2 (en) * 2005-07-27 2014-01-14 The Board Of Trustees Of The University Of Illinois Bi-direction rapid action electrostatically actuated microvalve
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20090181421A1 (en) * 2005-07-29 2009-07-16 Ravi Kapur Diagnosis of fetal abnormalities using nucleated red blood cells
US7666665B2 (en) 2005-08-31 2010-02-23 Alcatel-Lucent Usa Inc. Low adsorption surface
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US8287808B2 (en) * 2005-09-15 2012-10-16 Alcatel Lucent Surface for reversible wetting-dewetting
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US8721161B2 (en) 2005-09-15 2014-05-13 Alcatel Lucent Fluid oscillations on structured surfaces
US7412938B2 (en) * 2005-09-15 2008-08-19 Lucent Technologies Inc. Structured surfaces with controlled flow resistance
US20070059213A1 (en) * 2005-09-15 2007-03-15 Lucent Technologies Inc. Heat-induced transitions on a structured surface
GB2430393A (en) * 2005-09-23 2007-03-28 Univ Aston Micro Device for Automatic Spermatozoa Selection and Cell Sorting
WO2007041621A2 (fr) * 2005-10-03 2007-04-12 Xingsheng Sean Ling Sequençage assiste par hybridation et effectue avec une structure de nanopore
US8123834B2 (en) * 2005-10-06 2012-02-28 The Board Of Trustees Of The University Of Illinois High gain selective metal organic framework preconcentrators
WO2007066518A1 (fr) * 2005-12-08 2007-06-14 Nec Corporation Structure mouillee, structure de regulation du mouvement du liquide et procede de regulation du mouvement du liquide
TW200734641A (en) * 2005-12-26 2007-09-16 Inst Of Microchemical Technology Microchip for immunoassay, kit for immunoassay and immunoassay method
US7741197B1 (en) 2005-12-29 2010-06-22 Nanosys, Inc. Systems and methods for harvesting and reducing contamination in nanowires
WO2007136412A2 (fr) * 2005-12-29 2007-11-29 Nanosys, Inc. Procédés pour la croissance orientée de nanofils sur des substrats à motifs
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US20100233350A1 (en) * 2006-03-15 2010-09-16 Boston Scientific Scimed, Inc. Drug delivery composition and methods of making same using nanofabrication
WO2008057140A2 (fr) * 2006-04-14 2008-05-15 The Board Of Trustees Of The University Of Illinois Procédé de synthèse rapide de molécules de structure métallo-organique
US20070259156A1 (en) * 2006-05-03 2007-11-08 Lucent Technologies, Inc. Hydrophobic surfaces and fabrication process
US20080050739A1 (en) * 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080070792A1 (en) * 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
JP5173165B2 (ja) * 2006-08-14 2013-03-27 東京エレクトロン株式会社 クロマトグラフィ用のカラム及びその製造方法
WO2008097360A2 (fr) * 2006-09-14 2008-08-14 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Nanopiliers et nanotubes polymériques, leur fabrication et leurs utilisations
US7776760B2 (en) 2006-11-07 2010-08-17 Nanosys, Inc. Systems and methods for nanowire growth
US8047235B2 (en) * 2006-11-30 2011-11-01 Alcatel Lucent Fluid-permeable body having a superhydrophobic surface
US20080186801A1 (en) * 2007-02-06 2008-08-07 Qisda Corporation Bubble micro-pump and two-way fluid-driving device, particle-sorting device, fluid-mixing device, ring-shaped fluid-mixing device and compound-type fluid-mixing device using the same
US20080272053A1 (en) * 2007-05-01 2008-11-06 Chandler Darrell P Combinatorial separations and chromatography renewable microcolumn
KR100863753B1 (ko) 2007-06-08 2008-10-16 함평군 예쁜꼬마선충의 행동연구용 마이크로포스트 어레이 및 이의제조방법
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
EP2201136B1 (fr) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Séquençage par nanopore et hybridation de sondes pour former des complexes ternaires et l'alignement de plage variable
WO2009052214A2 (fr) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Analyse de séquence à l'aide d'acides nucléiques décorés
KR100873383B1 (ko) 2007-11-13 2008-12-10 이화여자대학교 산학협력단 선충의 주화성 연구용 미세 유체 소자
US8152908B2 (en) * 2008-01-16 2012-04-10 The Board Of Trustees Of The University Of Illinois Micromachined gas chromatography columns for fast separation of Organophosphonate and Organosulfur compounds and methods for deactivating same
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
US8269029B2 (en) * 2008-04-08 2012-09-18 The Board Of Trustees Of The University Of Illinois Water repellent metal-organic frameworks, process for making and uses regarding same
FR2930900B1 (fr) * 2008-05-06 2010-09-10 Commissariat Energie Atomique Dispositif de separation de biomolecules d'un fluide
WO2009140439A1 (fr) * 2008-05-13 2009-11-19 Nanoink, Inc. Dispositifs et procédés de nanofabrication
US20110124986A1 (en) * 2008-07-23 2011-05-26 Masaaki Takama Microchip, Blood Analysis System and Blood Analysis Method
JP5717634B2 (ja) * 2008-09-03 2015-05-13 ナブシス， インコーポレイテッド 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
LT2334812T (lt) 2008-09-20 2017-04-25 The Board Of Trustees Of The Leland Stanford Junior University Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu
US20100298453A1 (en) * 2009-01-26 2010-11-25 Invista North America S.A R.L. Board stock foam having biobased content
US8455260B2 (en) * 2009-03-27 2013-06-04 Massachusetts Institute Of Technology Tagged-fragment map assembly
US20100243449A1 (en) * 2009-03-27 2010-09-30 Oliver John S Devices and methods for analyzing biomolecules and probes bound thereto
WO2010129441A2 (fr) * 2009-05-04 2010-11-11 Gpb Scientific, Llc Procédé de séparation de cellules souches à partir de leur descendance plus différenciée à l'aide de dispositifs microfluidiques
ES2867474T3 (es) 2009-05-19 2021-10-20 Oned Mat Inc Materiales nanoestructurados para aplicaciones de batería
US8246799B2 (en) * 2009-05-28 2012-08-21 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US9873090B2 (en) * 2009-06-17 2018-01-23 The Regents Of The University Of California Apparatus and method for nanoporous inorganic membranes and films, methods of making and usage thereof
DE102009040182A1 (de) * 2009-09-07 2011-03-24 Dionex Benelux B.V. Trennkörper
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
CN102858995B (zh) 2009-09-10 2016-10-26 森特瑞隆技术控股公司 靶向测序方法
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
EP2640849B1 (fr) 2010-11-16 2016-04-06 Nabsys 2.0 LLC Procédés de séquençage d'une biomolécule par détection de positions relatives de sondes hybridées
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
WO2012170560A2 (fr) * 2011-06-06 2012-12-13 Cornell University Dispositif microfluidique pour l'extraction, l'isolement et l'analyse d'adn provenant de cellules
WO2013003624A2 (fr) 2011-06-29 2013-01-03 Academia Sinica Capture, purification et libération d'une substance biologique utilisant un revêtement de surface
WO2013062554A1 (fr) * 2011-10-27 2013-05-02 Hewlett-Packard Development Company, L.P. Appareil pour filtration d'espèces
US20140099238A1 (en) * 2012-10-08 2014-04-10 Waters Technologies Corporation Chiral Separation System
US9494500B2 (en) 2012-10-29 2016-11-15 Academia Sinica Collection and concentration system for biologic substance of interest and use thereof
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US10040018B2 (en) * 2013-01-09 2018-08-07 Imagine Tf, Llc Fluid filters and methods of use
WO2014113557A1 (fr) 2013-01-18 2014-07-24 Nabsys, Inc. Liaison améliorée d'une sonde
US9687847B1 (en) * 2013-02-13 2017-06-27 University Of South Florida Microfluidic platforms for optical biosensing
EP3569313A1 (fr) 2013-03-15 2019-11-20 GPB Scientific, LLC Traitement microfluidique sur puce de particules
EP2971279B1 (fr) 2013-03-15 2019-11-13 The Trustees of Princeton University Méthodes et dispositifs de purification à rendement élevé
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US9364832B2 (en) 2013-07-17 2016-06-14 International Business Machines Corporation Nanofluidic channels with gradual depth change for reducing entropic barrier of biopolymers
JP2015055482A (ja) * 2013-09-10 2015-03-23 セイコーエプソン株式会社 分析装置、分析方法、これらに用いる光学素子及び電子機器
CN106029202B (zh) * 2014-01-07 2019-01-08 想象Tf有限责任公司 流体过滤器和使用方法
US9322061B2 (en) 2014-03-06 2016-04-26 International Business Machines Corporation Nanochannel device with three dimensional gradient by single step etching for molecular detection
US10495644B2 (en) 2014-04-01 2019-12-03 Academia Sinica Methods and systems for cancer diagnosis and prognosis
US9861920B1 (en) 2015-05-01 2018-01-09 Imagine Tf, Llc Three dimensional nanometer filters and methods of use
EP2945085A1 (fr) 2014-05-12 2015-11-18 Angel Rivero Jimenez Système et procédé permettant d'améliorer les performances physiques et le contrôle d'équilibre nutritionnel
US10730047B2 (en) 2014-06-24 2020-08-04 Imagine Tf, Llc Micro-channel fluid filters and methods of use
TW201612308A (en) 2014-08-26 2016-04-01 Academia Sinica Collector architecture layout design
US10124275B2 (en) 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
US10058895B2 (en) * 2014-11-26 2018-08-28 International Business Machines Corporation Continuous flow, size-based separation of entities down to the nanometer scale using nanopillar arrays
US10758849B2 (en) 2015-02-18 2020-09-01 Imagine Tf, Llc Three dimensional filter devices and apparatuses
US10118842B2 (en) 2015-07-09 2018-11-06 Imagine Tf, Llc Deionizing fluid filter devices and methods of use
EP3130559A1 (fr) * 2015-08-14 2017-02-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Fabrication de substrats nanostructurés comprenant une pluralité de gradients de nanostructures sur un substrat unique
US10479046B2 (en) 2015-08-19 2019-11-19 Imagine Tf, Llc Absorbent microstructure arrays and methods of use
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
JP6885611B2 (ja) 2015-12-18 2021-06-16 ユニバーシティ オブ カンタベリー 分離媒体
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
US10507466B2 (en) 2016-04-27 2019-12-17 International Business Machines Corporation Metal assisted chemical etching for fabricating high aspect ratio and straight silicon nanopillar arrays for sorting applications
US11383240B2 (en) 2016-05-22 2022-07-12 Cornell University Single cell whole genome amplification via micropillar arrays under flow conditions
EP3281910B1 (fr) * 2016-08-11 2019-10-02 IMEC vzw Procédé de formation de micro-tuyaux sur un substrat et structure formée à partir de ceux-ci
US10844353B2 (en) 2017-09-01 2020-11-24 Gpb Scientific, Inc. Methods for preparing therapeutically active cells using microfluidics
CN107640739A (zh) * 2017-09-06 2018-01-30 邱丹丹 液滴在润湿梯度表面上长距离自驱动方法
WO2020113173A1 (fr) 2018-11-28 2020-06-04 Cornell University Analyse multi-omique d'analytes cellulaires à l'aide de systèmes microfluidiques
WO2020113192A1 (fr) 2018-11-28 2020-06-04 Cornell University Systèmes et procédés d'analyse sur puce d'acides nucléiques et d'analyse multiplexée de cellules
WO2021011907A1 (fr) 2019-07-18 2021-01-21 Gpb Scientific, Inc. Traitement ordonné de produits sanguins pour produire des cellules thérapeutiquement actives
EP4058194A4 (fr) * 2019-11-11 2023-11-01 Case Western Reserve University Dispositif microfluidique et ses utilisations
WO2021133897A1 (fr) 2019-12-28 2021-07-01 Gpb Scientific, Inc. Cartouches microfluidiques pour le traitement de particules et de cellules
TWI738581B (zh) * 2020-12-03 2021-09-01 國立臺灣師範大學 平板式氧化鋁氣相層析管柱及其製作方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5867266A (en) * 1996-04-17 1999-02-02 Cornell Research Foundation, Inc. Multiple optical channels for chemical analysis
EP0977030A1 (fr) * 1998-07-29 2000-02-02 Hewlett-Packard Company Puce pour la séparation électrophorétique des molécules et procédé l'utilisant
WO2000042233A1 (fr) * 1999-01-13 2000-07-20 Cornell Research Foundation, Inc. Fabrication de structures fluidiques monolithiques

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2165073A1 (de) 1971-12-28 1973-07-12 Sartorius Membranfilter Gmbh Mehrschichten-filtermembrane, verfahren zu deren herstellung und deren verwendung
US5130025A (en) 1978-04-20 1992-07-14 Unisearch Limited Membrane separation and purification of compounds
US4969998A (en) 1984-04-23 1990-11-13 W. L. Gore & Associates, Inc. Composite semipermeable membrane
CA1263845A (fr) 1985-08-28 1989-12-12 Oleh Kutowy Separation de substances des hydrocarbures de matiere fossile
US4814082A (en) 1986-10-20 1989-03-21 Memtec North America Corporation Ultrafiltration thin film membranes
SE460521B (sv) 1987-08-31 1989-10-23 Gambro Dialysatoren Permselektiv asymmetriskt membran samt foerfarande foer dess framstaellning
US4801380A (en) 1987-12-23 1989-01-31 The Texas A&M University System Method of producing a silicon film with micropores
ES2046273T3 (es) 1988-11-17 1994-02-01 Herco-Cff Chiralflow Filtertechnik Gmbh Aparato filtrante para separar un liquido turbio.
US5013337A (en) 1988-12-06 1991-05-07 Uop Process for separating a mixture of molecular species using crystalline microporous metal sulfide compositions
US5019263A (en) 1990-06-05 1991-05-28 Mobil Oil Corp. Membrane composed of a pure molecular sieve
US5145584A (en) 1990-12-05 1992-09-08 Allied-Signal Inc. Processes for using a thin film composite ultrafiltration membrane
FR2676007B1 (fr) 1991-04-30 1994-04-08 Tech Sep Membrane composite de nanofiltration.
NL9401260A (nl) 1993-11-12 1995-06-01 Cornelis Johannes Maria Van Ri Membraan voor microfiltratie, ultrafiltratie, gasscheiding en katalyse, werkwijze ter vervaardiging van een dergelijk membraan, mal ter vervaardiging van een dergelijk membraan, alsmede diverse scheidingssystemen omvattende een dergelijk membraan.
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5716527A (en) 1994-07-08 1998-02-10 Exxon Research & Engineering Company Zeolite membrane with a selectivity enhancing coating
GB9413863D0 (en) 1994-07-08 1994-08-24 Exxon Chemical Patents Inc Molecular sieves and processes for their manufacture
US5876830A (en) 1995-09-08 1999-03-02 Board Of Regents Of The University Of Colorado Method of assembly of molecular-sized nets and scaffolding
GB9600082D0 (en) 1996-01-04 1996-03-06 Exxon Chemical Patents Inc Molecular sieves and processes for their manufacture
SE9600970D0 (sv) 1996-03-14 1996-03-14 Johan Sterte Förfarande för framställning av mycket tunna filmer av molekylsiktar
ES2105988B1 (es) 1996-03-15 1998-07-01 Antibioticos Sa Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion.
US6043177A (en) 1997-01-21 2000-03-28 University Technology Corporation Modification of zeolite or molecular sieve membranes using atomic layer controlled chemical vapor deposition
US6060415A (en) 1997-02-10 2000-05-09 National Science Council Aligned molecular sieve crystals grown on anodic alumina membrane
US6264044B1 (en) 1997-04-11 2001-07-24 Cuno, Inc. Reinforced, three zone microporous membrane
US5993661A (en) 1997-04-14 1999-11-30 The Research Foundation Of State University Of New York Macroporous or microporous filtration membrane, method of preparation and use
US5938923A (en) 1997-04-15 1999-08-17 The Regents Of The University Of California Microfabricated filter and capsule using a substrate sandwich
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US6243348B1 (en) * 1998-06-05 2001-06-05 Massachusetts Institute Of Technology Very-high-density memory device utilizing a scintillating data-storage medium
AU4546899A (en) * 1998-06-05 1999-12-20 Sarnoff Corporation Apparatus for separating molecules
US6113795A (en) 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
US6361671B1 (en) * 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels
US6113794A (en) 1999-01-25 2000-09-05 Kumar; Ashwani Composite solvent resistant nanofiltration membranes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5867266A (en) * 1996-04-17 1999-02-02 Cornell Research Foundation, Inc. Multiple optical channels for chemical analysis
EP0977030A1 (fr) * 1998-07-29 2000-02-02 Hewlett-Packard Company Puce pour la séparation électrophorétique des molécules et procédé l'utilisant
WO2000042233A1 (fr) * 1999-01-13 2000-07-20 Cornell Research Foundation, Inc. Fabrication de structures fluidiques monolithiques

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2001 (2001-01-01), CHEN YONG ET AL: "Nanofabrication: Conventional and nonconventional methods.", XP002223278, Database accession no. PREV200100180069 *
ELECTROPHORESIS, vol. 22, no. 2, January 2001 (2001-01-01), pages 187 - 207, ISSN: 0173-0835 *
J. HAN AND H. G. CRAIGHEAD: "Entropic trapping and sieving of long DNA molecules in a nanofluidic channel", J.VAC.SCI.TECHNOL. A, vol. 17, no. 4, July 1999 (1999-07-01) - August 1999 (1999-08-01), pages 2142 - 2147, XP002223274 *
PARK, HARRISON, CHAIKIN, REGISTER, ADAMSON: "Block Copolymer Lithography: Periodic Arrays of about 10 to the 11th Holes in 1 Square Centimeter", SCIENCE, vol. 276, 30 May 1997 (1997-05-30), pages 1401 - 1404, XP002223276 *
T. A. J. DUKE AND R. H. AUSTIN: "Microfabricated Sieve for the Continuous Sorting of Macromolecules"", PHYSICAL REVIEW LETTERS, vol. 80, no. 7, 16 February 1998 (1998-02-16), pages 1552 - 1555, XP002223277 *
YANG XIAO M ET AL: "Guided self-assembly of symmetric diblock copolymer films on chemically nanopatterned substrates", MACROMOLECULES;MACROMOLECULES DEC 2000 ACS, WASHINGTON, DC, USA, vol. 33, no. 26, December 2000 (2000-12-01), pages 9575 - 9582, XP002223275 *

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