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WO2002056867A3 - Extended release pharmaceutical compositions containing beta-lactam antibiotics - Google Patents

Extended release pharmaceutical compositions containing beta-lactam antibiotics Download PDF

Info

Publication number
WO2002056867A3
WO2002056867A3 PCT/IN2002/000009 IN0200009W WO02056867A3 WO 2002056867 A3 WO2002056867 A3 WO 2002056867A3 IN 0200009 W IN0200009 W IN 0200009W WO 02056867 A3 WO02056867 A3 WO 02056867A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
extended release
lactam antibiotics
release pharmaceutical
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2002/000009
Other languages
French (fr)
Other versions
WO2002056867A2 (en
Inventor
Rama Rao Pendyala
Podili Khadgapathi
Venkaiah Chowdary Nannapaneni
Venkateswara Rao Pavuluri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natco Pharma Ltd
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Priority to CA002435305A priority Critical patent/CA2435305A1/en
Priority to JP2002557375A priority patent/JP2004520358A/en
Priority to EP02701537A priority patent/EP1353651A2/en
Priority to AU2002234868A priority patent/AU2002234868A1/en
Publication of WO2002056867A2 publication Critical patent/WO2002056867A2/en
Publication of WO2002056867A3 publication Critical patent/WO2002056867A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention disclosed in this application relates to an extended release oral pharmaceutical composition containing at least one β-lactam anti-biotic intended for releasing the drug over an extended period upon administration. The pharmaceutical composition is useful for maintaining the desired the therapeutic concentration of active ingredient in blood for extended time periods thus meeting the requirements for effective management of infectious diseases. The pharmaceutical composition is either in the form of a tablet, capsule or dry syrup for reconstitution at the time of administration, releasing the active ingredient as initial dose and maintenance dose at a specific rate. The invention disclosed in this application also relates to a process for formulation of an extended release pharmaceutical composition containing β-lactam antibiotics.
PCT/IN2002/000009 2001-01-18 2002-01-18 Extended release pharmaceutical compositions containing beta-lactam antibiotics Ceased WO2002056867A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002435305A CA2435305A1 (en) 2001-01-18 2002-01-18 Extended release pharmaceutical compositions containing beta-lactam antibiotics
JP2002557375A JP2004520358A (en) 2001-01-18 2002-01-18 Sustained-release pharmaceutical compositions containing beta-lactam antibiotics with improved therapeutic efficacy
EP02701537A EP1353651A2 (en) 2001-01-18 2002-01-18 Extended release pharmaceutical compositions containing beta-lactam antibiotics
AU2002234868A AU2002234868A1 (en) 2001-01-18 2002-01-18 Extended release pharmaceutical compositions containing beta-lactam antibiotics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN58/MAS/2001 2001-01-18
IN58CH2001 2001-01-18

Publications (2)

Publication Number Publication Date
WO2002056867A2 WO2002056867A2 (en) 2002-07-25
WO2002056867A3 true WO2002056867A3 (en) 2003-03-06

Family

ID=11096990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2002/000009 Ceased WO2002056867A2 (en) 2001-01-18 2002-01-18 Extended release pharmaceutical compositions containing beta-lactam antibiotics

Country Status (4)

Country Link
EP (1) EP1353651A2 (en)
JP (1) JP2004520358A (en)
CA (1) CA2435305A1 (en)
WO (1) WO2002056867A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2843880B1 (en) * 2002-09-02 2006-06-02 Flamel Tech Sa ORAL PHARMACEUTICAL FORMULATION AS AQUEOUS SUSPENSION OF MICROCAPSULES FOR MODIFIED AMOXICILLIN RELEASE
FR2872044B1 (en) * 2004-06-28 2007-06-29 Flamel Technologies Sa PHARMACEUTICAL FORMULATION BASED ON ANTIBIOTICS IN THE MICROCAPSULAR FORM
EP1855647A4 (en) * 2005-03-04 2010-11-17 Intelgenx Corp Delayed release pharmaceutical oral dosage form and method of making same
CN109260220B (en) * 2018-11-28 2020-11-24 重庆华森制药股份有限公司 Preparation method of oyster calcium carbonate particles
CN113440530B (en) * 2021-07-08 2023-08-08 广州白云山医药集团股份有限公司白云山制药总厂 Cefixime medicine and preparation method thereof
CN113908133B (en) * 2021-11-29 2023-11-03 河南省儿童医院郑州儿童医院 Cefixime sustained release tablet and preparation method thereof
CN114939113A (en) * 2022-06-01 2022-08-26 澳美制药(苏州)有限公司 Penicillin V potassium tablet and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129382A2 (en) * 1983-06-15 1984-12-27 Shionogi & Co., Ltd. Long-acting formulation of cefaclor and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129382A2 (en) * 1983-06-15 1984-12-27 Shionogi & Co., Ltd. Long-acting formulation of cefaclor and its preparation

Also Published As

Publication number Publication date
WO2002056867A2 (en) 2002-07-25
EP1353651A2 (en) 2003-10-22
JP2004520358A (en) 2004-07-08
CA2435305A1 (en) 2002-07-25

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