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WO2002040651A3 - A human trna-specific adenosine deaminase - Google Patents

A human trna-specific adenosine deaminase Download PDF

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Publication number
WO2002040651A3
WO2002040651A3 PCT/EP2001/013213 EP0113213W WO0240651A3 WO 2002040651 A3 WO2002040651 A3 WO 2002040651A3 EP 0113213 W EP0113213 W EP 0113213W WO 0240651 A3 WO0240651 A3 WO 0240651A3
Authority
WO
WIPO (PCT)
Prior art keywords
adenosine deaminase
human trna
specific adenosine
reagents
trna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/013213
Other languages
French (fr)
Other versions
WO2002040651A2 (en
Inventor
Rainer Kohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2002224853A priority Critical patent/AU2002224853A1/en
Publication of WO2002040651A2 publication Critical patent/WO2002040651A2/en
Publication of WO2002040651A3 publication Critical patent/WO2002040651A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human tRNA-specific adenosine deaminase and reagents which bind to human tRNA-specific adenosine deaminase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD and cancer.
PCT/EP2001/013213 2000-11-17 2001-11-15 A human trna-specific adenosine deaminase Ceased WO2002040651A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002224853A AU2002224853A1 (en) 2000-11-17 2001-11-15 A human trna-specific adenosine deaminase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24927400P 2000-11-17 2000-11-17
US60/249,274 2000-11-17

Publications (2)

Publication Number Publication Date
WO2002040651A2 WO2002040651A2 (en) 2002-05-23
WO2002040651A3 true WO2002040651A3 (en) 2003-01-23

Family

ID=22942758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013213 Ceased WO2002040651A2 (en) 2000-11-17 2001-11-15 A human trna-specific adenosine deaminase

Country Status (2)

Country Link
AU (1) AU2002224853A1 (en)
WO (1) WO2002040651A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1572877A3 (en) * 2001-07-06 2005-10-05 Incyte Genomics, Inc. Drug metabolizing enzymes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BARNES, P.J.: "Mechanisms in COPD: Differences From Asthma", CHEST, vol. 117, no. 2 suppl., February 2000 (2000-02-01), pages 10S - 14S, XP002209687 *
DATABASE EMBL, HEIDELBERG, FRG [online] 1 May 2000 (2000-05-01), KAY, M.: "DJ20N2.1 (Novel protein similar to yeast and bacterial cytosine deaminase, fragment)", XP002215982, Database accession no. Q9UJM6 *
DATABASE EMBL, HEIDELBERG, FRG [online] 21 September 2000 (2000-09-21), NIH-MGC: "601586187F1 NIH_MGC_7 Homo sapiens cDNA clone IMAGE: 3940436 5', mRNA sequence", XP002215981, Database accession no. BE791897 *
DATABASE EMBL, HEIDELBERG, FRG [online] 22 October 2001 (2001-10-22), XP002215985, Database accession no. AAI58041 *
DATABASE EMBL, HEIDELBERG, FRG [online] 22 October 2001 (2001-10-22), XP002215986, Database accession no. AAM38885 *
DATABASE EMBL, HEIDELBERG, FRG [online] 22 October 2001 (2001-10-22), XP002215987, Database accession no. AAI59827 *
DATABASE EMBL, HEIDELBERG, FRG [online] 22 October 2001 (2001-10-22), XP002215988, Database accession no. AAM40671 *
DATABASE EMBL, HEIDELBERG, FRG [online] 29 July 2000 (2000-07-29), NIH-MGC: "601308212F1 NIH_MGC_44 Homo sapiens cDNA clone IMAGE: 3626522 5', mRNA sequence", XP002215984, Database accession no. BE394934 *
DATABASE EMBL, HEIDELBERG, FRG [online] 31 January 1998 (1998-01-31), NCI-CGAP: "nz15c03.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 1287844 3' similar to SW: YJD5_YEAST P47058 HYPOTHETICAL 28.3 KD PROTEIN IN NSP1-KAR2 INTERGENIC REGION, mRNA sequence", XP002215983, Database accession no. AA769247 *
GERBER, A.P. & KELLER, W.: "An Adenosine Deaminase that Generates Inosine at the Wobble Position of tRNAs", SCIENCE, vol. 286, no. 5442, 5 November 1999 (1999-11-05), pages 1146 - 1149, XP002215979 *
PATTERSON, J.B. & SAMUEL, C.E.: "Expression and Regulation by Interferon of a Double-Stranded-RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 10, October 1995 (1995-10-01), pages 5376 - 5388, XP002215980 *

Also Published As

Publication number Publication date
AU2002224853A1 (en) 2002-05-27
WO2002040651A2 (en) 2002-05-23

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