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WO2002040512A3 - Human beta-defensin-3 - Google Patents

Human beta-defensin-3 Download PDF

Info

Publication number
WO2002040512A3
WO2002040512A3 PCT/EP2001/013174 EP0113174W WO0240512A3 WO 2002040512 A3 WO2002040512 A3 WO 2002040512A3 EP 0113174 W EP0113174 W EP 0113174W WO 0240512 A3 WO0240512 A3 WO 0240512A3
Authority
WO
WIPO (PCT)
Prior art keywords
defensin
human beta
inventive peptides
treat
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/013174
Other languages
German (de)
French (fr)
Other versions
WO2002040512A2 (en
Inventor
Wolf-Georg Forssmann
Enno Kluever
Jose-Ramon Conejo-Garcia
Knut Adermann
Robert Bals
Hans-Juergen Maegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IPF Pharmaceuticals GmbH
Original Assignee
IPF Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IPF Pharmaceuticals GmbH filed Critical IPF Pharmaceuticals GmbH
Priority to AU2002227925A priority Critical patent/AU2002227925A1/en
Publication of WO2002040512A2 publication Critical patent/WO2002040512A2/en
Publication of WO2002040512A3 publication Critical patent/WO2002040512A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a peptide, hBD-3 (human beta-defensin-3) and to derivatives and fragments thereof, in addition to a method for producing the same. The inventive peptides can be made available as medicaments and can be used to resist and combat pathogenic germs. They are particularly useful for treating bacterial diseases of the respiratory system, in particular for infections caused by Burkholderia cepacia and Pseudomonas aeroginosa and for treating cystic fibrosis. The inventive peptides can also be used to treat inflammatory diseases of the gastro-intestinal tract, urogenital tract and to treat septicaemia.
PCT/EP2001/013174 2000-11-14 2001-11-14 Human beta-defensin-3 Ceased WO2002040512A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002227925A AU2002227925A1 (en) 2000-11-14 2001-11-14 Human beta-defensin-3

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10056365.1 2000-11-14
DE10056365 2000-11-14
DE10116220.0 2001-03-30
DE10116220 2001-03-30

Publications (2)

Publication Number Publication Date
WO2002040512A2 WO2002040512A2 (en) 2002-05-23
WO2002040512A3 true WO2002040512A3 (en) 2002-12-19

Family

ID=26007661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013174 Ceased WO2002040512A2 (en) 2000-11-14 2001-11-14 Human beta-defensin-3

Country Status (2)

Country Link
AU (1) AU2002227925A1 (en)
WO (1) WO2002040512A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576755B1 (en) 1997-09-10 2003-06-10 Zymogenetics, Inc. Beta-defensins
EP2949663A1 (en) * 2006-04-27 2015-12-02 Singapore Health Services Pte Ltd Antimicrobial peptides
EP2396023A2 (en) * 2009-02-11 2011-12-21 Yeda Research and Development Co. Ltd. Short beta-defensin-derived peptides
KR101249702B1 (en) * 2010-06-16 2013-04-05 주식회사 나이벡 Antibacterial or Anti-inflammatory Peptides and Pharmaceutical Composition Containing Thereof
CN102533857B (en) * 2012-02-21 2014-05-07 西北农林科技大学 HBD3 tracheal epithelium specificity expression vector and recombinant cell constructed from same
SG11201506885UA (en) 2013-03-21 2015-09-29 Sanofi Aventis Deutschland Synthesis of cyclic imide containing peptide products
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
ES2710973T3 (en) * 2014-08-29 2019-04-29 Ceinge Biotecnologie Avanzate S C A R L Analogs of cyclic beta defensins for the treatment of infections
KR101693533B1 (en) 2015-03-26 2017-01-06 서울대학교산학협력단 Anti-Cancer Peptide for Inhibition of Proliferation on the Cancer Stem Cells and Use Thereof
KR102244161B1 (en) * 2018-08-31 2021-04-26 주식회사 나이벡 Use of Peptides having Ability to inhibit multiple disease biomarkers' expression

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013080A1 (en) * 1997-09-10 1999-03-18 Zymogenetics, Inc. Beta-defensins
WO2000046245A2 (en) * 1999-02-01 2000-08-10 Schering Aktiengesellschaft Human antibiotic proteins
WO2001092309A2 (en) * 2000-06-01 2001-12-06 University Of Iowa Research Foundation Human beta-defensin-3 (hbd-3), a highly cationic beta-defensin antimicrobial peptide
WO2002004487A2 (en) * 2000-07-11 2002-01-17 Ipf Pharmaceuticals Gmbh Method for producing and using novel human defensins as biologically active proteins for treating infections and other illnesses
WO2002009738A1 (en) * 2000-07-28 2002-02-07 Murphy Christopher J Transplant media

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013080A1 (en) * 1997-09-10 1999-03-18 Zymogenetics, Inc. Beta-defensins
WO2000046245A2 (en) * 1999-02-01 2000-08-10 Schering Aktiengesellschaft Human antibiotic proteins
WO2001092309A2 (en) * 2000-06-01 2001-12-06 University Of Iowa Research Foundation Human beta-defensin-3 (hbd-3), a highly cationic beta-defensin antimicrobial peptide
WO2002004487A2 (en) * 2000-07-11 2002-01-17 Ipf Pharmaceuticals Gmbh Method for producing and using novel human defensins as biologically active proteins for treating infections and other illnesses
WO2002009738A1 (en) * 2000-07-28 2002-02-07 Murphy Christopher J Transplant media

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDREU D ET AL: "Animal antimicrobial peptides: an overview.", BIOPOLYMERS. UNITED STATES 1998, vol. 47, no. 6, 1998, pages 415 - 433, XP000996625, ISSN: 0006-3525 *
COLE A M ET AL: "Human antimicrobial peptides: analysis and application.", BIOTECHNIQUES. UNITED STATES OCT 2000, vol. 29, no. 4, October 2000 (2000-10-01), pages 822 - 826, 828, 830 - 831, XP001093806, ISSN: 0736-6205 *
DATABASE EBI [online] 21 September 2000 (2000-09-21), CHRISTOPHERS, E. ET AL.: "Human antibiotic protein", XP002209339, retrieved from EBI Database accession no. AX033352 *
DATABASE EBI [online] 6 July 1999 (1999-07-06), ADLER, D. ET AL.: "New zamp1 polypeptide and polynucleotide, human beta-defensins - useful as diagnostic reagents and for treatment of microbial infections, and AIDS", XP002209338, retrieved from EBI Database accession no. AAY07243 *
GARCÍA J R ET AL: "Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.", CELL AND TISSUE RESEARCH. GERMANY NOV 2001, vol. 306, no. 2, November 2001 (2001-11-01), pages 257 - 264, XP002206910, ISSN: 0302-766X *
HARDER J ET AL: "Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 23 FEB 2001, vol. 276, no. 8, 23 February 2001 (2001-02-23), pages 5707 - 5713, XP002206911, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2002227925A1 (en) 2002-05-27
WO2002040512A2 (en) 2002-05-23

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