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WO2001037819A3 - Utilisation de derives d'indirubine pour la fabrication de medicaments - Google Patents

Utilisation de derives d'indirubine pour la fabrication de medicaments Download PDF

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Publication number
WO2001037819A3
WO2001037819A3 PCT/FR2000/003264 FR0003264W WO0137819A3 WO 2001037819 A3 WO2001037819 A3 WO 2001037819A3 FR 0003264 W FR0003264 W FR 0003264W WO 0137819 A3 WO0137819 A3 WO 0137819A3
Authority
WO
WIPO (PCT)
Prior art keywords
indirubine
derivatives
making medicines
indirubine derivatives
making
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2000/003264
Other languages
English (en)
Other versions
WO2001037819A2 (fr
Inventor
Gerhard Eisenbrand
Laurent Meijer
Ralph Hoessel
Andrea Thommet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to JP2001539434A priority Critical patent/JP2003514850A/ja
Priority to EP00985309A priority patent/EP1231916A2/fr
Priority to AU21770/01A priority patent/AU2177001A/en
Priority to CA002387591A priority patent/CA2387591A1/fr
Publication of WO2001037819A2 publication Critical patent/WO2001037819A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001037819A3 publication Critical patent/WO2001037819A3/fr
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention vise l'utilisation pour la fabrication de médicaments inhibiteurs de la GSK-3β de dérivés d'indirubine. Application pour le traitement de pathologies impliquant GSK-3β et CDK5.
PCT/FR2000/003264 1999-11-23 2000-11-23 Utilisation de derives d'indirubine pour la fabrication de medicaments Ceased WO2001037819A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001539434A JP2003514850A (ja) 1999-11-23 2000-11-23 薬剤を調製するためのインジルビン誘導体の使用
EP00985309A EP1231916A2 (fr) 1999-11-23 2000-11-23 Utilisation de derives d'indirubine pour la fabrication de medicaments
AU21770/01A AU2177001A (en) 1999-11-23 2000-11-23 Use of indirubine derivatives for making medicines
CA002387591A CA2387591A1 (fr) 1999-11-23 2000-11-23 Utilisation de derives d'indirubine pour la fabrication de medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/14749 1999-11-23
FR9914749A FR2801216A1 (fr) 1999-11-23 1999-11-23 Utilisation de derives d'indirubine pour la fabrication de medicaments

Publications (2)

Publication Number Publication Date
WO2001037819A2 WO2001037819A2 (fr) 2001-05-31
WO2001037819A3 true WO2001037819A3 (fr) 2002-06-13

Family

ID=9552458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003264 Ceased WO2001037819A2 (fr) 1999-11-23 2000-11-23 Utilisation de derives d'indirubine pour la fabrication de medicaments

Country Status (6)

Country Link
EP (1) EP1231916A2 (fr)
JP (1) JP2003514850A (fr)
AU (1) AU2177001A (fr)
CA (1) CA2387591A1 (fr)
FR (1) FR2801216A1 (fr)
WO (1) WO2001037819A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598288B2 (en) 2001-09-27 2009-10-06 Alcon, Inc. Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US10703718B2 (en) 2014-03-14 2020-07-07 City Of Hope 5-bromo-indirubins
US11306072B2 (en) 2013-03-14 2022-04-19 City Of Hope 5-bromo-indirubins

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002213132A1 (en) * 2000-10-10 2002-04-22 Board Of Regents, The University Of Texas System Suppression of cyclin kinase activity for prevention and treatment of infections
DE10114138C2 (de) * 2001-03-16 2003-03-27 Schering Ag Cdk-inhibitorische Indirubinderivate mit erhöhter Löslichkeit
DE10125763A1 (de) * 2001-05-17 2002-11-28 Schering Ag Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren
DE10129028A1 (de) * 2001-06-11 2003-01-02 Schering Ag Lösliche Cdk-inhibitorische Indirubinderivate
CN1199946C (zh) * 2002-10-29 2005-05-04 无锡杰西医药科技有限公司 一种特异性吲哚类化合物及制备方法与其在治疗和预防癌症等疾病中的应用
US20060217368A1 (en) * 2003-04-18 2006-09-28 Kyowa Hakko Kogyo Co., Ltd. Drug for nerve regeneration
KR100588803B1 (ko) * 2004-01-27 2006-06-12 학교법인조선대학교 암세포주에 항암활성을 지닌 인디루빈 유도체
EP1885454A2 (fr) 2005-05-04 2008-02-13 DeveloGen Aktiengesellschaft Utilisation des inhibiteurs gsk-3 dans la prevention et le traitement des maladies auto-immunes pancreatiques
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
WO2007047978A2 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
EP1942879A1 (fr) 2005-10-31 2008-07-16 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
WO2007099402A2 (fr) * 2005-12-23 2007-09-07 Centre National De La Recherche Scientifique (Cnrs) Nouvelles indirubines substituees en 3' et 7 et leurs applications
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008067756A1 (fr) 2006-12-04 2008-06-12 Jiangsu Simcere Pharmaceutical R & D Co., Ltd. Dérivés de 3-pyrrolo-cyclohexylène-2-dihydro-indolinone et utilisations de ceux-ci
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041854A1 (fr) * 1996-05-07 1997-11-13 The Trustees Of The University Of Pennsylvania Inhibiteurs de glycogene synthetase kinase-3 et procedes d'identification et d'utilisation de ces inhibiteurs
EP0966963A1 (fr) * 1998-05-29 1999-12-29 Gerhard Prof. Dr. Eisenbrand Utilisation des bisindole indigoides comme inhibiteurs de CDK1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041854A1 (fr) * 1996-05-07 1997-11-13 The Trustees Of The University Of Pennsylvania Inhibiteurs de glycogene synthetase kinase-3 et procedes d'identification et d'utilisation de ces inhibiteurs
EP0966963A1 (fr) * 1998-05-29 1999-12-29 Gerhard Prof. Dr. Eisenbrand Utilisation des bisindole indigoides comme inhibiteurs de CDK1

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GRAY N ET AL: "ATP-SITE DIRECTED INHIBITORS OF CYCLIN-DEPENDENT KINASES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 9, September 1999 (1999-09-01), pages 859 - 875, XP000856195, ISSN: 0929-8673 *
HOESSEL R ET AL: "INDIRUBIN, THE ACTIVE CONSTITUENT OF A CHINESE ANTILEUKAEMIA MEDICINE, INHIBITS CYCLIN-DEPENDENT KINASES", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 1, no. 1, 1 May 1999 (1999-05-01), pages 60 - 67, XP000856197, ISSN: 1465-7392 *
MEIJER L. ET AL: "Properties and potential applications of chemical inhibitors of cyclin-dependent Kinases.", PHARMACOLOGY AND THERAPEUTICS, (1999) 82/2 (279-284)., XP000938154 *
MEIJER L.: "Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents.", DRUG RESISTANCE UPDATES, (2000) 3/2 (83-88)., XP000931278 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598288B2 (en) 2001-09-27 2009-10-06 Alcon, Inc. Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US11306072B2 (en) 2013-03-14 2022-04-19 City Of Hope 5-bromo-indirubins
US10703718B2 (en) 2014-03-14 2020-07-07 City Of Hope 5-bromo-indirubins

Also Published As

Publication number Publication date
CA2387591A1 (fr) 2001-05-31
AU2177001A (en) 2001-06-04
FR2801216A1 (fr) 2001-05-25
WO2001037819A2 (fr) 2001-05-31
EP1231916A2 (fr) 2002-08-21
JP2003514850A (ja) 2003-04-22

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