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WO2001029032A8 - Process for the preparation of paroxetine - Google Patents

Process for the preparation of paroxetine

Info

Publication number
WO2001029032A8
WO2001029032A8 PCT/GB2000/004066 GB0004066W WO0129032A8 WO 2001029032 A8 WO2001029032 A8 WO 2001029032A8 GB 0004066 W GB0004066 W GB 0004066W WO 0129032 A8 WO0129032 A8 WO 0129032A8
Authority
WO
WIPO (PCT)
Prior art keywords
paroxetine
preparation
arecoline
starting
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/004066
Other languages
French (fr)
Other versions
WO2001029032A1 (en
Inventor
David Crowe
Neal Ward
Andrew Stephen Wells
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to AU10385/01A priority Critical patent/AU1038501A/en
Publication of WO2001029032A1 publication Critical patent/WO2001029032A1/en
Publication of WO2001029032A8 publication Critical patent/WO2001029032A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Three process schemes (1, 2, and 3) for a complete route to paroxetine starting from arecoline are disclosed.
PCT/GB2000/004066 1999-10-20 2000-10-20 Process for the preparation of paroxetine Ceased WO2001029032A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10385/01A AU1038501A (en) 1999-10-20 2000-10-20 Novel processes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9924882.5 1999-10-20
GBGB9924882.5A GB9924882D0 (en) 1999-10-20 1999-10-20 Novel process

Publications (2)

Publication Number Publication Date
WO2001029032A1 WO2001029032A1 (en) 2001-04-26
WO2001029032A8 true WO2001029032A8 (en) 2001-05-25

Family

ID=10863097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/004066 Ceased WO2001029032A1 (en) 1999-10-20 2000-10-20 Process for the preparation of paroxetine

Country Status (3)

Country Link
AU (1) AU1038501A (en)
GB (1) GB9924882D0 (en)
WO (1) WO2001029032A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
US7138523B2 (en) 2002-05-16 2006-11-21 Apotex Pharmachem Inc. Preparation of 4-(4-fluorophenyl)-N-alkylnipecotinate esters, 4-(4-fluorophenyl)-N-arylnipecotinate esters and 4-(4-fluorophenyl)-N-aralkylnipecotinate esters
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
WO2005063707A1 (en) * 2003-12-26 2005-07-14 Natco Pharma Limited Enantiospecific process for the preparation of paroxetine intermediate
WO2007015262A2 (en) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine
CN101205211B (en) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 Method for preparing hydrochloric paroxetine key intermediates
CN117964546B (en) * 2024-03-28 2024-06-11 成都硕德药业有限公司 A preparation method of niraparib intermediate
CN120441473B (en) * 2025-07-08 2025-10-10 山东金城医药研究院有限公司 Betulin preparation method, buccal bag base material and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0223334B1 (en) * 1985-08-10 1991-07-10 Beecham Group Plc Process for the preparation of aryl-piperidine carbinols
GB8520154D0 (en) * 1985-08-10 1985-09-18 Beecham Group Plc Chemical process
FR2702220B1 (en) * 1993-03-03 1995-05-12 Synthelabo Enzymatic duplication of 4-alkyl-2-piperidine-carboxylate derivatives and use of the compounds obtained, as synthesis intermediates.
EP1384720A1 (en) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
WO1998002556A2 (en) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
ATE433959T1 (en) * 1997-04-07 2009-07-15 Univ Georgetown ANALOGUES OF COCAINE
WO2000020390A1 (en) * 1998-10-07 2000-04-13 Georgetown University Monomeric and dimeric heterocycles, and therapeutic uses thereof

Also Published As

Publication number Publication date
WO2001029032A1 (en) 2001-04-26
GB9924882D0 (en) 1999-12-22
AU1038501A (en) 2001-04-30

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