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WO2001009175A3 - Plant defensin variants with modified cystein residues - Google Patents

Plant defensin variants with modified cystein residues Download PDF

Info

Publication number
WO2001009175A3
WO2001009175A3 PCT/GB2000/002968 GB0002968W WO0109175A3 WO 2001009175 A3 WO2001009175 A3 WO 2001009175A3 GB 0002968 W GB0002968 W GB 0002968W WO 0109175 A3 WO0109175 A3 WO 0109175A3
Authority
WO
WIPO (PCT)
Prior art keywords
plant defensin
modified
cystein residues
defensin variants
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/002968
Other languages
French (fr)
Other versions
WO2001009175A2 (en
Inventor
Geertruida Afina Posthuma
Wilhelmus Martinus Ma Schaaper
Lolke Sijtsma
Amerongen Aart Van
Franky Fant
Frans Alois Mekania Borremans
Sarah Bronwen Rees
Rupert William Osborn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Syngenta Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Ltd filed Critical Syngenta Ltd
Priority to EP00949764A priority Critical patent/EP1208215A2/en
Priority to JP2001513981A priority patent/JP2003507010A/en
Priority to CA002378441A priority patent/CA2378441A1/en
Priority to AU63037/00A priority patent/AU779466B2/en
Publication of WO2001009175A2 publication Critical patent/WO2001009175A2/en
Publication of WO2001009175A3 publication Critical patent/WO2001009175A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Mycology (AREA)
  • Agronomy & Crop Science (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A modified cysteine-containing antimicrobial peptide derived from a plant defensin said modification comprising (a) introducing one or more cysteine residues and/or (b) replacing or altering one or more, cysteine residues to block their ability to form disulphide bridges. The modified peptides can have improved antimicrobial activity.
PCT/GB2000/002968 1999-08-02 2000-07-31 Plant defensin variants with modified cystein residues Ceased WO2001009175A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00949764A EP1208215A2 (en) 1999-08-02 2000-07-31 Plant defensin variants with modified cystein residues
JP2001513981A JP2003507010A (en) 1999-08-02 2000-07-31 Synthetic peptide
CA002378441A CA2378441A1 (en) 1999-08-02 2000-07-31 Plant defensin variants with modified systein residues
AU63037/00A AU779466B2 (en) 1999-08-02 2000-07-31 Synthetic peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9918156.2 1999-08-02
GBGB9918156.2A GB9918156D0 (en) 1999-08-02 1999-08-02 Synthetic peptides

Publications (2)

Publication Number Publication Date
WO2001009175A2 WO2001009175A2 (en) 2001-02-08
WO2001009175A3 true WO2001009175A3 (en) 2001-08-23

Family

ID=10858412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/002968 Ceased WO2001009175A2 (en) 1999-08-02 2000-07-31 Plant defensin variants with modified cystein residues

Country Status (6)

Country Link
EP (1) EP1208215A2 (en)
JP (1) JP2003507010A (en)
AU (1) AU779466B2 (en)
CA (1) CA2378441A1 (en)
GB (1) GB9918156D0 (en)
WO (1) WO2001009175A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003215257A1 (en) 2002-02-19 2003-09-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Modified defensins and their use
WO2003091429A1 (en) 2002-04-25 2003-11-06 Toagosei Co.,Ltd. Antimicrobial polypeptide and utizliation thereof
US7674771B2 (en) 2003-10-29 2010-03-09 Toagosei Co., Ltd Antimicrobial peptides and utilization of the same
JP4507080B2 (en) 2004-07-30 2010-07-21 東亞合成株式会社 Antibacterial peptides and their use
JP4730584B2 (en) 2004-12-06 2011-07-20 東亞合成株式会社 Antibacterial peptides and their use
EP1849474B1 (en) 2005-02-15 2016-09-07 Toagosei Co., Ltd. Antimicrobial peptide and use thereof
AR075257A1 (en) 2008-02-01 2011-03-23 Hexima Ltd PLANTS PROTECTION SYSTEM AGAINST INFECTION BY PATHOGEN AGENTS
US9889184B2 (en) 2008-08-05 2018-02-13 Hexima Limited Anti-pathogen systems
SG192063A1 (en) * 2011-02-07 2013-08-30 Hexima Ltd Modified plant defensins useful as anti-pathogenic agents
IT202100018530A1 (en) 2021-07-14 2023-01-14 Clever Bioscience S R L Synergistic antimicrobial compositions containing selected peptides and fatty acids
IT202100018542A1 (en) 2021-07-14 2023-01-14 Clever Bioscience S R L Liposomes containing synergistic antimicrobial combinations based on selected peptides and fatty acids
CN116003541B (en) * 2022-07-27 2024-05-28 武汉大学 Multifunctional fungal defensin modified peptide, preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005153A1 (en) * 1991-08-29 1993-03-18 Zeneca Limited Biocidal proteins
WO1995018229A1 (en) * 1993-12-24 1995-07-06 Zeneca Limited Antimicrobial proteins
WO1997021815A2 (en) * 1995-12-13 1997-06-19 Zeneca Limited Antifungal proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005153A1 (en) * 1991-08-29 1993-03-18 Zeneca Limited Biocidal proteins
WO1995018229A1 (en) * 1993-12-24 1995-07-06 Zeneca Limited Antimicrobial proteins
WO1997021815A2 (en) * 1995-12-13 1997-06-19 Zeneca Limited Antifungal proteins

Also Published As

Publication number Publication date
CA2378441A1 (en) 2001-02-08
AU779466B2 (en) 2005-01-27
AU6303700A (en) 2001-02-19
EP1208215A2 (en) 2002-05-29
JP2003507010A (en) 2003-02-25
GB9918156D0 (en) 1999-10-06
WO2001009175A2 (en) 2001-02-08

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