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WO2000047622A3 - Peptides with anti-angiogenic activity - Google Patents

Peptides with anti-angiogenic activity Download PDF

Info

Publication number
WO2000047622A3
WO2000047622A3 PCT/GB2000/000520 GB0000520W WO0047622A3 WO 2000047622 A3 WO2000047622 A3 WO 2000047622A3 GB 0000520 W GB0000520 W GB 0000520W WO 0047622 A3 WO0047622 A3 WO 0047622A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
angiogenic activity
trp
type
angiogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2000/000520
Other languages
French (fr)
Other versions
WO2000047622A2 (en
Inventor
Nicholas Mazarakis
Enca Martin-Rendon
Susan Mary Kingsman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Oxford Biomedica UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU25596/00A priority Critical patent/AU2559600A/en
Priority to IL14437600A priority patent/IL144376A0/en
Priority to EP00903839A priority patent/EP1161454A2/en
Priority to GB0120713A priority patent/GB2362887A/en
Priority to JP2000598537A priority patent/JP2002542762A/en
Priority to KR1020017010110A priority patent/KR20010092800A/en
Application filed by Oxford Biomedica UK Ltd filed Critical Oxford Biomedica UK Ltd
Priority to CA002359750A priority patent/CA2359750A1/en
Publication of WO2000047622A2 publication Critical patent/WO2000047622A2/en
Publication of WO2000047622A3 publication Critical patent/WO2000047622A3/en
Priority to NO20013933A priority patent/NO20013933L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A non-naturally occuring Type I Repeat Peptide (TRP) and expression methods thereof.
PCT/GB2000/000520 1999-02-15 2000-02-15 Peptides with anti-angiogenic activity Ceased WO2000047622A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL14437600A IL144376A0 (en) 1999-02-15 2000-02-15 Peptides
EP00903839A EP1161454A2 (en) 1999-02-15 2000-02-15 Peptides with anti-angiogenic activity
GB0120713A GB2362887A (en) 1999-02-15 2000-02-15 Peptides
JP2000598537A JP2002542762A (en) 1999-02-15 2000-02-15 peptide
KR1020017010110A KR20010092800A (en) 1999-02-15 2000-02-15 Peptides
AU25596/00A AU2559600A (en) 1999-02-15 2000-02-15 Peptides
CA002359750A CA2359750A1 (en) 1999-02-15 2000-02-15 Peptides with anti-angiogenic activity
NO20013933A NO20013933L (en) 1999-02-15 2001-08-13 peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9903408.4 1999-02-15
GBGB9903408.4A GB9903408D0 (en) 1999-02-15 1999-02-15 Peptides

Publications (2)

Publication Number Publication Date
WO2000047622A2 WO2000047622A2 (en) 2000-08-17
WO2000047622A3 true WO2000047622A3 (en) 2001-01-11

Family

ID=10847793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000520 Ceased WO2000047622A2 (en) 1999-02-15 2000-02-15 Peptides with anti-angiogenic activity

Country Status (10)

Country Link
EP (1) EP1161454A2 (en)
JP (1) JP2002542762A (en)
KR (1) KR20010092800A (en)
CN (1) CN1340059A (en)
AU (1) AU2559600A (en)
CA (1) CA2359750A1 (en)
GB (2) GB9903408D0 (en)
IL (1) IL144376A0 (en)
NO (1) NO20013933L (en)
WO (1) WO2000047622A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
US20100184668A1 (en) * 2007-06-19 2010-07-22 Erwin Van Meir method of treating abnormal angiogenesis via the bai family of proteins and their protein fragments
AU2009279676C1 (en) * 2008-08-07 2015-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Radioprotectants targeting thrombospondin-1 and CD47
CN110227159B (en) * 2018-03-05 2021-09-21 义慧科技(深圳)有限公司 Medicine for improving drug resistance of solid tumor to anti-vascular drugs and application of CPT1a inhibitor in medicine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011395A1 (en) * 1992-11-10 1994-05-26 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Peptide inhibitors of fibronectin and related collagen-binding proteins
WO1996037621A2 (en) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Für Proteinoptimierung Mbh Multimeric proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011395A1 (en) * 1992-11-10 1994-05-26 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Peptide inhibitors of fibronectin and related collagen-binding proteins
WO1996037621A2 (en) * 1995-05-23 1996-11-28 Morphosys Gesellschaft Für Proteinoptimierung Mbh Multimeric proteins

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 November 1996 (1996-11-01), HINXTON, GB, XP002142872 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 1 November 1996 (1996-11-01), HINXTON, GB, XP002142873 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 12 April 1991 (1991-04-12), HINXTON, GB, XP002142874 *
GUO N -H ET AL: "ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES OF D-REVERSE PEPTIDES DERIVED FROM THE SECOND TYPE-1 REPEAT OF THROMBOSPONDIN-1", JOURNAL OF PEPTIDE RESEARCH,DK,MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, vol. 50, no. 3, 1 September 1997 (1997-09-01), pages 210 - 221, XP000696384, ISSN: 1397-002X *
IRUELA-ARISPE LUISA: "Inhibitors of the angiogenic response: One domain, multiple proteins.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 29, no. 7, 1997, XIX Annual Meeting of the International Society for Heart Research;Vancouver, British Columbia, Canada; July 23-27, 1997, pages A267, XP000925248, ISSN: 0022-2828 *
IRUELA-ARISPE M LUISA ET AL: "Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats.", CIRCULATION, vol. 100, no. 13, pages 1423 - 1431, XP000923386, ISSN: 0009-7322 *
KALKA CHRISTOPH ET AL.,: "Novel genes containing the thrombospondin type I domain suppress the development of angiogenesis in an in-vivo model of peripheral vascular ischemia.", CIRCULATION, vol. 98, no. (17 SUPPL.), 27 October 1998 (1998-10-27), pages pI729-I730, XP000923490 *
KUNO ET AL: "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 1, no. 272, 3 January 1997 (1997-01-03), pages 556 - 562, XP002076038, ISSN: 0021-9258 *
NISHIMORI HIROYUKI ET AL: "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis.", ONCOGENE, vol. 15, no. 18, October 1997 (1997-10-01), pages 2145 - 2150, XP000923392, ISSN: 0950-9232 *
QABAR AZIZ N ET AL: "A chimeric murine TSP3/human TSP1 is a pentamer with abolished antiangiogenic activity.", ANNUAL MEETING OF THE PROFESSIONAL RESEARCH SCIENTISTS ON EXPERIMENTAL BIOLOGY 97;NEW ORLEANS, LOUISIANA, USA. 6-7 APRIL 1997, XP000914726 *
TOLSMA S S ET AL: "PEPTIDES DERIVED FROM TWO SEPARATE DOMAINS OF THE MATRIX PROTEIN THROMBOSPONDIN-1 HAVE ANTI-ANGIOGENIC ACTIVITY", JOURNAL OF CELL BIOLOGY,US,NEW YORK, US, vol. 122, no. 2, 1 July 1993 (1993-07-01), pages 497 - 511, XP000578336, ISSN: 0021-9525 *
VAZQUEZ FRANCISCA ET AL: "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23349 - 23357, XP002142875, ISSN: 0021-9258 *
YU HAINI ET AL: "Specificities of heparin-binding sites from the amino-terminus and type 1 repeats of thrombospondin-1.", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 374, no. 1, 1 February 2000 (2000-02-01), pages 13 - 23, XP000925001, ISSN: 0003-9861 *

Also Published As

Publication number Publication date
GB2362887A (en) 2001-12-05
IL144376A0 (en) 2002-05-23
EP1161454A2 (en) 2001-12-12
GB9903408D0 (en) 1999-04-07
KR20010092800A (en) 2001-10-27
WO2000047622A2 (en) 2000-08-17
GB0120713D0 (en) 2001-10-17
AU2559600A (en) 2000-08-29
CN1340059A (en) 2002-03-13
CA2359750A1 (en) 2000-08-17
JP2002542762A (en) 2002-12-17
NO20013933L (en) 2001-10-15
NO20013933D0 (en) 2001-08-13

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