[go: up one dir, main page]

WO2001000796A3 - Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori - Google Patents

Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori Download PDF

Info

Publication number
WO2001000796A3
WO2001000796A3 PCT/CA2000/000777 CA0000777W WO0100796A3 WO 2001000796 A3 WO2001000796 A3 WO 2001000796A3 CA 0000777 W CA0000777 W CA 0000777W WO 0100796 A3 WO0100796 A3 WO 0100796A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycosyltransferases
helicobacter pylori
disclosed
polynucleotide sequences
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000777
Other languages
English (en)
Other versions
WO2001000796A2 (fr
Inventor
Susan M Logan
Warren Wakarchuk
Wayne Conlan
Mario A Monteiro
Eleonora Altman
Koji Hiratsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Priority to AU56684/00A priority Critical patent/AU5668400A/en
Priority to CA002377427A priority patent/CA2377427A1/fr
Publication of WO2001000796A2 publication Critical patent/WO2001000796A2/fr
Priority to PCT/CA2001/000970 priority patent/WO2002000888A1/fr
Priority to PCT/CA2001/000969 priority patent/WO2002000851A2/fr
Priority to CA002417699A priority patent/CA2417699A1/fr
Priority to EP01947091A priority patent/EP1299549A1/fr
Priority to AU2001268885A priority patent/AU2001268885A1/en
Priority to EP01947090A priority patent/EP1299527A2/fr
Priority to CA002417692A priority patent/CA2417692A1/fr
Priority to US10/451,685 priority patent/US20040110261A1/en
Priority to AU2001268886A priority patent/AU2001268886A1/en
Publication of WO2001000796A3 publication Critical patent/WO2001000796A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne de nouveaux polynucléotides isolés codant pour les glycosyltransférases participant à la biosynthèse du lipopolysaccharide de Helicobacter pylori ainsi que des structures d'ADN et des vecteurs recombinants contenant des séquences polynucléotidiques codant pour ces glycosyltransférases. Ces structures d'acides nucléiques et vecteurs peuvent être utilisés dans la préparation des glycosyltransférases pour lesquelles elles codent au moyen de l'expression des séquences polynucléotidiques codantes dans des cellules cibles appropriés. L'invention concerne aussi des polypeptides isolés possédant l'activité enzymatique des glycosyltransférases de Helicobacter. Ces polypeptides sont particulièrement utiles pour cribler les modulateurs de leur activité enzymatique, notamment les inhibiteurs enzymatiques possédant une éventuelle activité antibactérienne.
PCT/CA2000/000777 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori Ceased WO2001000796A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU56684/00A AU5668400A (en) 1999-06-28 2000-06-28 Glycosyltransferases of helicobacter pylori as a new target in prevention and treatment of h. pylori infections
CA002377427A CA2377427A1 (fr) 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori
AU2001268886A AU2001268886A1 (en) 2000-06-28 2001-06-28 Helicobacter pylori heptosyl transferase polypeptides
PCT/CA2001/000970 WO2002000888A1 (fr) 2000-06-28 2001-06-28 Polypeptides de l'heptosyltransferase d'helicobacter pylori
PCT/CA2001/000969 WO2002000851A2 (fr) 2000-06-28 2001-06-28 Helicobacter dd-heptosyltransferase
CA002417699A CA2417699A1 (fr) 2000-06-28 2001-06-28 Polypeptides de l'heptosyltransferase d'helicobacter pylori
EP01947091A EP1299549A1 (fr) 2000-06-28 2001-06-28 Polypeptides de l'heptosyltransferase d'helicobacter pylori
AU2001268885A AU2001268885A1 (en) 2000-06-28 2001-06-28 Helicobacter dd-heptosyltransferase
EP01947090A EP1299527A2 (fr) 2000-06-28 2001-06-28 Helicobacter dd-heptosyltransferase
CA002417692A CA2417692A1 (fr) 2000-06-28 2001-06-28 Helicobacter dd-heptosyltransferase
US10/451,685 US20040110261A1 (en) 2000-06-28 2001-06-28 Helicobacter dd-heptosyltransferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14082099P 1999-06-28 1999-06-28
US60/140,820 1999-06-28

Publications (2)

Publication Number Publication Date
WO2001000796A2 WO2001000796A2 (fr) 2001-01-04
WO2001000796A3 true WO2001000796A3 (fr) 2001-08-09

Family

ID=22492927

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000777 Ceased WO2001000796A2 (fr) 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori

Country Status (3)

Country Link
AU (1) AU5668400A (fr)
CA (1) CA2377427A1 (fr)
WO (1) WO2001000796A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11221079A (ja) 1998-02-04 1999-08-17 Kyowa Hakko Kogyo Co Ltd 糖転移酵素および該酵素をコードするｄｎａ
AU2001268885A1 (en) * 2000-06-28 2002-01-08 National Research Council Of Canada Helicobacter dd-heptosyltransferase
EP1299549A1 (fr) * 2000-06-28 2003-04-09 National Research Council of Canada Polypeptides de l'heptosyltransferase d'helicobacter pylori
GB0017149D0 (en) * 2000-07-12 2000-08-30 Chiron Spa Helicobacter pylori mutants
DK3583126T3 (da) * 2017-02-17 2025-11-17 Sanofi Sa Multispecifikke bindingsmolekyler med specificitet for dystroglycan og laminin-2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040893A1 (fr) * 1995-06-07 1996-12-19 Astra Aktiebolag Sequences d'acide nucleique et d'acides amines concernant helicobacter pylori, utilisees a des fins diagnostiques et therapeutiques
WO1999040205A1 (fr) * 1998-02-04 1999-08-12 Kyowa Hakko Kogyo Co., Ltd. Glycosyltransferase et adn la codant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040893A1 (fr) * 1995-06-07 1996-12-19 Astra Aktiebolag Sequences d'acide nucleique et d'acides amines concernant helicobacter pylori, utilisees a des fins diagnostiques et therapeutiques
WO1999040205A1 (fr) * 1998-02-04 1999-08-12 Kyowa Hakko Kogyo Co., Ltd. Glycosyltransferase et adn la codant
EP1054062A1 (fr) * 1998-02-04 2000-11-22 Kyowa Hakko Kogyo Co., Ltd. Glycosyltransferase et adn la codant

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAN N W ET AL: "THE BIOSYNTHESIS OF LEWIS X IN HELICOBACTER PYLORI", GLYCOBIOLOGY,GB,IRL PRESS,, vol. 5, no. 7, 1995, pages 683 - 688, XP002920175, ISSN: 0959-6658 *
DATABASE EMBL 25 August 1997 (1997-08-25), TOMB J -F ET AL: "Helicobacter pylori 26695 section 72 of 134 of the complete genome.", XP002155934 *
MARTIN S L ET AL: "Lewis X biosynthesis in Helicobacter pylori", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 34, 22 August 1997 (1997-08-22), pages 21349 - 21356, XP002085414, ISSN: 0021-9258 *
TOMB J -F ET AL: "THE COMPLETE GENOME SEQUENCE OF THE GASTRIC PATHOGEN HELICOBACTER PYLORI", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 388, no. 6642, 7 August 1997 (1997-08-07), pages 539 - 547,TABEL, XP002062106, ISSN: 0028-0836 *
WANG G ET AL: "MOLECULAR GENETIC BASIS FOR THE VARIABLE EXPRESSION OF LEWIS Y ANTIGEN IN HELICOBACTER PYLORI: ANALYSIS OF THE ALPHA(1,2) FUCOSYLTRANSFERASE GENE", MOLECULAR MICROBIOLOGY,GB,BLACKWELL SCIENTIFIC, OXFORD, vol. 31, no. 4, February 1999 (1999-02-01), pages 1265 - 1274, XP000889904, ISSN: 0950-382X *

Also Published As

Publication number Publication date
CA2377427A1 (fr) 2001-01-04
AU5668400A (en) 2001-01-31
WO2001000796A2 (fr) 2001-01-04

Similar Documents

Publication Publication Date Title
WO2000027994A3 (fr) Sequence genomique de chlamydia pneumoniae
WO2003000941A3 (fr) Polypeptides presentant une activite de cellobiohydrolase i et polynucleotides codant pour ceux-ci
AU3246300A (en) Polypeptides having galactose oxidase activity and nucleic acids encoding same
WO2001079463A3 (fr) Acides nucleiques codant pour des polypeptides ayant une activite haloperoxydase
WO2001079462A3 (fr) Acides nucleiques codant pour des polypeptides presentant une activite haloperoxydase
WO2004056981A3 (fr) Polypeptides possedant une activite cellobiohydrolase ii polynucleotides codant pour ces polypeptides
WO2003011015A3 (fr) Procedes d'amelioration de caracteristiques de semence et de graine
CA2315274A1 (fr) Polypeptides a activite aminopeptidase, et acides nucleiques codant ces polypeptides
WO2005001064A3 (fr) Polypeptides a activite alpha-amylase et polynucleotides codant pour ceux-ci
WO2001029222A3 (fr) Polypeptides ayant une activite phospholipase b et acides nucleiques codant ces derniers
WO2003089598A3 (fr) Polypeptides a activite xyloglucanase, et acides nucleiques codant ceux-ci
AU6903596A (en) Chimeric fucosyltransferase polypeptides and nucleic acid sequences encoding them
WO2006039541A3 (fr) Polypeptides presentant une activite lipase et polynucleotides codant lesdits polypeptides
ZA981762B (en) Nucleic acid molecules encoding enzymes having fructosyl polymerase activity.
WO2003025117A3 (fr) Clonage et sequençage de genes de pyruvate decarboxylase (pdc) provenant de bacteries et utilisations correspondantes
AU7381098A (en) Polypeptides having prolyl pipeptidyl aminopeptidase activity and nucleic acids encoding same
CY1109797T1 (el) Μορια πυρηνικου οξεος, κωδικοποιουντα ενζυμα, τα οποια διαθετουν δραστηριοτητα φρουκτοζυλικης τρανσφερασης, και η χρηση αυτων
WO1998021343A8 (fr) Genes codant des proteines de telomerase
WO2002074807A3 (fr) Immunoadhesines d'erythropoietine de chimpanze (chepo)
WO2001000796A3 (fr) Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori
WO1999014337A3 (fr) Nouveaux genes de plantes
WO2001098469A3 (fr) Polypeptides presentant une activite de la peroxydase et acides nucleiques codant pour ces polypeptides
WO1999010504A3 (fr) Caspase-14, en tant que protease de l'apoptose, son codage par acides nucleiques, et procedes d'utilisation
WO2001019861A3 (fr) Anticorps du recepteur d'apo-2
HK1039793A1 (zh) 一種細胞凋亡蛋白酶天冬氨酸特異性半胱氨酸蛋白酶-14，編碼核酸及其使用方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2377427

Country of ref document: CA

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP