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WO2001096571A3 - Human protein phosphatase iic abi2 - Google Patents

Human protein phosphatase iic abi2 Download PDF

Info

Publication number
WO2001096571A3
WO2001096571A3 PCT/EP2001/006666 EP0106666W WO0196571A3 WO 2001096571 A3 WO2001096571 A3 WO 2001096571A3 EP 0106666 W EP0106666 W EP 0106666W WO 0196571 A3 WO0196571 A3 WO 0196571A3
Authority
WO
WIPO (PCT)
Prior art keywords
abi2
human protein
protein phosphatase
phosphatase iic
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/006666
Other languages
French (fr)
Other versions
WO2001096571A2 (en
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001285738A priority Critical patent/AU2001285738A1/en
Publication of WO2001096571A2 publication Critical patent/WO2001096571A2/en
Anticipated expiration legal-status Critical
Publication of WO2001096571A3 publication Critical patent/WO2001096571A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human protein phosphatase IIC ABI2 activity and reagents which bind to human protein phosphatase IIC ABI2 gene products can be used, inter alia, to treat Asthma, COPD and disorders associated with an increase in apoptosis, including AIDS and other infectious or genetic immunodeficiencies, peripheral or central nervous system disease including neurodenerative disease, myelodysplasia, ischemic injuries, toxin-induced diseases, wasting diseases, viral infections, and osteoporosis. Regulation of human protein phosphatase IIC ABI2 also can be used to treat disorders associated with a decrease in apoptosis, including cancer. Inflammatory disorders also can be treated.
PCT/EP2001/006666 2000-06-16 2001-06-13 Human protein phosphatase iic abi2 Ceased WO2001096571A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001285738A AU2001285738A1 (en) 2000-06-16 2001-06-13 Human protein phosphatase iic abi2

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21204300P 2000-06-16 2000-06-16
US60/212,043 2000-06-16
US22332200P 2000-08-07 2000-08-07
US60/223,322 2000-08-07
US25487700P 2000-12-13 2000-12-13
US60/254,877 2000-12-13

Publications (2)

Publication Number Publication Date
WO2001096571A2 WO2001096571A2 (en) 2001-12-20
WO2001096571A3 true WO2001096571A3 (en) 2003-05-15

Family

ID=27395681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006666 Ceased WO2001096571A2 (en) 2000-06-16 2001-06-13 Human protein phosphatase iic abi2

Country Status (2)

Country Link
AU (1) AU2001285738A1 (en)
WO (1) WO2001096571A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653102B2 (en) 2000-10-17 2003-11-25 Myriad Genetics, Inc. Nucleic acid encoding a phosphatase 2C that interacts with Fe 65
WO2003042390A1 (en) * 2001-11-13 2003-05-22 Sugen, Inc. Mammalian protein phosphatases
AU2003235100A1 (en) * 2002-04-23 2003-11-10 K. K. Dnaform Novel proteins and dnas encoding the same
AU2020231463B2 (en) 2019-03-06 2025-10-09 Gambro Lundia Ab Blood treatment device comprising alkaline phosphatase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055425A1 (en) * 2000-01-26 2001-08-02 Biodoor Gene Technology Ltd. Shanghai Novel polypeptide---human protein phosphatase 2c26 and polynucleotide encoding it
WO2001096546A2 (en) * 2000-06-16 2001-12-20 Incyte Genomics, Inc. Protein phosphatases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055425A1 (en) * 2000-01-26 2001-08-02 Biodoor Gene Technology Ltd. Shanghai Novel polypeptide---human protein phosphatase 2c26 and polynucleotide encoding it
WO2001096546A2 (en) * 2000-06-16 2001-12-20 Incyte Genomics, Inc. Protein phosphatases

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BARFORD D: "Molecular mechanisms of the protein serine/threonine phosphatases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 11, 1 November 1996 (1996-11-01), pages 407 - 412, XP004071015, ISSN: 0968-0004 *
DATABASE EMBL [online] 11 September 1997 (1997-09-11), XP002212586, retrieved from EBI Database accession no. AA550736 *
DATABASE EMBL [online] 15 December 1998 (1998-12-15), "PP2C ABI2 (abscissic acid-insensitive 2)", XP002212603, retrieved from NCBI Database accession no. O04719 *
DATABASE EMBL [online] 17 January 2000 (2000-01-17), XP002212587, retrieved from EBI Database accession no. AW293194 *
DATABASE EMBL [online] 17 January 2000 (2000-01-17), XP002212588, retrieved from EBI Database accession no. AW293197 *
DATABASE EMBL [online] 2 February 1997 (1997-02-02), "zr88b03.r1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 682733 5' similar to SW:P2C2_SCHPO Q09172 PROTEIN PHOSPHATASE 2C HOMOLOG 2", XP002212337, retrieved from EBI Database accession no. HSAA19756 *
DATABASE EMBL [online] 2 September 1993 (1993-09-02), XP002212589, retrieved from EBI Database accession no. T07284 *
DATABASE EMBL [online] 31 October 2001 (2001-10-31), "Human protein phosphatase 2C26 coding sequence", XP002212545, retrieved from EBI Database accession no. AAH43207 *
DATABASE EMBL [online] 31 October 2001 (2001-10-31), "Human protein phosphatase 2C26", XP002212544, retrieved from EBI Database accession no. AAB47431 *
DATABASE EMBL [online] 6 February 2002 (2002-02-06), "Sequence 1 from Patent WO0196546", XP002212542, retrieved from EBI Database accession no. AX354523 *
DATABASE EMBL [online] 6 February 2002 (2002-02-06), "Sequence 10 from patent WO0196546", XP002212543, retrieved from EBI Database accession no. AX354532 *

Also Published As

Publication number Publication date
WO2001096571A2 (en) 2001-12-20
AU2001285738A1 (en) 2001-12-24

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