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WO2002098918A3 - Novel targets for a therapeutic intervention in ebv related diseases - Google Patents

Novel targets for a therapeutic intervention in ebv related diseases Download PDF

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Publication number
WO2002098918A3
WO2002098918A3 PCT/EP2002/006002 EP0206002W WO02098918A3 WO 2002098918 A3 WO2002098918 A3 WO 2002098918A3 EP 0206002 W EP0206002 W EP 0206002W WO 02098918 A3 WO02098918 A3 WO 02098918A3
Authority
WO
WIPO (PCT)
Prior art keywords
ebv
binding
infection
protein
related diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/006002
Other languages
French (fr)
Other versions
WO2002098918A2 (en
Inventor
Bettina Kempkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Original Assignee
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH filed Critical Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Priority to AU2002344370A priority Critical patent/AU2002344370A1/en
Publication of WO2002098918A2 publication Critical patent/WO2002098918A2/en
Publication of WO2002098918A3 publication Critical patent/WO2002098918A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a mutant RBP-J DNA binding protein capable of binding Notch protein but incapable of binding EBNA2 and to methods of isolating said mutant RBP-J protein. The present invention provides methods for identifying and producing drugs for treatment of EBV-infection or of disorders or diseases related to EBV-infection. The present invention further provides methods for treating an EBV-infection or a disorder or disease related to EBV-infection. Furthermore, the invention provises a mutant RBP-J DNA binding protein capable of binding EBNA2 protein but incapable of binding Notch.
PCT/EP2002/006002 2001-06-05 2002-05-31 Novel targets for a therapeutic intervention in ebv related diseases Ceased WO2002098918A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002344370A AU2002344370A1 (en) 2001-06-05 2002-05-31 Novel targets for a therapeutic intervention in ebv related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29554901P 2001-06-05 2001-06-05
US60/295,549 2001-06-05

Publications (2)

Publication Number Publication Date
WO2002098918A2 WO2002098918A2 (en) 2002-12-12
WO2002098918A3 true WO2002098918A3 (en) 2003-09-04

Family

ID=23138173

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006002 Ceased WO2002098918A2 (en) 2001-06-05 2002-05-31 Novel targets for a therapeutic intervention in ebv related diseases

Country Status (2)

Country Link
AU (1) AU2002344370A1 (en)
WO (1) WO2002098918A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0300428D0 (en) * 2003-01-09 2003-02-05 Lorantis Ltd Medical treatment
GB0307472D0 (en) * 2003-04-01 2003-05-07 Lorantis Ltd Medical treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030081A1 (en) * 1996-02-13 1997-08-21 The Johns Hopkins University School Of Medicine Ebna2 peptides and methods of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030081A1 (en) * 1996-02-13 1997-08-21 The Johns Hopkins University School Of Medicine Ebna2 peptides and methods of using same

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DUMONT E ET AL: "Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling.", ONCOGENE. ENGLAND 27 JAN 2000, vol. 19, no. 4, 27 January 2000 (2000-01-27), pages 556 - 561, XP008015076, ISSN: 0950-9232 *
FUCHS KLAUS PETER ET AL: "Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction.", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 268, no. 17, September 2001 (2001-09-01), pages 4639 - 4646, XP002234641, ISSN: 0014-2956 *
HSIEH JAMES J -D ET AL: "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation.", JOURNAL OF VIROLOGY, vol. 71, no. 3, 1997, pages 1938 - 1945, XP002234638, ISSN: 0022-538X *
SAKAI T ET AL: "Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.", JOURNAL OF VIROLOGY. UNITED STATES JUL 1998, vol. 72, no. 7, July 1998 (1998-07-01), pages 6034 - 6039, XP002234639, ISSN: 0022-538X *
TANI S ET AL: "The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.", NUCLEIC ACIDS RESEARCH. ENGLAND 15 MAR 2001, vol. 29, no. 6, 15 March 2001 (2001-03-15), pages 1373 - 1380, XP002234640, ISSN: 1362-4962 *

Also Published As

Publication number Publication date
AU2002344370A1 (en) 2002-12-16
WO2002098918A2 (en) 2002-12-12

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