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WO2001096377A3 - Vaccin contre les tremblements congenitaux du porc - Google Patents

Vaccin contre les tremblements congenitaux du porc Download PDF

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Publication number
WO2001096377A3
WO2001096377A3 PCT/US2001/019220 US0119220W WO0196377A3 WO 2001096377 A3 WO2001096377 A3 WO 2001096377A3 US 0119220 W US0119220 W US 0119220W WO 0196377 A3 WO0196377 A3 WO 0196377A3
Authority
WO
WIPO (PCT)
Prior art keywords
pcv
pig
congenital tremors
pigs
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/019220
Other languages
English (en)
Other versions
WO2001096377A2 (fr
Inventor
Suresh K Mittal
Gregory W Stevenson
Jiwon Choi
Matti Kiupel
Charles L Kanitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to JP2002510517A priority Critical patent/JP2004503234A/ja
Priority to AU2001266940A priority patent/AU2001266940A1/en
Priority to US10/311,423 priority patent/US20040071728A1/en
Priority to EP01944540A priority patent/EP1290016A2/fr
Priority to CA002410229A priority patent/CA2410229A1/fr
Priority to MXPA02012352A priority patent/MXPA02012352A/es
Publication of WO2001096377A2 publication Critical patent/WO2001096377A2/fr
Publication of WO2001096377A3 publication Critical patent/WO2001096377A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention repose sur le clonage de souches du circovirus porcin (CVP) provenant de porcs atteints de tremblements congénitaux. L'invention constitue une première étape dans la mise au point d'applications diagnostiques et thérapeutiques destinées à traiter les tremblements congénitaux chez les porcs. Le procédé diagnostique de l'invention consiste à déterminer si le porc a été infecté par une souche de circovirus porcin de type 1 ou de type 2. L'invention concerne également un procédé permettant de traiter ou de prévenir les tremblements congénitaux chez le porc, selon lequel on administre au porc une quantité efficace d'un polypeptide immunogène de CVP1 ou CVP2 ou d'un acide nucléique codant ledit polypeptide. L'invention concerne également de nouvelles séquences d'acide nucléique du CVP qui ont été identifiées par les inventeurs et les polypeptides codés par ces séquences, ainsi que de nouveaux isolats de CVP et des préparations immunogènes fabriquées à partir de ces derniers.
PCT/US2001/019220 2000-06-15 2001-06-15 Vaccin contre les tremblements congenitaux du porc Ceased WO2001096377A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002510517A JP2004503234A (ja) 2000-06-15 2001-06-15 ブタの先天性振せん用ワクチン
AU2001266940A AU2001266940A1 (en) 2000-06-15 2001-06-15 Vaccine for congenital tremors in pigs
US10/311,423 US20040071728A1 (en) 2001-06-15 2001-06-15 Vaccine for congenital tremors in pigs
EP01944540A EP1290016A2 (fr) 2000-06-15 2001-06-15 Vaccin contre les tremblements congenitaux du porc
CA002410229A CA2410229A1 (fr) 2000-06-15 2001-06-15 Vaccin contre les tremblements congenitaux du porc
MXPA02012352A MXPA02012352A (es) 2000-06-15 2001-06-15 Vacuna para temblores congenitos en cerdos.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21171000P 2000-06-15 2000-06-15
US60/211,710 2000-06-15

Publications (2)

Publication Number Publication Date
WO2001096377A2 WO2001096377A2 (fr) 2001-12-20
WO2001096377A3 true WO2001096377A3 (fr) 2002-06-13

Family

ID=22788038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019220 Ceased WO2001096377A2 (fr) 2000-06-15 2001-06-15 Vaccin contre les tremblements congenitaux du porc

Country Status (6)

Country Link
EP (1) EP1290016A2 (fr)
JP (1) JP2004503234A (fr)
AU (1) AU2001266940A1 (fr)
CA (1) CA2410229A1 (fr)
MX (1) MXPA02012352A (fr)
WO (1) WO2001096377A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916353B2 (en) 1997-12-05 2014-12-23 Zoetis W Llc Circovirus sequences associated with piglet weight loss disease (PWD)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
GB0318096D0 (en) * 2003-08-01 2003-09-03 Queen Mary & Westfield College Vaccine
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
CN102660578B (zh) * 2004-12-30 2016-12-14 勃林格殷格翰动物保健有限公司 Pcv2免疫原性组合物和产生这种组合物的方法
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
DK1869471T3 (en) * 2005-04-13 2016-08-01 Merial Inc PROCEDURE FOR MANUFACTURING PIG CIRCOVIRUS
WO2006132598A1 (fr) * 2005-06-07 2006-12-14 Temasek Life Sciences Laboratory Limited Vaccins contre le circovirus porcin de type 2
PL3320919T3 (pl) 2005-12-29 2020-11-30 Boehringer Ingelheim Animal Health USA Inc. Multiwalentne immunogenne kompozycje PCV2 i sposoby wytwarzania takich kompozycji
CN101426522B (zh) 2005-12-29 2014-11-12 贝林格尔.英格海姆维特梅迪卡有限公司 Pcv2免疫原性组合物用于减轻猪临床症状的用途
US20100129397A1 (en) 2006-12-11 2010-05-27 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
RU2520087C2 (ru) 2006-12-15 2014-06-20 Бёрингер Ингельхайм Ветмедика, Инк. Лечение свиней с помощью антигена pcv2
EP1941903A1 (fr) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxie et traitement du PRDC
EP1958644A1 (fr) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prévention et traitement du PCVD subclinique
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
BRPI0907438A2 (pt) 2008-01-23 2015-08-04 Boehringer Ingelheim Vetmed Composições imunogênicas para mycoplasma hyopneumoniae e pcv2 e métodos para produzir tais composições
WO2009093251A2 (fr) * 2008-01-24 2009-07-30 Gavish-Galilee Bio Applications Ltd Vaccin contenant un réovirus basé sur une séquence de protéine sigma c
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
HUP1100470A2 (en) * 2011-08-30 2013-03-28 Mezoegazdasagi Biotechnologiai Kutatokoezpont Nanoparticle-based veterinary vaccine
KR20160046879A (ko) 2013-09-25 2016-04-29 조에티스 서비시즈 엘엘씨 Pcv2b 분지형 백신 조성물 및 사용 방법
WO2015051099A1 (fr) 2013-10-02 2015-04-09 Boehringer Ingelheim Vetmedica, Inc. Variant de protéine orf2 de pcv2 et particules de type viral composées de celui-ci
CN104109704B (zh) * 2014-07-09 2016-05-04 福州大学 一种重组猪圆环病毒衣壳蛋白包涵体的分离纯化方法
EA036116B1 (ru) 2015-08-31 2020-09-30 Берингер Ингельхайм Ветмедика Гмбх Пестивирусные вакцины против врожденного тремора
CN111087452A (zh) * 2019-12-18 2020-05-01 中国农业科学院兰州兽医研究所 一种猪圆环病毒2b亚型Cap蛋白的原核可溶性表达方法
CN111154915A (zh) * 2020-01-06 2020-05-15 咸阳职业技术学院 一种猪圆环病毒4型与3型pcr鉴别诊断试剂盒及其检测方法
CN112014561B (zh) * 2020-09-03 2022-04-19 扬州大学 猪圆环病毒4型特异的抗原在制备检测猪圆环病毒4型抗体的试剂盒中的应用及试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018214A1 (fr) * 1997-10-03 1999-04-15 Merial Circovirus porcins, vaccins et reactifs de diagnostic
WO1999029717A2 (fr) * 1997-12-11 1999-06-17 University Of Saskatchewan Virus porcins du syndrome de deperissement multisystemique apres sevrage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999018214A1 (fr) * 1997-10-03 1999-04-15 Merial Circovirus porcins, vaccins et reactifs de diagnostic
WO1999029717A2 (fr) * 1997-12-11 1999-06-17 University Of Saskatchewan Virus porcins du syndrome de deperissement multisystemique apres sevrage

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. MEEHAN ET AL.: "Characterisation of novel circovirus DNAs associated with wasting syndromes in pigs", J. GEN. VIROL., vol. 79, 1998, pages 2171 - 2179, XP002194335 *
G. ALLAN ET AL.: "Porcine circoviruses: a review", J. VET. DIAGN. INVEST., vol. 12, 2000, pages 3 - 14, XP001064282 *
G. STEVENSON ET AL.: "Tissue distribution and genetic typing of porcine circoviruses in pigs with naturally ocurring congenital timours", J. VET DIAGN. INVEST, vol. 13, 2001, pages 57 - 62, XP001064291 *
J. TSCHACHTSCHAL ET AL.: "Das Porzine Circovirus - Eine Literaturübersicht", TIERÄRTZLICHE UMSCHAU, vol. 56, - 2001, pages 185 - 198, XP001064247 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8916353B2 (en) 1997-12-05 2014-12-23 Zoetis W Llc Circovirus sequences associated with piglet weight loss disease (PWD)

Also Published As

Publication number Publication date
JP2004503234A (ja) 2004-02-05
CA2410229A1 (fr) 2001-12-20
EP1290016A2 (fr) 2003-03-12
AU2001266940A1 (en) 2001-12-24
WO2001096377A2 (fr) 2001-12-20
MXPA02012352A (es) 2004-09-06

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