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WO2001094333A3 - Procedes de couplage de composes de benzoyle et de derives bicycliques amino substitues, et compositions enantiomeriquement pures ou enrichies en etant faites - Google Patents

Procedes de couplage de composes de benzoyle et de derives bicycliques amino substitues, et compositions enantiomeriquement pures ou enrichies en etant faites Download PDF

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Publication number
WO2001094333A3
WO2001094333A3 PCT/US2001/017765 US0117765W WO0194333A3 WO 2001094333 A3 WO2001094333 A3 WO 2001094333A3 US 0117765 W US0117765 W US 0117765W WO 0194333 A3 WO0194333 A3 WO 0194333A3
Authority
WO
WIPO (PCT)
Prior art keywords
chiral
preparation
substituted bicyclic
bicyclic compounds
benzopyran derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/017765
Other languages
English (en)
Other versions
WO2001094333A2 (fr
Inventor
Luc Antoine
Pascal Bouquel
Alfio Borghese
Matthew Fisher
Hugo Gorissen
Joseph A Jakubowski
Vien V Khau
Michael Martinelli
Alain Merschaert
Michael Paal
Gerd Ruhter
Carine Rypens
Theo Schotten
Wolfgang Stenzel
Hoeck Jean-Pierre Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to AU2001275115A priority Critical patent/AU2001275115A1/en
Priority to EP01941787A priority patent/EP1286982A2/fr
Priority to JP2002501883A priority patent/JP2003535856A/ja
Publication of WO2001094333A2 publication Critical patent/WO2001094333A2/fr
Publication of WO2001094333A3 publication Critical patent/WO2001094333A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur des procédés permettant de fixer des dérivés amino substitués de 2-chromanyle à des dérivés de benzoyle par l'intermédiaire d'une liaison amide, et sur des intermédiaires servant à l'obtention d'inhibiteurs de l'agrégation plaquettaire et d'inhibiteurs puissants de l'agrégation plaquettaire. L'invention porte également sur des procédés d'obtention de ces composés à partir d'intermédiaires chiraux pour produire les énantiomères désirés, et sur des méthodes d'utilisation desdits composés comme inhibiteurs de l'agrégation plaquettaire.
PCT/US2001/017765 2000-06-02 2001-06-01 Procedes de couplage de composes de benzoyle et de derives bicycliques amino substitues, et compositions enantiomeriquement pures ou enrichies en etant faites Ceased WO2001094333A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001275115A AU2001275115A1 (en) 2000-06-02 2001-06-01 Methods for coupling benzoyl compounds and amino substituted bicyclic derivatives and enantiomerically pure or enriched compositions made therefrom
EP01941787A EP1286982A2 (fr) 2000-06-02 2001-06-01 Procedes de couplage de composes de benzoyle et de derives bicycliques amino substitues, et compositions enantiomeriquement pures ou enrichies en etant faites
JP2002501883A JP2003535856A (ja) 2000-06-02 2001-06-01 ベンゾイル置換二環式化合物およびキラルベンゾピラン誘導体の調製方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20876200P 2000-06-02 2000-06-02
US60/208,762 2000-06-02

Publications (2)

Publication Number Publication Date
WO2001094333A2 WO2001094333A2 (fr) 2001-12-13
WO2001094333A3 true WO2001094333A3 (fr) 2002-06-06

Family

ID=22775949

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017765 Ceased WO2001094333A2 (fr) 2000-06-02 2001-06-01 Procedes de couplage de composes de benzoyle et de derives bicycliques amino substitues, et compositions enantiomeriquement pures ou enrichies en etant faites

Country Status (4)

Country Link
EP (1) EP1286982A2 (fr)
JP (1) JP2003535856A (fr)
AU (1) AU2001275115A1 (fr)
WO (1) WO2001094333A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015509917A (ja) * 2012-01-10 2015-04-02 イーライ リリー アンド カンパニー ロイコトリエンｂ４アンタゴニスト化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
WO1994029273A1 (fr) * 1993-06-09 1994-12-22 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene
WO1996018602A1 (fr) * 1994-12-13 1996-06-20 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
WO1994029273A1 (fr) * 1993-06-09 1994-12-22 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
WO1996018602A1 (fr) * 1994-12-13 1996-06-20 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. J. FISHER ET. AL.: "Fused Bicyclic Gly-Asp-beta-Turn Mimics with Specific Affinity for GPIIb-IIIa", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 23, 18 November 1999 (1999-11-18), pages 4875 - 89, XP002180361 *

Also Published As

Publication number Publication date
EP1286982A2 (fr) 2003-03-05
JP2003535856A (ja) 2003-12-02
WO2001094333A2 (fr) 2001-12-13
AU2001275115A1 (en) 2001-12-17

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