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WO2001087277A3 - Method of manufacturing particles - Google Patents

Method of manufacturing particles Download PDF

Info

Publication number
WO2001087277A3
WO2001087277A3 PCT/GB2001/002137 GB0102137W WO0187277A3 WO 2001087277 A3 WO2001087277 A3 WO 2001087277A3 GB 0102137 W GB0102137 W GB 0102137W WO 0187277 A3 WO0187277 A3 WO 0187277A3
Authority
WO
WIPO (PCT)
Prior art keywords
powders
manufacturing particles
active material
solution
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/002137
Other languages
French (fr)
Other versions
WO2001087277A2 (en
Inventor
David Alexander Vodden Morton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vectura Ltd
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0011712A external-priority patent/GB0011712D0/en
Priority claimed from GB0029265A external-priority patent/GB0029265D0/en
Application filed by Vectura Ltd filed Critical Vectura Ltd
Priority to AU2001254995A priority Critical patent/AU2001254995A1/en
Publication of WO2001087277A2 publication Critical patent/WO2001087277A2/en
Publication of WO2001087277A3 publication Critical patent/WO2001087277A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Powders of pharmaceutically active material are prepared by providing a solution comprising the active material and a low-boiling fraction and expelling the solution through an orifice to form droplets, allowing the low-boiling fraction to evaporate and collecting the particles formed. The powders may be used in medicinal powders for inhalation.
PCT/GB2001/002137 2000-05-15 2001-05-15 Method of manufacturing particles Ceased WO2001087277A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001254995A AU2001254995A1 (en) 2000-05-15 2001-05-15 Method of manufacturing particles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0011712A GB0011712D0 (en) 2000-05-15 2000-05-15 Method of manufacturing particles
GB0011712.7 2000-05-15
GB0029265.6 2000-11-30
GB0029265A GB0029265D0 (en) 2000-11-30 2000-11-30 Method of manufacturing particles

Publications (2)

Publication Number Publication Date
WO2001087277A2 WO2001087277A2 (en) 2001-11-22
WO2001087277A3 true WO2001087277A3 (en) 2002-04-04

Family

ID=26244273

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002137 Ceased WO2001087277A2 (en) 2000-05-15 2001-05-15 Method of manufacturing particles

Country Status (2)

Country Link
AU (1) AU2001254995A1 (en)
WO (1) WO2001087277A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL224720B1 (en) * 2003-02-21 2017-01-31 Univ Bath Process for the production of particles
GB0801876D0 (en) 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021688A1 (en) * 1994-02-15 1995-08-17 Eckhard Weidner Process for preparing particles or powders
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation
WO1999016419A1 (en) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Perforated microparticles and methods of use
WO1999042124A1 (en) * 1998-02-20 1999-08-26 Inhale Therapeutic Systems, Inc. Liquid crystal forms of cyclosporin
WO2000000176A1 (en) * 1998-06-30 2000-01-06 Quadrant Healthcare (Uk) Limited Microparticle formulation for inhalation
WO2000074653A1 (en) * 1999-06-04 2000-12-14 Skyepharma, Inc. Oil-core compositions for the sustained release of hydrophobic drugs
WO2001003671A2 (en) * 1999-07-13 2001-01-18 Skw Trostberg Aktiengesellschaft Method for producing powdery particle-reduced formulations with the aid of compressed gases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021688A1 (en) * 1994-02-15 1995-08-17 Eckhard Weidner Process for preparing particles or powders
WO1998016204A1 (en) * 1996-10-14 1998-04-23 F. Hoffmann-La Roche Ag Process for the manufacture of a pulverous preparation
WO1999016419A1 (en) * 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Perforated microparticles and methods of use
WO1999042124A1 (en) * 1998-02-20 1999-08-26 Inhale Therapeutic Systems, Inc. Liquid crystal forms of cyclosporin
WO2000000176A1 (en) * 1998-06-30 2000-01-06 Quadrant Healthcare (Uk) Limited Microparticle formulation for inhalation
WO2000074653A1 (en) * 1999-06-04 2000-12-14 Skyepharma, Inc. Oil-core compositions for the sustained release of hydrophobic drugs
WO2001003671A2 (en) * 1999-07-13 2001-01-18 Skw Trostberg Aktiengesellschaft Method for producing powdery particle-reduced formulations with the aid of compressed gases

Also Published As

Publication number Publication date
AU2001254995A1 (en) 2001-11-26
WO2001087277A2 (en) 2001-11-22

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