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WO2001087256A1 - Composition a activite cosmetique - Google Patents

Composition a activite cosmetique Download PDF

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Publication number
WO2001087256A1
WO2001087256A1 PCT/CH2001/000263 CH0100263W WO0187256A1 WO 2001087256 A1 WO2001087256 A1 WO 2001087256A1 CH 0100263 W CH0100263 W CH 0100263W WO 0187256 A1 WO0187256 A1 WO 0187256A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
oil
aqueous
cosmetically
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CH2001/000263
Other languages
German (de)
English (en)
Inventor
Frank Markus Gafner
Andreas Sigrist
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Nutritional Products AG
Original Assignee
Pentapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm AG filed Critical Pentapharm AG
Priority to EP01921101A priority Critical patent/EP1283696A1/fr
Priority to AU2001248215A priority patent/AU2001248215A1/en
Publication of WO2001087256A1 publication Critical patent/WO2001087256A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Definitions

  • the present invention relates to an aqueous concentrate which is suitable for the production of cosmetically and / or dermatologically active compositions, preferably for topical use, and which is an extract of the Edelweiss plant, in particular of the Leontopodium alpinum Cass type. (Asteraceae) and / or the type Leontopodium haplophylloides, contains.
  • the Edelweiss plant for example of the Leontopodium alpinum Cass type. (Asteraceae) or Leontopodium haplophylloides, is a symbol of the Alps and is also called Leontopodium alpinum.
  • the Edelweiss extract to be used according to the invention is preferably obtained from the root, the stem, the leaves and the flower.
  • composition according to the invention is dermatologically active and has a protective, calming and healing effect on human skin.
  • extracts of the Edelweiss plant of type Leontopodium alpinum Cass. (Asteraceae) and Leontopodium haplophylloides for example, contain beta-sitosterol with anti-inflammatory, fungicidal and bactericidal properties, as well as caffeine acid with antioxidant properties, chlorogenic acid (a radical quencher), luteolin (a hyaluronidase inhibitor), luteolin-4 '-glucoside -5 inhibitor with anti-inflammatory properties) as well as bisabolan derivatives with anti-inflammatory properties.
  • the present invention is not bound by this explanation.
  • Plants are preferably used which have been cultivated in optimal soils and at an appropriate height.
  • the present extract of the Edelweiss plant destroys free radicals to a high degree, that is to say it has a high RPF factor (Radical Protection Factor).
  • RPF factor Radar Protection Factor
  • the alfa tocopherol acetate used as a radical scavenger has an RPF factor of 48
  • the present extract of the Edelweiss plant has an RPF factor of at least 250 (or higher), preferably at least 270 (or higher).
  • the meaning of the RPF factor and its determination can be found, for example, in Th. Herrling, L. Zastrow, N. Groth, S ⁇ FW-Journal, 124th year 5/98, pages 282-284.
  • alpha-tocopherol acetate is fat-soluble, while the present extract is water-soluble and the use of a higher dose, especially in aqueous systems, is permitted.
  • Alfa-tocopherol acetate is used due to its fat solubility in concentrations of approximately 0.1% by weight, while the present water-soluble extract can be used in concentrations of 3% by weight to 5% by weight, based on the total composition.
  • the present invention is defined in the claims.
  • the present invention relates to an aqueous concentrate, which is characterized in that it is an extract of the Edelweiss plant, in particular of the Leontopodium alpinum Cass type. (Asteraceae) and / or the type Leontopodium haplophylloides, and is suitable for the production of cosmetically and / or dermatologically active compositions according to the invention.
  • the present invention also relates to the use of the aqueous concentrate according to the invention for the production of cosmetically and / or dermatologically active compositions.
  • the present invention relates to a cosmetically and / or dermatologically active composition for cosmetic and / or dermatological use, which is characterized in that it contains at least one extract of the Edelweiss plant, in particular of the Leontopodium alpinum Cass type. (Asteraceae) and / or the type Leontopodium haplophylloides, in a cosmetically and / or dermatologically effective concentration.
  • the present invention also relates to a process for the preparation of an aqueous concentrate according to the invention, comprising an extract of the edelweiss plant which is suitable for the production of the cosmetically and / or dermatologically active compositions according to the invention, characterized in that a dried edelweiss plant with a mixture of water and Alcohol, preferably water and ethanol extracted and the suspension obtained is optionally filtered, freed from alcohol and concentrated.
  • the Edelweiss plant is known and is described, for example, in Hegi, Illustrated Flora of Central Europe, 1st Edition, Volume 4, A. Pichler, Vienna.
  • Leontopodium alpinum Cass. Asteraceae
  • Leontopodium haplophylloides Methods for the production of plant extracts are known per se.
  • the extract or concentrate to be used according to the invention is obtained in a manner known per se.
  • the dried plant material of the edelweiss plant is finely chopped and preferably with a mixture of water and alcohol, preferably water and ethanol, in a weight ratio of 20:80 to 50:50, preferably with a mixture of about 30% by weight of water and about 70 % By weight of ethanol, optionally several times, extracted.
  • the suspension obtained is filtered.
  • the filtrate is then preferably freed from the alcohol by distillation, if appropriate under reduced pressure.
  • the aqueous residue i.e. the extract of the Edelweiss plant present as an aqueous concentrate, can now be mixed with glycerin or another compatible solvent, e.g. Propylene glycol, or a mixture of such solvents, can be formulated.
  • the extract produced in this way is generally a slightly opaque liquid with a characteristic odor and has an acid value (pH) of about 5.0 to 6.0, preferably of about 5.4; a relative density (d 2 o / 2o) in the range from approximately 1,175 to 1,180 g / cm 3 and a refractive index (n 25 ) in the range from approximately 1,420 to 1,430.
  • the extract generally contains from about 5% by weight to 20% by weight, preferably from 7% by weight to 10% by weight, based on the dry substance Total weight of the aqueous extract. This " extract is preferably used in concentrations of 3% by weight to 5% by weight, based on the total composition.
  • the extract obtained from the Edelweiss plant can be processed further at room temperature or at a slightly elevated temperature, for example at about 40 ° C to 80 ° C.
  • the extract is preferably incorporated into the aqueous phase of the cosmetic formulation.
  • the cosmetically and / or dermatologically active composition according to the invention can be present or prepared in any desired form of use.
  • these formulations can be an aqueous or anhydrous preparation, an emulsion or microemulsion of the water-in-oil (w / o) or oil-in-water (o / w) type, a multiple emulsion, for example of the water- in-oil-in-water (w / o / w), a gel, a solid form, or an aerosol.
  • the formulations according to the invention can be present, for example, as a powder, as a moist compress, as a lotion, as a cream or ointment, shampoos and washing formulations, or in any other cosmetically approved form.
  • the effective concentration of edelweiss extract dry matter is preferably about 0.1% by weight to 1.0% by weight, preferably about 0.1 to 0.9% by weight, based on the total weight of the cosmetic composition.
  • water, vegetable, animal or synthetic and semi-synthetic substances such as humectants, alcohols, polyols, fatty acids, fats, oils, waxes, thickeners, surface-active compounds such as emulsifiers, fillers, antiseptic compounds, antioxidants, UV radiation-absorbing compounds and UV quencher, vitamins, such as vitamin A, vitamin B and / or vitamin E, preservatives, bactericides, aroma and fragrance substances as well as dyes, foam stabilizers and / or silicones.
  • humectants such as humectants, alcohols, polyols, fatty acids, fats, oils, waxes, thickeners, surface-active compounds such as emulsifiers, fillers, antiseptic compounds, antioxidants, UV radiation-absorbing compounds and UV quencher, vitamins, such as vitamin A, vitamin B and / or vitamin E, preservatives, bactericides, aroma and fragrance substances as well as dyes, foam stabilizers and / or silicones
  • the basic ingredients and additives for use in the present invention are, in particular, glycerol, polyglycerol compounds, ethylene glycol, propylene glycol, polyethylene glycols, polypropylene glycols, ethyl alcohol, isopropyl alcohol, agar gum, tragacanth gum, gum arabic, vegetable or animal gelatin, methyl cellulose, ethyl cellulose, carboxymethyl cellulose , hydroxymethyl cellulose, hydroxypropyl cellulose, sodium alginate, polyvinyl alcohol, polyvinyl alcohol-acetate ester, C 6 - hole 22 -Fettalko- such as cetyl alcohol, C.
  • fatty acid esters especially stearic acid, palmitic acid, lauric acid and corresponding methyl, ethyl and propyl esters, lanolin, liquid paraffins or natural or synthetic waxes, such as petroleum jelly or beeswax, vegetable oils, such as olive oil, coconut oil, soybean oil, castor oil, and Corresponding hardened oils, hydroxyl-containing compounds modified with polyalkylene oxides, and further basic substances known in the production of cosmetic formulations.
  • fatty acid esters especially stearic acid, palmitic acid, lauric acid and corresponding methyl, ethyl and propyl esters, lanolin, liquid paraffins or natural or synthetic waxes, such as petroleum jelly or beeswax, vegetable oils, such as olive oil, coconut oil, soybean oil, castor oil, and Corresponding hardened oils, hydroxyl-containing compounds modified with polyalkylene oxides, and further basic substances known in the production of cosmetic formulations.
  • Mineral or natural oils or waxes are preferably used to produce the lipid phase.
  • synthetically produced esters of fatty acids with alcohols can be used, such as esters of fatty acids with ethanol, propanol, is ⁇ propanol, propylene glycol or glycerol, or esters of fatty alcohols with organic C 3 - 2 o-acids.
  • esters of myristic acid, palmitic acid, stearic acid, oleic acid such as, for example, propyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, butyl stearate, hexyl laurate, 2-hexyl decyl stearate, or natural oils such as jojoba oil or a mixture of such compounds are also preferred.
  • Preferred silicones are in particular dimethylpolysiloxanes, preferably in cyclic or linear form.
  • the aqueous phase of the formulations according to the invention can contain numerous water-soluble or emulsified compounds, as is known to the person skilled in the art.
  • Such compounds are, for example, natural or synthetic compounds, such as alcohols, polyols and / or ethers, as already mentioned.
  • Further auxiliaries and additives for aqueous or oily cosmetic formulations are, for example, fillers such as titanium oxide, zinc oxide, magnesium carbonate, talc, kaolin, silica, preferably in colloidal form, or starch.
  • the formulations according to the invention can furthermore contain acids or bases for adjusting the acid (pH) value, such as, for example, sodium hydroxide, phosphoric acid or lactic acid, triethanolamine, preferably in the form of a buffer system.
  • the investigations as the basis for the present invention were carried out in cooperation with the Swiss Agronomic Institute (RAC) in the canton of Valais.
  • the plants were cultivated according to GAP (good agronomic practice) without the use of pesticides, fungicides or mineral fertilizers under natural conditions and processed by the company ALPAFLOR, Switzerland, in accordance with the quality standard ISO 9001. Every processing step was subjected to careful quality control, starting with the seed to the finished production of the extract.
  • the concentrate or extract of the Edelweiss plant to be used according to the invention can be stored in airtight containers, protected from light, at a temperature of 4 ° C. to 8 ° C. for at least one year without damage.
  • the concentrate obtained was formulated with glycerin by stirring equal parts of glycerin into the concentrate.
  • the product obtained was a slightly opaque liquid with a characteristic odor, with an acid value (pH) of about 5.4; a relative density (d 2 o / 2o) of 1,178 g / cm 3 and a refractive index (n 2S ) of 1.4243. No pathogenic germs were found. All safety tests common in the cosmetic industry have been fulfilled. Likewise, the test results gave no indication of any existing environmental risks. You can add up to equal parts of glycerol or another compatible solvent or, if necessary, more to the concentrate.
  • This concentrate can be processed further into a formulation in a manner known per se, for example by adding other compatible solvents and additives, as already described above in the text. Both the concentrate and the cosmetic products made from it have a calming and anti-inflammatory effect on sensitive skin and slow down aging.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un concentré aqueux contenant un extrait d'edelweiss, notamment du type leontopodium alpinum cass. (asteracease) et/ou du type leontopodium haplophylloïdes, ainsi que des compositions obtenues à partir dudit concentré aqueux et à activité cosmétique et/ou dermatologique. Ce concentré est de préférence un liquide légèrement opaque ayant un indice d'acidité (pH) compris entre environ 5,0 et 6,0 ; une masse volumique relative (d20/20) de l'ordre d'environ 1,175 à 1,180 g/cm<3> et un indice de réfraction compris entre environ 1,420 et 1,430.
PCT/CH2001/000263 2000-05-16 2001-04-26 Composition a activite cosmetique Ceased WO2001087256A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01921101A EP1283696A1 (fr) 2000-05-16 2001-04-26 Composition a activite cosmetique
AU2001248215A AU2001248215A1 (en) 2000-05-16 2001-04-26 Cosmetically active composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00966/00A CH694611A5 (de) 2000-05-16 2000-05-16 Kosmetisch wirksame Zusammensetzung.
CH966/00 2000-05-16

Publications (1)

Publication Number Publication Date
WO2001087256A1 true WO2001087256A1 (fr) 2001-11-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2001/000263 Ceased WO2001087256A1 (fr) 2000-05-16 2001-04-26 Composition a activite cosmetique

Country Status (5)

Country Link
EP (1) EP1283696A1 (fr)
KR (1) KR20030011844A (fr)
AU (1) AU2001248215A1 (fr)
CH (1) CH694611A5 (fr)
WO (1) WO2001087256A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100512690B1 (ko) * 2002-11-29 2005-09-07 나드리화장품주식회사 자란 및 에델바이스 추출물을 함유하는 화장료 조성물
EP2087901A1 (fr) * 2008-02-08 2009-08-12 Claus Morgenstern Dispositif de gain de matières contenant de l'edelweiss, son utilisation et sa composition
ITMI20091165A1 (it) * 2009-07-01 2011-01-02 Skinworld Lab S R L Combinazione di cellule staminali, e/o loro estratti, di lippia citriodora e leontopodium alpinum, ed il suo uso in prodotti cosmetici
US7988982B2 (en) 2006-06-12 2011-08-02 Lvmh Recherche Cosmetic composition with anti-free radical activity
US8367085B2 (en) 2006-06-12 2013-02-05 Lvmh Recherche Cosmetic composition with anti-free radical activity
US8372455B2 (en) 2006-06-12 2013-02-12 Lvmh Recherche Cosmetic composition with anti-free radical activity
FR2980361A1 (fr) * 2011-09-28 2013-03-29 Dermatologiques Uriage Lab Composition cosmetique et/ou dermatologique pour maintenir ou regenerer les qualites physiques, optiques, mecaniques ou biochimiques de la peau
EP2623094A1 (fr) 2012-02-02 2013-08-07 DSM IP Assets B.V. Utilisation d'extrait d'edelweiss
EP2873414A1 (fr) 2013-11-19 2015-05-20 DSM IP Assets B.V. Utilisation d'un extrait d'edelweiss dans les soins capillaires pour la prévention de cheveux grisonnants
EP2873440A1 (fr) 2013-11-19 2015-05-20 DSM IP Assets B.V. Utilisation d'un extrait d'edelweiss dans les soins capillaires pour stimuler la pousse des cheveux
WO2015082520A1 (fr) * 2013-12-03 2015-06-11 Galephar M/F Composition pour reduire les troubles de la senescence cutanee comprenant un rétinalaldéhyde et un extrait de leontopodium alpinum
WO2017063748A1 (fr) * 2015-10-16 2017-04-20 Bernd Kuhs Composition et procédé pour fabriquer des préparations dermatologiques et cosmétiques ayant des structures lamellaires distinctes en utilisant de la phosphatidylcholine et par fermentation de micro-organismes
WO2018077991A1 (fr) 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Méthode de protection des kératinocytes contre les effets nocifs de la pollution de l'air
EP2233127B1 (fr) 2004-03-17 2020-05-27 Stada Arzneimittel Ag Utilisation d'antioxydants pour préparer des compositions pharmaceutiques ou cosmétiques pour protéger la peau contre les dommages provoqués par les rayonnements infra-rouges
CH715829A1 (fr) * 2019-02-12 2020-08-14 Fabrice Thueler Eau végétale.
CN112941010A (zh) * 2021-01-30 2021-06-11 湖北嘉弘福科技有限责任公司 一种植物愈伤组织功效滤液和外泌体提取方法
WO2023192538A1 (fr) 2022-03-31 2023-10-05 Galderma Holding SA Compositions de soins personnels pour peau sensible et procédés d'utilisation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100654844B1 (ko) * 2004-11-10 2006-12-06 한국콜마 주식회사 친유형으로 변형된 폴리프록토스계 고분자물질을 이용한나노사이즈의 수중유형인지질 에멀젼 상 화장료 및 그제조방법
KR100817525B1 (ko) 2006-11-24 2008-03-27 (주)아모레퍼시픽 밀착감이 우수한 유중수 유화형 메이크업 화장료 조성물
KR102517413B1 (ko) * 2022-07-01 2023-04-03 주식회사 덤스토리 미백 및 주름개선용 화장료 조성물

Citations (1)

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WO2001047538A1 (fr) * 1999-12-23 2001-07-05 L'oreal Extrait de vegetal du genre leontopodium et compositions le contenant

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DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002175866, Database accession no. 1998:382137 *
INSIDE COSMETICS, August 1998 (1998-08-01), pages 35, XP002175865 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100512690B1 (ko) * 2002-11-29 2005-09-07 나드리화장품주식회사 자란 및 에델바이스 추출물을 함유하는 화장료 조성물
EP2233127B1 (fr) 2004-03-17 2020-05-27 Stada Arzneimittel Ag Utilisation d'antioxydants pour préparer des compositions pharmaceutiques ou cosmétiques pour protéger la peau contre les dommages provoqués par les rayonnements infra-rouges
US7988982B2 (en) 2006-06-12 2011-08-02 Lvmh Recherche Cosmetic composition with anti-free radical activity
US8367085B2 (en) 2006-06-12 2013-02-05 Lvmh Recherche Cosmetic composition with anti-free radical activity
US8372455B2 (en) 2006-06-12 2013-02-12 Lvmh Recherche Cosmetic composition with anti-free radical activity
EP2087901A1 (fr) * 2008-02-08 2009-08-12 Claus Morgenstern Dispositif de gain de matières contenant de l'edelweiss, son utilisation et sa composition
WO2009098145A3 (fr) * 2008-02-08 2009-12-03 Claus Morgenstern Procédé d'obtention de constituants d'edelweiss, leur utilisation et leur composition
ITMI20091165A1 (it) * 2009-07-01 2011-01-02 Skinworld Lab S R L Combinazione di cellule staminali, e/o loro estratti, di lippia citriodora e leontopodium alpinum, ed il suo uso in prodotti cosmetici
FR2980361A1 (fr) * 2011-09-28 2013-03-29 Dermatologiques Uriage Lab Composition cosmetique et/ou dermatologique pour maintenir ou regenerer les qualites physiques, optiques, mecaniques ou biochimiques de la peau
EP2623094A1 (fr) 2012-02-02 2013-08-07 DSM IP Assets B.V. Utilisation d'extrait d'edelweiss
EP2873440A1 (fr) 2013-11-19 2015-05-20 DSM IP Assets B.V. Utilisation d'un extrait d'edelweiss dans les soins capillaires pour stimuler la pousse des cheveux
EP2873414A1 (fr) 2013-11-19 2015-05-20 DSM IP Assets B.V. Utilisation d'un extrait d'edelweiss dans les soins capillaires pour la prévention de cheveux grisonnants
WO2015082520A1 (fr) * 2013-12-03 2015-06-11 Galephar M/F Composition pour reduire les troubles de la senescence cutanee comprenant un rétinalaldéhyde et un extrait de leontopodium alpinum
WO2017063748A1 (fr) * 2015-10-16 2017-04-20 Bernd Kuhs Composition et procédé pour fabriquer des préparations dermatologiques et cosmétiques ayant des structures lamellaires distinctes en utilisant de la phosphatidylcholine et par fermentation de micro-organismes
WO2018077991A1 (fr) 2016-10-27 2018-05-03 Dsm Ip Assets B.V. Méthode de protection des kératinocytes contre les effets nocifs de la pollution de l'air
CH715829A1 (fr) * 2019-02-12 2020-08-14 Fabrice Thueler Eau végétale.
CN112941010A (zh) * 2021-01-30 2021-06-11 湖北嘉弘福科技有限责任公司 一种植物愈伤组织功效滤液和外泌体提取方法
WO2023192538A1 (fr) 2022-03-31 2023-10-05 Galderma Holding SA Compositions de soins personnels pour peau sensible et procédés d'utilisation
DE112023001807T5 (de) 2022-03-31 2025-01-23 Galderma Holding SA Körperpflegezusammensetzungen für empfindliche Haut und Anwendungsmethoden

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EP1283696A1 (fr) 2003-02-19
CH694611A5 (de) 2005-04-29
AU2001248215A1 (en) 2001-11-26
KR20030011844A (ko) 2003-02-11

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