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WO2001081366A3 - Purification of ace inhibiting polypeptides containing vpp from milk - Google Patents

Purification of ace inhibiting polypeptides containing vpp from milk Download PDF

Info

Publication number
WO2001081366A3
WO2001081366A3 PCT/US2001/012672 US0112672W WO0181366A3 WO 2001081366 A3 WO2001081366 A3 WO 2001081366A3 US 0112672 W US0112672 W US 0112672W WO 0181366 A3 WO0181366 A3 WO 0181366A3
Authority
WO
WIPO (PCT)
Prior art keywords
milk
purification
polypeptides containing
vpp
ace inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/012672
Other languages
French (fr)
Other versions
WO2001081366A2 (en
Inventor
Joseph M Kobzeff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Technology LLC
Original Assignee
Monsanto Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology LLC filed Critical Monsanto Technology LLC
Priority to AU2001255469A priority Critical patent/AU2001255469A1/en
Publication of WO2001081366A2 publication Critical patent/WO2001081366A2/en
Publication of WO2001081366A3 publication Critical patent/WO2001081366A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a method of producing the anti-hypertensive tripeptide VPP. The invention also relates to pharmaceutical, nutritional, and food compositions employing VPP as an active ingredient.
PCT/US2001/012672 2000-04-21 2001-04-19 Purification of ace inhibiting polypeptides containing vpp from milk Ceased WO2001081366A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001255469A AU2001255469A1 (en) 2000-04-21 2001-04-19 Purification of ace inhibiting polypeptides containing vpp from milk

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19967500P 2000-04-21 2000-04-21
US60/199,675 2000-04-21

Publications (2)

Publication Number Publication Date
WO2001081366A2 WO2001081366A2 (en) 2001-11-01
WO2001081366A3 true WO2001081366A3 (en) 2002-05-16

Family

ID=22738540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012672 Ceased WO2001081366A2 (en) 2000-04-21 2001-04-19 Purification of ace inhibiting polypeptides containing vpp from milk

Country Status (2)

Country Link
AU (1) AU2001255469A1 (en)
WO (1) WO2001081366A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879804B2 (en) 2004-12-22 2011-02-01 Dsm Ip Assets B.V. Blood pressure lowering peptides in a single enzymatic step
CN101171024A (en) * 2005-04-28 2008-04-30 帝斯曼知识产权资产管理有限公司 Antihypertensive protein hydrolyzate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583074A2 (en) * 1992-07-23 1994-02-16 The Calpis Food Industry Co., Ltd. Angiotensin converting enzyme inhibitor and method for preparing same
WO1996017054A1 (en) * 1994-12-01 1996-06-06 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption
US5763739A (en) * 1993-03-01 1998-06-09 Astra Aktiebolag Transgenic non-human mammals producing BSSL variants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583074A2 (en) * 1992-07-23 1994-02-16 The Calpis Food Industry Co., Ltd. Angiotensin converting enzyme inhibitor and method for preparing same
US5763739A (en) * 1993-03-01 1998-06-09 Astra Aktiebolag Transgenic non-human mammals producing BSSL variants
WO1996017054A1 (en) * 1994-12-01 1996-06-06 Oklahoma Medical Research Foundation Method and compositions for reducing cholesterol absorption

Also Published As

Publication number Publication date
WO2001081366A2 (en) 2001-11-01
AU2001255469A1 (en) 2001-11-07

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