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WO2003086267A3 - Multi-phase, multi-compartment capsular system - Google Patents

Multi-phase, multi-compartment capsular system Download PDF

Info

Publication number
WO2003086267A3
WO2003086267A3 PCT/US2003/010816 US0310816W WO03086267A3 WO 2003086267 A3 WO2003086267 A3 WO 2003086267A3 US 0310816 W US0310816 W US 0310816W WO 03086267 A3 WO03086267 A3 WO 03086267A3
Authority
WO
WIPO (PCT)
Prior art keywords
ingredient
receiving chamber
phase
physical state
capsular system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/010816
Other languages
French (fr)
Other versions
WO2003086267A2 (en
WO2003086267B1 (en
Inventor
Fred H Miller
Lance R Ausec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/368,951 external-priority patent/US20030194428A1/en
Priority to JP2003583294A priority Critical patent/JP2005528383A/en
Priority to NZ536267A priority patent/NZ536267A/en
Priority to EP03717010A priority patent/EP1499303A4/en
Priority to CA2481486A priority patent/CA2481486C/en
Priority to AU2003220689A priority patent/AU2003220689A1/en
Application filed by Individual filed Critical Individual
Publication of WO2003086267A2 publication Critical patent/WO2003086267A2/en
Publication of WO2003086267A3 publication Critical patent/WO2003086267A3/en
Priority to US10/804,576 priority patent/US7670612B2/en
Publication of WO2003086267B1 publication Critical patent/WO2003086267B1/en
Anticipated expiration legal-status Critical
Priority to US12/689,669 priority patent/US8361497B2/en
Priority to US13/746,743 priority patent/US20130136791A1/en
Priority to US14/036,521 priority patent/US9241911B2/en
Priority to US15/005,508 priority patent/US9539216B2/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
    • B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C39/10—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. casting around inserts or for coating articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0058—Liquid or visquous
    • B29K2105/0061—Gel or sol

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A multi-compartment capsule, comprising, a first receiving chamber comprising at least one ingredient having a first physical state, wherein said ingredient is selected from the group consisting of a nutraceutical, a vitamin, a dietary supplement and a mineral; and a second receiving chamber comprising at least one ingredient having a second physical state, wherein said ingredient is selected from the group consisting of a nutraceutical, a vitamin, a dietary supplement and a mineral; wherein said first physical state of said ingredient of said first receiving chamber being different from said second physical state of said ingredient of said second receiving chamber; and said ingredient of said first receiving chamber being different from said ingredient of said second receiving chamber.
PCT/US2003/010816 2002-04-10 2003-04-09 Multi-phase, multi-compartment capsular system Ceased WO2003086267A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2003583294A JP2005528383A (en) 2002-04-10 2003-04-09 Multiphase, multiple compartment capsule system
NZ536267A NZ536267A (en) 2002-04-10 2003-04-09 Multi-phase, multi-compartment and multi-ingredient capsular system
EP03717010A EP1499303A4 (en) 2002-04-10 2003-04-09 Multi-phase, multi-compartment capsular system
CA2481486A CA2481486C (en) 2002-04-10 2003-04-09 Multi-phase, multi-compartment capsular system
AU2003220689A AU2003220689A1 (en) 2002-04-10 2003-04-09 Multi-phase, multi-compartment capsular system
US10/804,576 US7670612B2 (en) 2002-04-10 2004-03-19 Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US12/689,669 US8361497B2 (en) 2002-04-10 2010-01-19 Multi-phase, multi-compartment, capsular delivery apparatus and methods for using the same
US13/746,743 US20130136791A1 (en) 2002-04-10 2013-01-22 Multi-phase, mult-compartment capsular delivery apparatus and methods for using same
US14/036,521 US9241911B2 (en) 2002-04-10 2013-09-25 Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same
US15/005,508 US9539216B2 (en) 2002-04-10 2016-01-25 Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US37144802P 2002-04-10 2002-04-10
US60/371,448 2002-04-10
US10/368,951 US20030194428A1 (en) 2002-04-10 2003-02-18 Process for encapsulating multi-phase, multi-compartment capsules
US10/369,247 2003-02-18
US10/369,427 2003-02-18
US10/369,247 US20030194430A1 (en) 2002-04-10 2003-02-18 Process for encapsulating multi-phase, multi-compartment capsules for therapeutic compositions
US10/369,427 US20030194431A1 (en) 2002-04-10 2003-02-18 Multi-phase,multi-compartment capsular delivery apparatus and methods for using same
US10/369,244 US20030194429A1 (en) 2002-04-10 2003-02-18 Multi-phase, multi-compartment capsular delivery apparatus for therapeutic compositions and methods for using same
US10/368,951 2003-02-18
US10/369,244 2003-02-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US37144802P Substitution 2002-04-10 2002-04-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/804,576 Continuation-In-Part US7670612B2 (en) 2002-04-10 2004-03-19 Multi-phase, multi-compartment capsular delivery apparatus and methods for using same

Publications (3)

Publication Number Publication Date
WO2003086267A2 WO2003086267A2 (en) 2003-10-23
WO2003086267A3 true WO2003086267A3 (en) 2003-12-18
WO2003086267B1 WO2003086267B1 (en) 2004-04-29

Family

ID=29255682

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/010816 Ceased WO2003086267A2 (en) 2002-04-10 2003-04-09 Multi-phase, multi-compartment capsular system

Country Status (6)

Country Link
EP (1) EP1499303A4 (en)
JP (2) JP2005528383A (en)
AU (3) AU2003220689A1 (en)
CA (1) CA2481486C (en)
NZ (1) NZ536267A (en)
WO (1) WO2003086267A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383579B2 (en) 2004-11-19 2013-02-26 GlaxoSmithKline, LLC Method for customized dispensing of variable dose drug combination products for individualizing of therapies

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BR0012869A (en) 1999-07-30 2002-05-21 Smithkline Beecham Plc Multi-component Pharmaceutical Dosage Form
US7790762B2 (en) 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
DE10359792A1 (en) * 2003-12-19 2005-07-21 Bayer Technology Services Gmbh Multiphasic drug formulation
WO2005099761A1 (en) * 2004-04-07 2005-10-27 Resveratrol Partners, Llc Dietary supplement and method of processing same
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
JP2006321730A (en) * 2005-05-17 2006-11-30 Maruzen Pharmaceut Co Ltd Antioxidant, antiaging agent, skin cosmetics, and food or drink
US7781572B2 (en) * 2005-10-05 2010-08-24 Nse Products, Inc. Nanosized carotenoid cyclodextrin complexes
SI3095447T1 (en) 2006-02-03 2022-02-28 Opko Renal, Llc Treatment shortages vitamin D s 25-hydroxyvitamin D2 in 25-hydroxyvitamin D3
ES2670029T3 (en) 2006-06-21 2018-05-29 Opko Ireland Global Holdings, Ltd. Therapy using vitamin D replenishment agent and vitamin D hormone replacement agent
AU2007278986B2 (en) 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
US20130115320A1 (en) 2007-03-30 2013-05-09 Dynova Laboratories, Inc. Therapeutic agent for intranasal administration and method of making and using same
DK2148661T3 (en) 2007-04-25 2013-03-25 Cytochroma Inc Controlled-release oral preparations comprising vitamin D compound and waxy carrier
EP2148684B1 (en) 2007-04-25 2013-01-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
US7867524B2 (en) 2007-10-05 2011-01-11 David Rowland Energizing formulation
WO2010122499A2 (en) * 2009-04-20 2010-10-28 Ecole Polytechnique Federale De Lausanne (Epfl) Containers assembled in fluid and corresponding production
KR101143997B1 (en) * 2010-03-04 2012-05-09 한미사이언스 주식회사 Complex formulation for oral administration comprising probiotic formulation and 5-ht4 receptor agonist and method for the preparation thereof
CA2797537C (en) 2010-03-29 2021-11-23 Cytochroma Inc. Use of 25-hydroxyvitamin d compound for reducing parathyroid levels
CA3065589C (en) 2010-06-03 2022-04-26 Catalent Ontario Limited Multi phase soft gel capsules, apparatus and method thereof
EP2595597B1 (en) * 2010-07-19 2017-09-13 Procaps S.A. Apparatus and process for encapsulating capsules or other solid dosage forms within capsules
US20120082719A1 (en) * 2010-10-05 2012-04-05 Sam Poon Ang Compositions For Treating Chronic Viral Infections
CN102335095A (en) * 2011-10-12 2012-02-01 李思思 Manufacturing technology of d-limonene hard capsules
US10130760B2 (en) * 2013-03-15 2018-11-20 Incube Labs, Llc Multi-stage biodegradable drug delivery platform
KR101847947B1 (en) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 Stabilized modified release vitamin d formulation
WO2016020508A2 (en) * 2014-08-07 2016-02-11 Opko Ireland Global Holdings Ltd. Adjunctive therapy with 25-hydroxyvitamin d
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
US9468659B2 (en) 2014-11-06 2016-10-18 NWO Stem Cure, LLC Nutraceutical supplement with Lactobacillus rhamnosus
US9980993B2 (en) 2014-11-06 2018-05-29 NWO Stem Cure, LLC Nutraceutical supplement with Lactobacillus rhamnosus
KR20230054752A (en) 2016-03-28 2023-04-25 옵코 아일랜드 글로벌 홀딩스 리미티드 Methods of vitamin d treatment
CN108753621A (en) * 2018-05-30 2018-11-06 昆明理工大学 A method of based on molasses give up mash improve single needle algae oil and fat accumulation
JP7229012B2 (en) * 2018-12-25 2023-02-27 小林製薬株式会社 Pharmaceutical composition for internal use
IT201900025063A1 (en) * 2019-12-20 2021-06-20 Idi Integratori Dietetici Italiani S R L GASTRORESISTANT COMPOSITIONS INCLUDING INOSITOL AND / OR SYLVESTRE GYMNEMA EXTRACT, THEIR PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS AND THEIR USE
US20210315930A1 (en) * 2020-04-14 2021-10-14 David A. Cuddeback Nutraceutical composition for multimodal prophylaxis against and treatment of viral and bacterial infection and inflammation
KR20230031287A (en) * 2021-08-26 2023-03-07 컨템포러리 엠퍼렉스 테크놀로지 씨오., 리미티드 liquid bags, battery cells, batteries and electrical devices
CN118948861B (en) * 2024-10-15 2024-12-24 山东和美欣动物药业有限公司 A chicken bile extract taurochenodeoxycholic acid composition and its application in preparing an anti-stress drug for improving the egg-laying period of rutin chickens

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US4185740A (en) * 1978-08-02 1980-01-29 Johnson & Johnson Disposable capsules
US4940499A (en) * 1989-05-23 1990-07-10 Warner-Lambert Company Method and apparatus for sealing capsules containing medicaments

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AP1806A (en) * 1999-04-13 2007-12-14 Beecham Pharmaceuticals Pte Ltd The use of a high dosage regimen of amoxycillin and potassium chavulate for the treatment of bacterial infections.
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4185740A (en) * 1978-08-02 1980-01-29 Johnson & Johnson Disposable capsules
US4940499A (en) * 1989-05-23 1990-07-10 Warner-Lambert Company Method and apparatus for sealing capsules containing medicaments

Non-Patent Citations (1)

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Title
See also references of EP1499303A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383579B2 (en) 2004-11-19 2013-02-26 GlaxoSmithKline, LLC Method for customized dispensing of variable dose drug combination products for individualizing of therapies

Also Published As

Publication number Publication date
AU2009202495A1 (en) 2009-07-16
AU2011202164A1 (en) 2011-06-02
NZ536267A (en) 2007-06-29
AU2009202495B2 (en) 2011-02-10
WO2003086267A2 (en) 2003-10-23
CA2481486C (en) 2012-06-12
WO2003086267B1 (en) 2004-04-29
EP1499303A2 (en) 2005-01-26
JP2005528383A (en) 2005-09-22
CA2481486A1 (en) 2003-10-23
EP1499303A4 (en) 2007-07-25
JP2011068664A (en) 2011-04-07
AU2003220689A1 (en) 2003-10-27

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