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WO2001079438A3 - A new polypeptide- human amyloid precursor protein-binding protein 9 and the polynucleotide encoding it - Google Patents

A new polypeptide- human amyloid precursor protein-binding protein 9 and the polynucleotide encoding it Download PDF

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Publication number
WO2001079438A3
WO2001079438A3 PCT/CN2001/000530 CN0100530W WO0179438A3 WO 2001079438 A3 WO2001079438 A3 WO 2001079438A3 CN 0100530 W CN0100530 W CN 0100530W WO 0179438 A3 WO0179438 A3 WO 0179438A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide encoding
amyloid precursor
human amyloid
protein
binding protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2001/000530
Other languages
French (fr)
Chinese (zh)
Other versions
WO2001079438A2 (en
Inventor
Yumin Mao
Yi Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Biowindow Gene Development Inc
Original Assignee
Shanghai Biowindow Gene Development Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Biowindow Gene Development Inc filed Critical Shanghai Biowindow Gene Development Inc
Priority to AU73782/01A priority Critical patent/AU7378201A/en
Publication of WO2001079438A2 publication Critical patent/WO2001079438A2/en
Publication of WO2001079438A3 publication Critical patent/WO2001079438A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention disclose a new polypeptide- human amyloid precursor protein-binding protein 9, the polynucleotide encoding it and a method producing the polypeptide by DNA recombinant technology. The present invention further disclose a method treating various disorders, e.g., Alzeihmer disease, malignant neoplasm, hemopathy, development disorders, HIV infection and immunological disease and various inflammation etc. The present invention also disclose an antagonist of the polypeptide and its therapeutic action. The present invention further disclose the use of the polynucleotide encoding the new human amyloid precursor protein-binding protein 9.
PCT/CN2001/000530 2000-03-29 2001-03-26 A new polypeptide- human amyloid precursor protein-binding protein 9 and the polynucleotide encoding it Ceased WO2001079438A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73782/01A AU7378201A (en) 2000-03-29 2001-03-26 A novel polypeptide, a human 9-binding amyloid precursor protein and the polynucleotide encoding the polypeptide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN00115261A CN1315439A (en) 2000-03-29 2000-03-29 Polypeptide-human amyloid precursor protein bindin 9 and polynucleotide for coding it
CN00115261.0 2000-03-29

Publications (2)

Publication Number Publication Date
WO2001079438A2 WO2001079438A2 (en) 2001-10-25
WO2001079438A3 true WO2001079438A3 (en) 2002-02-28

Family

ID=4584729

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2001/000530 Ceased WO2001079438A2 (en) 2000-03-29 2001-03-26 A new polypeptide- human amyloid precursor protein-binding protein 9 and the polynucleotide encoding it

Country Status (3)

Country Link
CN (1) CN1315439A (en)
AU (1) AU7378201A (en)
WO (1) WO2001079438A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001429A1 (en) * 1993-06-30 1995-01-12 Rhone-Poulenc Rorer S.A. Pharmaceutical compositions and their use, namely for the treatment of neurodegenerative diseases
WO1997016458A1 (en) * 1995-11-01 1997-05-09 Kos Pharmaceuticals, Inc. Apolipoprotein e2 and treatment of alzheimer's disease
WO1998016557A1 (en) * 1996-10-11 1998-04-23 The General Hospital Corporation Assays for g-protein-linked receptors
WO2000002911A2 (en) * 1998-07-10 2000-01-20 Curagen Corporation INTERACTION OF HUMAN BETA AMYLOID PRECURSOR PROTEIN (β-APP) WITH HUMAN LON-PROTEASE LIKE PROTEIN (HSLON)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001429A1 (en) * 1993-06-30 1995-01-12 Rhone-Poulenc Rorer S.A. Pharmaceutical compositions and their use, namely for the treatment of neurodegenerative diseases
WO1997016458A1 (en) * 1995-11-01 1997-05-09 Kos Pharmaceuticals, Inc. Apolipoprotein e2 and treatment of alzheimer's disease
WO1998016557A1 (en) * 1996-10-11 1998-04-23 The General Hospital Corporation Assays for g-protein-linked receptors
WO2000002911A2 (en) * 1998-07-10 2000-01-20 Curagen Corporation INTERACTION OF HUMAN BETA AMYLOID PRECURSOR PROTEIN (β-APP) WITH HUMAN LON-PROTEASE LIKE PROTEIN (HSLON)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLAVERIE J.-M. AND MAKALOWSKI W.: "Alu alert", NATURE, vol. 371, 27 October 1994 (1994-10-27), pages 752, XP002070602 *
JURKA J. AND MILOSAVLJEVIC A.: "Reconstruction and analysis of human Alu genes", J. MOL. EVOL., vol. 32, no. 2, 1991, pages 105 - 121 *

Also Published As

Publication number Publication date
WO2001079438A2 (en) 2001-10-25
CN1315439A (en) 2001-10-03
AU7378201A (en) 2001-10-30

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