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WO2001064189A1 - Granules revetus et compositions moussantes les contenant - Google Patents

Granules revetus et compositions moussantes les contenant Download PDF

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Publication number
WO2001064189A1
WO2001064189A1 PCT/JP2001/001624 JP0101624W WO0164189A1 WO 2001064189 A1 WO2001064189 A1 WO 2001064189A1 JP 0101624 W JP0101624 W JP 0101624W WO 0164189 A1 WO0164189 A1 WO 0164189A1
Authority
WO
WIPO (PCT)
Prior art keywords
coated granules
acid
carbonate
coated
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/001624
Other languages
English (en)
Japanese (ja)
Inventor
Kunihiko Yokota
Yoshitomi Kakiguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to AU2001236055A priority Critical patent/AU2001236055A1/en
Publication of WO2001064189A1 publication Critical patent/WO2001064189A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/624—Coated by macromolecular compounds

Definitions

  • the present invention relates to coated granules and effervescent compositions containing the same, and more specifically, coated granules useful for the production of effervescent preparations used as pharmaceuticals, quasi-drugs, cosmetics, and foods, and uses thereof.
  • the present invention relates to an effervescent composition containing a water-soluble vitamin such as L-ascorbic acid.
  • effervescent preparations such as solid effervescent tablets utilizing carbon dioxide generated by the reaction between a carbonate and an organic acid in the presence of water are known.
  • Effervescent products such as ramune confectionery, can be put directly into the mouth for eating or drinking, or dissolved in water or hot water to make them foam, and used as a drink or bath agent. Gender is affected.
  • L-ascorbic acid and other water-soluble vitamins in solid effervescent preparations are affected by a small amount of water.
  • Japanese Patent Application Laid-Open No. 62-212123 / 18 proposes to mix polyethylene glycol as a stabilizer in a composition in which carbonate and organic acid are mixed in order to improve the stability of the foaming bath agent. Have been.
  • An object of the present invention is to provide an effervescent preparation in which the components in the effervescent preparation are stable and easy to produce, particularly an effervescent preparation containing a water-soluble vitamin such as L-ascorbic acid.
  • a further object of the present invention is to provide a pharmaceutical, quasi-drug, bath preparation, cosmetic, toothpaste having both the pharmacological effect and the foaming function of a water-soluble vitamin such as magnesium L-alkorbyl phosphate and L-ascorbic acid 12-darcoside.
  • the present inventors have divided the pharmaceutical composition into an acid component portion containing an organic acid and a portion containing a carbonate for foaming, and at least one of them is coated and granulated with polyethylene glycol. As a result, they have found that the above object can be achieved, and have completed the present invention.
  • coated granules obtained by coating and granulating an acid component containing a 2 to 3 base organic acid with polyethylene glycol,
  • the 2-3 basic organic acid is one or more organic acids selected from succinic acid, oxalic acid, malic acid, tartaric acid, fumaric acid and citric acid. Item coated granules,
  • coated granules obtained by coating and granulating an alkali component including a carbonate for foaming with polyethylene dalicol;
  • the carbonate for foaming is one or more selected from sodium bicarbonate, ammonium bicarbonate, potassium carbonate, anhydrous potassium carbonate, sodium carbonate, anhydrous sodium carbonate, ammonium carbonate, calcium carbonate and magnesium carbonate. ) Coated granules.
  • Examples of the 2-3 basic acid used as an organic acid for foaming contained in the coated granules of the acid component in the present invention include succinic acid, oxalic acid, malic acid, tartaric acid, fumaric acid, citric acid and the like. These can be used alone or in combination of two or more.
  • the amount of the 2-3 basic organic acid used can be appropriately selected according to the desired foaming preparation, but is usually 1 to 20% by weight, preferably 3 to 10% by weight based on the coated granules of the acid component. Used in.
  • Examples of the water-soluble vitamins contained in the coated granules of the acid component include water-soluble vitamins generally used as foods and pharmaceuticals, and L-ascorbic acid is particularly preferable because the effect of water can be minimized.
  • L-ascorbic acid or a mixture of L-ascorbic acid and other water-soluble vitamins are preferable to include L-ascorbic acid or a mixture of L-ascorbic acid and other water-soluble vitamins in the coated granules of the acid component.
  • Other water-soluble vitamins include water-soluble vitamins other than L-ascorbic acid and salts thereof.
  • These water soluble '14 vitamins may be pure or substantially pure vitamins, both natural and synthetic, or chemical derivatives and mixtures thereof.
  • the amount of L-ascorbic acid and other water-soluble vitamins to be contained is not particularly limited, and can be appropriately selected.
  • the polyethylene dalicol used for coating is polyethylene glycol having a number average molecular weight of 1,000 to 20,000 and a freezing point of 35 to 65 ° C, from the viewpoint of viscosity and coagulability. Are preferably used in combination of two or more.
  • polyethylene glycol having a number-average molecular weight of less than 1,000 has a liquid or petrolatum-like shape. Even if this is used as a coating agent, the coating effect is poor and the flowability of the preparation is poor. Causes disadvantages.
  • the coated granulation In general, it is preferred to carry out the coated granulation with 1 to 10% by weight, preferably 3 to 9% by weight, of polyethylene glycol, based on the total weight of the coated granules containing the acid component.
  • Coating and granulation of the acid component is carried out, for example, by heating a 2 to 3 base organic acid to 60 to 85 ° C and mixing at a high speed with a mixer (eg, 200 to 800 rpm). ), Water-soluble vitamins and other ingredients to be coated into granules are sequentially added to the organic acid together with a small amount of polyethylene glycol, and after cooling, the coated granules with the desired average particle size are passed through the nodes. This can be done by obtaining
  • Examples of the foaming carbonate contained in the coated granules of the alkali component of the present invention include sodium hydrogencarbonate, ammonium hydrogencarbonate, potassium carbonate, anhydrous potassium carbonate, sodium carbonate, anhydrous sodium carbonate, ammonium carbonate, calcium carbonate, and carbonate.
  • Magnesium and other powers can be used, and these can be used alone or in combination of two or more.
  • the amount of the carbonate to be used can be appropriately selected according to the desired foaming preparation, but is usually used in a proportion of 1 to 20% by weight, preferably 5 to 10% by weight, based on the coated granules of the alkali component.
  • L-ascorbic acid can also be contained in the coated granules of the alkali component, but since free L-ascorbic acid reacts with the carbonate, sodium L-ascorbic acid is used. It is used in the form of L-ascorbate such as calcium salt or calcium L-ascorbate.
  • the polyethylene dalicol used is the same as the coated granules of the acid component, and the coated granulation can be performed in the same manner as the coated granules of the acid component except that a carbonate is used instead of the organic acid.
  • the foamable composition of the present invention is a composition obtained by combining the coated granules of the acid component obtained above with the coated granules of the alcohol component obtained above or the uncoated foaming carbonate, or the above-mentioned composition.
  • the composition is obtained by combining the coated granules of the obtained alcohol component and the uncoated 2-3 base organic acid.
  • Combination of both components can be carried out by a usual mixing method, and the mixing ratio can be selected as appropriate, but it is usually preferable that the ratio is such that foaming and dissolving occur within about 2 minutes.
  • the weight ratio of the 2 to 3 base organic acid: carbonate is adjusted to be 1: 0.3 to: 1.5, preferably 1: 0.4 to 0.8.
  • the average particle size of the 2-3 basic organic acid is equal to or larger than the average particle size of the foaming carbonate. It is preferable that the average particle size of the organic acid having 2 to 3 bases passes through 20 mesh, preferably about 32 mesh, and the average particle size of the carbonate passes through 20 mesh, preferably 60 mesh.
  • the content of polyethylene glycol be 20% by weight or less, preferably 3 to 20% by weight based on the total amount of the composition.
  • the effervescent composition obtained is as-is, effervescent dry powder, granular juice, food and drink such as confectionery and health food, pharmaceuticals such as vitamins, quasi-drugs, bath preparations and cosmetics It can be provided as a tablet, if necessary, using an appropriate tableting machine, and can be made into tablets according to a standard method.
  • active ingredients and additives may be appropriately added as required. These components may be used in an appropriate amount according to the purpose of each additive. It can be added to one or both of the alkali components.It can be added as a component to be coated and granulated or as a component outside the coated granule. It is good.
  • active ingredients include water-soluble vitamins and the like, and additives include sweeteners, excipients, powdered juice, flavors and the like.
  • water-soluble vitamins examples include L-ascorbate (sodium salt, calcium salt), L-ascorbyl magnesium phosphate, and L-ascorbic acid-2-darcoside. These water-soluble vitamins are commercially available.
  • the water-soluble vitamin having high stability to water may be added as a component outside the coated granules, or may be added after mixing the coated granules.
  • phosphoric acid L- ⁇ Schorr building magnesium stable are hydrates (1 ⁇ 2 0 ⁇ 5 ⁇ 2 ⁇ )
  • coated granules Is preferably added after mixing.
  • the amount of the water-soluble vitamin added outside the coated granules varies depending on the type of the water-soluble vitamin and the use of the composition, but is usually 0.1 to 5.0% by weight.
  • the effervescent composition of the present invention to which the water-soluble vitamin is added has both the pharmacological effect and the effervescent function of the water-soluble vitamin, and is a new medicine, a quasi-drug, a bath agent or a cosmetic, especially a face wash (eg, face wash), It can be used as a shaving agent (eg, shaving cream), bath or dentifrice.
  • a shaving agent eg, shaving cream
  • the foamable composition of the present invention to which L-ascorbyl phosphate is added can be used for face washing water, shaving cream, It is suitably used as a bath or dentifrice.
  • sweetener examples include D-gnorecose, D-fructoses, sucrose, acesulfam K, saccharin, sucralose, stevia, aspartame, and the like. These may be used alone or in combination of two or more. .
  • Excipients include, for example, monosaccharides and their sugar alcohols (eg, L-arabinose, D-xylose, D-2-deoxyribose, D-ribose, D- and L-galactose, D-glucose, D-mannose, D-fructoses, L-sorbose, L-fucose, L-rhamnose, D-darcosamine, b-sorbitol, D-mannitol-gal, galactitol, erythritol, etc.), disaccharides and their sugar alcohols (sucrose, cellbio) , Gentios, isomaltose, kodibiose, lactose, lactitol, laminaribiose, maltose, melibiose, nigrose, sophorose, palatinose, ⁇ , trehalose, palatinit, etc.), dextrin And reduced maltose starch
  • powdered juice examples include orange juice, lemon juice, grape juice, grapefruit juice, summer orange juice and the like.
  • Flavors include various fruit flavors.
  • polyethylene dalicol may be abbreviated as PEG.
  • the number attached to the polyethylene glycol is the number average molecular weight.
  • the high-speed mixer was charged with citrate and heated to 65 ° C while stirring at 200 rpm. While stirring at 600 rpm, a part of the PEG 6,000 and a part of the reduced maltose syrup were added and mixed, and then L-ascorbic acid was added and mixed. While stirring at 500 rpm, a part of PEG 6,000 and a part of reduced maltose starch syrup are added to the mixture, mixed at a stirring speed of 400 rpm, and gradually cooled to 63 ° C. Add part of 00, part of reduced maltose syrup, powdered orange juice and aspartame.Mix and stir at 300 rpm while cooling.Add remaining PEG6,000 and reduced maltose syrup. ⁇ Mixed and coated and granulated the acid component and removed from the high speed mixer at 55 ° C.
  • coated granules were passed through a node, and the portion passed through 16 mesh was made into coated granules of an acid component.
  • the resulting coated granules were passed through a node, and the amount passed through a 16 mesh was used as the coated granules of the alkali component.
  • a 150 ml aqueous solution of the granules (6.7 g) had a pH of 4.1 at 7 ° C and a disintegration time of about 1 minute.
  • the high-speed mixer was charged with citrate and heated to 65 ° C while stirring at 200 rpm. While stirring at 600 rpm, a part of PEG 6,000 and a part of powdered sugar were added and mixed, and then L-ascorbic acid was added and mixed. While stirring at 500 rpm, a part of PEG 6,000 and a part of powdered sugar are added and mixed, and the mixture is gradually cooled to 63 ° C at a stirring speed of 400 rpm, and then a part of PEG 6,000 is mixed. And powdered sugar, powdered orange juice, stevia and mix, then add the remaining PEG 6,000 and powdered sugar while stirring and cooling at 300 rpm. And removed from the high speed mixer at 55 ° C.
  • the resulting coated granules are passed through a node, and the amount passed through 16 mesh is converted to acid-coated granules.
  • a high-speed mixer was charged with sodium bicarbonate and heated to 67 ° C with stirring at 200 rpm. While stirring at 800 rpm, PEG 20,000, a part of PEG 6,000 and a part of powdered sugar were added and mixed, and then, sodium L-ascorbate was added and mixed. While stirring at 500 rpm, a part of PEG6, 000 and a part of powdered sugar were added and mixed, and the mixture was gradually cooled to 65 ° C, and then stirred at 300 rpm to remove the remaining PEG6, 000 and powdered sugar were added, mixed and cooled to granulate the alkaline component and removed from the high speed mixer at 55 ° C.
  • coated granules thus obtained were passed through a decoration, and a portion passed through 16 mesh was used as coated granules of an alkali component.
  • a 150 ml aqueous solution of the granules (6.7 g) had a pH of 4.1 at 7 ° C and a disintegration time of about 1 minute.
  • Cuenic acid and ascorbic acid were charged into a high-speed mixer, and heated to 65 ° C or higher while stirring at 200 rpm. While stirring at 500 rpm, PEG 6,000 and PEG 20,000 were added to the mixture, mixed, and then dextrin was added, mixed, and then lactose was added and mixed. After the stirring speed was set to 300 rpm and the temperature was gradually cooled to 55 ° C or less, the coated granules were removed from the high speed mixer.
  • the resulting coated granules are passed through a node, and the amount passed through 12 mesh is converted to acid-coated granules.
  • a high-speed mixer was charged with sodium bicarbonate and heated to at least 65 ° C while stirring at 200 rpm. While stirring at 1000 rpm, PEG 20,000 was added to this, mixed, then added dextrin, mixed, and then added lactose, mixed. After the stirring speed was set to 300 rpm and the temperature was gradually cooled to 55 ° C. or less, the coated granules were taken out from the high speed mixer. The coated granules thus obtained were passed through a node, and a portion passing through 12 mesh was used as coated granules of an alkali component.
  • a total of 100 parts by weight of both the obtained coated granules and 4 parts by weight of L-ascorbyl magnesium phosphate (trade name: Cymate, Takeda Pharmaceutical Co., Ltd.) were mixed and used for facial cleansing water. An effervescent granule was obtained.
  • the effervescent preparation of the present invention containing a water-soluble vitamin such as sodium ascorbate is used as a face wash, a shaving agent, a bath agent, a dentifrice and the like.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions moussantes stables que l'on peut produire aisément, notamment des compositions moussantes contenant des vitamines solubles dans l'eau telles que l'acide L-ascorbique. L'invention concerne également des granules revêtus préparés par granulation de composants acides contenant un acide organique diacide ou triacide et, si on le souhaite, une vitamine soluble dans l'eau telle que l'acide L-ascorbique, et par revêtement de polyéthylène glycol, ainsi que des granules revêtus préparés par granulation de composants alcalins contenant un carbonate moussant et si on le souhaite, un L-ascorbate et par revêtement de polyéthylène glycol. On peut obtenir une composition moussante en combinant les granules revêtus des composants acides avec les granules revêtus des composants alcalins ou du carbonate moussant non revêtu. On peut également l'obtenir en combinant les granules revêtus des composant alcalins avec un acide organique diacide ou triacide.
PCT/JP2001/001624 2000-03-02 2001-03-02 Granules revetus et compositions moussantes les contenant Ceased WO2001064189A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001236055A AU2001236055A1 (en) 2000-03-02 2001-03-02 Coated granules and foaming compositions containing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000-57166 2000-03-02
JP2000057166 2000-03-02
JP2000-366947 2000-12-01
JP2000366947 2000-12-01

Publications (1)

Publication Number Publication Date
WO2001064189A1 true WO2001064189A1 (fr) 2001-09-07

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PCT/JP2001/001624 Ceased WO2001064189A1 (fr) 2000-03-02 2001-03-02 Granules revetus et compositions moussantes les contenant

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WO (1) WO2001064189A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521995A (ja) * 2004-11-30 2008-06-26 エルジー ハウスホールド アンド ヘルス ケア エルティーディー． 衣類の肌触りを向上させることができる粉末洗剤組成物及びその製造方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05194275A (ja) * 1991-09-03 1993-08-03 Takeda Chem Ind Ltd 製剤用組成物、固形製剤および薬物の防臭方法
JPH05255067A (ja) * 1991-04-25 1993-10-05 Takeda Chem Ind Ltd 浮遊性製剤およびその製造方法
JPH05255066A (ja) * 1991-04-25 1993-10-05 Takeda Chem Ind Ltd 製剤用組成物、製剤およびそれらの製造方法
EP0629398A1 (fr) * 1993-06-18 1994-12-21 Tanabe Seiyaku Co., Ltd. Composition pharmaceutique à liberation contrôlée d'un principe actif sur un lieu cible dans le tractus intestinal
EP0761212A2 (fr) * 1995-09-08 1997-03-12 Takeda Chemical Industries, Ltd. Composition effervescente et sa préparation
JPH11139960A (ja) * 1997-09-05 1999-05-25 Takeda Chem Ind Ltd 医 薬
WO1999059544A2 (fr) * 1998-05-18 1999-11-25 Takeda Chemical Industries, Ltd. Comprimes se desintegrant dans la bouche

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05255067A (ja) * 1991-04-25 1993-10-05 Takeda Chem Ind Ltd 浮遊性製剤およびその製造方法
JPH05255066A (ja) * 1991-04-25 1993-10-05 Takeda Chem Ind Ltd 製剤用組成物、製剤およびそれらの製造方法
JPH05194275A (ja) * 1991-09-03 1993-08-03 Takeda Chem Ind Ltd 製剤用組成物、固形製剤および薬物の防臭方法
EP0629398A1 (fr) * 1993-06-18 1994-12-21 Tanabe Seiyaku Co., Ltd. Composition pharmaceutique à liberation contrôlée d'un principe actif sur un lieu cible dans le tractus intestinal
EP0761212A2 (fr) * 1995-09-08 1997-03-12 Takeda Chemical Industries, Ltd. Composition effervescente et sa préparation
JPH11139960A (ja) * 1997-09-05 1999-05-25 Takeda Chem Ind Ltd 医 薬
WO1999059544A2 (fr) * 1998-05-18 1999-11-25 Takeda Chemical Industries, Ltd. Comprimes se desintegrant dans la bouche

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521995A (ja) * 2004-11-30 2008-06-26 エルジー ハウスホールド アンド ヘルス ケア エルティーディー． 衣類の肌触りを向上させることができる粉末洗剤組成物及びその製造方法

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