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WO2001058464A1 - Forme posologique d'ivermectine a dispersion aqueuse utilisee pour soigner ectoparasitose et endoparasitose - Google Patents

Forme posologique d'ivermectine a dispersion aqueuse utilisee pour soigner ectoparasitose et endoparasitose Download PDF

Info

Publication number
WO2001058464A1
WO2001058464A1 PCT/RU2001/000019 RU0100019W WO0158464A1 WO 2001058464 A1 WO2001058464 A1 WO 2001058464A1 RU 0100019 W RU0100019 W RU 0100019W WO 0158464 A1 WO0158464 A1 WO 0158464A1
Authority
WO
WIPO (PCT)
Prior art keywords
ecto
curing
ivermectin
dosage form
water dispersed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2001/000019
Other languages
English (en)
Russian (ru)
Inventor
Sergei Vyacheslavovich Semenov
Dmitry Alexandrovich Zhemerichkin
Vladimir Alexandrovich Sidorkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU30645/01A priority Critical patent/AU3064501A/en
Publication of WO2001058464A1 publication Critical patent/WO2001058464A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Definitions

  • the invention is subject to the veterinary science and medicine and may be used for the treatment of ecto- and endoparasites.
  • the present invention is a patent of the USA ⁇ °
  • the component (stabilizing the active substance) is glycerol or glycerin, or polypropylene glycol in concentration of 10% to 60% weight / volume;
  • a convenient indicated form of treatment is a high overall rate associated with a large increase in the rate of introduction in the first hours.
  • the drug With an effective concentration of this drug, the drug is identical to a drug with non-narcotic excipients.
  • Task ⁇ g ⁇ iz ⁇ b ⁇ e ⁇ eniya - s ⁇ zdanie le ⁇ a ⁇ s ⁇ venn ⁇ y ⁇ my ive ⁇ me ⁇ - ⁇ ina, ud ⁇ bn ⁇ y in ⁇ imenenii, ne ⁇ sichn ⁇ y in ⁇ e ⁇ a ⁇ ev ⁇ iches ⁇ i ⁇ d ⁇ za ⁇ and e ⁇ - ⁇ e ⁇ ivn ⁇ y ⁇ ntsen ⁇ atsiey in ⁇ ganizme, d ⁇ s ⁇ a ⁇ chn ⁇ y for ⁇ ln ⁇ g ⁇ cure ⁇ sle ⁇ dn ⁇ a ⁇ n ⁇ y ine ⁇ tsii ⁇ e ⁇ a ⁇ a ⁇ a.
  • Agents (Agent (P ⁇ ) 4 - 20
  • the food is distilled
  • a component, ivoremectin or averomectin, ⁇ , vitamin ⁇ stirs up to a complete decomposition at a temperature of 30 -50 ° ⁇ .
  • a buffer of 6.0–7.0 with the calculated quantity of water.
  • the rp ⁇ module is connected, and then the treated drug is sterilized by membrane filtration and aseptic is used.
  • SIGNIFICANT FOX (DR. 26) ⁇ ⁇ 01/58464 ⁇ / ⁇ 01 / 00019
  • ⁇ veromectin ⁇ 1 a and ⁇ 1 c Iveromectin (22.23-dihydrogen averomectin ⁇ a and ⁇ b);
  • the name of the components is quantitative, wt.% Ivermectin 1.0
  • the food is distilled
  • a process with a maximum number of components and related components is provided.
  • Iveromectin or Averomectin 1 Iveromectin or Averomectin 1, 0
  • SIGNIFICANT FOX (DR. 26) ⁇ ⁇ 01/58464 ⁇ / ⁇ / 00019
  • the food is distributed distantly
  • the increase in the amount of the share of the product is up to 60%, which results in a decrease in the type of package due to the incapability of the user and the risk of illness.
  • With a further increase in the quantity of the solvent or an increase in the aforementioned components the destruction of micelles (external dispersion) and the expansion of the liquid occur.
  • a process with a minimum number of components and related components is provided.
  • the food is distilled
  • Tests of the declared medicinal form are carried out on agricultural and laboratory live animals. There is a simple reduction in the effect on the body of the drug due to increased doses of the drug, as well as the occurrence of an effective concentration in plasma. Investigated the therapeutic efficacy of the declared medicinal form for endo- and ectoparasitic diseases of agricultural comparison.
  • the variants of the declared medicinal form are more convenient in application than the direct and analogue - and you can also enter them internally, which is less than the case, especially. With the introduction of both an effective and internal muscle, they do not cause irritation or local reaction of the tissue.
  • the therapeutic efficacy of the declared medicinal form in comparison with the direct and analogous to the various endogenous and metabolic disease is 41%; father - by 36.6-43.4% respectively.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la médecine vétérinaire et la médecine et peut être utilisée pour soigner l'ectoparasitose et endoparasitose. La forme posologique d'ivermectine ou d'avermectine à dispersion aqueuse contient de l'eau comme diluant, dimethyl acétamide ou propylène glycol ou glyceroformale comme co-diluant, des détergents tels que tween 80, solutol, cremophore et autres dérivés de polyoxythylène d'huiles naturels comme agents formant des micelles, alcool benzylique ou parabènes comme conservateurs, solution tampon à base de phosphate et de citrate, et aussi la vitamine E (tocophérols). L'efficacité thérapeutique de cette forme posologique comparée avec un analogue qu'on a utilisés dans divers cas d'ectoparasitose et d'endoparasitose des bovins et des moutons est respectivement supérieure de 41,1à 50,5 % et de 36,6 à 43,4 %. L'effet maximal thérapeutique est obtenu à une injection par 50 kg du poids de corps. La forme posologique appliquée en doses thérapeutiques n'est pas toxique.
PCT/RU2001/000019 2000-02-14 2001-01-18 Forme posologique d'ivermectine a dispersion aqueuse utilisee pour soigner ectoparasitose et endoparasitose Ceased WO2001058464A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30645/01A AU3064501A (en) 2000-02-14 2001-01-18 Water dispersed ivermectin dosage form used for curing ecto- and endoparasitic diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2000103591/13A RU2162699C1 (ru) 2000-02-14 2000-02-14 Водно-дисперсная лекарственная форма ивермектина для лечения экто- и эндопаразитозов
RU2000103591 2000-02-14

Publications (1)

Publication Number Publication Date
WO2001058464A1 true WO2001058464A1 (fr) 2001-08-16

Family

ID=20230607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2001/000019 Ceased WO2001058464A1 (fr) 2000-02-14 2001-01-18 Forme posologique d'ivermectine a dispersion aqueuse utilisee pour soigner ectoparasitose et endoparasitose

Country Status (4)

Country Link
AU (1) AU3064501A (fr)
EA (1) EA002628B1 (fr)
RU (1) RU2162699C1 (fr)
WO (1) WO2001058464A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2519085C1 (ru) * 2013-04-01 2014-06-10 Автономная некоммерческая организация "Научно-исследовательский институт диагностики и профилактики болезней человека и животных" (АНО "НИИ ДПБ") Противопаразитарное средство для сельскохозяйственных животных
RU2655729C1 (ru) * 2017-11-21 2018-05-29 Карина Микаилевна Мирзаева Препарат ниацид-к для лечения животных от паразитозов
RU2694546C1 (ru) * 2018-10-29 2019-07-16 Федеральное государственное бюджетное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. К.И. Скрябина и Я.Р. Коваленко" Способ лечения и профилактики паразитозов птиц с оптимизацией их обмена веществ и естественной резистентности
CN111920765A (zh) * 2020-09-24 2020-11-13 河北新世纪药业有限公司 一种复方伊维菌素注射液及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045655A2 (fr) * 1980-08-04 1982-02-10 Merck & Co. Inc. Solubilisation de l'ivermectine dans l'eau
EP0299527A1 (fr) * 1987-07-16 1989-01-18 Bristol-Myers Squibb Company Solutions aqueuses de chlorhydrate de doxorubicine
RU2033150C1 (ru) * 1992-06-10 1995-04-20 Виктор Антонович Дриняев Препарат для лечения и профилактики псороптоза у животных "аверсект"
WO1995031217A1 (fr) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Compositions de tocopherol destinees a l'apport d'agents biologiquement actifs
RU2054848C1 (ru) * 1995-02-28 1996-02-20 Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед" Способ получения авермектинового комплекса и препарат авермектинового комплекса для профилактики и комплексного лечения заболеваний, вызванных эндо- и эктопаразитами животных

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389397A (en) * 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
RU2124895C1 (ru) * 1998-05-28 1999-01-20 Головкина Любовь Павловна Противопаразитарная мазь "авермектиновая"

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045655A2 (fr) * 1980-08-04 1982-02-10 Merck & Co. Inc. Solubilisation de l'ivermectine dans l'eau
EP0299527A1 (fr) * 1987-07-16 1989-01-18 Bristol-Myers Squibb Company Solutions aqueuses de chlorhydrate de doxorubicine
RU2033150C1 (ru) * 1992-06-10 1995-04-20 Виктор Антонович Дриняев Препарат для лечения и профилактики псороптоза у животных "аверсект"
WO1995031217A1 (fr) * 1994-05-16 1995-11-23 Dumex-Alpharma A/S Compositions de tocopherol destinees a l'apport d'agents biologiquement actifs
RU2054848C1 (ru) * 1995-02-28 1996-02-20 Товарищество с ограниченной ответственностью Научно-производственное объединение "Фармбиомед" Способ получения авермектинового комплекса и препарат авермектинового комплекса для профилактики и комплексного лечения заболеваний, вызванных эндо- и эктопаразитами животных

Also Published As

Publication number Publication date
EA200100223A3 (ru) 2001-12-24
AU3064501A (en) 2001-08-20
RU2162699C1 (ru) 2001-02-10
EA002628B1 (ru) 2002-08-29
EA200100223A2 (ru) 2001-08-27

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