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WO2000036976A1 - Detecteur - Google Patents

Detecteur Download PDF

Info

Publication number
WO2000036976A1
WO2000036976A1 PCT/GB1999/004340 GB9904340W WO0036976A1 WO 2000036976 A1 WO2000036976 A1 WO 2000036976A1 GB 9904340 W GB9904340 W GB 9904340W WO 0036976 A1 WO0036976 A1 WO 0036976A1
Authority
WO
WIPO (PCT)
Prior art keywords
breath
temperature
exhaled breath
detecting
operable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/004340
Other languages
English (en)
Inventor
Peter Barnes
Sergei Kharitonov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boditech Diagnostics Ltd
Original Assignee
Boditech Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boditech Diagnostics Ltd filed Critical Boditech Diagnostics Ltd
Priority to AU18753/00A priority Critical patent/AU1875300A/en
Publication of WO2000036976A1 publication Critical patent/WO2000036976A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Definitions

  • This invention relates to detectors.
  • nitric oxide (NO) content which can indicate a level of lung inflammation due to allergen challenge.
  • This invention provides apparatus for detecting the temperature of exhaled breath along with the level of at least one gaseous component of the exhaled breath.
  • the at least one gaseous component is NO, carbon monoxide (CO), or both.
  • the time dependence of the detected temperature and gas component levels are detected and/or analysed during at least a part of the duration of exhalation of a breath.
  • any results obtained with reference to an initial portion of the breath are discarded or disregarded.
  • a flow rate of the exhaled breath is also detected; this information can in part be used to calibrate one or more of the other measurements.
  • FIG. 1 schematically illustrates a sampling system.
  • a tube 10 having a disposable mouthpiece 20 (for hygiene) has a temperature probe 30 supported at or near to the mouthpiece end of the tube (although it could be elsewhere in the air flow path).
  • the probe 30, for example a thermocouple is connected to temperature detection circuitry 40.
  • a tube 50 taps off a proportion of the air exhaled into the mouthpiece and communicates with a detection apparatus 60 for NO & CO.
  • Further tubes 70 (and there may be more) are used in conjunction with a flow rate detector 80 to detect rate of flow through the tube 10.
  • a restriction 90 imposes a back pressure against the exhalation, assisting in the proper detection of NO.
  • results relating to a first part of the breath can be disregarded or discarded.
  • Figure 2 illustrates some preliminary results obtained for temperature measurement. Asthma sufferers are found to have a more rapid temperature rise time than "normal" patients. Kartaghemer syndrome sufferers have a slower rise time but a higher asymptotic temperature. These results can be correlated with the detected NO & CO levels to provide a more accurate diagnostic detection of these or other medical problems or situations.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif (30) de diagnostic permettant de détecter simultanément la température de l'air expiré et la concentration d'au moins un composant gazeux de l'air expiré.
PCT/GB1999/004340 1998-12-18 1999-12-17 Detecteur Ceased WO2000036976A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18753/00A AU1875300A (en) 1998-12-18 1999-12-17 Detector

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9828076.1 1998-12-18
GB9828076A GB2344885A (en) 1998-12-18 1998-12-18 Diagnostic device

Publications (1)

Publication Number Publication Date
WO2000036976A1 true WO2000036976A1 (fr) 2000-06-29

Family

ID=10844610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004340 Ceased WO2000036976A1 (fr) 1998-12-18 1999-12-17 Detecteur

Country Status (3)

Country Link
AU (1) AU1875300A (fr)
GB (1) GB2344885A (fr)
WO (1) WO2000036976A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012930A1 (fr) * 2005-07-27 2007-02-01 Delmedica Investment Limited Procédé et dispositif permettant de mesurer la température d'un gaz respiratoire expiré
WO2012006704A1 (fr) 2010-07-16 2012-01-19 Universidade De São Paulo- Usp Procédé non invasif pour diagnostiquer la gravité d'une insuffisance cardiaque, utilisation d'un biomarqueur pour diagnostiquer une insuffisance cardiaque décompensée, dispositif destiné à collecter le biomarqueur d'insuffisance cardiaque à partir de l'air expiré et trousse de diagnostic

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10110838C2 (de) * 2001-03-06 2003-04-03 Mlu Halle Wittenberg Verfahren zur Diagnostik von Allergien, Pseudoallergien und Intoleranzen
DE10231541A1 (de) * 2002-07-11 2004-01-29 Gäbler, Ralph, Dr. Verfahren zur Bestimmung der Reaktion eines biologischen Systems
CN105167776A (zh) * 2014-11-26 2015-12-23 深圳市一体医疗科技有限公司 一种肺部监测系统

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884219A (en) * 1973-04-02 1975-05-20 Medical Monitor Systems System for determining temperature and respiration rate
US4248245A (en) * 1978-04-15 1981-02-03 Dragerwerk Aktiengesellschaft Method and device for determining and separating the alveolar air proportion from the breathing air
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus
WO1995010980A1 (fr) * 1993-10-22 1995-04-27 Medtrac Technologies Inc. Spirometre electronique portatif
GB2301440A (en) * 1992-11-04 1996-12-04 Fisher & Paykel Medical airway temperature sensor
US5622182A (en) * 1994-06-27 1997-04-22 Jaffe; Richard A. System for measuring core body temperature in vivo

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1374142A (en) * 1971-06-18 1974-11-13 Borg Warner Breath testing system with breath temperature variance compensation
US4671298A (en) * 1984-11-26 1987-06-09 Meridian Medical Corporation Isothermal rebreathing apparatus and method
US4809810A (en) * 1986-05-01 1989-03-07 Autosense Corporation Breath alcohol analyzer
AU5613894A (en) * 1993-04-01 1994-10-24 Alcohol Sensors International, Ltd. Breath sensor apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3884219A (en) * 1973-04-02 1975-05-20 Medical Monitor Systems System for determining temperature and respiration rate
US4248245A (en) * 1978-04-15 1981-02-03 Dragerwerk Aktiengesellschaft Method and device for determining and separating the alveolar air proportion from the breathing air
US5383469A (en) * 1992-01-31 1995-01-24 Board Of Trustees Of The Leland Stanford Junior University Neonatal hemolysis detection using end-tidal breath sampler and analyzer apparatus
GB2301440A (en) * 1992-11-04 1996-12-04 Fisher & Paykel Medical airway temperature sensor
WO1995010980A1 (fr) * 1993-10-22 1995-04-27 Medtrac Technologies Inc. Spirometre electronique portatif
US5622182A (en) * 1994-06-27 1997-04-22 Jaffe; Richard A. System for measuring core body temperature in vivo

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012930A1 (fr) * 2005-07-27 2007-02-01 Delmedica Investment Limited Procédé et dispositif permettant de mesurer la température d'un gaz respiratoire expiré
BG65874B1 (bg) * 2005-07-27 2010-04-30 ДУНЕВ Стефан Устройство за измерване температурата на издишвания въздух
US8323207B2 (en) 2005-07-27 2012-12-04 Delmedica Investments Limited Method and device for measurement of exhaled respiratory gas temperature
WO2012006704A1 (fr) 2010-07-16 2012-01-19 Universidade De São Paulo- Usp Procédé non invasif pour diagnostiquer la gravité d'une insuffisance cardiaque, utilisation d'un biomarqueur pour diagnostiquer une insuffisance cardiaque décompensée, dispositif destiné à collecter le biomarqueur d'insuffisance cardiaque à partir de l'air expiré et trousse de diagnostic
US8747325B2 (en) 2010-07-16 2014-06-10 Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo (Fapesp) Non-invasive method for diagnosing the severity of heart failure by extracting and analyzing acetone concentrations in captured exhaled breath

Also Published As

Publication number Publication date
AU1875300A (en) 2000-07-12
GB2344885A (en) 2000-06-21
GB9828076D0 (en) 1999-02-17

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