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WO2000030589A3 - Synthesis of intermediates useful in preparing tricyclic compounds - Google Patents

Synthesis of intermediates useful in preparing tricyclic compounds Download PDF

Info

Publication number
WO2000030589A3
WO2000030589A3 PCT/US1999/026010 US9926010W WO0030589A3 WO 2000030589 A3 WO2000030589 A3 WO 2000030589A3 US 9926010 W US9926010 W US 9926010W WO 0030589 A3 WO0030589 A3 WO 0030589A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
intermediates useful
tricyclic compounds
formula
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/026010
Other languages
French (fr)
Other versions
WO2000030589A2 (en
Inventor
Charles F Bernard
Michael Casey
Frank Xing Chen
Denise C Grogan
Marc Poirier
Robert P Williams
Yee-Shing Wong
George G Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to HK02100248.8A priority Critical patent/HK1038698A1/en
Priority to JP2000583474A priority patent/JP4663122B2/en
Priority to AU37902/00A priority patent/AU3790200A/en
Priority to EP99972525A priority patent/EP1131296A2/en
Priority to CA002351693A priority patent/CA2351693C/en
Publication of WO2000030589A2 publication Critical patent/WO2000030589A2/en
Publication of WO2000030589A3 publication Critical patent/WO2000030589A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

A process for preparing a compound having formula (I) by (A) reacting a compound having formula (II), wherein R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having formula (IIa); and (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). The imines and a process for preparing a compound having formula (III) are disclosed.
PCT/US1999/026010 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds Ceased WO2000030589A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HK02100248.8A HK1038698A1 (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds
JP2000583474A JP4663122B2 (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in the preparation of tricyclic compounds.
AU37902/00A AU3790200A (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds
EP99972525A EP1131296A2 (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds
CA002351693A CA2351693C (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19700398A 1998-11-20 1998-11-20
US09/197,003 1998-11-20

Publications (2)

Publication Number Publication Date
WO2000030589A2 WO2000030589A2 (en) 2000-06-02
WO2000030589A3 true WO2000030589A3 (en) 2001-01-04

Family

ID=22727622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026010 Ceased WO2000030589A2 (en) 1998-11-20 1999-11-18 Synthesis of intermediates useful in preparing tricyclic compounds

Country Status (13)

Country Link
EP (1) EP1131296A2 (en)
JP (2) JP4663122B2 (en)
CN (1) CN1162404C (en)
AR (1) AR028138A1 (en)
AU (1) AU3790200A (en)
CA (1) CA2351693C (en)
CO (1) CO5150169A1 (en)
HK (1) HK1038698A1 (en)
MY (1) MY121795A (en)
PE (1) PE20001243A1 (en)
TW (1) TW509680B (en)
WO (1) WO2000030589A2 (en)
ZA (1) ZA200103246B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1274688B1 (en) 2000-04-18 2006-12-20 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
WO2004058719A1 (en) * 2002-12-26 2004-07-15 Cadila Healthcare Limited A process for preparing benzocyclohetapyridin-11-ones
CN108218773A (en) * 2018-02-28 2018-06-29 朱路英 A kind of method for preparing resisting allergic rhinitis drug loratadine intermedite

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208855A1 (en) * 1985-05-13 1987-01-21 Schering Corporation Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
EP0582825A1 (en) * 1989-02-28 1994-02-16 F. Hoffmann-La Roche Ag Amidation of pyridines
WO1996031478A1 (en) * 1995-04-07 1996-10-10 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
EP0806415A1 (en) * 1996-05-09 1997-11-12 Lonza Ag Process for the preparation of arylamides of heteroaromatic carboxylic acids
WO1998042676A1 (en) * 1997-03-25 1998-10-01 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
US5672750A (en) * 1994-12-16 1997-09-30 Eastman Chemical Company Preparation of aromatic amides from carbon monoxide, an amine and an aromatic chloride
CA2240846C (en) 1995-12-22 2002-07-16 Schering Corporation Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases
US5958890A (en) * 1996-09-13 1999-09-28 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208855A1 (en) * 1985-05-13 1987-01-21 Schering Corporation Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
EP0582825A1 (en) * 1989-02-28 1994-02-16 F. Hoffmann-La Roche Ag Amidation of pyridines
WO1996031478A1 (en) * 1995-04-07 1996-10-10 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
EP0806415A1 (en) * 1996-05-09 1997-11-12 Lonza Ag Process for the preparation of arylamides of heteroaromatic carboxylic acids
WO1998042676A1 (en) * 1997-03-25 1998-10-01 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds

Also Published As

Publication number Publication date
TW509680B (en) 2002-11-11
CA2351693C (en) 2009-01-20
CN1162404C (en) 2004-08-18
CA2351693A1 (en) 2000-06-02
AU3790200A (en) 2000-06-13
CN1326444A (en) 2001-12-12
MY121795A (en) 2006-02-28
JP2002530307A (en) 2002-09-17
WO2000030589A2 (en) 2000-06-02
JP4663122B2 (en) 2011-03-30
HK1038698A1 (en) 2002-03-28
PE20001243A1 (en) 2000-11-15
JP2010132701A (en) 2010-06-17
CO5150169A1 (en) 2002-04-29
EP1131296A2 (en) 2001-09-12
ZA200103246B (en) 2002-07-22
AR028138A1 (en) 2003-04-30

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