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WO2000010547A3 - New use of taxoid derivatives - Google Patents

New use of taxoid derivatives Download PDF

Info

Publication number
WO2000010547A3
WO2000010547A3 PCT/EP1999/006292 EP9906292W WO0010547A3 WO 2000010547 A3 WO2000010547 A3 WO 2000010547A3 EP 9906292 W EP9906292 W EP 9906292W WO 0010547 A3 WO0010547 A3 WO 0010547A3
Authority
WO
WIPO (PCT)
Prior art keywords
new use
hydroxy
colon cancer
relates
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/006292
Other languages
French (fr)
Other versions
WO2000010547A2 (en
Inventor
Marie-Christine Bissery
Patricia Vrignaud
Simon Roberts
Clive Brealey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98115650A external-priority patent/EP0982028A1/en
Priority to CA002341191A priority Critical patent/CA2341191A1/en
Priority to AU57420/99A priority patent/AU5742099A/en
Priority to EP99944532A priority patent/EP1105119A2/en
Priority to HU0104000A priority patent/HUP0104000A3/en
Priority to EA200100250A priority patent/EA200100250A1/en
Priority to MXPA01001721A priority patent/MXPA01001721A/en
Priority to IL14123199A priority patent/IL141231A0/en
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to JP2000565869A priority patent/JP2002523364A/en
Priority to KR1020017002136A priority patent/KR20010079665A/en
Priority to BR9913071-8A priority patent/BR9913071A/en
Priority to SK235-2001A priority patent/SK2352001A3/en
Priority to EEP200100082A priority patent/EE200100082A/en
Publication of WO2000010547A2 publication Critical patent/WO2000010547A2/en
Publication of WO2000010547A3 publication Critical patent/WO2000010547A3/en
Priority to NO20010655A priority patent/NO20010655L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates a new use of taxoid derivatives. It relates more precisely to a method for treating abnormal cell proliferation of different resistant cell lines expressing multidrug resistance P-glycoprotein. This type of cells are representative of colon cancer cells. The products of the present invention are also usable to treat the colon cancer of mammals including men. The preferred compound is 4α-acetoxy-2α-benzoyloxy-5β, 20-epoxy-1β-hydroxy-7β-dimethoxy-9-oxo-11-taxen-13α-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate.
PCT/EP1999/006292 1998-08-20 1999-08-18 New use of taxoid derivatives Ceased WO2000010547A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
EEP200100082A EE200100082A (en) 1998-08-20 1999-08-18 Use of taxoid derivatives in the preparation of a medicament for the treatment of abnormal cell proliferation in broad-spectrum drug-resistant P-glycoprotein-expressing cell lines
JP2000565869A JP2002523364A (en) 1998-08-20 1999-08-18 Novel use of taxoid derivatives
EP99944532A EP1105119A2 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
HU0104000A HUP0104000A3 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
EA200100250A EA200100250A1 (en) 1998-08-20 1999-08-18 NEW APPLICATION OF TAXO DERIVATIVES
MXPA01001721A MXPA01001721A (en) 1998-08-20 1999-08-18 New use of taxoid derivatives.
IL14123199A IL141231A0 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
CA002341191A CA2341191A1 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
KR1020017002136A KR20010079665A (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
BR9913071-8A BR9913071A (en) 1998-08-20 1999-08-18 Use of a compound derived from taxoid
AU57420/99A AU5742099A (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
SK235-2001A SK2352001A3 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives
NO20010655A NO20010655L (en) 1998-08-20 2001-02-07 New use of taxoid derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98115650.8 1998-08-20
EP98115650A EP0982028A1 (en) 1998-08-20 1998-08-20 New use of taxoid derivatives
US12384399P 1999-03-11 1999-03-11
US60/123,843 1999-03-11

Publications (2)

Publication Number Publication Date
WO2000010547A2 WO2000010547A2 (en) 2000-03-02
WO2000010547A3 true WO2000010547A3 (en) 2000-06-29

Family

ID=26149552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/006292 Ceased WO2000010547A2 (en) 1998-08-20 1999-08-18 New use of taxoid derivatives

Country Status (15)

Country Link
EP (1) EP1105119A2 (en)
JP (1) JP2002523364A (en)
KR (1) KR20010079665A (en)
CN (1) CN1313764A (en)
AU (1) AU5742099A (en)
BG (1) BG105273A (en)
CA (1) CA2341191A1 (en)
EE (1) EE200100082A (en)
HU (1) HUP0104000A3 (en)
IL (1) IL141231A0 (en)
MX (1) MXPA01001721A (en)
NO (1) NO20010655L (en)
SK (1) SK2352001A3 (en)
TR (1) TR200100575T2 (en)
WO (1) WO2000010547A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2922107B1 (en) * 2007-10-10 2010-02-26 Aventis Pharma Sa NEW TAXOID COMPOSITIONS
PL2493466T3 (en) 2009-10-29 2021-11-15 Sanofi Mature Ip NEW ANTI-TUMBLE APPLICATION OF CABAZYTAXEL

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010169A1 (en) * 1992-10-30 1994-05-11 Rhone-Poulenc Rorer S.A. Method for preparing taxane derivatives
WO1996030355A1 (en) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof and pharmaceutical compositions containing same
WO1996032387A1 (en) * 1995-04-14 1996-10-17 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof, and pharmaceutical compositions containing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010169A1 (en) * 1992-10-30 1994-05-11 Rhone-Poulenc Rorer S.A. Method for preparing taxane derivatives
WO1996030355A1 (en) * 1995-03-27 1996-10-03 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof and pharmaceutical compositions containing same
WO1996032387A1 (en) * 1995-04-14 1996-10-17 Rhone-Poulenc Rorer S.A. Novel taxoids, preparation thereof, and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
WO2000010547A2 (en) 2000-03-02
NO20010655D0 (en) 2001-02-07
HUP0104000A3 (en) 2003-01-28
CN1313764A (en) 2001-09-19
BG105273A (en) 2001-11-30
NO20010655L (en) 2001-02-07
CA2341191A1 (en) 2000-03-02
EP1105119A2 (en) 2001-06-13
KR20010079665A (en) 2001-08-22
MXPA01001721A (en) 2005-06-03
TR200100575T2 (en) 2001-07-23
IL141231A0 (en) 2002-03-10
AU5742099A (en) 2000-03-14
EE200100082A (en) 2002-06-17
JP2002523364A (en) 2002-07-30
HUP0104000A2 (en) 2002-04-29
SK2352001A3 (en) 2001-07-10

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