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WO2000073270A8 - Remedies for periodontal diseases - Google Patents

Remedies for periodontal diseases

Info

Publication number
WO2000073270A8
WO2000073270A8 PCT/JP2000/003483 JP0003483W WO0073270A8 WO 2000073270 A8 WO2000073270 A8 WO 2000073270A8 JP 0003483 W JP0003483 W JP 0003483W WO 0073270 A8 WO0073270 A8 WO 0073270A8
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen
periodontal diseases
carboxyl
remedies
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2000/003483
Other languages
French (fr)
Japanese (ja)
Other versions
WO2000073270A1 (en
Inventor
Kenji Matsushita
Takahisa Imamura
Ikuro Maruyama
Munehiro Tomikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to AU51028/00A priority Critical patent/AU5102800A/en
Publication of WO2000073270A1 publication Critical patent/WO2000073270A1/en
Publication of WO2000073270A8 publication Critical patent/WO2000073270A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Preventive and/or therapeutic drugs for periodontal diseases containing as the active ingredient compounds of general formula (1) or salts thereof and being capable of preventing and/or treating effectively various periodontal diseases such as periodontitis, wherein R1 is hydrogen or the like; R2 is hydrogen, lower alkyl, or the like; R3 is hydrogen, carboxyl, or the like; R4 is hydrogen, halogeno, or the like; n is a number of 0 to 4; A is C¿1?-C4 alkylene which may be substituted with one or two members selected from among hydroxyalkyl, carboxyl, and alkoxycarbonyl, or the like, X is a single bond, oxygen, or the like; and Y is an optionally substituted, saturated or unsaturated, five- or six-membered heterocyclic group or the like.
PCT/JP2000/003483 1999-05-31 2000-05-31 Remedies for periodontal diseases Ceased WO2000073270A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51028/00A AU5102800A (en) 1999-05-31 2000-05-31 Remedies for periodontal diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11/151721 1999-05-31
JP15172199 1999-05-31

Publications (2)

Publication Number Publication Date
WO2000073270A1 WO2000073270A1 (en) 2000-12-07
WO2000073270A8 true WO2000073270A8 (en) 2001-03-01

Family

ID=15524843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/003483 Ceased WO2000073270A1 (en) 1999-05-31 2000-05-31 Remedies for periodontal diseases

Country Status (2)

Country Link
AU (1) AU5102800A (en)
WO (1) WO2000073270A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI761946A7 (en) * 1975-07-04 1977-01-05 Gaba Ag
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JPH06345360A (en) * 1993-06-02 1994-12-20 Fujita Corp Temporarily provided elevator
JPH07267839A (en) * 1994-03-30 1995-10-17 Sunstar Inc Ointment composition adhesive to oral mucosa
JPH0820532A (en) * 1994-07-05 1996-01-23 Dai Ichi Seiyaku Co Ltd Anti-pancreatitic agent
AU1208999A (en) * 1997-11-10 1999-05-31 Array Biopharma, Inc. Compounds which inhibit tryptase activity

Also Published As

Publication number Publication date
WO2000073270A1 (en) 2000-12-07
AU5102800A (en) 2000-12-18

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