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WO2000065061A3 - Nucleic acid sequences from candida yeasts which code cytochrome b5 polypeptides - Google Patents

Nucleic acid sequences from candida yeasts which code cytochrome b5 polypeptides Download PDF

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Publication number
WO2000065061A3
WO2000065061A3 PCT/DE2000/001246 DE0001246W WO0065061A3 WO 2000065061 A3 WO2000065061 A3 WO 2000065061A3 DE 0001246 W DE0001246 W DE 0001246W WO 0065061 A3 WO0065061 A3 WO 0065061A3
Authority
WO
WIPO (PCT)
Prior art keywords
cytochrome
polypeptides
code
nucleic acid
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2000/001246
Other languages
German (de)
French (fr)
Other versions
WO2000065061A2 (en
Inventor
Wolf-Hagen Schunck
Alexei Chernogolov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority to AU50602/00A priority Critical patent/AU5060200A/en
Publication of WO2000065061A2 publication Critical patent/WO2000065061A2/en
Publication of WO2000065061A3 publication Critical patent/WO2000065061A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to nucleic acid sequences from Candida yeasts, preferably from Candida maltosa, which code cytochrome b5 polypeptides, as well as to the corresponding cytochrome b5 polypeptides and their use for increasing the activity of cytochrome P450 systems, especially for stimulating the activity of alkane-hydroxylating and fatty acid-hydroxylating cytochrome P450 systems during the production of long-chained dicarboxylic acids (≥C10).
PCT/DE2000/001246 1999-04-24 2000-04-18 Nucleic acid sequences from candida yeasts which code cytochrome b5 polypeptides Ceased WO2000065061A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50602/00A AU5060200A (en) 1999-04-24 2000-04-18 Nucleic acid sequences from (candida) yeasts which code cytochrome b5 polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918763 1999-04-24
DE19918763.0 1999-04-24

Publications (2)

Publication Number Publication Date
WO2000065061A2 WO2000065061A2 (en) 2000-11-02
WO2000065061A3 true WO2000065061A3 (en) 2001-03-15

Family

ID=7905808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/001246 Ceased WO2000065061A2 (en) 1999-04-24 2000-04-18 Nucleic acid sequences from candida yeasts which code cytochrome b5 polypeptides

Country Status (3)

Country Link
AU (1) AU5060200A (en)
DE (1) DE10019864A1 (en)
WO (1) WO2000065061A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503734B1 (en) 2000-07-26 2003-01-07 Cognis Corporation Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002200A1 (en) * 1991-07-15 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Yeast strains with stable integration of heterologous genes
JPH07289252A (en) * 1994-04-28 1995-11-07 Sumitomo Chem Co Ltd Method for improving monoatomic oxygen addition activity of cytochrome P450
WO1996027678A1 (en) * 1995-03-03 1996-09-12 Max-Delbrück-Centrum für Molekulare Medizin Process for hydroxylating long-chain alkanes, fatty acids and other alkyl compounds
WO1999004014A2 (en) * 1997-07-21 1999-01-28 E.I. Du Pont De Nemours And Company Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993002200A1 (en) * 1991-07-15 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Yeast strains with stable integration of heterologous genes
JPH07289252A (en) * 1994-04-28 1995-11-07 Sumitomo Chem Co Ltd Method for improving monoatomic oxygen addition activity of cytochrome P450
WO1996027678A1 (en) * 1995-03-03 1996-09-12 Max-Delbrück-Centrum für Molekulare Medizin Process for hydroxylating long-chain alkanes, fatty acids and other alkyl compounds
WO1999004014A2 (en) * 1997-07-21 1999-01-28 E.I. Du Pont De Nemours And Company Transformed yeast strains and their use for the production of monoterminal and diterminal aliphatic carboxylates

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERTRAND, J.-C., ET AL.: "Isolation and characterization of cytochrome b5 from Candida tropicalis grown on alkane", BIOCHIMIE, vol. 64, 1982, pages 1041 - 1048, XP000961223 *
CYTOCHROME P-450: BIOCHEM. BIOPHYS., PROC. INT. CONF. BIOCHEM. BIOPHYS. CYTOCHROME P-450, 7TH (1992), MEETING DATE 1991, 492-4. EDITOR(S): ARCHAKOV, A. I.;BACHMANOVA, G. I. PUBLISHER: INCO-TNC, MOSCOW, RUSSIA. *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AVETISOVA, S. ET AL: "Localization and substrate specificity of the cytochrome P-450 monooxygenase system of Candida-- maltosa yeast", XP002154273, retrieved from STN Database accession no. 120:48609 CA *
MANJUNATH, S.S. ET AL.: "The Omega-Hydroxylation of Lauric Acid: Oxidation of 12-Hydroxylauric Acid to Dodecanedioic Acid by a Purified Recombinant Fusion Protein Containing P450 4A1 and NADPH-P450 Reductase", ARCH. BIOCHEM. BIOPHYS., vol. 330, no. 1, 1 June 1996 (1996-06-01), pages 199 - 208, XP000961198 *
PERRET, A. ET AL.: "Electron-Shuttle between Membrane-Bound Cytochrome P450 3A4 and b5 Rules Uncoupling Mechanisms", BIOCHEMISTRY, vol. 37, 1998, XP002154274 *

Also Published As

Publication number Publication date
WO2000065061A2 (en) 2000-11-02
DE10019864A1 (en) 2001-02-15
AU5060200A (en) 2000-11-10

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