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WO1999033437A1 - Composition de nettoyage des dents sous forme de comprime - Google Patents

Composition de nettoyage des dents sous forme de comprime Download PDF

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Publication number
WO1999033437A1
WO1999033437A1 PCT/US1997/024121 US9724121W WO9933437A1 WO 1999033437 A1 WO1999033437 A1 WO 1999033437A1 US 9724121 W US9724121 W US 9724121W WO 9933437 A1 WO9933437 A1 WO 9933437A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
tablet
toothpaste
present
tableting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/024121
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English (en)
Inventor
Ashok Premchand Luhadiya
Vikram Goel
Stanislaus Valerain D'souza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Priority to AU57257/98A priority Critical patent/AU5725798A/en
Priority to PCT/US1997/024121 priority patent/WO1999033437A1/fr
Publication of WO1999033437A1 publication Critical patent/WO1999033437A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms

Definitions

  • the present invention relates generally to a tooth cleaning composition. More particularly, the present invention relates to a tooth cleaning composition in tablet form comprising a polishing agent in combination with a tableting carrier.
  • a satisfactory dentifrice composition should clean and remove debris, thereby aiding the prevention of tooth decay and promoting gingival health.
  • cleaning agents such as abrasives, polishing aids and therapeutic aids.
  • the purpose of the use of these agents is to aid in removal of the film that tends to tightly adhere to the tooth enamel within minutes after eating and which, in many persons, contains pigments which color it brown or yellow.
  • Common practices to clean the teeth include "brushing" the teeth by applying cleaning products.
  • cleaning products There are various types or forms of cleaning products available, for example, pastes, gels, powders, and tablets.
  • the paste form is a common and popular form as a tooth cleaning product and generally is provided by filling laminate tubes with the paste. However, depending on the viscosity of the paste, which is generally high, it may be difficult to squeeze the last drop of the toothpaste from the tube sufficiently. The tubes may further tend to dent during the packing process or during shipment.
  • Tablet is a typical product form seen in various industries, especially in pharmaceuticals, because of the associated ease of manufacturing and handling, e.g., storing, carrying in bags, or using. Consumers often prefer to use tooth cleaning products which are easy to handle when traveling or paticipating in outdoor activities such as camping, sometimes more preferably without brushing. In addition, the convenience of tablets and the fact that water may not be necessary for their use may be desirable in other situations.
  • a variety of approaches for making toothpaste products in tablet form have been developed. See Aberg U.S. Patents 4,753,792 and 5,057,305 disclosing a tooth cleaning tablet that requires chewing the tablet.
  • tooth cleaning compostion in tablet form contain lower levels of water than those in conventional paste form. Due to such lower concentration of water, it is believed that the stability of the tablet products in view of microbial growth, drying out, liquid separation, discoloration, and the like, is improved.
  • the present invention is directed to a toothpaste tablet comprising: (a) from about 20 to about 80 % of a polishing agent; (b) from about 0.2 to about 5.5 % of a thickening agent; and (c) from about 30 to about 80 % of a tableting carrier.
  • the present invention relates to a toothpaste tablet comprising: (a) from about 20 to about 80 % of a polishing agent; (b) from about 0.2 to about 5.5 % of a thickening agent; and (c) from about 30 to about 80 % of a tableting carrier.
  • the tablet of the present invention provides desirable dissolution and disintegration of the tablet in a liquid form rapidly in the mouth when contacted with saliva, water, or both.
  • the dissolved form of the tablet of the present invention is preferably characterized by a thick form such as a paste like form, and can be used to clean the teeth without brushing, for example, by distributing the dissolved tablet around the inside of the mouth, such as by moving the tongue over the surface of the teeth or by swirling throughout the mouth.
  • the tablets can also provide better cost effectiveness for manufacturing and shipment than those in paste form, which tend to dent or deform as a result of having been packed into laminate tubes.
  • the tablet of the present invention further provides improved stability of the products due to containing low levels of water.
  • the tooth cleaning compostion in tablet form of the present invention includes a polishing agent.
  • the polishing agent generally tends for remove debris and reduce tooth decay.
  • the polishing agent of the present invention can be any material which cleans the teeth, removes debris, and/or remove the adhering layers of bacterial film without excessively abrading dentine from the teeth.
  • silicas including gels and precipitates, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, and resinous polishing materials such as particulate condensation products of urea and formaldehyde, and other such as disclosed by Cooley et al. U.S. Patent 3,070,510, incorporated herein by reference.
  • silica polishing agents provide the unique benefits of exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentine.
  • Silica polishing agents are exceptionally compatible with sources of soluble fluoride and polyphosphonates. For these reasons they are preferred for use herein.
  • the silica polishing agents useful herein which can be used alone or in combination with other polishing agents, generally have an average particle size ranging from between about 0.1 to about 30 microns, preferably between about 5 and about 15 microns.
  • the silica polishing agent can be precipitated silica or silica gels such as the silica xerogels described in Pader et al. U.S. Patent
  • the amount of polishing agent herein is present at a level of from about 20% to about 80%, preferably from about 35% to about 70%.
  • the tooth cleaning composition in tablet form of the present invention also includes a thickening agent. These agents can provide a desirable consistency when the toothpaste tablet of the present invention is dissolved in the mouth.
  • Nonlimiting examples of the thickening agents herein include, pregelatinized starch, gums such as agars, locust bean gums, guar gums, and tara gums, carrageenan, alginate, xanthan, dextran, cellulose derivatives such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose. Natural gums such as gum karaya, gum arabic, and gum tragacanth can also be used. Synthetic silicates such as colloidal magnesium aluminum silicate or finely divided silica can be used as part of the thickening agent to further improve texture.
  • the thickening agent is preferably present from about 0.2% to about 5.5% by weight of the total composition.
  • the toothpaste tablet of the present invention includes a tableting carrier.
  • Tabletting carrier means a material which is used for making tablets that provide desirable dissolution and disintegration in the mouth.
  • the tableting carrier is selected depending upon its compatibility with the other ingredients, especially the polishing agent, and the desired characteristic of the product.
  • the tableting carrier is present at an effective level, preferably at a level of from about 20% to about 80%, more preferably from about 38% to about 65% by weight.
  • the tableting carriers useful herein include those selected from the group consisting of sugar, sugar alcohols, and mixtures thereof.
  • sugars useful herein include lactose, glucose, maltodextrins, and sucrose.
  • Sugar alcohols useful herein include sorbitol, xylitol, mannitol and maltitol.
  • the tableting carrier herein is sugar alcohol in combination with lower level of sugar, preferably from about 5 to about 50 % of sugar and from about 5 to about 60 % of sugar alcohol.
  • a preferred combination of the tableting carriers in the present invention is mannitol with a lower level of sucrose.
  • the tableting carrier of the present invention may further include a binding agent, if needed.
  • a binding agent such as mannitol
  • the levels and types of binding agent are selected depending upon the character of the carriers, compatibility with other components, and desired characteristic of the final product.
  • some tableting carriers of the present invention may also have properties as a binding agent for making tablets.
  • tableting carriers herein preferably sugar
  • useful binding agents other than those described as tableting carriers above include starches such as starch paste and pregelatinized starch, polyvinylpyrrolidone, cellulose derivatives, gelatin, gums, and mixtures thereof.
  • the binding agent and the tableting carrier may be made of the same material. Alternatively, the binding agent and the tableting carrier may be altogether different.
  • the binding agents may be present in an effective amount, preferably from about 0.1% to about 5% by weight, more preferably from about 0.5% to about 3%.
  • the toothpaste tablet of the present invention can further include one or more therapeutic agents as dental actives.
  • “Therapeutic agents” herein means agents for prevention and treatment of dental caries or periodontal diseases of the soft tissues of the oral cavity.
  • the therapeutic agents useful for the present invention are selected from the group consisting of an anticaries agent, an anticalculus agent, an antimicrobial agent, an anti-inflammatory agent, and mixtures thereof.
  • anticaries agents as therapeutic agents herein include, but are not limited to, a water-soluble fluoride ion source.
  • the number of such fluoride ion sources is great, and see Norris et al. U.S. Patent 2,946,735, Briner & Widder U.S. Patent 3,535,421 , and Widder et al. U.S. Patent 3,678,154, all of which are incorporated herein by reference.
  • Preferred fluoride ion source materials include: sodium fluoride, potassium fluoride, indium fluoride, stannous fluoride, and sodium monofluorophosphate and mixtures thereof.
  • Sodium fluoride is the preferred fluoride ion source.
  • the amount of the fluoride ion source in the compositions of the present invention, if present, is preferably sufficient to provide from about 0.005% to about 0.35%, more preferably from about 0.05% to about 0.3% of fluoride ions in the compositions.
  • the toothpaste tablet of the present invention can include one or more anticalculus agents as the therapeutic agent, on the condition that they are compatible with the other components of the toothpaste tablets.
  • Anticalculus agents which may be useful herein include, but are not limited to, diphosphonates such as 1 -azocycloheptane-2,2-diphosphonate (AHP) and ethane-1-hydroxy-1 ,1-diphosphonate (EHDP), sodium zinc citrate, phosphocitrate, tripolyphosphate, and linear polycarboxylate (LPC); pyrophosphates or polyphosphates, see Parran & Sakkab U.S. Patent 4,590,066 (e.g.
  • tetrasodium pyrophosphate tetrapotassium pyrophosphate, and dihydrogen disodium pyrophosphate
  • polyacrylates and other polycarboxylates see Shedlovsky U.S. Patent 3,429,963, and Chang U.S. Patent 4,304,766; and Benedict & Sunberg U.S. Patent 4,661 ,341 ; polyepoxysuccinates, see Benedict U.S. Patent 4,846,650; ethylenediaminetetraacetic acid, see British Patent No. 490,384; nitrilotriacetic acid and related compounds, see Widder & Briner U.S. Patent 3,678,154; polyphosphonates see Francis U.S.
  • the anticalculus agents generally comprise from about 0.2% to about 13%, preferably from about 0.4% to about 6%, of the compositions of the present invention.
  • Preferred anticalculus agents are pyrophosphates.
  • Antimicrobial agents include compounds which can be employed as antiplaque agents and antibacterial agents. Antimicrobial agents herein can be present in the toothpaste tablet on the condition that they are compatible with the other ingredients and/or compounds included. Such agents may be noncationic and substantially water insoluble; that is, solubility is less than about 1% by weight in water at 25°C. Nonlimiting examples of the antimicrobial agents herein include triclosan, 2,4,4'- trichloro-2'-hydroxydiphenyl ether, as described The Merck Index, 11th Ed. (1989), p. 1520 (entry No. 9573); in U.S. Pat. No.
  • TPC tetradecylpyridinium chloride
  • TDEPC N- tetradecyl-4-ethylpyridinium chloride
  • octenidine delmopinol, octapinol, and other piperidino derivatives
  • octenidine delmopinol, octapinol, and other piperidino derivatives
  • octenidine delmopinol, octapinol, and other piperidino derivatives
  • octenidine delmopinol, octapinol, and other piperidino derivatives
  • octapinol octapinol, and other piperidino derivatives
  • octenidine delmopinol, octapinol, and other piperidino derivatives
  • octapinol octapinol, and other piperidino derivatives
  • octenidine de
  • stannous salts such as stannous pyrophosphate and stannous gluconate and antimicrobials such as quaternary ammonium salts, such as cetyl pyridinium chloride and tetradecylethyl pyridinium chloride, bis-biquanide salts, copper bisglycinate, nonionic anti microbial salts and flavor oils.
  • antimicrobial agents may comprise from about 0.01% to about 6%, preferably from about 0.1% to about 5% by weight of the compositions of the present invention.
  • anti-inflammatory agents include herein, but are not limited to, aspirin, acetaminophen, ibuprofen, naproxen, indomethacin, piroxicam, meclofenamate sodium, tenidap, tebufelone, benoxaprofen, flurbiprofen, ketoprofen, ketorolac, etodolac, fenoprofen, fenbufen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofen, their pharmaceutically-acceptable salts, and mixtures thereof.
  • the typical concentrations of anti-inflammatory agents in the dental compositions of the present invention are from about 0.004% to about 20%, preferably from about 0.02% to about 4%, more preferably from about 0.04% to about 2%, and most preferably from about 0.2% to about 0.8% of the compositions of the present invention.
  • the toothpaste tablet of the present invention may further include an oral carriers.
  • Oral carrier means one or more compatible solid or liquid substances which are suitable for oral administration to a human.
  • the oral carriers must be of sufficiently high purity and sufficiently low toxicity to render them suitable for administration to human beings.
  • the oral carrier herein include a surfactant, an effervescent agent, a humectant, a tableting aid, a sweetening agent, a flavoring agent, a coloring agent, a preservative, a cooling agent, a buffering agent, and mixtures thereof.
  • Surfactant The toothpaste tablet of the present invention may include a surfactant as the oral carrier.
  • Surfactants used for emulsif ⁇ cation herein are those which are reasonably stable and foam throughout a wide pH range.
  • the surfactants useful herein include anionic surfactants; nonionic surfactants produced by the condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic such as aliphatics or alkylaromatics in nature; cationic such as aliphatic quaternary ammonium compounds having one long alkyl chain containing from about 8 to 18 carbons; and zwitterionic and amphoteric synthetic surfactants such as derivatives of aliphatic quaternary ammonium, phos- phomium, and sulfonium compounds, preferably those sodium and potassium salts.
  • Preferred surfactants useful herein are anionic surfactants including the water-soluble salts, sodium or potassium salts of alkyl sulfates having from 10 to 18 carbon atoms in the alkyl radical and sulfonated monoglycerides of fatty acids having from 10 to 18 carbons.
  • Sodium lauryl sulfate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type. Mixtures of anionic surfactants can also be utilized.
  • Betaine surfactants can also be used for the composition of the present invention.
  • the betaine surfactants herein include alkyl dimethyl betaines include decyl betaine or 2-(N-decyl-N,N-dimethylammonio) acetate, coco betaine or 2-(N- coc-N, N-dimethyl ammonio) acetate, myristyl betaine, palmityl betaine, lauryl betaine, cetyl betaine, stearyl betaine, etc.
  • the amidobetaines are exemplified by cocoamidoethyl betaine, cocoamidopropyl betaine, lauramidopropyl betaine and the like.
  • the betaines of choice are preferably the cocoamidopropyl betaine and, more preferably, the lauramido propel betaine. See Polefka et al. U.S. Patent 5,180,577.
  • the surfactants are generally used at levels of from about 0.035% to about 7.0% by weight. 2. Effervescent agent
  • the toothpaste tablet of the present invention may include an effervescent agent to provide bubbles which are sometimes desired for aesthetic purposes.
  • "Effervescent agent” herein means a material that provides effervescence by the reaction of a carbonate source with an acidic source, for example, in the combination of a carbonate salt and a carboxylic acid. Any ingredients which would be useful conventionally as an effervescence agent in the pharmaceutical area may be acceptable herein.
  • the carbonate sources herein include calcium carbonate, sodium carbonate, and sodium bicarbonate.
  • Preferred acid sources useful herein include a citric acid, and a malic acid.
  • the effervescent agent may be present at levels of from about 0.5 to about 20% by weight.
  • humectant material in the toothpaste tablet of the present invention to keep it from hardening upon exposure to air and to give the tablet a moist feel to the mouth.
  • Suitable humectants include polyethylene glycol, sorbitol, xylitol, other edible polyhydric alcohols, and mixtures thereof, at a level of from about 0% to about 70%, preferably from about 2% to about 55%, by weight.
  • Tableting aids can be added in order to facilitate forming the toothpaste tablets.
  • tablettes refers to an ingredient that is generally added to the granules in small quantities, to provide flowability to the granules, to reduce friction, and/or to ease removal of the tablets from the tableting machine.
  • the tableting aids useful herein include, for example, magnesium stearate, stearic acid, aerosol, talc, and mixtures thereof.
  • the tableting aid of the compositions of the present invention is preferably present in an amount sufficient to prevent the tablet from sticking to the machine and improve flow characteristic of the compression mixture.
  • the tabelting aids are present at levels from about 2% to about 8%. 5.
  • Sweetening agents can be added to the present compositions. These include aspartame, acesulfame, sodium saccharin, dextrose, sucrose, lactose, maltose, xylitol, levulose, thaumatin, dihydrochalcones, sodium cyclamate and mixtures thereof. Sweetening agents are generally useful herein the toothpaste tablet at levels of from about 0.05% to about 2%. 6. Flavoring agents
  • Flavoring agents can also be added to the toothpaste tablet of the present invention.
  • flavoring agents useful in the present invention include oil of peppermint, oil of sassafras, clove bud oil, peppermint, menthol, anethole, thymol, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, oil of wintergreen, alpha-irisone, oil of spearmint, marjoram, lemon, orange, propenyl guaethol, cinnamon, and mixtures thereof.
  • Flavoring agents are generally used in the toothpaste tablet at levels of from about 0.01% to about 5% by weight of the composition. 7. Coloring agent
  • the composition may further include a coloring agent. Titanium dioxide which is a white pigment in powder form may also be added.
  • the coloring agent including titanium dioxide may be present at an effective level from about 0.025% to about 1%. 8. Preservatives
  • preservatives prevent microbial growth in the compositions.
  • Suitable preservatives include methylparaben, propylparaben, and benzoates.
  • the preservatives generally comprise from about 0% to about 5%, preferably from about 0.1% to about 2%.
  • Suitable cooling agents are those described in Watson et al. U.S. Patent 4,136,163, Rowsell et al. U.S. Patents 4,032,661 and 4,230,688, and Grub et al. U.S. Patent 5,266,592, all of which are herein incorporated by reference.
  • Particularly preferred cooling agents include N-ethyl-p-menthane-3-carboxamide outlined by the above incorporated U.S. Patent 4,136,163 and N,2,3-trimethyl-2- isopropylbutanamide which is stated by the above incorporated U.S. Patent 4,230,688.
  • Another particularly preferred cooling agent is 3-1-menthoxypropane 1 ,2-diol. See Amano et al. U.S. Patent 4,459,425.
  • the cooling agent generally comprise from about 0% to about 5%, preferably from about 0.1 % to about 2%.
  • the toothpaste tablet herein may also include a buffering agent.
  • Buffering agents refer to agents that can be used to adjust the pH of the compositions to a range of about pH 7 to about pH 9. These agents include mono and trisodium phosphate, sodium carbonate, tris(hydroxymethyl)aminomethane, tetra and disodium pyrophosphate and tetrapotassium pyrophosphate, at a level of from about 0.5% to about 10%.
  • the resulting toothpaste tablets dissolve and/or disintegrate smoothly when contacted with saliva, water, or both and produce little to no gritty sensation in the user's mouth.
  • the toothpaste tablets of the present invention can be produced by any method useful for forming conventional tablets known in the art. These conventional methods include granulating methods: either wet or dry granulating method, preferably wet granulating. Depending on the properties of the ingredients (e.g., polishing agents, tableting carriers, flavors, coloring agents, and the like) to be formulated into granules, one method may provide a more favorable end product over the other method.
  • the wet granulation method is widely used and usually produces the most satisfactory results in tablets. See E.J. de Jong; "The preparation of microgranulates, an improved tableting technique," Pharmaceutical Weekblad, 104(23), pages 469-474, 1969 and E.J. de Jong, U.S. Patent 3,266,992. Direct compression without granulation step may also be chosen for the present composition, as long as producing non-gritty tablets does not cause capping.
  • a method for making a toothpaste tablet of the present invention comprises:
  • polishing agents and tableting carriers such as sugar, sugar alcohol, and any of oral carriers (e.g., coloring agent), if needed, to make granules;
  • step (4) mixing the granules of step (4) with oral carriers other than those of step(1) (e.g., thickening agent, sweetening agent, flavour, tableting aids); and
  • step (6) compressing the mixture of step (5) to form tablets by conventional method.
  • the toothpaste tablets of the present invention can be used to clean the teeth by:
  • the embodiments disclosed and represented by the present examples have many advantages. For example, they can provide improved dissolution and disintegration properties of tablet in a liquid form rapidly in the mouth when contacted with saliva, water, or both without the need to chew the tablet or use a brush to effect cleaning of the teeth.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un comprimé de dentifrice comprenant: (a) environ 20 à environ 80 % d'un agent de polissage; (b) environ 0,2 à environ 5,5 % d'un agent épaississant; (c) environ 30 à environ 80 % d'un excipient à comprimés.
PCT/US1997/024121 1997-12-29 1997-12-29 Composition de nettoyage des dents sous forme de comprime Ceased WO1999033437A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU57257/98A AU5725798A (en) 1997-12-29 1997-12-29 Tooth cleaning composition in tablet form
PCT/US1997/024121 WO1999033437A1 (fr) 1997-12-29 1997-12-29 Composition de nettoyage des dents sous forme de comprime

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/024121 WO1999033437A1 (fr) 1997-12-29 1997-12-29 Composition de nettoyage des dents sous forme de comprime

Publications (1)

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WO1999033437A1 true WO1999033437A1 (fr) 1999-07-08

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084500A1 (fr) * 2002-04-11 2003-10-16 Beiersdorf Ag Emulsions de nettoyage moussantes contenant de l'amidon
WO2007098809A1 (fr) * 2006-03-03 2007-09-07 Symrise Gmbh & Co. Kg Agglomérats pressés adaptés à la consommation qui présentent une libération retardée d'arôme
US7279449B2 (en) 2002-04-11 2007-10-09 Beiersdorf Ag Hair shampoo containing pregelatinized, cross-linked starch derivatives
WO2007122146A1 (fr) * 2006-04-26 2007-11-01 Unilever Plc Dentifrice
WO2009009953A1 (fr) * 2007-07-16 2009-01-22 Waiming Wong Composition de comprimé pour gargarisme par voie orale et son procédé de préparation
WO2014085331A1 (fr) * 2012-11-27 2014-06-05 Breathalyzer Equalizer, LLC Composition d'égalisation d'alcool de l'air expiré
EP2296612A4 (fr) * 2008-07-07 2015-03-04 Obthestvo S Ogranichennoyj Otvetstvennostjyu Wds Formulation thérapeutique et prophylactique pour soin buccal
WO2015094153A1 (fr) * 2013-12-16 2015-06-25 Colgate-Palmolive Company Compositions de soins buccaux comprenant du carbonate de calcium et du talc
US20190133893A1 (en) * 2017-07-20 2019-05-09 Oscar E. Recio Saucedo Tooth Paste Gummy
US20190343737A1 (en) * 2018-05-14 2019-11-14 The Procter & Gamble Company Oral Care Compositions Comprising Fluoride Ions
WO2020172424A1 (fr) * 2019-02-20 2020-08-27 One Home Brands, Inc. Formulation de concentré de dentifrice anhydre stable et son procédé de production
IT201900019986A1 (it) * 2019-10-29 2021-04-29 Perfetti Van Melle Spa Prodotto di confetteria per lo sbiancamento ottico istantaneo dei denti
US11911492B2 (en) 2018-05-14 2024-02-27 The Procter & Gamble Company Oral care compositions comprising metal ions
RU2834230C1 (ru) * 2019-10-29 2025-02-04 Перфетти Ван Мелле С.П.А. Кондитерское изделие для мгновенного оптического отбеливания зубов

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431339A (en) * 1966-07-20 1969-03-04 Colgate Palmolive Co Dentifrices
US3962417A (en) * 1974-03-27 1976-06-08 Howell Charles J Dentifrice
GB2163348A (en) * 1984-08-21 1986-02-26 Dentab U K Limited Tooth cleaning tablet

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431339A (en) * 1966-07-20 1969-03-04 Colgate Palmolive Co Dentifrices
US3962417A (en) * 1974-03-27 1976-06-08 Howell Charles J Dentifrice
GB2163348A (en) * 1984-08-21 1986-02-26 Dentab U K Limited Tooth cleaning tablet

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003084500A1 (fr) * 2002-04-11 2003-10-16 Beiersdorf Ag Emulsions de nettoyage moussantes contenant de l'amidon
US7279449B2 (en) 2002-04-11 2007-10-09 Beiersdorf Ag Hair shampoo containing pregelatinized, cross-linked starch derivatives
WO2007098809A1 (fr) * 2006-03-03 2007-09-07 Symrise Gmbh & Co. Kg Agglomérats pressés adaptés à la consommation qui présentent une libération retardée d'arôme
US8524294B2 (en) 2006-03-03 2013-09-03 Symrise Ag Pressed agglomerates suitable for consumption having retarded aroma release
WO2007122146A1 (fr) * 2006-04-26 2007-11-01 Unilever Plc Dentifrice
WO2009009953A1 (fr) * 2007-07-16 2009-01-22 Waiming Wong Composition de comprimé pour gargarisme par voie orale et son procédé de préparation
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