[go: up one dir, main page]

WO1999023070A8 - N-acetylserotonin derivatives and uses thereof - Google Patents

N-acetylserotonin derivatives and uses thereof

Info

Publication number
WO1999023070A8
WO1999023070A8 PCT/US1998/023206 US9823206W WO9923070A8 WO 1999023070 A8 WO1999023070 A8 WO 1999023070A8 US 9823206 W US9823206 W US 9823206W WO 9923070 A8 WO9923070 A8 WO 9923070A8
Authority
WO
WIPO (PCT)
Prior art keywords
acetylserotonin
derivatives
compounds
treatment
nas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/023206
Other languages
French (fr)
Other versions
WO1999023070A1 (en
Inventor
Gregory F Oxenkrug
Pura J Requintina
Sergei O Bachurin
Andrey Zakharovic Afanasiev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Elizabeths Medical Center of Boston Inc
Original Assignee
St Elizabeths Medical Center of Boston Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Elizabeths Medical Center of Boston Inc filed Critical St Elizabeths Medical Center of Boston Inc
Priority to AU16988/99A priority Critical patent/AU1698899A/en
Publication of WO1999023070A1 publication Critical patent/WO1999023070A1/en
Publication of WO1999023070A8 publication Critical patent/WO1999023070A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to pharmaceutically active compounds, including derivatives of N-acetylserotonin (NAS), and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment of hypertension.
PCT/US1998/023206 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof Ceased WO1999023070A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16988/99A AU1698899A (en) 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6457597P 1997-11-04 1997-11-04
US60/064,575 1997-11-04

Publications (2)

Publication Number Publication Date
WO1999023070A1 WO1999023070A1 (en) 1999-05-14
WO1999023070A8 true WO1999023070A8 (en) 1999-07-01

Family

ID=22056900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023206 Ceased WO1999023070A1 (en) 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof

Country Status (2)

Country Link
AU (1) AU1698899A (en)
WO (1) WO1999023070A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562858B2 (en) 1999-05-17 2003-05-13 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression
US6239162B1 (en) 1999-05-17 2001-05-29 St. Elizabeth's Medical Center Method for treating depression
ES2172415B2 (en) * 2000-07-28 2003-11-16 Univ Madrid Complutense TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION THROUGH A MELATONINE ANALOG.
US20070088073A1 (en) * 2005-10-19 2007-04-19 Allergan, Inc. Method for treating pain
US7902251B2 (en) 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
US20190016680A1 (en) 2016-01-14 2019-01-17 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255199B (en) * 1992-07-01 1995-10-20 Franco Fraschini SYNTHESIZED DRUG ANALOG OF MELATONIN PARTICULARLY EFFECTIVE IN THE PATHOLOGIES THAT INTERFER WITH CIRCADIAN RHYTHMS
WO1998044924A1 (en) * 1997-04-04 1998-10-15 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression, obsessive compulsive disorder or anxiety
WO1998044796A1 (en) * 1997-04-04 1998-10-15 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating hypertension

Also Published As

Publication number Publication date
WO1999023070A1 (en) 1999-05-14
AU1698899A (en) 1999-05-24

Similar Documents

Publication Publication Date Title
MY133996A (en) Compounds for the treatment of ischemia
BE2015C026I2 (en) 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens
WO1999043651A3 (en) Inhibitors of phospholipase enzymes
AU5669398A (en) Novel cyclosporin derivatives, method of preparation and pharmaceutical compositions containing them
HUP0200309A3 (en) Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them
BG106030A (en) Pharmaceutical composition
CA2303498A1 (en) Dioxocyclopentyl hydroxamic acids
WO2000066104A3 (en) Ace-2 inhibiting compounds and methods of use thereof
ATE272628T1 (en) SUBSTITUTED GAMMA-PHENYL-DELTA-LACTONES AND ANALOGUES THEREOF, AND USES THEREOF
AU4155897A (en) Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles
IE840301L (en) Benzazocinone and benzazoninone derivatives
TR199801861T2 (en) Pharmaceutically useful compositions.
IL161582A0 (en) Use of oxindole hydrazide derivatives for the preparation of pharmaceutical compositions, certain such new derivatives and their preparation
WO1997029739A3 (en) Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors
CA2378428A1 (en) Use of cgrp antagonists and cgrp release inhibitors for combating menopausal hot flushes
EP1032556A4 (en) Pharmaceutically active compounds and methods of use
CA2161533A1 (en) Indole Derivatives
AU6469401A (en) Pharmaceutically active compounds and methods of use
CA2236641A1 (en) Preparation of fagopyritols and uses therefor
WO2000040232A3 (en) Bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
CA2282279A1 (en) Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
AU5239999A (en) Heterocyclyl sulphonamide derivatives
WO1999023070A8 (en) N-acetylserotonin derivatives and uses thereof
AU9157698A (en) Piperazine derivatives active on the lower urinary tract
ZA979647B (en) Heterocyclic compounds, compositions and uses.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: C1

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase in:

Ref country code: CA