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WO1999065526A1 - Composition d'onguent s'utilisant en application locale pour traiter les brulures - Google Patents

Composition d'onguent s'utilisant en application locale pour traiter les brulures Download PDF

Info

Publication number
WO1999065526A1
WO1999065526A1 PCT/BR1998/000031 BR9800031W WO9965526A1 WO 1999065526 A1 WO1999065526 A1 WO 1999065526A1 BR 9800031 W BR9800031 W BR 9800031W WO 9965526 A1 WO9965526 A1 WO 9965526A1
Authority
WO
WIPO (PCT)
Prior art keywords
fact
burn treatment
topical ointment
composition
treatment according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR1998/000031
Other languages
English (en)
Inventor
Alfred Louis Bagos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR9604441A priority Critical patent/BR9604441A/pt
Application filed by Individual filed Critical Individual
Priority to PCT/BR1998/000031 priority patent/WO1999065526A1/fr
Publication of WO1999065526A1 publication Critical patent/WO1999065526A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Definitions

  • the present invention relates to the direct treatment of burns by means of a topical burn treatment composition.
  • the present invention describes a process to prepare a medicinal formulation in the form of a cream or ointment that, when spread over the injured skin area efficiently promotes the restoration of the skin tissue within a short time, even in cases in which the skin has been severely damaged.
  • compositions for topical use are commercially available, said compositions having anaesthetic properties combined with one of the following: bactericidal, anti-inflammatory or hydrating. Said compositions are employed to lessen the pain consequent to the burn, avoid the onset of infection and provide proper hydration conditions leading to the regeneration of the skin structures that have been damaged and dehydrated by intense and localized heat.
  • US patent 4500511 describes the preparation of an analgesic and antiinflamatory gel composition employing as the pharmacologically active ingredient 6-chloro-5-cyclohexalindanoic acid, commercially known as Clidanac.
  • the principal object of the present invention is to provide a process to prepare a medicinal composition having the form of an ointment or cream, simultaneously comprising active components with bactericidal, analgesic, keratolytic and tissue regeneration activating actions, as well as warding off pathogenic conditions due to infection and furnishing the necessary hydration and activation conditions conducive to restoration of the damaged skin structures.
  • Another object of the invention is to provide a medicinal ointment or cream comprising components that enhance the absorption or permeation of the active components in sufficient concentration, as well as a duration of time of contact with the afflicted tissues sufficient for the speedy and efficient regeneration of said tissues.
  • It is yet another object of the invention to provide a medicinal ointment or cream composition comprising components that enhance the absorption or permeation of active components in sufficient concentration to achieve local anaesthesia, relieving the pain and the itching that afflict patients suffering from burns. It is a further object of the invention to provide a medicinal ointment or cream comprising aromatic components that impart to the injured patient a pleasant sensation in the course of the recovery.
  • the above objects are achieved by means of a composition
  • a composition comprising from 8% to 15% by weight of a local anaesthetic, from 1% to 8% by weight of a keratolytic and aromatic compound, from 10% to 40 by weight of a mixture of metallic salt and oxide having bactericidal and regenerative effects, as well as a mixture of natural organic extracts conducive to skin hydration and enhancement of the active components permeation or absorption through the skin barrier. Therefore, in addition to the bactericidal, anaethetic, keratolytic, regeneration activating, hydrating and aromatic actions, the composition provides means that enhance the absorption and/or permeation of the active components thorough the skin.
  • a process to prepare a medicinal composition in the form of an ointment or cream comprising the following steps: • mixing the salt and the oxide, such as, for example, zinc chloride, cerium nitrate, bismuth oxide, bismuth subnitrate or zinc oxide, comprising from about 4 to about 10 weight percent of the salt and from about 6 to about 30 weight percent of the oxide, in about 35 to about 55 weight percent fluid hammamelis extract to which about 0,5 to about 2 weight percent wood derived tar such as Archangel or Sweden tar has been previously mixed.
  • the oxide such as, for example, zinc chloride, cerium nitrate, bismuth oxide, bismuth subnitrate or zinc oxide
  • the above composition may comprise the addition of one or more of the components in ointment form.
  • Table II shows the above mentioned characteristics for the four exemplificative embodiments.
  • the affected area is first washed with physiological saline solution. Then the ointment is spread so as to cover thoroughly said harmed area, which is then dressed with sterile gauze.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une composition d'onguent s'utilisant en application locale pour traiter les brûlures. Cet onguent, qui a la consistance d'une pommade ou d'une crème, est destiné à soigner les tissus de la peau, et plus particulièrement les blessures infligées à la peau par brûlure. A cet effet, cet onguent provoque une régénération rapide et efficace des zones lésées de la peau. La réalisation préférée de la composition comprend un mélange de différents principes actifs, et notamment un bactéricide, un anesthésique, un kératolytique, un hydratant, un activateur de la régénération tissulaire, de l'absorption tissulaire et de la perméabilité tissulaire, ainsi qu'un agent aromatisant.
PCT/BR1998/000031 1996-10-23 1998-06-15 Composition d'onguent s'utilisant en application locale pour traiter les brulures Ceased WO1999065526A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR9604441A BR9604441A (pt) 1996-10-23 1996-10-23 Pomada para queimaduras
PCT/BR1998/000031 WO1999065526A1 (fr) 1996-10-23 1998-06-15 Composition d'onguent s'utilisant en application locale pour traiter les brulures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR9604441A BR9604441A (pt) 1996-10-23 1996-10-23 Pomada para queimaduras
PCT/BR1998/000031 WO1999065526A1 (fr) 1996-10-23 1998-06-15 Composition d'onguent s'utilisant en application locale pour traiter les brulures

Publications (1)

Publication Number Publication Date
WO1999065526A1 true WO1999065526A1 (fr) 1999-12-23

Family

ID=25664775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR1998/000031 Ceased WO1999065526A1 (fr) 1996-10-23 1998-06-15 Composition d'onguent s'utilisant en application locale pour traiter les brulures

Country Status (2)

Country Link
BR (1) BR9604441A (fr)
WO (1) WO1999065526A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008035085A1 (fr) * 2006-09-22 2008-03-27 Syntopix Limited Formulations antimicrobiennes
US20150132240A1 (en) * 2010-11-15 2015-05-14 Barry Knapp Topical Composition And Method For Skin Treatment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HELWIG H., OTTO H. H., Arzneimittel, 8th Edition, Vol. I, Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, 1992, pages 22-2 to 22-17 and 22-29 to 22-31 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008035085A1 (fr) * 2006-09-22 2008-03-27 Syntopix Limited Formulations antimicrobiennes
US20150132240A1 (en) * 2010-11-15 2015-05-14 Barry Knapp Topical Composition And Method For Skin Treatment

Also Published As

Publication number Publication date
BR9604441A (pt) 1998-06-23

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