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WO1999044440A1 - Compositions alimentaires pour prevenir la parodontose ou la progression de la parodontose et methode de prevention et de traitement de la parodontose - Google Patents

Compositions alimentaires pour prevenir la parodontose ou la progression de la parodontose et methode de prevention et de traitement de la parodontose Download PDF

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Publication number
WO1999044440A1
WO1999044440A1 PCT/JP1999/000981 JP9900981W WO9944440A1 WO 1999044440 A1 WO1999044440 A1 WO 1999044440A1 JP 9900981 W JP9900981 W JP 9900981W WO 9944440 A1 WO9944440 A1 WO 9944440A1
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Prior art keywords
extract
calcium
preventing
food composition
periodontal disease
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English (en)
Japanese (ja)
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Miwako Murashima
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Sunstar Inc
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Sunstar Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a novel food composition for preventing periodontal disease or preventing progression of periodontal disease and a method for preventing or treating periodontal disease.
  • Periodontal disease is an infectious disease caused by a specific periodontal pathogen, and a bacterium known as a periodontal pathogen is represented by P. porphyromonas zinzino'risu. Gram-negative anaerobic bacteria. These bacteria grow in the oral cavity in plaques attached to the root surface of the cervix, causing chronic inflammation in surrounding tissue areas, including the gums, periodontal ligament and alveolar bone. Rather, it causes periodontal disease. From this point of view, as one of the means to prevent periodontal disease, attempts have been made to suppress the growth of periodontal pathogens using antibacterial agents. Specifically, chronorehexidine is used.
  • Synthetic antibacterial agents such as and cetinorepirinidium chloride, have been blended into dentifrices and mice, and their effects have been confirmed. In addition, these synthetic antibacterial agents are also incorporated into lozenges (troches), and are used in the mouth and throat. Drugs intended for sterilization are commercially available.
  • periodontal disease is an oral disease that tends to recur once it occurs, so long-term use of the drug is considered.In such cases, it is preferable to use a highly safe antibacterial agent .
  • the antibacterial activity is as weak as 1 Z10 times to 1 Z100 times, and the concentration range in which the effect can be exerted in the oral cavity is too high.
  • periodontal disease is a disease in which the resorption of the alveolar bone supporting teeth progresses due to chronic inflammation caused by periodontal pathogens, and is the largest cause of tooth loss in developed countries. ing. Calcium also maintains or enhances alveolar bone calcium levels in growing children, pregnant women, etc. Nutrients that are necessary for
  • soybean isoflavonoid extract contains abundant components having a natural bone metabolism improving effect in addition to components having antibacterial properties.
  • the trade names OsteoSoy (FreeLif e, U.S.A.) and Soylife (Schouten, U.S.A.) extract the soybean isoflavone extract from calcium salt, vitamin Combined with D and sold as an oral nutritional supplement for osteoporosis prevention and whole-body bone strengthening.
  • OsteoSoy FreeLif e, U.S.A.
  • Soylife Korean, U.S.A.
  • FIG. 1 is a diagram showing the results of Test Example 1 described below.
  • Figure 2 shows the alveolar bone resorption distance in Test Example 2 described below.
  • FIG. 3 is a diagram showing the plaque deposition area in Test Example 2 described later. Disclosure of the invention
  • An object of the present invention is to provide a food composition having high safety and practical prevention of periodontal disease or prevention of progression of periodontal disease.
  • the present inventor found that a composition containing a highly soluble calcium salt and an antibacterial plant extract was obtained.
  • the antibacterial plant extract is surprisingly unexpected.
  • the substance was found to adhere to the cervix at a high concentration and remained, and the antibacterial activity was sustained.
  • the present invention provides the following food composition for preventing or treating periodontal disease and a method for preventing or treating periodontal disease.
  • a food composition for preventing periodontal disease or preventing progression of periodontal disease comprising an antibacterial plant extract and a highly soluble calcium salt.
  • the antibacterial plant extract is at least one selected from the group consisting of an oil-soluble licorice extract, a soybean isoflavonoid extract, and a tea polyphenol extract.
  • the food composition according to (1) is at least one selected from the group consisting of an oil-soluble licorice extract, a soybean isoflavonoid extract, and a tea polyphenol extract.
  • the highly soluble calcium salts are canolecum gluconate, canolecium lactate, canolecium chloride, calcium phosphate glyme, and calcium phosphate.
  • the food composition according to the above (1) wherein the highly soluble calcium salt is a mixed amorphous body of calcium gluconate and calcium lactate.
  • xylitol, paratinit, erythritol, maltitol, sorbitol, reduced starch sugar and reduced isomalt oligo The food composition according to the above (1), comprising at least one type of sugar alcohol selected from the group consisting of sugars.
  • At least one antibacterial plant extract selected from the group consisting of oil-soluble licorice extract, soybean isoflavonoid extract and tea polyphenol extract;
  • a highly soluble calcium salt which is a mixed amorphous form of cassolecum gluconate and canolexium lactate, and further contains calcium tertiary phosphate (8)
  • the present invention includes the following embodiments.
  • prevention of periodontal disease progression means to suppress or prevent progression of periodontal disease in the case of periodontal disease.
  • prevention of periodontal disease in the “method of preventing or treating periodontal disease” includes prevention of periodontal disease and prevention of progression of periodontal disease.
  • the food composition for preventing periodontal disease or preventing periodontal disease progression and the method for preventing or treating periodontal disease of the present invention will be described in more detail.
  • the antibacterial plant extract used in the food composition of the present invention is not particularly limited as long as it has antibacterial properties.
  • the antibacterial plant extract include licorice (plant name: Glitchi Liza Gravula, Glitchi Liza 'Inflata, Glitchi Liza Alara Reasis) Oil-soluble licorice extract extracted from coconut oil (containing antibacterial components: grab lysin, grabren, lycochalcone), tea polyphenol extract extracted from green tea (containing antibacterial components: Epigallocatechin Etc.), it is preferable to use an isoflavone extract extracted from soybean (containing antibacterial components: genistin, daidzein, genistin, daidzin).
  • the antibacterial plant extract may be used alone or in combination of two or more.
  • oil-soluble licorice extract and tea polyphenol extract oil-soluble licorice extract and soybean isoflavon extract
  • tea polyphenol Preference is given to a combination of an extract with a soybean isoflavone extract, an oil-soluble licorice extract, a tea polyphenol extract and a soybean isoflavone extract.
  • an oil-soluble licorice extract and a soybean isoflavone extract, or a combination of a tea polyphenol extract and a soybean isoflavone extract are preferred.
  • the content of the plant extract is not particularly limited as long as the desired effects of the present invention can be obtained, but the dry weight of the extract is 0.0 based on the total amount of the composition. It is preferable that the content be about 0.05 to 10% by weight, particularly about 0.05 to 1% by weight.
  • the oil-soluble licorice extract for example, those obtained by using the method described in Japanese Patent Application Laid-Open No. 4-164021 can be used. According to the method, the oil-soluble licorice extract can be used. Licorice or its congeners, or preferably its roots, are converted to organic solvents (e.g., methanol, ethanol, acetate, ethyl acetate, chloroform). Can be obtained by extraction using a mouth form. Either raw or dried licorice root may be used as an extraction raw material.
  • organic solvents e.g., methanol, ethanol, acetate, ethyl acetate, chloroform
  • the content of the oil-soluble licorice extract as an antibacterial plant extract is not particularly limited as long as a desired effect can be obtained.
  • the dry weight of the extract is preferably about 0.0005 to 10% by weight, particularly about 0.005 to 5% by weight, based on the total amount of the substance.
  • Soybean isoflavone extract is derived from soybean (Glycine max Merrill) seeds and hypocotyls, a leguminous plant (Legufflinosae), and is an active ingredient with antibacterial activity. It contains glycine, daidzein, and glycosides of these isoflavones (genistin, daidzin).
  • the soybean isoflavone extract can be obtained as a glycoside by a general method described in, for example, JP-A-62-126186. It is preferable to use the soybean isoflavone extract obtained by the above method.
  • the extract obtained according to the method can be subjected to the method described in JP-A-1-258669, or to an acid heating or / S-glutamine at the purification stage. Lonida By hydrolyzing with an enzyme, isoflavone glycosides contained in the extract are hydrolyzed, and those with an increased content of genistein and daidzein are blended. Is also good.
  • soybean isoflavone extract is often extracted together with soybean-derived soybean protein, and a mixture of these is added to the composition of the present invention. It is also possible.
  • the amount of the soybean isoflavone extract used in the composition of the present invention is not particularly limited as long as the intended effect of the present invention can be obtained. Based on this, it is preferable that the dry weight of the extract be about 0.001 to 10% by weight, particularly about 0.01 to 1% by weight.
  • the raw material for the tea polyphenol extract is appropriately selected from green tea, oolong tea, black tea, puar tea, etc., including commonly consumed tea (Camellia sinensis). be able to.
  • the tea polyphenol extract contains epigallocatechins, epicatechins, and gallocatechins as antibacterial active ingredients. These tea polyphenol extracts are described in, for example, Japanese Patent Application Laid-Open Nos.
  • tea polyolefin extract as described in the above publication is used as a food material by Mitsui Norin Co., Ltd. (trade name: polyfininone) or Taiyo Chemical Co., Ltd. Name; Sanfuenon) and is available.
  • these commercially available food materials can be used as they are as a tea polyphenol extract.
  • the amount of tea polyphenol extract used is not particularly limited as long as the desired effects of the present invention can be obtained, but the total amount of the composition of the present invention is not limited.
  • the dry weight of the extract is preferably about 0.01 to 1% by weight, particularly about 0.01 to 0.5% by weight.
  • the compounding ratio thereof is 1: 100 to 100: 1: (Weight ratio) is preferable, and when the tea polyphenol extract and the soybean isoflavone extract are combined, the compounding ratio is preferably used. Is preferably 1: 1 to 100: 1 (weight ratio).
  • Highly soluble calcium salt used in the food composition of the present invention The calcium salt is not limited as long as it has a relatively high solubility in water and can achieve the intended effect of the present invention.
  • the highly soluble calcium salt is, for example, a canoledium salt having a dissolution concentration of about 2 mg Z ml or more as a pure caneolidium in an aqueous solution in the oral and salivary pH range. This is preferred.
  • the pH range of oral saliva is usually about 6.5 to 8.0, but may vary depending on the health condition of the individual, and may be outside the above range.
  • the highly soluble calcium salt used in the present invention include canolecium gluconate, canolecium lactate, caneoleum caneoleum, cane calcium phosphate, glycemic calcium phosphate, and .
  • Examples of the highly soluble calcium salt according to the present invention include a dalconic acid solution, a lactic acid solution, and a hydrochloric acid solution.
  • a highly soluble calcium salt mixture amorphous body obtained by drying a supersaturated solution of salt by a conventional method such as oven drying, freeze drying, spray drying, etc. Including.
  • Amorphous form of such a mixture of highly soluble calcium salts As an example, a mixed amorphous body of canolecitrum gluconate and canolecimate lactate can be preferably used.
  • Calcium dalconate.Amorphous calcium lactate is commercially available under the trade name Gurkinal from Axonobel Co., Ltd., and the commercially available product is used in the composition of the present invention. It may be.
  • the mixing ratio of calcium gluconate and calcium lactate in the amorphous is as follows: Although not particularly limited, it is desirable that the weight ratio be within the range of 9: 1 force and 3: 7.
  • the highly soluble calcium salt of the present invention includes a calcium salt having high solubility as exemplified above and another calcium salt having low water solubility (for example, canola tertiary phosphate). , Canedium carbonate, calcium citrate, etc.).
  • the calcium salt may be a synthesized one or a naturally-occurring one (such as an animal bone).
  • bovine bone meal can be used as calcium tertiary phosphate.
  • the content of the calcium salt having high solubility in such a mixture is not particularly limited as long as the intended effect of the present invention can be obtained, but is preferably about 20% by weight.
  • the amount of the highly soluble calcium salt used in the composition of the present invention may be about 1 to 50% by weight, especially about 5 to 25% by weight, based on the total amount of the composition. I like it.
  • the mixing ratio of the antibacterial plant extract and the highly soluble calcium salt is not particularly limited as long as the intended purpose of the present invention can be achieved.
  • the effect of preventing or treating periodontal disease is most excellent. Yes, especially preferred.
  • the food composition of the present invention may contain additives or food materials usually contained in food compositions, for example, pH adjustment.
  • An agent, an organic acid, a sugar alcohol, a sweetener, a flavor, a bone metabolism vitamin, a bone resorption suppressing material, a plaque formation suppressing material, a bad breath suppressing material, and the like can be appropriately combined.
  • additives or food materials include phosphate, linoleic acid, citric acid, lactic acid, pantotinic acid, xylitol, , 0 Latinit, No, 0 Latinose, Erythritol, Maltitol, Sorbitol, Reduced Starch Sugar, Reduced Isomalto Oligosaccharide, etc. Saccharified or sugar alcohols, gum base, gum arabic, gelatin, cetyl methylcellulose, saccharinnatrium, ashha.
  • Luteme Ste A-phosphate magnesiate c arm, granular over sugar, powdered sugar, starch syrup, microcrystalline cell Le b over scan, 1 - e n t Lumpur, bi- data Mi emission D group such as a bicycloalkyl data Mi emission D 3,
  • Examples include vitamin K group such as vitamin K, vitamin P, lysine, magnesium salt, calcitonin, ipriflavone and the like.
  • sugar alcohols include xylitol, quinone, ⁇ latinit, erythritol and manoleci. Preference is given to the use of tonore, sonoreto tonore, reduced starch sugar and reduced isomalt oligosaccharide.
  • sugar alcohol improves the solubility of calcium salts, it is expected to increase the retention of antibacterial plant extracts in the oral cavity and the intestinal absorption of calcium after swallowing. I like it.
  • vitamin D 3 is added to vitamin D 3 and vitamin D 3
  • K Kasoreshtonin
  • a pre-flavon it is preferable to use K, Kasoreshtonin, or a pre-flavon.
  • the use amount of these additives is not particularly limited, and can be appropriately selected according to the purpose of use.
  • the composition of the present invention is applied to the oral cavity, and the antibacterial plant extract can adhere to the cervix when ingested. Even after the ingestion, the antibacterial plant extract can be applied to the cervix. Adheres to the surface
  • the form is not limited as long as it can be performed. For example, by chewing or licking in the mouth at the time of ingestion, the ingredients (antibacterial plant extract and highly soluble calcium salt) are dissolved and dispersed in the oral cavity, and the antibacterial plant extract is added to the cervix. That can adhere to the surface of the part.
  • the antibacterial plant extract may be adhered to the cervical surface for a sufficient time so that the antibacterial plant extract exerts antibacterial properties.
  • the food composition of the present invention may be in such a form that all of the components of the composition are swallowed after ingestion from the oral cavity, and a part of the components, particularly, antibacterial plant extracts and Components other than highly soluble calcium salts may be in a form that prevents swallowing o
  • composition of the present invention comprises troches, lozenges, chewable tablets, granule capsules, granules, chewing gum, candies, gummy candies, wafers, biscuits. It can be prepared in the form of foods such as pits.
  • the food composition of the present invention is prepared by using an antibacterial plant extract and a highly soluble calcium salt together with the above-mentioned additives, food materials, edible carriers and the like, according to a conventional method in each food form. It can be.
  • the intake of the food composition of the present invention depends on the age of the human to be ingested, It can be appropriately determined according to body weight, gender, purpose, etc., and is not particularly limited. Usually, the weight of a food composition is 0.01 to 1 day; about LOO g; ⁇ ; LO g is preferable.
  • the food composition of the present invention is divided into 2 to 5 times a day and taken after or between meals.
  • a food containing an antibacterial plant extract and a food containing a highly soluble calcium salt may be separately prepared, and these foods may be ingested simultaneously.
  • the same effect as when a food composition containing an antibacterial plant extract and a highly soluble calcium salt is ingested can be obtained.
  • the amount of intake depends on the age, weight, sex, purpose, etc. of the human to be ingested. Can be determined as appropriate, and can be the same as a food containing these two components.
  • the antibacterial plant extract easily adheres to the cervix when ingested from the oral cavity, and the duration of the antibacterial activity is long. Therefore, the composition of the present invention can more effectively suppress the growth of periodontal pathogenic bacteria as compared to the case where the antibacterial plant extract is taken alone.
  • the long-lasting antibacterial activity allows the highly soluble calcium swallowed to be swallowed. A better alveolar bone strengthening action can be expected from the salt.
  • the antibacterial component to be incorporated in the present invention is derived from a plant.
  • an antibacterial active plant extract such as an oil-soluble licorice extract, a soybean isoflavone extract, or a tea polyolefin extract is used. Has been ingested as a crude drug or food for a long time, and can be taken for a long period of time without worry.
  • oil-soluble licorice extract soy isoflavone extract or tea polyphenol extract as antibacterial plant extracts, and as highly soluble calcium salts, canolecitrum gluconate 'calcium lactate Amorphous or calcium gluconate 'A mixture of amorphous calcium lactate and calcium tertiary phosphate, mixed with other food ingredients as shown in Table 1
  • the tubes were prepared according to a conventional method.
  • rewritable tablets were prepared in the same manner as in the examples using only the antibacterial plant extract.
  • Comparative Example A2 In place of the soluble calcium salt, calcium tertiary phosphate, which is a low-soluble calcium salt, was used, and other food materials were blended as shown in Table 1 and the results are shown in Table 1. In the same manner, a chewable tablet was prepared.
  • lubricants magnesium stearate or sugar ester
  • gum arabic gum arabic
  • each of the tea burtablets obtained in the above Examples and Comparative Examples was placed in 7.1 lml of artificial saliva (component composition: 0.21% phosphate buffer (pH 7.0)). Solution containing 0.06% of calcium phosphate, 0.24% of potassium chloride, 0.09% of potassium sulfate, and 0.5% of albumin), followed by stirring and disintegration. Then, the mixture was stirred with a rotary stir bar at 37 ° C for 30 minutes to obtain a dispersion solution. Then, under the condition of 37 ° C, a hydroxya tight disc (13 mm in diameter and 2 mm in thickness; hereafter referred to as “ ⁇ ⁇ ⁇ ⁇ disc”) is used in the dispersion solution.
  • ⁇ ⁇ ⁇ ⁇ disc hydroxya tight disc
  • Comparative Examples Al, B, Ji which consist only of antibacterial plant extracts, and furthermore, canolesum phosphate, calcium phosphate calcium, calcium dalconate, calcium lactate amorphous Body
  • Examples 1 to 9 in which a mixture of calcium gluconate / calcium lactate amorphous and other food materials were blended, the antibacterial plant extract of the example was applied to the HAP disc surface.
  • Examples 1 to 5 are higher than Comparative Example A1
  • Examples 6 to 7 are higher than Comparative Example B
  • Examples 8 to 9 are higher than Comparative Example C. This can be seen from the results shown in Fig. 1.
  • Comparative Example A2 in which calcium tertiary phosphate, which is a low-solubility calcium salt, was added, such an effect of increasing the amount of adhesion was not observed.
  • Test example 2 in which calcium tertiary phosphate, which is a low-solubility calcium salt, was added, such an effect of increasing the amount of adhesion was not observed.
  • Soybean isoflavone Soybean isoflavone Composition of components Extract (0.05% concentration) Extract (0.05X concentration) Oil solubility: / 'Bau extract Oil-soluble persimmon' plant ⁇ extract (0.053 ⁇ 4 concentration) (0.053 ⁇ 4 ⁇ concentration) concentration)
  • the second group in which only calcium dalconate and calcium lactate were added to tap water, compared with the first group, in which only tap water was ingested, had alveolar bone resorption distance and M2 cervical black. The area was not reduced, and there was no effect of ingesting calcium gluconate / calcium lactate amorphous material.
  • This effect is considered to be the result of the highly soluble calcium salt increasing the adhesion of the antibacterial plant extract to the tooth surface in the oral cavity and increasing the effect of preventing the deposition of periodontopathogenic plaque.
  • the adhesiveness of the antibacterial plant extract is enhanced and the antibacterial property is maintained, thereby enhancing the alveolar bone strengthening effect of the highly soluble calcium salt absorbed in the intestinal tract. .
  • formulation examples of the food composition of the present invention are shown.
  • the following examples are provided for illustrating the present invention, and the present invention is not limited to these examples.
  • the examples shown below are manufactured by a conventional method in each dosage form.
  • Formulation example 10 (granules)
  • Granules containing a highly soluble calcium salt and an antibacterial plant extract were prepared according to the following formulation.
  • a chewable tablet containing a highly soluble calcium salt and an antibacterial plant extract was prepared according to the following formula.
  • a chewable tablet containing a highly soluble calcium salt and an antibacterial plant extract was prepared according to the following formula.
  • Chewing gum containing highly soluble calcium and an antibacterial plant extract was prepared according to the following formula.
  • a chewing gum containing a highly soluble calcium salt and an antibacterial plant extract was prepared according to the following formula.
  • Calcium gluconate 500 0 0 Soybean isoflavone extract 0 0 0 Tea polyphenol extract 0 0 5 0 Vitamin D 3 0 0 0 2 Gum base 2 0 0 0 0 Manorechi Tonore 54.8 8 4 8 No. Latinite 100.000 Reduced starch decomposed product 500.000 Glycerin 300.000 Perfume 0.100 Aspartame 0.1.00 Total 0.000.0 parts by weight Formulation example 1 5
  • a candy containing a highly soluble calcium salt and an antibacterial plant extract was prepared according to the following formula.
  • the canone gluconate / calcium lactate amorphous, xylitol, oil-soluble licorice extract, tea polyphenol extract, and powdered flavor are in the form of candies in powder form. Formulated in one center.
  • a candy containing a highly soluble calcium salt and an antibacterial plant extract was prepared according to the following formula.
  • a troche-type tablet containing highly soluble calcium salt and an antibacterial plant extract was prepared.
  • Aqueous calcium citrate, calcium ruconate (1 9) 20.000 Calcium tertiary phosphate 30.0.000 Extract from soybean isoflavones 1.0 0 0 Vitamin D 3 0. 0 0 2 Para Hee Tsu door 2 3. 8 6 8 steer Li Nsanma Gune Siu-time 0 0 0 co-core Nono 0 ⁇ da one 4 0 0 0 ⁇ scan Bruno,. Luteme 0 0 3 0 Fragrance 0.10 0 0 Total 1 0 0 0 0 0 Parts by weight

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  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne des compositions alimentaires destinées à prévenir la parodontose ou la progression de la parodontose, lesquelles compositions renferment des extraits végétaux antibactériens et un sel de calcium très soluble. L'invention concerne également une méthode de prévention ou de traitement de la parodontose par administration de ces compositions. Ces compositions et cette méthode sont sans danger et trouvent une utilisation pratique.
PCT/JP1999/000981 1998-03-04 1999-03-01 Compositions alimentaires pour prevenir la parodontose ou la progression de la parodontose et methode de prevention et de traitement de la parodontose Ceased WO1999044440A1 (fr)

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Application Number Priority Date Filing Date Title
JP05235598A JP3648587B2 (ja) 1998-03-04 1998-03-04 歯周病予防又は歯周病進行予防食品組成物
JP10/52355 1998-03-04

Publications (1)

Publication Number Publication Date
WO1999044440A1 true WO1999044440A1 (fr) 1999-09-10

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PCT/JP1999/000981 Ceased WO1999044440A1 (fr) 1998-03-04 1999-03-01 Compositions alimentaires pour prevenir la parodontose ou la progression de la parodontose et methode de prevention et de traitement de la parodontose

Country Status (2)

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JP (1) JP3648587B2 (fr)
WO (1) WO1999044440A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080946A1 (fr) * 2001-04-02 2002-10-17 Wakamoto Pharmaceutical Co.,Ltd. Compositions servant a prevenir et/ou a traiter les maladies orales
US6703000B2 (en) 2001-05-15 2004-03-09 The Procter & Gamble Co. Confectionery compositions
US6706256B2 (en) 2001-05-15 2004-03-16 The Procter & Gamble Co. Oral care compositions
WO2005023210A1 (fr) * 2003-09-05 2005-03-17 Kabushiki Kaisha Sangi Agent, composition orale, aliment et boisson favorisant la recalcification
WO2005092327A1 (fr) * 2004-03-26 2005-10-06 Asahi Breweries, Ltd. Agent de protection du ligament alveolo-dentaire
CN102696728A (zh) * 2012-05-31 2012-10-03 马健 一种绿茶饼干的制作方法
RU2763343C1 (ru) * 2020-09-15 2021-12-28 федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России) Профилактическая карамель, улучшающая реминерализующий потенциал ротовой жидкости

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JP4886107B2 (ja) * 2000-10-13 2012-02-29 サンスター株式会社 歯周病予防用口腔内溶解錠
JP2002121146A (ja) * 2000-10-13 2002-04-23 Sunstar Inc 歯周病予防用製剤
TWI329516B (en) * 2000-12-12 2010-09-01 Kaneka Corp Composition for preventing or ameliorating multiple risk factor syndromes and visceral fat-type obesity
EP1440688A4 (fr) * 2001-10-11 2005-11-30 Kaneka Corp Ligands de recepteurs actives par le proliferateur de peroxisome et procede de fabrication correspondant
EP1669080B1 (fr) 2003-09-19 2012-08-01 Sunstar Inc. Procede d'inhibition de resorption alveolaire et de perte de la membrane parodontale et composition a usage interne de mise en oeuvre
JP4757475B2 (ja) * 2004-10-22 2011-08-24 日本ゼトック株式会社 口腔用組成物
DE102005040423A1 (de) * 2005-08-25 2007-03-01 Lahrsow, Jobst, Dr. med. dent. Nahrungsmittelzusatz zur Versorgung mit Mineralstoffen
JP5772169B2 (ja) * 2010-04-16 2015-09-02 大正製薬株式会社 イプリフラボン含有直打錠剤
US9877929B2 (en) 2011-10-13 2018-01-30 Premier Dental Products Company Topical vitamin D and ubiquinol oral supplement compositions
US9877930B2 (en) 2012-10-12 2018-01-30 Premier Dental Products Company Topical ubiquinol oral supplement compositions with amorphous calcium phosphate
CN104902906A (zh) * 2012-10-12 2015-09-09 第一牙科产品公司 局部用的维生素d和泛醇口腔补充组合物
JP6075345B2 (ja) * 2014-09-24 2017-02-08 株式会社東洋新薬 コンドロイチン製剤
JP2018104302A (ja) * 2016-12-22 2018-07-05 花王株式会社 歯磨剤用顆粒の製造方法
WO2025004662A1 (fr) * 2023-06-29 2025-01-02 サンスター株式会社 Composition pour activer les mitochondries

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JPH0881367A (ja) * 1994-09-16 1996-03-26 Nissui Pharm Co Ltd 高濃度カルシウム含有液剤
JPH0881380A (ja) * 1994-09-09 1996-03-26 Suntory Ltd 高分子量ポリフェノールを有効成分として含有する抗歯周病剤並びに抗歯周病性食品
JPH09107918A (ja) * 1995-10-20 1997-04-28 Natl Food Res Inst 飲食物の製造法
JPH09143042A (ja) * 1995-11-24 1997-06-03 Lion Corp 口腔用組成物
JPH10108648A (ja) * 1996-10-02 1998-04-28 Advance Co Ltd 抗う蝕抗歯周病滞留性食品添加物並びに口腔組成物

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JPS63179823A (ja) * 1987-01-19 1988-07-23 Sunstar Inc 歯周疾患治療用外用剤
JPH04283518A (ja) * 1991-03-12 1992-10-08 Kikkoman Corp 抗歯周症剤
JPH05944A (ja) * 1991-06-21 1993-01-08 Taiyo Kagaku Co Ltd 歯周病原因菌付着阻害用組成物
JPH0523153A (ja) * 1991-07-16 1993-02-02 Food Design Gijutsu Kenkyu Kumiai ハトムギエキスを含む飲食品または口腔用製品
JPH05276873A (ja) * 1992-04-02 1993-10-26 Fujimi Green Eng Kk 歯磨ガム
JPH07309733A (ja) * 1994-05-19 1995-11-28 Kanebo Ltd 口腔用組成物
JPH0881380A (ja) * 1994-09-09 1996-03-26 Suntory Ltd 高分子量ポリフェノールを有効成分として含有する抗歯周病剤並びに抗歯周病性食品
JPH0881367A (ja) * 1994-09-16 1996-03-26 Nissui Pharm Co Ltd 高濃度カルシウム含有液剤
JPH09107918A (ja) * 1995-10-20 1997-04-28 Natl Food Res Inst 飲食物の製造法
JPH09143042A (ja) * 1995-11-24 1997-06-03 Lion Corp 口腔用組成物
JPH10108648A (ja) * 1996-10-02 1998-04-28 Advance Co Ltd 抗う蝕抗歯周病滞留性食品添加物並びに口腔組成物

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002080946A1 (fr) * 2001-04-02 2002-10-17 Wakamoto Pharmaceutical Co.,Ltd. Compositions servant a prevenir et/ou a traiter les maladies orales
US6703000B2 (en) 2001-05-15 2004-03-09 The Procter & Gamble Co. Confectionery compositions
US6706256B2 (en) 2001-05-15 2004-03-16 The Procter & Gamble Co. Oral care compositions
WO2005023210A1 (fr) * 2003-09-05 2005-03-17 Kabushiki Kaisha Sangi Agent, composition orale, aliment et boisson favorisant la recalcification
WO2005092327A1 (fr) * 2004-03-26 2005-10-06 Asahi Breweries, Ltd. Agent de protection du ligament alveolo-dentaire
CN102696728A (zh) * 2012-05-31 2012-10-03 马健 一种绿茶饼干的制作方法
RU2763343C1 (ru) * 2020-09-15 2021-12-28 федеральное государственное бюджетное образовательное учреждение высшего образования "Тюменский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Тюменский ГМУ Минздрава России) Профилактическая карамель, улучшающая реминерализующий потенциал ротовой жидкости

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